| Name | plasmin |
|---|---|
| Synonyms | PL; PNLIP; Pancreatic lipase; Pancreatic triacylglycerol lipase; Pancreatic triacylglycerol lipase precursor; PL; Pancreatic lipases; Pancreatic triacylglycerol lipases… |
| Name | carbon tetrachloride |
|---|---|
| CAS | tetrachloromethane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17482686 | Kawao N, Okada K, Kawata S, Okamoto C, Tsuritani M, Ueshima S, Matsuo O: Plasmin decreases the BH3-only protein BimEL via the ERK1/2 signaling pathway in hepatocytes. Biochim Biophys Acta. 2007 Jun;1773(6):718-27. Epub 2007 Apr 1. |
6(0,0,0,6) | Details |
| 17134505 | Shanmukhappa K, Sabla GE, Degen JL, Bezerra JA: Urokinase-type plasminogen activator supports liver repair independent of its cellular receptor. BMC Gastroenterol. 2006 Nov 29;6:40. BACKGROUND: The urokinase-type (uPA) and tissue-type (tPA) plasminogen activators regulate liver matrix remodelling through the conversion of plasminogen (Plg) to the active protease plasmin. METHODS: To test this hypothesis, we administered one dose of carbon tetrachloride (CCl4) to mice with single or combined deficiencies of uPA, uPAR and tPA, and examined hepatic morphology, cellular proliferation, fibrin clearance, and hepatic proteolysis 2-14 days later. |
2(0,0,0,2) | Details |
| 18685433 | Okada K, Ueshima S, Kawao N, Okamoto C, Matsuo K, Akao M, Seki T, Ariga T, Tanaka M, Matsuo O: Binding of plasminogen to hepatocytes isolated from injured mouse liver and nonparenchymal-cell-dependent proliferation of hepatocytes. Blood Coagul Fibrinolysis. 2008 Sep;19(6):503-11. Plasmin is an essential enzyme located in the pericellular microenvironment of liver cells during liver regeneration. |
2(0,0,0,2) | Details |
| 19286661 | Shanmukhappa K, Matte U, Degen JL, Bezerra JA: Plasmin-mediated proteolysis is required for hepatocyte growth factor activation during liver repair. J Biol Chem. 2009 May 8;284(19):12917-23. Epub 2009 Mar 13. |
1(0,0,0,1) | Details |
| 19386599 | Okumura N, Koh T, Hasebe Y, Seki T, Ariga T: A novel function of thrombin-activatable fibrinolysis inhibitor during rat liver regeneration and in growth-promoted hepatocytes in primary culture. J Biol Chem. 2009 Jun 12;284(24):16553-61. Epub 2009 Apr 22. In rat models, partial hepatectomy or carbon tetrachloride (CCl4)-induced acute liver injury suppressed the levels of plasma TAFI activity and hepatic TAFI mRNA, whereas this operation markedly increased both the hepatic plasmin activity and the level of proliferating cell nuclear antigen. |
33(0,1,1,3) | Details |
| 16006527 | Shanmukhappa K, Mourya R, Sabla GE, Degen JL, Bezerra JA: Hepatic to pancreatic switch defines a role for hemostatic factors in cellular plasticity in mice. Proc Natl Acad Sci U S A. 2005 Jul 19;102(29):10182-7. Epub 2005 Jul 8. Collectively, these data reveal a regulatory role for the hemostatic factors plasmin (ogen) and fibrin (ogen) in cellular plasticity within adult tissues of the digestive system. To this end, we generated biotinylated cRNA pools from livers of Plg (o) mice and controls before and after a single dose of the hepatotoxin carbon tetrachloride and hybridized them against high-density oligonucleotide arrays. |
1(0,0,0,1) | Details |
| 18761555 | Hu PF, Zhu YW, Zhong W, Chen YX, Lin Y, Zhang X, Yin C, Yue HY, Xie WF: Inhibition of plasminogen activator inhibitor-1 expression by siRNA in rat hepatic stellate cells. J Gastroenterol Hepatol. 2008 Dec;23(12):1917-25. Epub 2008 Aug 28. BACKGROUND AND AIM: The plasminogen activator/plasmin system is known to regulate the extracellular matrix turnover. |
1(0,0,0,1) | Details |