| Name | Urokinase type plasminogen activator |
|---|---|
| Synonyms | ATF; PLAU; PLAU protein; Plasminogen activator urinary; Plasminogen activator urokinase; U plasminogen activator; UPA; URK… |
| Name | carbon tetrachloride |
|---|---|
| CAS | tetrachloromethane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18481824 | Sun C, Li DG, Chen YW, Chen YW, Wang BC, Sun QL, Lu HM: Transplantation of urokinase-type plasminogen activator gene-modified bone marrow-derived liver stem cells reduces liver fibrosis in rats. J Gene Med. 2008 Aug;10(8):855-66. In the present study, we investigated the therapeutic effects of uPA gene-modified BDLSC transplantation on carbon tetrachloride (CCl4)-induced liver fibrosis in rats. |
3(0,0,0,3) | Details |
| 15452360 | Perez-Liz G, Flores-Hernandez J, Arias-Montano JA, Reyes-Esparza JA, Rodriguez-Fragoso L: Modulation of urokinase-type plasminogen activator by transforming growth factor beta1 in -activated hepatic stellate cells. Pharmacology. 2005 Jan;73(1):23-30. Epub 2004 Sep 27. |
2(0,0,0,2) | Details |
| 15320789 | Choi-Miura NH: Novel human plasma proteins, IHRP (acute phase protein) and PHBP (serine protease), which bind to glycosaminoglycans. Curr Med Chem Cardiovasc Hematol Agents. 2004 Jul;2(3):239-48. PHBP digested alpha-chain and beta-chain of fibrinogen to prevent coagulation and cleaved single chain urokinase type plasminogen activator (scuPA) to the active hetero dimer form (tcuPA). Partial hepatectomy and administration of carbon tetrachloride or galactosamine caused the conversion of pro-PHBP to the active form in mouse but administrations of turpentine and mercury did not, suggesting the hepatic injury specific activation of PHBP. |
1(0,0,0,1) | Details |
| 19615318 | Chen JM, Wang L, Liu T, Xing LJ, Zheng PY, Ji G: [Effects of Qinggan Huoxue Recipe and its separated recipes on urokinase-type plasminogen activator and plasminogen activator inhibitor-1 fibrinolytic system in rats with alcoholic liver fibrosis]. Zhong Xi Yi Jie He Xue Bao. 2009 Jul;7(7):642-50. METHODS: A total of 150 SD rats were divided into three groups: blank group, carbon tetrachloride (C (4)) group and ALF-inducing group. |
1(0,0,0,1) | Details |
| 15754396 | Wu LM, Li LD, Liu H, Ning KY, Li YK: Effects of Guiyuanfang and autologous transplantation of bone marrow stem cells on rats with liver fibrosis. World J Gastroenterol. 2005 Feb 28;11(8):1155-60. METHODS: Liver fibrosis model was induced by carbon tetrachloride, high lipid and assessed biochemically and histologically. Immunohistochemical SABC methods were used to detect transplanted BMSCs and expression of urokinase plasminogen activator (uPA). |
1(0,0,0,1) | Details |
| 19080687 | Sun C, Li DG, Chen YW, Chen YW, Wang BC: [Effects of gene-transfected bone marrow-derived liver stem cell transplantation on accumulation of extracellular matrix in rats with liver fibrosis]. Zhonghua Yi Xue Za Zhi. 2008 Oct 21;88(38):2685-9. OBJECTIVE: To explore the effects of urokinase-type plasminogen activator (uPA) gene-modified bone marrow-derived stem cell (BDLSC) transplantation on accumulation of extracellular matrix (ECM) in hepatic tissue in liver fibrosis. Twenty-seven female rats were randomly divided into 3 equal groups to undergo subcutaneous injection of carbon tetrachloride to establish liver fibrosis models and then randomly divided into 3 equal groups: model group injected with normal saline via caudal vein, BDLSC group injected with 2 x 10 (6) BDLSCs via caudal vein, and BDLSC-uPA group injected with 2 x 10 (6) AduPA-transfected BDLSCs. |
1(0,0,0,1) | Details |
| 18279442 | Higazi AA, El-Haj M, Melhem A, Horani A, Pappo O, Alvarez CE, Muhanna N, Friedman SL, Safadi R: Immunomodulatory effects of plasminogen activators on hepatic fibrogenesis. Clin Exp Immunol. 2008 Apr;152(1):163-73. Epub 2008 Feb 14. Tissue-type plasminogen activators (tPA) and urokinase-type plasminogen activators (uPA) are involved in liver repair. We examined the potential immunomodulatory actions of uPA, tPA and uPA-receptor (uPAR) in carbon-tetrachloride-induced hepatic fibrosis in wild-type (WT), tPA-/-, uPA-/- and uPAR-/- mice. |
1(0,0,0,1) | Details |
| 17134505 | Shanmukhappa K, Sabla GE, Degen JL, Bezerra JA: Urokinase-type plasminogen activator supports liver repair independent of its cellular receptor. BMC Gastroenterol. 2006 Nov 29;6:40. METHODS: To test this hypothesis, we administered one dose of carbon tetrachloride (CCl4) to mice with single or combined deficiencies of uPA, uPAR and tPA, and examined hepatic morphology, cellular proliferation, fibrin clearance, and hepatic proteolysis 2-14 days later. |
1(0,0,0,1) | Details |
| 17935821 | Miura K, Yoshino R, Hirai Y, Goto T, Ohshima S, Mikami K, Yoneyama K, Watanabe D, Sato M, Senoo H, Kodama Y, Osawa Y, Brenner DA, Watanabe S: Epimorphin, a morphogenic protein, induces proteases in rodent hepatocytes through NF-kappaB. J Hepatol. 2007 Dec;47(6):834-43. Epub 2007 Sep 25. First, we explored the relationship between epimorphin expression and distribution of protease-positive cells in carbon tetrachloride-induced acute liver injury. In vitro, epimorphin induced matrix metalloproteinase (MMP) 9, MMP 3 and urokinase type plasminogen activator (uPA) in hepatocytes. |
1(0,0,0,1) | Details |
| 17823541 | Salas AL, Montezuma TD, Farina GG, Reyes-Esparza J, Rodriguez-Fragoso L: modifies liver fibrosis and improves liver function by inducing uPA expression and proteolytic activity in CCl4-treated rats. Pharmacology. 2008;81(1):41-9. Epub 2007 Sep 7. METHODS: Hepatic fibrosis was brought about by chronic administration of carbon tetrachloride to rats. Urokinase-type plasminogen activator (uPA) expression during experimental fibrosis was localized by immunohistochemistry. |
1(0,0,0,1) | Details |