| Name | desmin |
|---|---|
| Synonyms | CMD1I; CSM 1; CSM 2; CSM1; CSM2; DES; DES Skeletin; Desmin… |
| Name | carbon tetrachloride |
|---|---|
| CAS | tetrachloromethane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15728706 | van de Bovenkamp M, Groothuis GM, Draaisma AL, Merema MT, Bezuijen JI, van Gils MJ, Meijer DK, Friedman SL, Olinga P: Precision-cut liver slices as a new model to study toxicity-induced hepatic stellate cell activation in a physiologic milieu. Toxicol Sci. 2005 May;85(1):632-8. Epub 2005 Feb 23. Liver slices (8 mm diameter, 250 microm thickness) were generated from normal rat liver and incubated for 3 or 16 h with increasing doses of carbon tetrachloride (CCl4). In unstimulated liver slices, mRNA and protein levels of desmin, heat shock protein 47, and alpha B-crystallin remained constant, indicating quiescence of HSC, whereas Kruppel-like factor 6 expression was increased. |
1(0,0,0,1) | Details |
| 16480920 | Yoshino R, Miura K, Segawa D, Hirai Y, Goto T, Ohshima S, Mikami K, Yoneyama K, Shibuya T, Watanabe D, Kataoka E, Takeuchi S, Endoh A, Sato W, Watanabe S: Epimorphin expression and stellate cell status in mouse liver injury. Hepatol Res. 2006 Apr;34(4):238-49. Epub 2006 Feb 9. We studied the relationship between epimorphin expression and stellate cell status in carbon tetrachloride-induced acute and chronic injury to mouse liver and in mouse liver regeneration following 70% partial hepatectomy. Epimorphin-positive cells in sinusoids expressed desmin, indicating that they are stellate cells. |
1(0,0,0,1) | Details |
| 18627004 | Hannivoort RA, Dunning S, Vander Borght S, Schroyen B, Woudenberg J, Oakley F, Buist-Homan M, van den Heuvel FA, Geuken M, Geerts A, Roskams T, Faber KN, Moshage H: Multidrug resistance-associated proteins are crucial for the viability of activated rat hepatic stellate cells. Hepatology. 2008 Aug;48(2):624-34. An in vivo model of carbon tetrachloride (CCl (4))-induced liver fibrosis was used. Mrp1 protein staining correlated with desmin staining in livers from CCl (4)-treated rats. |
1(0,0,0,1) | Details |
| 16799993 | Lafdil F, Chobert MN, Couchie D, Brouillet A, Zafrani ES, Mavier P, Laperche Y: Induction of Gas6 protein in CCl4-induced rat liver injury and anti-apoptotic effect on hepatic stellate cells. Hepatology. 2006 Jul;44(1):228-39. Three days after CCl4-induced liver injury in the rat, we detected the expression of Gas6 in ED1-positive macrophages as well as in desmin-positive HSC, which accumulated in injured areas. |
1(0,0,0,1) | Details |
| 16085334 | Sansoe G, Aragno M, Mastrocola R, Restivo F, Mengozzi G, Smedile A, Rosina F, Danni O, Parola M, Rizzetto M: Neutral endopeptidase (EC 3.4.24.11) in cirrhotic liver: a new target to treat portal hypertension?. J Hepatol. 2005 Nov;43(5):791-8. Epub 2005 Jun 20. In the cytosol fraction of rat cirrhotic livers a 280% increase in NEP content was found (P <0.01), chiefly localized in desmin-positive myofibroblast-like cells of fibrous septa. |
1(0,0,0,1) | Details |
| 20052656 | Taura K, Miura K, Iwaisako K, Osterreicher CH, Kodama Y, Penz-Osterreicher M, Brenner DA: Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice. Hepatology. 2010 Mar;51(3):1027-36. We induced liver fibrosis by repetitive carbon tetrachloride (CCl (4)) injections. All beta-gal-positive cells exhibited abundant cytoplasm, a typical morphology of hepatocytes, and expressed none of the mesenchymal markers including alpha-SMA, FSP-1, desmin, and vimentin. |
