| Name | glutathione S transferase |
|---|---|
| Synonyms | GST class alpha 2; Gst2; GST class alpha; GST class alpha member 2; GST gamma; GSTA 2; GSTA2; GSTA2 2… |
| Name | carbon tetrachloride |
|---|---|
| CAS | tetrachloromethane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18482221 | Hort MA, Dalbo S, Brighente IM, Pizzolatti MG, Pedrosa RC, Ribeiro-do-Valle RM: Antioxidant and hepatoprotective effects of Cyathea phalerata Mart. (Cyatheaceae). Basic Clin Pharmacol Toxicol. 2008 Jul;103(1):17-24. Epub 2008 Jul 1. The in vivo evaluation of oxidative stress (DNA fragmentation, membrane lipoperoxidation and carbonyl protein formation) and the antioxidant defenses (concentration of as well as catalase and glutathione S-transferase activities) were measured in mice pre-treated with EAF (10, 30 or 100 mg/kg, orally) and later exposed to carbon tetrachloride (CCl (4)). |
7(0,0,1,2) | Details |
| 16325313 | Dwivedi S, Sharma R, Sharma A, Zimniak P, Ceci JD, Awasthi YC, Boor PJ: The course of CCl4 induced hepatotoxicity is altered in mGSTA4-4 null (-/-) mice. Toxicology. 2006 Jan 20;218(1):58-66. Epub 2005 Dec 1. Glutathione S-transferases (GSTs) play a key role in cellular detoxification of environmental toxicants through their conjugation to glutathione (GSH). Since the hepatotoxicity of carbon tetrachloride (CCl (4)) has been suggested to be due to the generation of free radicals leading to membrane LPO, the present studies were designed to compare hepatotoxicity of CCl (4) in GSTA4-4 null (-/-) and wild type (+/+) mice. |
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| 18436364 | Lee KJ, Choi JH, Khanal T, Hwang YP, Chung YC, Jeong HG: Protective effect of phenethyl ester against carbon tetrachloride-induced hepatotoxicity in mice. Toxicology. 2008 Jun 3;248(1):18-24. Epub 2008 Mar 20. In addition, CAPE attenuated the CCl (4)-mediated depletion of antioxidant enzyme (catalase, superoxide dismutase and glutathione-S-transferase) activities. |
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| 15960080 | Aneja R, Upadhyaya G, Prakash S, Dass SK, Chandra R: Ameliorating effect of phytoestrogens on CCl4-induced oxidative stress in the livers of male Wistar rats. Artif Cells Blood Substit Immobil Biotechnol. 2005;33(2):201-13. In the present study, the protective effects, if any, of isoflavone phytoestrogens-- and daidzein on the carbon tetrachloride (CCl4) induced changes in the activity of alanine aminotransferase (ALT), aspartate aminotransferase (AST), glutathione S transferase (GSH) and levels of (GSH) and thiobarbituric acid reactive substances (TBARS)-were studied. |
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| 20141739 | Shen DZ, Tao Q, DU JX, Ding SD, Chen GF, Hu YY, Liu P: [Effects of Yiguanjian Decoction on liver cirrhosis formation:a differential proteomics study in rats.]. Zhong Xi Yi Jie He Xue Bao. 2010 Feb;8(2):158-67. Rat cirrhosis model was established by intraperitoneal injection of 50% carbon tetrachloride (CCl4) plus olive oil solution (1 mL/kg, twice weekly for 9 weeks). In all 50 protein spots identified by MALDI-TOF/TOF-MS and database querying, there were 5 protein spots related to oxidative stress named Cu/Zn SOD, DJ-1, glutathione synthetase, glutathione S-transferase Yb-1 subunit and aldo-keto reductase family 7, A2 respectively. |
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| 20354059 | Ajiboye TO: In vivo antioxidant potentials of Piliostigma thonningii (Schum) leaves: Studies on hepatic marker enzyme, antioxidant system, drug detoxifying enzyme and lipid peroxidation. Hum Exp Toxicol. 2010 Mar 30. In this study, the in vivo antioxidant potentials of Piliostigma thonningii were investigated in carbon tetrachloride-induced hepatic and oxidative damage in rat. Antioxidant enzyme activity as well as level of uridyl diphosphoglucuronosyl transferase, quinone oxidoreductase and glutathione S-transferase was significantly induced. |
