| 17125596 |
Niiranen K, Keinanen TA, Pirinen E, Heikkinen S, Tusa M, Fatrai S, Suppola S, Pietila M, Uimari A, Laakso M, Alhonen L, Janne J: Mice with targeted disruption of spermidine/spermine N1-acetyltransferase gene maintain nearly normal tissue polyamine homeostasis but show signs of insulin resistance upon aging. J Cell Mol Med. 2006 Oct-Dec;10(4):933-45.
Surprisingly, liver polyamine pools were depleted similarly in wild-type and SSAT-KO mice in response to carbon tetrachloride treatment. |
13(0,0,1,8) |
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| 19956991 |
Hyvonen MT, Sinervirta R, Grigorenko N, Khomutov AR, Vepsalainen J, Keinanen TA, Alhonen L: alpha-Methylspermidine protects against carbon tetrachloride-induced hepatic and pancreatic damage. Amino Acids. 2010 Feb;38(2):575-81. Epub 2009 Dec 3.
In syngenic rats, administration of CCl (4) resulted in the induction of hepatic spermidine/spermine N (1)-acetyltransferase (SSAT), accumulation of putrescine, reduction in spermine level and appearance of moderate hepatic injury within 24 h. |
3(0,0,0,3) |
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