| Name | plasminogen activator inhibitor |
|---|---|
| Synonyms | Endothelial plasminogen activator inhibitor; PAI; PAI 1; PAI1; PAIE; PLANH 1; Plasminogen activator inhibitor 1… |
| Name | carbon tetrachloride |
|---|---|
| CAS | tetrachloromethane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18502066 | Yang Y, Yang S, Chen M, Zhang X, Zou Y, Zhang X: Compound Astragalus and Salvia miltiorrhiza Extract exerts anti-fibrosis by mediating TGF-beta/Smad signaling in myofibroblasts. J Ethnopharmacol. 2008 Jul 23;118(2):264-70. Epub 2008 Apr 18. To test this hypothesis, we induced fibrosis in rats by twice weekly injections of carbon tetrachloride (CCl (4)) and Smad2 phosphorylation was measured by immunohistochemical method; protein expression in myofibroblasts (MFBs) induced by TGF-beta1 was analyzed by western blotting and plasminogen activator inhibitor type 1 (PAI-1) transcriptional activity in MFBs was evaluated. |
81(1,1,1,1) | Details |
| 18761555 | Hu PF, Zhu YW, Zhong W, Chen YX, Lin Y, Zhang X, Yin C, Yue HY, Xie WF: Inhibition of plasminogen activator inhibitor-1 expression by siRNA in rat hepatic stellate cells. J Gastroenterol Hepatol. 2008 Dec;23(12):1917-25. Epub 2008 Aug 28. |
2(0,0,0,2) | Details |
| 20203062 | von Montfort C, Beier JI, Kaiser JP, Guo L, Joshi-Barve S, Pritchard MT, States JC, Arteel GE: PAI-1 plays a protective role in CCl4-induced hepatic fibrosis in mice: role of hepatocyte division. Am J Physiol Gastrointest Liver Physiol. 2010 Mar 4. Background & Aims: Plasminogen activator inhibitor-1 (PAI-1) is an acute phase protein that has been shown to play a role in experimental fibrosis caused by bile duct ligation (BDL) in mice. However, its role in more severe models of hepatic fibrosis (e.g., carbon tetrachloride; CCl (4)) has not been determined and is important for extrapolation to human disease. |
1(0,0,0,1) | Details |
| 18395096 | Inagaki Y, Higashi K, Kushida M, Hong YY, Nakao S, Higashiyama R, Moro T, Itoh J, Mikami T, Kimura T, Shiota G, Kuwabara I, Okazaki I: Hepatocyte growth factor suppresses profibrogenic signal transduction via nuclear export of Smad3 with galectin-7. Gastroenterology. 2008 Apr;134(4):1180-90. Epub 2008 Jan 11. Transfection of cells with galectin-7 small interfering RNA inhibited nuclear export of Smad3 and abolished suppressive effect of HGF on expression of TGF-beta-responsive genes such as COL1A2 and plasminogen activator inhibitor-1. RESULTS: Over expression of HGF inhibited COL1A2 transcription in cultured HSC and suppressed activation of COL1A2 promoter in liver tissue induced by carbon tetrachloride administration. |
1(0,0,0,1) | Details |
| 15154911 | Flanders KC: Smad3 as a mediator of the fibrotic response. Int J Exp Pathol. 2004 Apr;85(2):47-64. The loss of Smad3 also interferes with TGF-beta-mediated induction of EMT and genes for collagens, plasminogen activator inhibitor-1 and the tissue inhibitor of metalloprotease-1. Smad3 null mice are resistant to radiation-induced cutaneous fibrosis, bleomycin-induced pulmonary fibrosis, carbon tetrachloride-induced hepatic fibrosis as well as glomerular fibrosis induced by induction of type 1 diabetes with streptozotocin. |
1(0,0,0,1) | Details |
| 19615318 | Chen JM, Wang L, Liu T, Xing LJ, Zheng PY, Ji G: [Effects of Qinggan Huoxue Recipe and its separated recipes on urokinase-type plasminogen activator and plasminogen activator inhibitor-1 fibrinolytic system in rats with alcoholic liver fibrosis]. Zhong Xi Yi Jie He Xue Bao. 2009 Jul;7(7):642-50. METHODS: A total of 150 SD rats were divided into three groups: blank group, carbon tetrachloride (C (4)) group and ALF-inducing group. |
1(0,0,0,1) | Details |