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| 17803529 | Subramanian P, Mirunalini S, Dakshayani KB, Pandi-Perumal SR, Trakht I, Cardinali DP: Prevention by of hepatocarcinogenesis in rats injected with N-nitrosodiethylamine. J Pineal Res. 2007 Oct;43(3):305-12. To evaluate the chemopreventive function of in this experimental model, Wistar male rats received a single i.p. injection of NDEA or vehicle followed by weekly s.c. injections of carbon tetrachloride or vehicle for 6 weeks. The activity of superoxide dismutase (SOD), catalase (CAT), peroxidase (GPx) and glutathione S-transferase (GST) was assessed in liver and erythrocyte fraction of NDEA-treated rats. |
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| 19702266 | Hsu JD, Kao SH, Tu CC, Li YJ, Wang CJ: Solanum nigrum L. extract inhibits 2-acetylaminofluorene-induced hepatocarcinogenesis through overexpression of glutathione S-transferase and antioxidant enzymes. J Agric Food Chem. 2009 Sep 23;57(18):8628-34. Our previous study has found that SN water extract (SNWE) alleviated carbon tetrachloride-induced liver damage in rats. |
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| 15900908 | Sultana S, Ahmad S, Khan N, Jahangir T: Effect of Emblica officinalis (Gaertn) on CCl4 induced hepatic toxicity and DNA synthesis in Wistar rats. Indian J Exp Biol. 2005 May;43(5):430-6. A single dose of CCl4 (1 ml/kg body weight, po in corn oil) increased the levels of SGOT (serum transaminase), SGPT (serum glutamate pyruvate transaminase), LDH (lactate dehydrogenase), glutathione-S-transferase and depletion in peroxidase and glutathione reductase. |
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| 16676162 | Young SC, Wang CJ, Lin JJ, Peng PL, Hsu JL, Chou FP: Protection effect of piper betel leaf extract against carbon tetrachloride-induced liver fibrosis in rats. Arch Toxicol. 2007 Jan;81(1):45-55. Epub 2006 May 5. It also attenuated total glutathione S-transferase (GST) activity and GST alpha isoform activity, and on the other hand, enhanced superoxide dismutase (SOD) and catalase (CAT) activities. |
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| 15046820 | Fukao T, Hosono T, Misawa S, Seki T, Ariga T: The effects of allyl sulfides on the induction of phase II detoxification enzymes and liver injury by carbon tetrachloride. Food Chem Toxicol. 2004 May;42(5):743-9. With respect to the phase II enzymes, DATS (10 micromol/kg) and DADS at a 10-fold higher dose (100 micromol/kg) significantly increased the activities of glutathione S-transferase, quinone reductase, and antioxidative enzyme peroxidase; whereas DAS did not. |
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| 17188414 | Lee CP, Shih PH, Hsu CL, Yen GC: Hepatoprotection of tea seed oil (Camellia oleifera Abel.) against CCl4-induced oxidative damage in rats. Food Chem Toxicol. 2007 Jun;45(6):888-95. Epub 2006 Nov 21. Pre-treatment of animals with tea seed oil (150 g/kg diet) could increase the activities of peroxidase, glutathione reductase and glutathione S transferase in liver when compared with CCl (4)-treated group (p <0.05). |
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| 15630193 | Fukao T, Hosono T, Misawa S, Seki T, Ariga T: Chemoprotective effect of diallyl trisulfide from garlic against carbon tetrachloride-induced acute liver injury of rats. Biofactors. 2004;21(1-4):171-4. DATS (10 micromol/kg) and DADS at a 10-fold higher dose (100 micromol/kg) significantly increased the activities of glutathione S-transferase (GST) and quinone reductase (QR); whereas DAS did not. |
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| 18221844 | Tsujimura K, Ichinose F, Hara T, Yamasaki K, Otsuka M, Fukushima S: The inhalation exposure of carbon tetrachloride promote rat liver carcinogenesis in a medium-term liver bioassay. Toxicol Lett. 2008 Feb 15;176(3):207-14. Epub 2007 Dec 3. The numbers and area of glutathione S-transferase placental (GST-P) positive foci were then determined. |
