| Name | plasminogen |
|---|---|
| Synonyms | A; Apo(a); APOA2; Plasminogen; APOA 2; Angiostatin; Apolipoprotein A II; Microplasmin… |
| Name | carbon tetrachloride |
|---|---|
| CAS | tetrachloromethane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15452360 | Perez-Liz G, Flores-Hernandez J, Arias-Montano JA, Reyes-Esparza JA, Rodriguez-Fragoso L: Modulation of urokinase-type plasminogen activator by transforming growth factor beta1 in -activated hepatic stellate cells. Pharmacology. 2005 Jan;73(1):23-30. Epub 2004 Sep 27. Further studies on the molecular mechanisms responsible for the regulation of the plasminogen system by TGF-beta1 and other molecules in the presence of will contribute to a better understanding of the processes involved in fibrogenesis. |
1(0,0,0,1) | Details |
| 18761555 | Hu PF, Zhu YW, Zhong W, Chen YX, Lin Y, Zhang X, Yin C, Yue HY, Xie WF: Inhibition of plasminogen activator inhibitor-1 expression by siRNA in rat hepatic stellate cells. J Gastroenterol Hepatol. 2008 Dec;23(12):1917-25. Epub 2008 Aug 28. BACKGROUND AND AIM: The plasminogen activator/plasmin system is known to regulate the extracellular matrix turnover. |
1(0,0,0,1) | Details |
| 14716496 | Vogten JM, Drixler TA, te Velde EA, Schipper ME, van Vroonhoven TJ, Voest EE, Borel Rinkes IH: Angiostatin inhibits experimental liver fibrosis in mice. Int J Colorectal Dis. 2004 Jul;19(4):387-94. Epub 2004 Jan 10. Angiostatin mice received carbon tetrachloride for 5 weeks and angiostatin during weeks 4 and 5. |
12(0,0,1,7) | Details |
| 18685433 | Okada K, Ueshima S, Kawao N, Okamoto C, Matsuo K, Akao M, Seki T, Ariga T, Tanaka M, Matsuo O: Binding of plasminogen to hepatocytes isolated from injured mouse liver and nonparenchymal-cell-dependent proliferation of hepatocytes. Blood Coagul Fibrinolysis. 2008 Sep;19(6):503-11. |
9(0,0,0,9) | Details |
| 17134505 | Shanmukhappa K, Sabla GE, Degen JL, Bezerra JA: Urokinase-type plasminogen activator supports liver repair independent of its cellular receptor. BMC Gastroenterol. 2006 Nov 29;6:40. BACKGROUND: The urokinase-type (uPA) and tissue-type (tPA) plasminogen activators regulate liver matrix remodelling through the conversion of plasminogen (Plg) to the active protease plasmin. METHODS: To test this hypothesis, we administered one dose of carbon tetrachloride (CCl4) to mice with single or combined deficiencies of uPA, uPAR and tPA, and examined hepatic morphology, cellular proliferation, fibrin clearance, and hepatic proteolysis 2-14 days later. |
3(0,0,0,3) | Details |
| 17482686 | Kawao N, Okada K, Kawata S, Okamoto C, Tsuritani M, Ueshima S, Matsuo O: Plasmin decreases the BH3-only protein BimEL via the ERK1/2 signaling pathway in hepatocytes. Biochim Biophys Acta. 2007 Jun;1773(6):718-27. Epub 2007 Apr 1. Since the signal transduction mechanisms responsible for liver regeneration mediated by the plasminogen/plasmin system remain largely undetermined, we have investigated whether plasmin regulates the pro-apoptotic protein Bim (EL) in primary hepatocytes. |
3(0,0,0,3) | Details |
| 19386599 | Okumura N, Koh T, Hasebe Y, Seki T, Ariga T: A novel function of thrombin-activatable fibrinolysis inhibitor during rat liver regeneration and in growth-promoted hepatocytes in primary culture. J Biol Chem. 2009 Jun 12;284(24):16553-61. Epub 2009 Apr 22. Thrombin-activatable fibrinolysis inhibitor (TAFI) exhibits anti-fibrinolytic activity by removing C-terminal residues from fibrin or plasminogen receptor proteins on the cellular surface, and plays an important role in the regulation of fibrinolysis. In rat models, partial hepatectomy or carbon tetrachloride (CCl4)-induced acute liver injury suppressed the levels of plasma TAFI activity and hepatic TAFI mRNA, whereas this operation markedly increased both the hepatic plasmin activity and the level of proliferating cell nuclear antigen. |
2(0,0,0,2) | Details |
| 18279442 | Higazi AA, El-Haj M, Melhem A, Horani A, Pappo O, Alvarez CE, Muhanna N, Friedman SL, Safadi R: Immunomodulatory effects of plasminogen activators on hepatic fibrogenesis. Clin Exp Immunol. 2008 Apr;152(1):163-73. Epub 2008 Feb 14. We examined the potential immunomodulatory actions of uPA, tPA and uPA-receptor (uPAR) in carbon-tetrachloride-induced hepatic fibrosis in wild-type (WT), tPA-/-, uPA-/- and uPAR-/- mice. |
2(0,0,0,2) | Details |
| 19286661 | Shanmukhappa K, Matte U, Degen JL, Bezerra JA: Plasmin-mediated proteolysis is required for hepatocyte growth factor activation during liver repair. J Biol Chem. 2009 May 8;284(19):12917-23. Epub 2009 Mar 13. The physiological relevance of the activation of hepatocyte growth factor (Hgf) by the plasminogen (Plg) system of proteases and its contribution to tissue repair are largely undefined. |
1(0,0,0,1) | Details |
| 16006527 | Shanmukhappa K, Mourya R, Sabla GE, Degen JL, Bezerra JA: Hepatic to pancreatic switch defines a role for hemostatic factors in cellular plasticity in mice. Proc Natl Acad Sci U S A. 2005 Jul 19;102(29):10182-7. Epub 2005 Jul 8. In multiple systems, impaired proteolysis associated with the loss of the hemostatic factor plasminogen (Plg) results in fibrin-dependent defects in tissue repair. To this end, we generated biotinylated cRNA pools from livers of Plg (o) mice and controls before and after a single dose of the hepatotoxin carbon tetrachloride and hybridized them against high-density oligonucleotide arrays. |
1(0,0,0,1) | Details |