1(0,0,0,1) | Details |
| 16732906 | He YJ, Shu JC, Lu X, Fang L, Sheng Y: [Prophylactic effect of on hepatic fibrosis and its relationship with activated hepatic stellate cells]. Zhonghua Gan Zang Bing Za Zhi. 2006 May;14(5):337-40. METHODS: A rat model of hepatic fibrosis was established by intraperitoneal injection of carbon tetrachloride. HSC apoptosis was detected by double-stainings of terminal deoxynucleotidyl transferase (TdT) nick-end labeling (TUNEL) and desmin immunohistochemistry staining. |
1(0,0,0,1) | Details |
| 15772939 | Song YH, Chen XL, Kong XJ, Liu NZ, Li W, Wu XL, Lin JS, Jin YX: Ribozymes against TGFbeta1 reverse character of activated hepatic stellate cells in vitro and inhibit liver fibrosis in rats. J Gene Med. 2005 Jul;7(7):965-76. The adenoviral vector expressing the ribozymes was constructed, and then delivered into rat models of hepatic fibrosis induced by carbon tetrachloride. |
0(0,0,0,0) | Details |
| 19575449 | Yovchev MI, Zhang J, Neufeld DS, Grozdanov PN, Dabeva MD: Thymus cell antigen-1-expressing cells in the oval cell compartment. Hepatology. 2009 Aug;50(2):601-11. We characterized these cells in normal liver, in carbon tetrachloride-injured liver, and in several models of OC activation. |
0(0,0,0,0) | Details |
| 16256175 | Noyan S, Cavusoglu I, Minbay FZ: The effect of on CCl4-induced hepatic injuries in rats: a histochemical, immunohistochemical and ultrastructural study. Acta Histochem. 2006;107(6):421-34. Epub 2005 Oct 26. Carbon tetrachloride intoxication was performed on rats for 2, 8, 12 or 20 weeks and 5x10 (4) IU (as was injected subcutaneously once every 4 weeks. Ito cells were detected by gold impregnation, as well as desmin and alpha-smooth muscle actin (alpha-SMA) immunohistochemistry. |
3(0,0,0,3) | Details |
| 16640026 | Jiroutova A, Majdiakova L, Cermakova M, Kohlerova R, Kanta J: Expression of cytoskeletal proteins in hepatic stellate cells isolated from normal and cirrhotic rat liver. Acta Medica (Hradec Kralove). 2005;48(3-4):137-44. We have studied the expression of alpha-smooth muscle actin and intermediate filament proteins vimentin, desmin and glial fibrillary acidic protein (GFAP) by immunocytochemistry in HSC cultured for 2 or 7 days after isolation. Liver cirrhosis was produced in rats by repeated carbon tetrachloride administration. |
2(0,0,0,2) | Details |
| 14739096 | Baba S, Fujii H, Hirose T, Yasuchika K, Azuma H, Hoppo T, Naito M, Machimoto T, Ikai I: Commitment of bone marrow cells to hepatic stellate cells in mouse. J Hepatol. 2004 Feb;40(2):255-60. We then examined the histology of liver tissues obtained from BM-transplanted mice with and without carbon tetrachloride-induced injury. These cells expressed the HSC lineage markers, such as desmin and glial fibrillary acidic protein (GFAP), by both RT-PCR and immunostaining. |
2(0,0,0,2) | Details |
| 17030452 | Lv P, Luo HS, Zhou XP, Chireyath Paul S, Xiao YJ, Si XM, Liu SQ: Thalidomide prevents rat liver cirrhosis via inhibition of oxidative stress. Pathol Res Pract. 2006;202(11):777-88. Epub 2006 Oct 6. The cirrhosis of rat was induced by intraperitoneal injection of carbon tetrachloride thrice weekly; meanwhile, thalidomide (10mg/kg or 100mg/kg) was given daily by intragastric administration for 8 weeks. Immunohistochemistry revealed alpha-smooth muscle actin (alpha-SMA), desmin, and tissue inhibitor of metalloproteinase-1 (TIMP-1) protein in the liver. |
2(0,0,0,2) | Details |