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| 17886222 | Ahn TH, Yang YS, Lee JC, Moon CJ, Kim SH, Jun W, Park SC, Kim JC: Ameliorative effects of pycnogenol on carbon tetrachloride-induced hepatic oxidative damage in rats. Phytother Res. 2007 Nov;21(11):1015-9. In addition, increased malondialdehyde (MDA) concentration, (GSH) content, and decreased catalase, superoxide dismutase (SOD) and glutathione-S-transferase (GST) activities were observed in the hepatic tissues. |
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| 18476390 | Anilakumar KR, Krishna KR, Chandramohan G, Khanum F, Bawa AS: Bees wax polyphenols as suppressor of CC1--induced oxidative stress in rats. Indian J Physiol Pharmacol. 2007 Oct-Dec;51(4):361-7. As the polyphenols are thought to protect cell constituents against oxidative damage through scavenging of free radicals, the present work was undertaken to evaluate the effects of polyphenols extracted from bees wax on the oxidative stress induced by carbon tetrachloride (CCl4) in rats. The results showed a significant decrease in hepatic antioxidant enzyme activities viz. catalase, glucose-6-phosphate dehydrogenase (G-6-PDH), peroxidase (GSH-Px), glutathione reductase, superoxide dismutase (SOD) and a significant increase in glutathione S-transferase (GST) and gamma-glutamyl transpeptidase (GGT) by CCl4, probably due to the peroxidative effects. |
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| 19060448 | Mamiya T, Katsuoka F, Hirayama A, Nakajima O, Kobayashi A, Maher JM, Matsui H, Hyodo I, Yamamoto M, Hosoya T: Hepatocyte-specific deletion of heme oxygenase-1 disrupts redox homeostasis in basal and oxidative environments. Tohoku J Exp Med. 2008 Dec;216(4):331-9. We found that several cytoprotective genes, such as NAD (P) H dehydrogenase 1 and glutathione S-transferase P1, showed markedly elevated expression, suggesting the increase of oxidative stress in HO-1 CKO mice even under quiescent conditions. HO-1 CKO mice were susceptible to carbon tetrachloride hepatotoxicity. |
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| 17010209 | Manna P, Sinha M, Sil PC: Aqueous extract of Terminalia arjuna prevents carbon tetrachloride induced hepatic and renal disorders. BMC Complement Altern Med. 2006 Sep 30;6:33. Antioxidant status in both the liver and kidney tissues were estimated by determining the activities of the antioxidative enzymes, superoxide dismutase (SOD), catalase (CAT) and glutathione-S-transferase (GST); as well as by determining the levels of thiobarbutaric acid reactive substances (TBARS) and reduced glutathione (GSH). |
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| 17690517 | Nagano K, Umeda Y, Saito M, Nishizawa T, Ikawa N, Arito H, Yamamoto S, Fukushima S: Thirteen-week inhalation toxicity of carbon tetrachloride in rats and mice. J Occup Health. 2007 Jul;49(4):249-59. Hematoxylin and eosin-stained altered cell foci of rats were recognized as glutathione-S-transferase placental form (GST-P) positive foci, which are preneoplastic lesions of hepatocarcinogenesis. |
1(0,0,0,1) | Details |
| 16213120 | Rao GM, Rao CV, Pushpangadan P, Shirwaikar A: Hepatoprotective effects of rubiadin, a major constituent of Rubia cordifolia Linn. J Ethnopharmacol. 2006 Feb 20;103(3):484-90. Epub 2005 Oct 5. The hepatoprotective effects of rubiadin, a major constituent isolated from Rubia cordifolia Linn., were evaluated against carbon tetrachloride (CCl4)-induced hepatic damage in rats. Meanwhile, the decreased activities of glutathione S-transferase and glutathione reductase were also restored towards normalization. |
1(0,0,0,1) | Details |
| 15583823 | Aziz TA, Aziz MA, Fouad HH, Rashed LA, Salama H, Abd-Alla S, Wehab MA, Ahmed T: Interferon-alpha gene therapy prevents aflatoxin and carbon tetrachloride promoted hepatic carcinogenesis in rats. Int J Mol Med. 2005 Jan;15(1):21-6. Two genes were examined in liver tissue by RT-PCR: the first was glutathione-S-transferase placental (GST-P) isoenzyme, as an early marker to detect hepatic malignancy; the second was IFN-alpha gene expression to detect the efficiency of gene uptake and its persistence after transduction. |
