| Name | tumor necrosis factor alpha |
|---|---|
| Synonyms | Cachectin; DIF; TNF; TNF alpha; TNF a; TNFA; TNFSF 2; TNFSF2… |
| Name | carbon tetrachloride |
|---|---|
| CAS | tetrachloromethane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 20128048 | Wu SJ, Tam KW, Tsai YH, Chang CC, Chao JC: and saikosaponin a inhibit chemical-induced liver inflammation and fibrosis in rats. Liver Int. 2006 Jun;26(5):579-86. Carbon tetrachloride (40% in olive oil) at a dose of 0.75 ml/kg was injected intraperitoneally once a week. Hepatic proinflammatory cytokines tumor necrosis factor-alpha, interleukin-1beta, and interleukin-6 were significantly inhibited, and anti-inflammatory cytokine interleukin-10 was significantly increased by supplementation with and/or saikosaponin A. |
1(0,0,0,1) | Details |
| 15902742 | Gui SY, Wei W, Wang H, Wu L, Sun WY, Wu CY: Protective effect of fufanghuangqiduogan against acute liver injury in mice. World J Gastroenterol. 2005 May 21;11(19):2984-9. METHODS: ALI was successfully induced by injecting carbon tetrachloride (CCl4) intraperitoneally and by tail vein injection of Bacillus Calmette Guerin (BCG) and lipopolysaccharide (LPS) in mice, respectively. The activities of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 (IL-1) were determined by radio-immunoassay. |
1(0,0,0,1) | Details |
| 15830285 | Mikami K, Goto T, Miura K, Ohshima S, Yoneyama K, Lin JG, Watanabe D, Segawa D, Kataoka E, Shibuya T, Watanabe S: Gabexate mesilate, a synthetic protease inhibitor, attenuates carbon tetrachloride-induced liver injury in rats. J Gastroenterol. 2005 Mar;40(3):260-5. Plasma tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) decreased significantly in the gabexate mesilate-treated rats compared with saline-treated rats. |
1(0,0,0,1) | Details |
| 17610505 | Zhang L, Wan J, Li H, Wu P, Jin S, Zhou X, Yuan P, Xiong W, Li Y, Ye D: Protective effects of BML-111, a lipoxin A (4) receptor agonist, on carbon tetrachloride-induced liver injury in mice. Hepatol Res. 2007 Nov;37(11):948-56. Epub 2007 Jul 4. The dampened liver injury was accompanied byreduced malondialdehyde (MDA) content in liver homogenates and decreased concentration of tumor necrosis factor-alpha (TNF-alpha) in the serum. |
1(0,0,0,1) | Details |
| 18990340 | Wu T, Liu T, Zheng PY, Xing LJ, Ji G: [Effects of Qinggan Huoxue Recipe and its separated recipes on the expression of tumor necrosis factor-alpha in rats with alcoholic liver injury]. Am J Chin Med. 2010;38(1):99-111. METHODS: One hundred male Wistar rats were randomly divided into normal control group (n=10), carbon tetrachloride (CCl4) group (n=10) and ALI group (n=80). |
1(0,0,0,1) | Details |
| 17904177 | Yamaji K, Ohnishi K, Zuinen R, Ochiai Y, Chikuma T, Hojo H: Interleukin-6 production by peritoneal mesothelial cells and its regulation by inflammatory factors in rats administered carbon tetrachloride intraperitoneally. Toxicol Appl Pharmacol. 2008 Jan 1;226(1):38-45. Epub 2007 Aug 24. Analyses of PEF revealed that the levels of (2) (PGE (2)), IL-1alpha, IL-1beta and tumor necrosis factor-alpha (TNF-alpha) increased immediately after ip CCl (4) administration. |
1(0,0,0,1) | Details |
