| Name | col1A2 |
|---|---|
| Synonyms | COL1A2; OI4; Collagen alpha 2(I) chain; Collagen alpha 2(I) chain precursor; osteogenesis imperfecta type IV; Collagen alpha 2(I) chains; Collagen alpha 2(I) chain precursors; osteogenesis imperfecta type IVs |
| Name | carbon tetrachloride |
|---|---|
| CAS | tetrachloromethane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19596008 | Higashiyama R, Moro T, Nakao S, Mikami K, Fukumitsu H, Ueda Y, Ikeda K, Adachi E, Bou-Gharios G, Okazaki I, Inagaki Y: Negligible contribution of bone marrow-derived cells to collagen production during hepatic fibrogenesis in mice. Gastroenterology. 2008 Apr;134(4):1180-90. Epub 2008 Jan 11. RESULTS: The tissue-specific COL1A2 enhancer/promoter was activated in hepatic stellate cells following a single carbon tetrachloride injection or during primary culture on plastic. |
86(1,1,1,6) | Details |
| 18771671 | Moro T, Shimoyama Y, Kushida M, Hong YY, Nakao S, Higashiyama R, Sugioka Y, Inoue H, Okazaki I, Inagaki Y: Glycyrrhizin and its metabolite inhibit Smad3-mediated type I collagen gene transcription and suppress experimental murine liver fibrosis. J Hepatol. 2009 Oct 24. KEY FINDINGS: Administration of glycyrrhizin or its metabolite, glycyrrhetinic acid, significantly suppressed COL1A2 promoter activation and progression of liver fibrosis induced by repeated carbon tetrachloride injections. |
84(1,1,1,4) | Details |
| 16012952 | Inagaki Y, Kushida M, Higashi K, Itoh J, Higashiyama R, Hong YY, Kawada N, Namikawa K, Kiyama H, Bou-Gharios G, Watanabe T, Okazaki I, Ikeda K: Cell type-specific intervention of transforming growth factor beta/Smad signaling suppresses collagen gene expression and hepatic fibrosis in mice. Gastroenterology. 2005 Jul;129(1):259-68. Adenovirus-mediated YB-1 expression under the control of the COL1A2 enhancer significantly decreased COL1A2 promoter activity after carbon tetrachloride injection and subsequently suppressed the progression of hepatic fibrosis. |
31(0,1,1,1) | Details |
| 15983038 | Nieto N, Cederbaum AI: blocks collagen I production by preventing transforming growth factor-beta induction of the COL1A2 promoter. J Biol Chem. 2005 Sep 2;280(35):30963-74. Epub 2005 Jun 27. To study the anti-fibrogenic mechanisms of transgenic mice harboring the -17 kb to +54 bp of the collagen alpha2 (I) promoter (COL1A2) cloned upstream from the beta-gal reporter gene were injected with carbon tetrachloride (CCl4) to induce fibrosis and coadministered either or saline. |
10(0,0,1,5) | Details |
| 18395096 | Inagaki Y, Higashi K, Kushida M, Hong YY, Nakao S, Higashiyama R, Moro T, Itoh J, Mikami T, Kimura T, Shiota G, Kuwabara I, Okazaki I: Hepatocyte growth factor suppresses profibrogenic signal transduction via nuclear export of Smad3 with galectin-7. e1-4. Epub 2009 Jan 6. RESULTS: Over expression of HGF inhibited COL1A2 transcription in cultured HSC and suppressed activation of COL1A2 promoter in liver tissue induced by carbon tetrachloride administration. |
83(1,1,1,3) | Details |
| 19250650 | Urtasun R, Cubero FJ, Vera M, Nieto N: Reactive species switch on early extracellular matrix remodeling via induction of MMP1 and TNFalpha. Gastroenterology. 2009 Apr;136(4):1410-22 Western blot, nuclear in vitro transcription, Northern blot, qPCR, and promoter transactivation analysis for COL1A1 and COL1A2 were carried out. |
2(0,0,0,2) | Details |
| 19913322 | Kao YH, Chen CL, Jawan B, Chung YH, Sun CK, Kuo SM, Hu TH, Lin YC, Chan HH, Cheng KH, Wu DC, Goto S, Cheng YF, Chao D, Tai MH: Upregulation of hepatoma-derived growth factor is involved in murine hepatic fibrogenesis. Gastroenterology. 2009 Oct;137(4):1459-66.e1. Epub 2009 Jul 29. METHODS: Liver fibrosis was induced in mice receiving bile duct ligation (BDL) or carbon tetrachloride (CCl (4)) administration. The HDGF upregulation was observed mainly in hepatocytes and correlated with the expression of TGF-beta1 and collagen COL1A1 and COL1A2 proteins. |
1(0,0,0,1) | Details |