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| 18786523 | Jayakumar T, Sakthivel M, Thomas PA, Geraldine P: Pleurotus ostreatus, an oyster mushroom, decreases the oxidative stress induced by carbon tetrachloride in rat kidneys, heart and brain. Chem Biol Interact. 2008 Nov 25;176(2-3):108-20. Epub 2008 Aug 22. Quantitative and qualitative analysis of catalase (CAT), superoxide dismutase (SOD), peroxidase (Gpx) and glutathione-S-transferase (GST) revealed lower activities of these antioxidant enzymes in the kidneys, heart and brain of rats exposed to CCl4. |
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| 16580113 | Itoh T, Moto M, Takahashi M, Sakai H, Mitsumori K: Liver initiation activity of norfloxacin but not nalidixic acid, pipemidic acid, and ciprofloxacin on in vivo short-term liver initiation assay in rats. Toxicology. 2006 May 15;222(3):240-6. Epub 2006 Mar 31. On day 19, a single oral dose of carbon tetrachloride at 0.8 mL/kg body weight was administered. On day 34, they were sacrificed under ether anesthesia, and liver slices were fixed in 10% neutral buffered formalin for immunohistochemical examination of glutathione S-transferase placental form (GST-P) positive foci. |
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| 19812219 | Hosono-Fukao T, Hosono T, Seki T, Ariga T: Diallyl trisulfide protects rats from carbon tetrachloride-induced liver injury. J Nutr. 2009 Dec;139(12):2252-6. Epub 2009 Oct 7. Western blot and spectrophotometric analyses indicated that DATS suppressed cytochrome P450 2E1 activity and its protein level and elevated those of glutathione S-transferase. |
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| 19915331 | Asaoka Y, Sakai H, Hirata A, Sasaki J, Goryo M, Miyamoto Y, Yanai T, Masegi T, Okada K: Detection of Initiation Activity of 1,2-Dimethylhydrazine in in vivo Medium-Term Liver Initiation Assay System using 4-Week-Old Rats without Hepatocellular Proliferative Stimuli during the Test Chemical Treatment Period. J Vet Med Sci. 2010 Feb;72(1):43-53. Epub 2009 Nov 13. Four-week-old rats were orally administered DMH (single dose, 4 or 16 mg/kg; or 4-day repeat, 1 or 4 mg/kg); subsequently, these rats were treated promotion treatment consisted of administration of 2-acetylaminofluorene and carbon tetrachloride. Four weeks after the first DMH administration, the glutathione S-transferase placental form (GST-P)-positive foci induced by DMH in the liver was measured immunohistochemically. |
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| 18984026 | Hwang YP, Choi JH, Jeong HG: Protective effect of the Aralia continentalis root extract against carbon tetrachloride-induced hepatotoxicity in mice. Food Chem Toxicol. 2009 Jan;47(1):75-81. Epub 2008 Oct 17. In addition, pretreatment with AC significantly prevented both the depletion of (GSH) content and the decrease in glutathione-S-transferase (GST) activity in the liver of CCl4-intoxicated mice. |
1(0,0,0,1) | Details |
| 17900780 | Yang YS, Ahn TH, Lee JC, Moon CJ, Kim SH, Jun W, Park SC, Kim HC, Kim JC: Protective effects of Pycnogenol on carbon tetrachloride-induced hepatotoxicity in Sprague-Dawley rats. Food Chem Toxicol. 2008 Jan;46(1):380-7. Epub 2007 Aug 21. Hepatotoxicity was assessed 24 h after the CCl4 treatment by measurement of serum aminotransferase (AST) and alanine aminotransferase (ALT) activities, hepatic malondialdehyde (MDA) and (GSH) concentrations, and catalase, superoxide dismutase (SOD), and glutathione-S-transferase (GST) activities. |
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| 16810758 | Shi ZM, Feng P, Jiang DQ, Wang XJ: Mistletoe alkali inhibits peroxidation in rat liver and kidney. . World J Gastroenterol. 2006 Jul 7;12(25):4052-5. METHODS: The antioxidant effect of mistletoe alkali on the oxidative stress induced by carbon tetrachloride (CCl4) in rats was investigated. Also, the level of (GSH), and activities of glutathione reductase (GR), peroxidase (GSPx), superoxide dismutase (SOD), and glutathione-S-transferase (GST) in liver and kidney were determined. |