| 16228231 | Ishikawa T, Terai S, Urata Y, Marumoto Y, Aoyama K, Sakaida I, Murata T, Nishina H, Shinoda K, Uchimura S, Hamamoto Y, Okita K: Fibroblast growth factor 2 facilitates the differentiation of transplanted bone marrow cells into hepatocytes. Cell Tissue Res. 2006 Feb;323(2):221-31. Epub 2005 Oct 14. We have developed an in vivo mouse model, the green fluorescent protein (GFP)/carbon tetrachloride (CCl (4)) model, and have previously reported that transplanted GFP-positive bone marrow cells (BMCs) differentiate into hepatocytes via hepatoblast intermediates. Transplantation of BMCs with rFGF2 specifically activated tumor necrosis factor-alpha (TNF-alpha) signaling. |
1(0,0,0,1) | Details |
| 17038628 | Horani A, Muhanna N, Pappo O, Melhem A, Alvarez CE, Doron S, Wehbi W, Dimitrios K, Friedman SL, Safadi R: Beneficial effect of glatiramer acetate (Copaxone) on immune modulation of experimental hepatic fibrosis. Am J Physiol Gastrointest Liver Physiol. 2007 Feb;292(2):G628-38. Epub 2006 Oct 12. After GA treatment, however, NK content, CD4 (+) CD25 (+) FoxP3 (+) cells, hepatic expression of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), and apoptosis of hepatic stellate cells were all increased. Hepatic fibrosis was induced in C57BL/6 mice by intraperitoneal administration of carbon tetrachloride (CCl (4)) for 6 wk. |
1(0,0,0,1) | Details |
| 15925388 | Wang H, Wei W, Wang NP, Gui SY, Wu L, Sun WY, Xu SY: ameliorates carbon tetrachloride-induced hepatic fibrogenesis in rats via inhibition of oxidative stress. Life Sci. 2005 Aug 26;77(15):1902-15. Tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) concentrations in Kupffer cells (KCs) culture supernatants were measured with ELISA. |
1(0,0,0,1) | Details |
| 16762003 | Roderfeld M, Geier A, Dietrich CG, Siewert E, Jansen B, Gartung C, Roeb E: Cytokine blockade inhibits hepatic tissue inhibitor of metalloproteinase-1 expression and up-regulates matrix metalloproteinase-9 in toxic liver injury. Exp Toxicol Pathol. 2009 Oct 14. METHODS: Intraperitoneal application of a single dose of either tumor necrosis factor (TNF)-alpha or interleukin (IL)-1beta in mice led to an enhanced expression of hepatic TIMP-1 after 4-16 h. Male Sprague-Dawley rats were treated with carbon tetrachloride (CCl4) in the presence and absence of specific TNF-alpha and IL-1beta inhibitors. |
1(0,0,0,1) | Details |
| 16941689 | Guarner C, Gonzalez-Navajas JM, Sanchez E, Soriando G, Frances R, Chiva M, Zapater P, Benlloch S, Munoz C, Pascual S, Balanzo J, Perez-Mateo M, Such J: The detection of bacterial DNA in blood of rats with CCl4-induced cirrhosis with ascites represents episodes of bacterial translocation. Hepatology. 2006 Sep;44(3):633-9. MLNs and ascitic and pleural fluids were collected at laparotomy and cultured; samples were collected for identification of bactDNA and measurement of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and (NO). |
1(0,0,0,1) | Details |
| 15573910 | Wei YH, Jun L, Qiang CJ: Effect of losartan, an angiotensin II antagonist, on hepatic fibrosis induced by CCl4 in rats. Arch Pharm Res. 2008 Sep;31(9):1160-5. Epub 2008 Sep 20. Tumor necrosis factor-alpha (TNF-alpha) and transforming growth factor-beta1 (TGF-beta1) levels in culture supernatants of Kupffer cells (KCs) stimulated with Ang II was determined by ELISA. |
1(0,0,0,1) | Details |
