| Name | uncoupling protein 2 |
|---|---|
| Synonyms | Mitochondrial uncoupling protein 2; SLC25A8; UCP 2; UCP2; UCPH; UPCH; Uncoupling protein 2; Uncoupling protein 2s |
| Name | carbon tetrachloride |
|---|---|
| CAS | tetrachloromethane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19056852 | Chen P, Li C, Pang W, Zhao Y, Dong W, Wang S, Zhang J: The protective role of Per2 against carbon tetrachloride-induced hepatotoxicity. Am J Pathol. 2009 Jan;174(1):63-70. Epub 2008 Dec 4. Here we report that Per2 plays a protective role in carbon tetrachloride (CCl (4))-induced hepatotoxicity via the modulation of uncoupling protein-2 (Ucp2) gene expression in mice. |
81(1,1,1,1) | Details |
| 19104935 | Wu Q, Gong D, Tian N, Zhu L, Guan L, Yang M, Yuan B, Qiu Q, Lv H, Zou Y: Protection of regenerating liver after partial hepatectomy from carbon tetrachloride hepatotoxicity in rats: roles of mitochondrial uncoupling protein 2 and ATP stores. Dig Dis Sci. 2009 Sep;54(9):1918-25. Epub 2008 Dec 23. |
7(0,0,1,2) | Details |
| 18314881 | Demori I, Burlando B, Gerdoni E, Lanni A, Fugassa E, Voci A: Uncoupling protein-2 induction in rat hepatocytes after acute carbon tetrachloride liver injury. J Cell Physiol. 2008 Aug;216(2):413-8. |
6(0,0,1,1) | Details |
| 15980055 | Fiorucci S, Rizzo G, Antonelli E, Renga B, Mencarelli A, Riccardi L, Morelli A, Pruzanski M, Pellicciari R: Cross-talk between farnesoid-X-receptor (FXR) and peroxisome proliferator-activated receptor gamma contributes to the antifibrotic activity of FXR ligands in rodent models of liver cirrhosis. J Pharmacol Exp Ther. 2005 Oct;315(1):58-68. Epub 2005 Jun 24. Here, we investigated whether FXR ligands regulate PPARgamma expression in HSCs and models of liver fibrosis induced in rats by porcine serum and carbon tetrachloride administration and bile duct ligation. Cotreatment with 6-ECDCA potentiates the antifibrotic activity of a PPARgamma ligand, in the porcine serum model as measured by morphometric analysis of liver collagen content, and liver expression of alpha1 (I) collagen mRNA, alpha-smooth muscle actin, fibronectin, TGFbeta1, and tissue inhibitor of metalloprotease 1 and 2, whereas it enhanced the expression of PPARgamma and uncoupling protein 2, a PPARgamma-regulated gene, by 2-fold. |
1(0,0,0,1) | Details |
| 20007753 | Yang P, Han Z, Chen P, Zhu L, Wang S, Hua Z, Zhang J: A contradictory role of A1 receptor in carbon tetrachloride- and bile duct ligation-induced liver fibrosis in mice. J Pharmacol Exp Ther. 2010 Mar;332(3):747-54. Epub 2009 Dec 10. Hepatocyte damage was reduced in A (1) AR (-/-) mice after a single injection of CCl (4), with down-regulation of CYP2E1 and UCP2 gene expression in livers, which resulted in impaired liver sensitivity to CCl (4). |
1(0,0,0,1) | Details |
| 17256749 | Donthamsetty S, Bhave VS, Mitra MS, Latendresse JR, Mehendale HM: Nonalcoholic fatty liver sensitizes rats to carbon tetrachloride hepatotoxicity. Hepatology. 2007 Feb;45(2):391-403. The hypothesis that fatty hepatocytes undergo cell cycle arrest due to (1) an inability to replenish ATP due to overexpressed uncoupling protein-2 (UCP-2) or (2) induction of growth inhibitor p21 leading to G1/S phase arrest was tested. |
1(0,0,0,1) | Details |