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| 19595748 | Chan WH, Liao JW, Chou CP, Chan PK, Wei CF, Ueng TH: Induction of CYP1A1, 2B, 2E1 and 3A in rat liver by organochlorine pesticide dicofol. Toxicol Lett. 2009 Oct 28;190(2):150-5. Epub 2009 Jul 10. The treatments also increased glutathione S-transferase and superoxide dismutase activities in liver cytosol. |
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| 19446540 | Singh BN, Singh BR, Sarma BK, Singh HB: Potential chemoprevention of N-nitrosodiethylamine-induced hepatocarcinogenesis by polyphenolics from Acacia nilotica bark. Chem Biol Interact. 2009 Sep 14;181(1):20-8. Epub 2009 May 14. Chemopreventive potential of Acacia nilotica bark extract (ANBE) against single intraperitoneal injection of N-nitrosodiethylamine (NDEA, 200mg/kg) followed by weekly subcutaneous injections of carbon tetrachloride (CCl (4), 3 ml/kg) for 6 weeks induced hepatocellular carcinoma (HCC) in rats was studied. Additionally, ANBE also increased the activities of antioxidant enzymes viz., catalase (CAT), superoxide dismutase (SOD), peroxidase (GPx), and glutathione-S-transferase (GST) in the liver of NDEA-administered rats. |
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| 14757975 | Tang MH, Chiu PY, Ko KM: Hepatoprotective action of schisandrin B against carbon tetrachloride toxicity was mediated by both enhancement of mitochondrial status and induction of heat shock proteins in mice. Biofactors. 2003;19(1-2):33-42. The stimulatory effect of Sch B then gradually subsided, but the activities of hepatic mitochondrial glutathione reductase (GR) and glutathione S-transferases (GST) as well as the level of HSP 25 remained relatively high even at 72 h post-dosing. |
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| 14713368 | Lee TY, Wang GJ, Chiu JH, Lin HC: Long-term administration of Salvia miltiorrhiza ameliorates carbon tetrachloride-induced hepatic fibrosis in rats. J Pharm Pharmacol. 2003 Nov;55(11):1561-8. Rats receiving CCl4 alone showed a decreased hepatic level and an increased glutathione-S-transferase content. |
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| 16117609 | Kim NY, Lee MK, Park MJ, Kim SJ, Park HJ, Choi JW, Kim SH, Cho SY, Lee JS: Momordin Ic and oleanolic acid from Kochiae Fructus reduce carbon tetrachloride-induced hepatotoxicity in rats. J Med Food. 2005 Summer;8(2):177-83. The CCl4-treated rats had significantly lower activities of glutathione reductase, glutathione S-transferase, superoxide dismutase, catalase, and peroxidase. |
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| 15267142 | Bhandarkar M, Khan A: Protective effect of Lawsonia alba Lam., against CCl4 induced hepatic damage in albino rats. Indian J Exp Biol. 2003 Jan;41(1):85-7. The oral administration in varying doses of aqueous suspension of extract of L. alba, bark extract to rats for 10 days afforded good hepatoprotection against CCl4 induced elevation in serum marker enzymes, serum liver lipid peroxidation and reduction in total serum protein, liver peroxidase, glutathione-s-transferase, superoxide dismutase and catalase activity. |
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| 19581077 | Adesanoye OA, Farombi EO: Hepatoprotective effects of Vernonia amygdalina (astereaceae) in rats treated with carbon tetrachloride. Exp Toxicol Pathol. 2010 Mar;62(2):197-206. Epub 2009 Jul 5. Similarly, administration of the extract increased the activities of the antioxidant enzymes: superoxide dismutase, glutathione S-transferase and concentration significantly at 500 mg/kg (P <0.05) and catalase activity at 500-1000 mg/kg doses. |