| 18007553 | Alvarez GC, Madrid-Marina V, Jimenez-Mendez R, Buitimea AL, Roman MB, Cortez-Gomez R, Esparza JR, Rodriguez-Fragoso L: Combined therapy with danazol, pegilated interferon, and ribavirin improves thrombocytopenia and liver injury in rats with fibrosis. Dig Dis Sci. 2004 Oct;49(10):1589-94. However, danazol + PEG-IFN + ribavirin reduced the expression of IL-6, IL-10, tumor necrosis factor alpha and transforming growth factor ss. |
1(0,0,0,1) | Details |
| 18187930 | Park SW, Lee CH, Kim YS, Kang SS, Jeon SJ, Son KH, Lee SM: Protective effect of baicalin against carbon tetrachloride-induced acute hepatic injury in mice. J Pharmacol Sci. 2008 Jan;106(1):136-43. Epub 2008 Jan 11. The serum level and mRNA expression of tumor necrosis factor-alpha were markedly increased by the CCl (4) treatment but suppressed by baicalin. |
1(0,0,0,1) | Details |
| 20354348 | Akachi T, Shiina Y, Ohishi Y, Kawaguchi T, Kawagishi H, Morita T, Mori M, Sugiyama K: Hepatoprotective Effects of Flavonoids from Shekwasha (Citrus depressa) against D-Galactosamine-Induced Liver Injury in Rats. Ann Hepatol. 2007 Oct-Dec;6(4):233-41. the most important compound in the n-hexane-soluble fraction, also had suppressive effects on liver injuries induced by carbon tetrachloride, and GalN/lipopolysaccharide (LPS) in addition to liver injury induced GalN. |
0(0,0,0,0) | Details |
| 15337842 | Askari FK, Dick R, Mao M, Brewer GJ: Tetrathiomolybdate therapy protects against concanavalin a and carbon tetrachloride hepatic damage in mice. Gut. 2007 Jul;56(7):974-81. Epub 2007 Feb 13. |
0(0,0,0,0) | Details |
| 19352025 | Quan J, Piao L, Xu H, Li T, Yin X: Protective effect of iridoid glucosides from Boschniakia rossica on acute liver injury induced by carbon tetrachloride in rats. Biosci Biotechnol Biochem. 2009 Apr 23;73(4):849-54. Epub 2009 Apr 7. The CCl4 challenge caused a marked increase in the levels of serum animotransferases, tumor necrosis factor-alpha (TNF-alpha) and of hepatic inducible synthase (iNOS) protein, depleted (GSH), and propagated lipid peroxidation. |
1(0,0,0,1) | Details |
| 15632045 | Joseph B, Bhargava KK, Tronco GG, Kumaran V, Palestro CJ, Gupta S: Regulation of hepatobiliary transport activity and noninvasive identification of cytokine-dependent liver inflammation. J Nucl Med. 2005 Jan;46(1):146-52. In vitro assays showed impairment in (99m) Tc-mebrofenin excretion after incubation of cultured hepatocytes with interleukin-6 and further impairment with interleukin-6 plus tumor necrosis factor-alpha. METHODS: To demonstrate regulation of hepatobiliary transport in disease, we used (99m) Tc-mebrofenin in a carbon tetrachloride-induced liver injury model in Fischer 344 rats. |
1(0,0,0,1) | Details |
| 18823985 | Taura K, De Minicis S, Seki E, Hatano E, Iwaisako K, Osterreicher CH, Kodama Y, Miura K, Ikai I, Uemoto S, Brenner DA: Hepatic stellate cells secrete angiopoietin 1 that induces angiogenesis in liver fibrosis. Gastroenterology. 2008 Nov;135(5):1729-38. Epub 2008 Aug 3. In primary cultures, activated HSCs express and secrete angiopoietin 1 more abundantly than quiescent HSCs, and the inflammatory cytokine tumor necrosis factor-alpha stimulates its expression in an nuclear factor-kappaB-dependent manner. |
1(0,0,0,1) | Details |
