| Name | matrix metalloproteinase 13 |
|---|---|
| Synonyms | CLG 3; CLG3; Collagenase 3; Collagenase 3 precursor; Collagenase 3 deletion variant COL3 DEL; Collagenase 3 splice variant COL3 9B 2; MMP 13; MMP13… |
| Name | carbon tetrachloride |
|---|---|
| CAS | tetrachloromethane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17404313 | Fallowfield JA, Mizuno M, Kendall TJ, Constandinou CM, Benyon RC, Duffield JS, Iredale JP: Scar-associated macrophages are a major source of hepatic matrix metalloproteinase-13 and facilitate the resolution of murine hepatic fibrosis. J Immunol. 2007 Apr 15;178(8):5288-95. |
6(0,0,0,6) | Details |
| 16332368 | Garciade Leon Mdel C, Montfort I, Tello Montes E, Lopez Vancell R, Olivos Garcia A, Gonzalez Canto A, Nequiz-Avendano M, Perez-Tamayo R: Hepatocyte production of modulators of extracellular liver matrix in normal and cirrhotic rat liver. Hepatology. 2007 Jan;45(1):213-22. In addition, we clearly detected the messenger ribonucleic acids (mRNA) of four matrix metalloproteinases (MMP-2, MMP-3, MMP-10, and MMP-13) and of two tissue inhibitors of matrix metalloproteinases (TIMP-1 and TIMP-2) in hepatocytes from both normal and cirrhotic rats by RT-PCR and by in situ hybridization. |
2(0,0,0,2) | Details |
| 17485851 | Fang HL, Lai JJ, Lin WL, Lin WC: A fermented substance from Aspergillus phoenicis reduces liver fibrosis induced by carbon tetrachloride in rats. Biosci Biotechnol Biochem. 2007 May;71(5):1154-61. Epub 2007 May 7. Real-time quantitative reverse transcriptase-polymerase chain reaction (RT-qPCR) analysis showed that FSAP treatment increased the expression of matrix metalloproteinase 13 and decreased the expression of adenosyltransferase 2A, collagen (alpha1)(I), collagen (alpha1)(III), transforming growth factor-beta1, and tissue inhibitor of metalloproteinase 1. |
1(0,0,0,1) | Details |
| 20178458 | Rabani V, Shahsavani M, Gharavi M, Piryaei A, Azhdari Z, Baharvand H: Mesenchymal stem cell infusion therapy in carbon tetrachloride-induced liver fibrosis model affects matrix metalloproteinase expression. Cell Biol Int. 2010 Feb 23. Quantitative RT-PCR analysis showed administration of MSCs has a significant antifibrotic effect as evidenced by the decrease in expression of liver collagen and increase in matrix metalloproteinase 13 (MMP13) in the CCl4/MSC group when compared to the CCl4 group, four weeks after transplantation. |
1(0,0,0,1) | Details |
| 18395095 | Strnad P, Tao GZ, Zhou Q, Harada M, Toivola DM, Brunt EM, Omary MB: Keratin mutation predisposes to mouse liver fibrosis and unmasks differential effects of the carbon tetrachloride and thioacetamide models. Gastroenterology. 2008 Apr;134(4):1169-79. Epub 2008 Jan 18. In contrast, thioacetamide caused more severe liver injury and fibrosis in K18 R89C as compared with WT and nontransgenic mice and resulted in increased messenger RNA levels of collagen, tissue inhibitor of metalloproteinase 1, matrix metalloproteinase 2, and matrix metalloproteinase 13. |
1(0,0,0,1) | Details |
| 17157831 | Wills PJ, Asha VV: Protective mechanism of Lygodium flexuosum extract in treating and preventing carbon tetrachloride induced hepatic fibrosis in rats. Chem Biol Interact. 2007 Jan 5;165(1):76-85. Epub 2006 Nov 2. The increased levels of matrix metalloproteinase-13 in extract treated rats were indicative of the protective action of L. flexuosum n-hexane extract. |
1(0,0,0,1) | Details |
| 15963578 | Krasnov A, Koskinen H, Rexroad C, Afanasyev S, Molsa H, Oikari A: Transcriptome responses to carbon tetrachloride and pyrene in the kidney and liver of juvenile rainbow trout (Oncorhynchus mykiss). Aquat Toxicol. 2005 Aug 15;74(1):70-81. Pyrene and CCl (4) caused opposite effects on expression of several genes, including HSP-27, macrophage receptor Marco, metalloproteinases (MMP9 and MMP13), and delta-6 fatty acid desaturase. |
1(0,0,0,1) | Details |
| 19359521 | Mitchell C, Couton D, Couty JP, Anson M, Crain AM, Bizet V, Renia L, Pol S, Mallet V, Gilgenkrantz H: Dual role of CCR2 in the constitution and the resolution of liver fibrosis in mice. Am J Pathol. 2009 May;174(5):1766-75. Epub 2009 Apr 9. The persistence of hepatic injury in mutant animals was correlated with sustained tissue inhibitor of metalloproteinase-1 mRNA expression levels and a reduction in matrix metalloproteinase-2 and matrix metalloproteinase-13 expression levels. |
1(0,0,0,1) | Details |
| 17976157 | Hagiwara S, Otsuka T, Yamazaki Y, Kosone T, Sohara N, Ichikawa T, Sato K, Kakizaki S, Takagi H, Mori M: Overexpression of NK2 promotes liver fibrosis in carbon tetrachloride-induced chronic liver injury. Liver Int. 2008 Jan;28(1):126-31. Epub 2007 Nov 1. Expression levels of mRNAs of transforming growth factor-beta1 (TGF-beta1) and matrix metalloproteinase-13 (MMP-13) were examined by real-time polymerase chain reaction. |
1(0,0,0,1) | Details |
| 19250650 | Urtasun R, Cubero FJ, Vera M, Nieto N: Reactive species switch on early extracellular matrix remodeling via induction of MMP1 and TNFalpha. Gastroenterology. 2009 Apr;136(4):1410-22 SIN-1 or ONOO- increased nitrosylation of MMP1/MMP13 and transactivation of the MMP1, MMP13, and TNFalpha promoters. |
1(0,0,0,1) | Details |
| 17187438 | Higashiyama R, Inagaki Y, Hong YY, Kushida M, Nakao S, Niioka M, Watanabe T, Okano H, Matsuzaki Y, Shiota G, Okazaki I: Bone marrow-derived cells express matrix metalloproteinases and contribute to regression of liver fibrosis in mice. e1-4. Epub 2009 Jan 6. To reveal the contribution of bone marrow (BM)-derived cells to the spontaneous regression of liver fibrosis, mice were treated with repeated carbon tetrachloride injections after hematopoietic reconstitution with enhanced green fluorescent protein (EGFP)-expressing BM cells. |
0(0,0,0,0) | Details |