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| 19742242 | Shaarawy SM, Tohamy AA, Elgendy SM, Elmageed ZY, Bahnasy A, Mohamed MS, Kandil E, Matrougui K: Protective effects of garlic and silymarin on NDEA-induced rats hepatotoxicity. Int J Biol Sci. 2009 Aug 11;5(6):549-57. BACKGROUND: The present study was conducted to investigate the chemopreventive effects of garlic extract and silymarin on N-nitrosodiethylamine (NDEA) and carbon tetrachloride (CCl (4))-induced hepatotoxicity in male albino rats. Serum transaminase (AST), transaminase (ALT), alkaline phosphatase (ALP), hepatic lipid peroxidation (LPO), superoxide dismutase (SOD), (GSH), glutathione-S-transferase (GST) and glutathione reductase (GSR) were measured. |
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| 16968418 | Dakshayani KB, Subramanian P, Manivasagam T, Mohamed Essa M: Metabolic normalization of alpha-ketoglutarate against N-nitrosodiethylamine-induced hepatocarcinogenesis in rats. Fundam Clin Pharmacol. 2006 Oct;20(5):477-80. Levels of antioxidants, and activities of its dependent enzymes, peroxidase and glutathione-S-transferase were found to be significantly higher in liver tissue of NDEA + CCl (4)-treated animals when compared with control animals. alpha-KG administration positively modulated the antioxidant levels to near normal range. |
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| 18215477 | Zhang J, Wang H, Peng D, Taylor EW: Further insight into the impact of selenite on selenoenzymes: high-dose selenite enhances hepatic thioredoxin reductase 1 activity as a consequence of liver injury. Toxicol Lett. 2008 Feb 15;176(3):223-9. Epub 2008 Jan 22. To corroborate this, we showed that hepatotoxic agents, thioacetamide or carbon tetrachloride, caused marked increases in hepatic TrxR1 activity. (Se) at supranutritional levels can enhance the activity of glutathione S-transferase (GST), whose gene is a target of nuclear factor erythroid-2 related factor 2 (Nrf2). |
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| 17611085 | Manna P, Sinha M, Sil PC: Phytomedicinal activity of Terminalia arjuna against carbon tetrachloride induced cardiac oxidative stress. Pathophysiology. 2007 Oct;14(2):71-8. Epub 2007 Jul 3. Oral administration of CCl (4) at a dose of 1ml/kg body weight for 2 days significantly reduced the activities of antioxidant enzymes, superoxide dismutase (SOD), catalase (CAT) and glutathione-S-transferase (GST), as well as depleted the level of (GSH) in the cardiac tissue. |
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| 18038910 | Hwang YP, Choi CY, Chung YC, Jeon SS, Jeong HG: Protective effects of puerarin on carbon tetrachloride-induced hepatotoxicity. Arch Pharm Res. 2007 Oct;30(10):1309-17. In addition, pretreatment with puerarin significantly prevented both the depletion of (GSH) content and the decrease in glutathione S-transferase (GST) activity in the liver of CCl4-intoxicated mice. |
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| 20192593 | Poojari R, Gupta S, Maru G, Khade B, Bhagwat S: Sida rhombifolia ssp. retusa Seed Extract Inhibits DEN Induced Murine Hepatic Preneoplasia and Carbon Tetrachloride Hepatotoxicity. Asian Pac J Cancer Prev. 2009;10(6):1107-12. Treatment with seed extract significantly inhibited the increase in DEN/CCl4 induced activities of pre-cancerous marker enzymes; gamma-glutamyl transpeptidase, glutathione-S-transferase, hepatotoxicity marker enzymes; glutamate pyruvate transaminase, transaminase and alkaline phosphatase as well as lipid peroxidase. |
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| 17084954 | Lima CF, Fernandes-Ferreira M, Pereira-Wilson C: Drinking of Salvia officinalis tea increases CCl (4)-induced hepatotoxicity in mice. Food Chem Toxicol. 2007 Mar;45(3):456-64. Epub 2006 Oct 1. In a previous study, the drinking of a Salvia officinalis tea (prepared as an infusion) for 14 days improved liver antioxidant status in mice and rats where, among other factors, an enhancement of glutathione-S-transferase (GST) activity was observed. Taking in consideration these effects, in the present study the potential protective effects of sage tea drinking against a situation of hepatotoxicity due to free radical formation, such as that caused by carbon tetrachloride (CCl (4)), were evaluated in mice of both genders. |
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