| 20038333 | Lan L, Chen YW, Sun C, Liu BW, Sun QL, Li DG: [Effect of interleukin 10 gene-modified bone marrow-derived liver stem cells transplantation on hepatic inflammatory response and liver regeneration in hepatic fibrosis rats]. Zhonghua Gan Zang Bing Za Zhi. 2009 Dec;17(12):915-20. METHODS: 50 female Wistar rats were randomly divided into 4 groups: (1) control group: 10 rats were subcutaneously injected with olive oil for 8 weeks; (2) fibrosis groups: 16 rats were subcutaneously injected with carbon tetrachloride (CCl4) for 8 weeks to induce liver fibrosis; (3) BDLSC group: 12 rats were subcutaneously injected with CCl4 for 8 weeks, and were transplanted with 2 x 10 (5) BDLSC at week 4; (4) BDLSC/IL-10 group: 12 rats were subcutaneously injected with CCl4 for 8 weeks, and were transplanted with 2 x 10 (5) IL-10 gene-modified BDLSC at week 4. IL-10 and tumor necrosis factor alpha (TNFa) in liver tissues were detected by ELISA. |
1(0,0,0,1) | Details |
| 18815054 | Shibata H, Yoshioka Y, Ohkawa A, Abe Y, Nomura T, Mukai Y, Nakagawa S, Taniai M, Ohta T, Mayumi T, Kamada H, Tsunoda S, Tsutsumi Y: The therapeutic effect of TNFR1-selective antagonistic mutant TNF-alpha in murine hepatitis models. J Nutr Sci Vitaminol. 2010;56(1):60-7. Tumor necrosis factor-alpha (TNF-alpha) is critically involved in a wide variety of inflammatory pathologies, such as hepatitis, via the TNF receptor-1 (TNFR1). In this study, we examined the therapeutic effect of R1antTNF in acute hepatitis using two independent experimental models, induced by carbon tetrachloride (CCl (4)) or concanavalin A (ConA). |
1(0,0,0,1) | Details |
| 17504260 | Hua J, Qiu de K, Li JQ, Li EL, Chen XY, Peng YS: Expression of Toll-like receptor 4 in rat liver during the course of carbon tetrachloride-induced liver injury. J Gastroenterol Hepatol. 2007 Jun;22(6):862-9. Epub 2007 May 17. The levels of tumor necrosis factor (TNF)-alpha in Kupffer cell culture supernatants were determined by enzyme-linked immunosorbent assay. |
1(0,0,0,1) | Details |
| 17706384 | Padhy BM, Srivastava A, Kumar VL: Calotropis procera latex affords protection against carbon tetrachloride induced hepatotoxicity in rats. J Ethnopharmacol. 2007 Sep 25;113(3):498-502. Epub 2007 Jul 10. Subcutaneous injection of CCl (4,) administered twice a week, produced a marked elevation in the serum levels of transaminase (AST), transaminase (ALT) and tumor necrosis factor alpha (TNF-alpha). |
1(0,0,0,1) | Details |
| 19177741 | Ibrahim ZS, Ishizuka M, Soliman M, ElBohi K, Sobhy W, Muzandu K, Elkattawy AM, Sakamoto KQ, Fujita S: Protection by Nigella sativa against carbon tetrachloride-induced downregulation of hepatic cytochrome P450 isozymes in rats. Jpn J Vet Res. 2008 Nov;56(3):119-28. Moreover, CCl4 increased iNOS and TNFalpha mRNA, while N. sativa oil administration for one week prior to CCl4 injection downregulated the CCl4-induced iNOS mRNA and up-regulated IL-10 mRNA. |
1(0,0,0,1) | Details |
| 15760680 | Sudo K, Yamada Y, Moriwaki H, Saito K, Seishima M: Lack of tumor necrosis factor receptor type 1 inhibits liver fibrosis induced by carbon tetrachloride in mice. Gastroenterology. 2008 Jan;134(1):248-58. Epub 2007 Sep 29. The proinflammatory cytokine tumor necrosis factor (TNF) is involved in the pathogenesis of many acute and chronic liver diseases. |
1(0,0,0,1) | Details |
