| Name | caspase 3 |
|---|---|
| Synonyms | Apopain; CASP 3; CASP3; CPP 32; CPP32; CPP32B; Caspase 3; Caspase 3 precursor… |
| Name | carbon tetrachloride |
|---|---|
| CAS | tetrachloromethane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17173083 | Wen T, Zhao JY, Mei S, Guan L, Zhang YL: [Protective effect of heme oxygenase-1 and its reaction product, on acute liver injury induced by carbon tetrachloride in rats]. Beijing Da Xue Xue Bao. 2006 Dec 18;38(6):618-22. RESULTS: The administration of carbon tetrachloride to rats caused a marked hepatic damage, characterized by significant elevation of serum ALT, AST levels (2 136.3+/-163.4 U, 1 422.7+/-221.7 U) and liver MDA content (5.28+/-0.93 micromol/g), caspase-3 activity (optical density value 4.69+/-1.02) and TNF-alpha level (256.3+/-27.3 ng/L) combined with a remarkable reduction in liver SOD activity (45.9+/-14.8 U/mg) as compared with the control rats. |
40(0,1,2,5) | Details |
| 18507761 | Yan C, Zhou L, Han YP: Contribution of hepatic stellate cells and matrix metalloproteinase 9 in acute liver failure. Liver Int. 2008 Aug;28(7):959-71. Epub 2008 May 27. METHODS: Mice were given lipopolysaccharide (LPS) and beta-galactosamine (GA) or carbon tetrachloride to create ALF and establish the association of IL-1, MMP-9, and caspase-3 in acute liver failure. |
8(0,0,1,3) | Details |
| 18042797 | Miyata E, Masuya M, Yoshida S, Nakamura S, Kato K, Sugimoto Y, Shibasaki T, Yamamura K, Ohishi K, Nishii K, Ishikawa F, Shiku H, Katayama N: Hematopoietic origin of hepatic stellate cells in the adult liver. . Blood. 2008 Feb 15;111(4):2427-35. Epub 2007 Nov 27. To test this hypothesis, we generated chimeric mice by transplantation of clonal populations of cells derived from single enhanced green fluorescent protein (EGFP)-marked Lin (-) Sca-1 (+) c-kit (+) CD34 (-) cells and examined the histology of liver tissues obtained from the chimeric mice with carbon tetrachloride (CCl (4))-induced injury. |
6(0,0,1,1) | Details |
| 17292878 | Park EJ, Zhao YZ, Kim YC, Sohn DH: Bakuchiol-induced caspase-3-dependent apoptosis occurs through c-Jun NH2-terminal kinase-mediated mitochondrial translocation of Bax in rat liver myofibroblasts. Eur J Pharmacol. 2007 Mar 22;559(2-3):115-23. Epub 2007 Jan 23. |
5(0,0,0,5) | Details |
| 18461658 | Perez R, Garcia-Fernandez M, Diaz-Sanchez M, Puche JE, Delgado G, Conchillo M, Muntane J, Castilla-Cortazar I: Mitochondrial protection by low doses of insulin-like growth factor- I in experimental cirrhosis. World J Gastroenterol. 2008 May 7;14(17):2731-9. Mitochondrial function was analyzed by flow cytometry in isolated hepatic mitochondria, caspase 3 activation was assessed by Western blot and apoptosis by TUNEL in the three experimental groups. |
3(0,0,0,3) | Details |
| 16038630 | Cai Y, Gong LK, Qi XM, Li XH, Ren J: Apoptosis initiated by carbon tetrachloride in mitochondria of rat primary cultured hepatocytes. Acta Pharmacol Sin. 2005 Aug;26(8):969-75. Caspase-3 activity was measured using the fluorogenic substrate Ac-DEVD-AMC. |
2(0,0,0,2) | Details |
| 16640835 | Lee TY, Chang HH, Wang GJ, Chiu JH, Yang YY, Lin HC: -soluble extract of Salvia miltiorrhiza ameliorates carbon tetrachloride-mediated hepatic apoptosis in rats. J Pharm Pharmacol. 2006 May;58(5):659-65. Hepatocyte DNA fragmentation and cytosolic caspase-3 and caspase-8 activity were determined in the experimental animals. |
2(0,0,0,2) | Details |
| 17879412 | Xue H, Guo H, Li YC, Hao ZM: Heme oxygenase-1 induction by hemin protects liver cells from ischemia/reperfusion injury in cirrhotic rats. World J Gastroenterol. 2007 Oct 28;13(40):5384-90. HO-1, NF-kappaB and caspase-3 expressions were assessed by immunohistochemical analysis. |
