Protein Information

Name Acetylcholinesterase
Synonyms ACHE; ACHE protein; AChE; ARACHE; AcChoEase; Acetylcholine acetylhydrolase; Acetylcholinesterase; Acetylcholinesterase isoform E4 E6 variant…

Compound Information

Name carbon tetrachloride
CAS tetrachloromethane

Reference List

PubMed Abstract RScore(About this table)
16496349 Garcia-Ayllon MS, Silveyra MX, Candela A, Compan A, Claria J, Jover R, Perez-Mateo M, Felipo V, Martinez S, Galceran J, Saez-Valero J: Changes in liver and plasma acetylcholinesterase in rats with cirrhosis induced by bile duct ligation. Hepatology. 2006 Mar;43(3):444-53.

A selective loss of tetrameric (G4) AChE was detected in BDL rats, an effect also observed in rats with carbon tetrachloride-induced cirrhosis.
15(0,0,1,10) Details
18472332 Lam HB, Yeh CH, Cheng KC, Hsu CT, Cheng JT: Effect of cholinergic denervation on hepatic fibrosis induced by carbon tetrachloride in rats. Neurosci Lett. 2008 Jun 13;438(1):90-5. Epub 2008 Apr 18.

Acetylcholinesterase (AChE) staining showed the distribution of cholinergic nerve around fibrosis scaring septa.
1(0,0,0,1) Details
15085244 Zabrodskii PF, Germanchuk VG, Kirichuk VF, Karpenko NI: Effect of tetrachloromethane on the immune system. Bull Exp Biol Med. 2004 Jan;137(1):47-9.


Immunotoxicity of tetrachloromethane is realized via initiation of lipid peroxidation and inhibition of acetylcholine esterase in T lymphocytes and alpha-naphthyl AS-acetate esterase and alpha-naphthyl butyrate esterase in splenocytes.
1(0,0,0,1) Details