| 18166357 | Jeong WI, Park O, Gao B: Abrogation of the antifibrotic effects of natural killer cells/interferon-gamma contributes to acceleration of liver fibrosis. e1-4. Epub 2009 Jan 6. Liver fibrosis was induced by administration of carbon tetrachloride (CCl (4)) for 2 weeks. Poly I:C activation of NK cell cytotoxicity against HSCs was attenuated in -fed mice compared with pair-fed mice, which was due to reduced natural killer group 2 member D (NKG2D), tumor necrosis factor-related apoptosis-inducing ligand, and IFN-gamma expression on NK cells from -fed mice. |
1(0,0,0,1) | Details |
| 15646798 | Lee KJ, Kim JY, Jung KS, Choi CY, Chung YC, Kim DH, Jeong HG: Suppressive effects of Platycodon grandiflorum on the progress of carbon tetrachloride-induced hepatic fibrosis. Arch Pharm Res. 2004 Dec;27(12):1238-44. CK significantly suppressed CCl4-induced hepatic necrosis and inflammation, as determined by the serum enzymatic activities of and aspartate aminotransferase and serum tumor necrosis factor-alpha levels, in dose-dependent manners. |
1(0,0,0,1) | Details |
| 19385008 | Tang X, Yang J, Li J: Accelerative effect of leflunomide on recovery from hepatic fibrosis involves TRAIL-mediated hepatic stellate cell apoptosis. Life Sci. 2009 Apr 10;84(15-16):552-7. MAIN METHODS: We harvested Kupffer cells from rats during spontaneous recovery from liver fibrosis induced by carbon tetrachloride (CCl4) and prepared recovery Kupffer cell conditioned medium (KCCM). Real-time quantitative PCR (Q-PCR) analysis showed increased expression of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in Kupffer cells during the spontaneous recovery phase. |
1(0,0,0,1) | Details |
| 16382349 | Lindros KO, Jarvelainen HA: Chronic systemic endotoxin exposure: an animal model in experimental hepatic encephalopathy. Metab Brain Dis. 2005 Dec;20(4):393-8. The chronic endotoxin model, mimicking the "leaky gut," may best be combined with more robust ways to impair liver function, such as carbon tetrachloride treatment, bile duct ligation, or galactosamine administration. Circulating LPS activates macrophages to produce tumor necrosis factor alpha (TNF-alpha) and other potentially cytotoxic proinflammatory mediators. |
1(0,0,0,1) | Details |
| 15242491 | Mikami K, Otaka M, Goto T, Miura K, Ohshima S, Yoneyama K, Lin JG, Watanabe D, Segawa D, Kataoka E, Odashima M, Watanabe S: Induction of a 72-kDa heat shock protein and protection against lipopolysaccharide-induced liver injury in cirrhotic rats. J Gastroenterol Hepatol. 2004 Aug;19(8):884-90. The plasma tumor necrosis factor (TNF)-alpha level was determined. In this study, we investigated the cytoprotective effect of HSP72 on lipopolysaccharide (LPS)-induced liver injury in carbon tetrachloride (CCl (4))-induced cirrhotic rats. |
1(0,0,0,1) | Details |
| 19151545 | Kim SH, Cheon HJ, Yun N, Oh ST, Shin E, Shim KS, Lee SM: Protective effect of a mixture of Aloe vera and Silybum marianum against carbon tetrachloride-induced acute hepatotoxicity and liver fibrosis. J Pharmacol Sci. 2009 Jan;109(1):119-27. The ACTIValoe N-931 complex attenuated the increase in tumor necrosis factor-alpha (TNF-alpha), and inducible synthase (iNOS), and cyclooxygenase-2 (COX-2), mRNA expressions in acute hepatotoxicity. |
1(0,0,0,1) | Details |
| 16045604 | Qiu DK, Hua J, Li JQ, Li EL: CD14 expression on Kupffer cells during the course of carbon tetrachloride-mediated liver injury. Chin J Dig Dis. 2005;6(3):137-41. Supernatants were then collected for measuring the concentration of tumor necrosis factor-alpha (TNF-alpha) by enzyme-linked immunosorbent assay (ELISA). |