2(0,0,0,2) | Details |
| 17466404 | Anselmi K, Stolz DB, Nalesnik M, Watkins SC, Kamath R, Gandhi CR: Gliotoxin causes apoptosis and necrosis of rat Kupffer cells in vitro and in vivo in the absence of oxidative stress: exacerbation by caspase and serine protease inhibition. J Hepatol. 2007 Jul;47(1):103-13. Epub 2007 Apr 5. This effect was associated with mitochondrial cytochrome c release, caspase-3 activation and ATP depletion. |
2(0,0,0,2) | Details |
| 18270870 | Tran TT, Groben P, Pisetsky DS: The release of DNA into the plasma of mice following hepatic cell death by apoptosis and necrosis. Biomarkers. 2008 Mar;13(2):184-200. For this purpose, the effects of varying doses of anti-Fas, or carbon tetrachloride (CCl (4)) were assessed in normal mice. Plasma DNA was measured fluorometrically by the dye PicoGreen while lactate dehydrogenase (LDH) and caspase 3, other molecules released with cell injury or death, were measured by enzymatic assays. |
2(0,0,0,2) | Details |
| 18436364 | Lee KJ, Choi JH, Khanal T, Hwang YP, Chung YC, Jeong HG: Protective effect of phenethyl ester against carbon tetrachloride-induced hepatotoxicity in mice. Toxicology. 2008 Jun 3;248(1):18-24. Epub 2008 Mar 20. To determine whether the Fas/Fas ligand (FasL) pathway is involved in CCl (4)-induced acute liver injury, Fas and FasL proteins and caspase-3 and -8 activities were tested by western blotting and ELISA. |
2(0,0,0,2) | Details |
| 18291569 | Lee KJ, Choi JH, Kim HG, Han EH, Hwang YP, Lee YC, Chung YC, Jeong HG: Protective effect of saponins derived from the roots of Platycodon grandiflorum against carbon tetrachloride induced hepatotoxicity in mice. Food Chem Toxicol. 2008 May;46(5):1778-85. Epub 2008 Jan 18. To determine whether Fas/Fas ligand (FasL) pathway involved in CCl (4)-induced acute liver injury, Fas and FasL proteins and caspase-3, -8 activities were tested by western blotting and ELISA. |
2(0,0,0,2) | Details |
| 19114984 | Liu Y, Lui EL, Friedman SL, Li L, Ye T, Chen Y, Poon RT, Wo J, Kok TW, Fan ST: PTK787/ZK22258 attenuates stellate cell activation and hepatic fibrosis in vivo by inhibiting VEGF signaling. Lab Invest. 2009 Feb;89(2):209-21. Epub 2008 Dec 29. PTK/ZK-induced apoptosis of HSCs, which was correlated with increased caspase-3 activation and suppressed Bcl-2 expression. In a murine fibrotic liver, PTK/ZK attenuated collagen deposition and alpha-SMA expression in carbon tetrachloride-induced fibrosis in both a 'prevention' and 'treatment' dosing scheme. |
1(0,0,0,1) | Details |
| 17761835 | Ikeda H, Kume Y, Tejima K, Tomiya T, Nishikawa T, Watanabe N, Ohtomo N, Arai M, Arai C, Omata M, Fujiwara K, Yatomi Y: Rho-kinase inhibitor prevents hepatocyte damage in acute liver injury induced by carbon tetrachloride in rats. Am J Physiol Gastrointest Liver Physiol. 2007 Oct;293(4):G911-7. Epub 2007 Aug 30. In cultured rat hepatocytes in serum-free condition, HA-1077 reduced apoptosis evaluated by quantitative determination of cytoplasmic histone-associated DNA oligonucleosome fragments with the reduction of caspase-3 activity and the enhancement of Bcl-2 expression. |
1(0,0,0,1) | Details |
| 17244260 | Wu ZM, Wen T, Tan YF, Liu Y, Ren F, Wu H: Effects of salvianolic acid a on oxidative stress and liver injury induced by carbon tetrachloride in rats. Basic Clin Pharmacol Toxicol. 2007 Feb;100(2):115-20. In addition, salvianolic acid A treatment remarkably reduced intrahepatic tumour necrosis factor-alpha concentrations and caspase-3 activities as compared with the CCl (4)-treated rats. |
1(0,0,0,1) | Details |
