| Name | Telomerase (protein family or complex) |
|---|---|
| Synonyms | Telomerase; Telomerases |
| Name | carbon tetrachloride |
|---|---|
| CAS | tetrachloromethane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17869215 | Song JS, Murase N, Demetris AJ, Michalopoulos GK, Ochoa ER: Protection from acute cellular injury using Sleeping Beauty mediated telomerase gene transfer. Biochem Biophys Res Commun. 2007 Nov 16;363(2):253-6. Epub 2007 Jun 8. Using the SB transposon system in vitro hTERT gene overexpression has protective effects from acute cellular injury by tert-butyl hydroperoxide (t-BH), carbon tetrachloride (CCl (4)), and d-galactosamine (d-GalN) in normal human cells IMR-90. pT3.hTERT.Con vector and helper plasmid co-transfection resulted in a approximately 3-fold increase in telomerase activity which was maintained for 14 days. |
11(0,0,1,6) | Details |
| 19118616 | Khan MR, Rizvi W, Khan GN, Khan RA, Shaheen S: Carbon tetrachloride-induced nephrotoxicity in rats: protective role of Digera muricata. J Ethnopharmacol. 2009 Feb 25;122(1):91-9. Epub 2008 Dec 11. Telomerase activity was determined in the CCl (4)-treated renal tissue homogenate. |
2(0,0,0,2) | Details |
| 15194652 | Sato R, Maesawa C, Fujisawa K, Wada K, Oikawa K, Takikawa Y, Suzuki K, Oikawa H, Ishikawa K, Masuda T: Prevention of critical telomere shortening by in human normal hepatic cultured cells and carbon tetrachloride induced rat liver fibrosis. Gut. 2004 Jul;53(7):1001-9. To prevent critical telomere shortening in hepatocytes, we have focused on oestrogen dependent transactivation of the human telomerase reverse transcriptase (hTERT) gene as a form of telomerase therapy in chronic liver disease. |
2(0,0,0,2) | Details |
| 15608677 | Wiemann SU, Satyanarayana A, Buer J, Kamino K, Manns MP, Rudolph KL: Contrasting effects of telomere shortening on organ homeostasis, tumor suppression, and survival during chronic liver damage. Oncogene. 2005 Feb 24;24(9):1501-9. Here we show that telomere shortening in telomerase knockout (mTERC-/-) mice in combination with chronic liver damage significantly reduced organismal survival even though telomere shortening strongly inhibited liver tumor formation. |
2(0,0,0,2) | Details |
| 19917719 | Ge J, Rudnick DA, He J, Crimmins DL, Ladenson JH, Bessler M, Mason PJ: Dyskerin ablation in mouse liver inhibits rRNA processing and cell division. Mol Cell Biol. 2010 Jan;30(2):413-22. Epub 2009 Nov 16. It is encoded by the DKC1 gene, the gene mutated in X-linked dyskeratosis congenita, and is also part of the telomerase complex. In response to carbon tetrachloride administration, when wild-type hepatocytes mount a rapid proliferative response, those without dyskerin do not divide. |
1(0,0,0,1) | Details |