| 17069927 | Guyot C, Combe C, Balabaud C, Bioulac-Sage P, Desmouliere A: Fibrogenic cell fate during fibrotic tissue remodelling observed in rat and human cultured liver slices. J Hepatol. 2007 Jan;46(1):142-50. Epub 2006 Oct 4. METHODS: Fibrosis was induced in rats by carbon tetrachloride (CCl4) treatment or bile duct ligation. PCLS were cultured for 6, 24, 48, or 72 h, and the expression of alpha-smooth muscle (SM) actin, platelet-derived growth factor (PDGF) receptor-beta, and active caspase 3 was studied by immunohistochemistry. |
1(0,0,0,1) | Details |
| 19069843 | Priya S, Sudhakaran PR: -induced recovery from hepatic injury involves induction of apoptosis of activated hepatic stellate cells. Indian J Biochem Biophys. 2008 Oct;45(5):317-25. Induction of apoptosis in vivo during hepatic recovery was also suggested by increase in caspase-3 activity. |
1(0,0,0,1) | Details |
| 18627004 | Hannivoort RA, Dunning S, Vander Borght S, Schroyen B, Woudenberg J, Oakley F, Buist-Homan M, van den Heuvel FA, Geuken M, Geerts A, Roskams T, Faber KN, Moshage H: Multidrug resistance-associated proteins are crucial for the viability of activated rat hepatic stellate cells. Hepatology. 2008 Aug;48(2):624-34. Apoptosis was determined by activated caspase-3 and acridine orange staining, and necrosis was determined by Sytox green nuclear staining. An in vivo model of carbon tetrachloride (CCl (4))-induced liver fibrosis was used. |
1(0,0,0,1) | Details |
| 17482686 | Kawao N, Okada K, Kawata S, Okamoto C, Tsuritani M, Ueshima S, Matsuo O: Plasmin decreases the BH3-only protein BimEL via the ERK1/2 signaling pathway in hepatocytes. Biochim Biophys Acta. 2007 Jun;1773(6):718-27. Epub 2007 Apr 1. Plasmin temporally decreased the starvation-induced expression of Bim (EL) and activation of caspase-3 via the ERK1/2 signaling pathway, resulting in an enhancement of cell survival. |
1(0,0,0,1) | Details |
| 18381592 | Park TJ, Jeong BR, Tateno C, Kim HS, Ogawa T, Lim IK, Yoshizato K: Pleiotrophin inhibits transforming growth factor beta1-induced apoptosis in hepatoma cell lines. Mol Carcinog. 2008 Oct;47(10):784-96. The TGFbeta1-induced caspase-3 activation was also suppressed in Huh-7 and FaO cells both transduced with PTN gene-bearing adenoviruses. First, we confirmed that hepatic stellate cells (HSCs) and Kupffer cells, and also later hepatocytes in hyperplastic nodules increased PTN mRNA expressions during carbon tetrachloride-induced liver fibrosis. |
1(0,0,0,1) | Details |
| 20097184 | Kim TH, Kim YW, Shin SM, Kim CW, Yu IJ, Kim SG: Synergistic hepatotoxicity of N,N-dimethylformamide with carbon tetrachloride in association with endoplasmic reticulum stress. Chem Biol Interact. 2010 Mar 30;184(3):492-501. Epub 2010 Jan 25. Moreover, DMF+CCl (4) caused PARP cleavage and caspase-3 activation, but decreased the level of Bcl-xL, all of which confirmed apoptosis of hepatocytes. |
1(0,0,0,1) | Details |
| 19034626 | Yen FL, Wu TH, Lin LT, Cham TM, Lin CC: -loaded nanoparticles improve the physicochemical properties and the hepatoprotective effects of in orally-administered rats with CCl (4)-induced acute liver failure. Pharm Res. 2009 Apr;26(4):893-902. Epub 2008 Nov 25. In addition, to evaluate its bioactivities and its oral treatment potential against liver injuries, we compared the hepatoprotective, antioxidant, and antiapoptotic effects of NARN and NAR on carbon tetrachloride (CCl (4))-induced hepatotoxicity in rats. Moreover, NARN was able to significantly inhibit the activation of caspase-3, -8, and -9 signaling, whereas NAR only markedly inhibited caspase-3 and -9 (P < 0.05). |
1(0,0,0,1) | Details |