1(0,0,0,1) | Details |
| 16964402 | Kawakami T, Takahashi T, Shimizu H, Nakahira K, Takeuchi M, Katayama H, Yokoyama M, Morita K, Akagi R, Sassa S: Highly liver-specific heme oxygenase-1 induction by interleukin-11 prevents carbon tetrachloride-induced hepatotoxicity. Int J Mol Med. 2006 Oct;18(4):537-46. As recombinant human interleukin-11 (rhIL-11) has been shown to induce HO-1 in cultured hepatoma cells, we examined the effect of rhIL-11 in vivo in rats on the CCl (4)-induced tissue injury. rhIL-11 treatment of animals by itself markedly induced HO-1 mRNA and its functional protein principally in the liver. rhIL-11 treatment (150 microg/kg) of the CCl (4)-administered (1 ml/kg) animals led to a further increase in HO-1 mRNA, while it markedly suppressed CCl (4)-induced serum transaminase, hepatic malondialdehyde formation, tumor necrosis factor-alpha mRNA, synthase mRNA, nuclear factor-kappaB DNA-binding activity, as well as inflammatory changes of hepatocytes. |
1(0,0,0,1) | Details |
| 17157831 | Wills PJ, Asha VV: Protective mechanism of Lygodium flexuosum extract in treating and preventing carbon tetrachloride induced hepatic fibrosis in rats. Chem Biol Interact. 2007 Jan 5;165(1):76-85. Epub 2006 Nov 2. The expression levels of tumor necrosis factor-alpha, interleukin-1beta, transforming growth factor-beta1, procollagen-I, procollagen-III and tissue inhibitor of metalloproteinase-1 were elevated during carbon tetrachloride administration and reduced the levels to normal by the treatment with the extract treatment. |
31(0,1,1,1) | Details |
| 16527836 | Frelin L, Brenndorfer ED, Ahlen G, Weiland M, Hultgren C, Alheim M, Glaumann H, Rozell B, Milich DR, Bode JG, Sallberg M: The hepatitis C virus and immune evasion: non-structural 3/4A transgenic mice are resistant to lethal tumour necrosis factor alpha mediated liver disease. Gut. 2006 Oct;55(10):1475-83. Epub 2006 Mar 9. Liver damage was induced using carbon tetrachloride (CCl (4)), lipopolysaccaride (LPS), tumour necrosis factor alpha (TNFalpha), and anti-Fas antibody. |
8(0,0,1,3) | Details |
| 17278221 | Dang SS, Wang BF, Cheng YA, Song P, Liu ZG, Li ZF: Inhibitory effects of saikosaponin-d on CCl4-induced hepatic fibrogenesis in rats. Zhong Xi Yi Jie He Xue Bao. 2008 Nov;6(11):1145-51. AIM: To investigate the suppressive effect of saikosaponin-d (SSd) on hepatic fibrosis in rats induced by CCl (4) injections in combination with and high fat, low protein feeding and its relationship with the expression of nuclear factor-kappaB (NF-kappaB), tumor necrosis factor-alpha (TNF-alpha) and interleukins-6 (IL-6). |
1(0,0,0,1) | Details |
| 19938218 | Chao J, Lee MS, Amagaya S, Liao JW, Wu JB, Ho LK, Peng WH: Hepatoprotective effect of shidagonglao on acute liver injury induced by carbon tetrachloride. World J Gastroenterol. 2007 Jan 28;13(4):557-63. Furthermore, SDGL (EtOH) (100 and 500 mg/kg) and silymarin attenuated the increased levels of tumor necrosis factor-alpha (TNF-alpha) in serum and (NO) in liver as compared to the CCl (4)-treated group. |
1(0,0,0,1) | Details |
| 18427963 | Bahcecioglu IH, Koca SS, Poyrazoglu OK, Yalniz M, Ozercan IH, Ustundag B, Sahin K, Dagli AF, Isik A: Hepatoprotective effect of infliximab, an anti-TNF-alpha agent, on carbon tetrachloride-induced hepatic fibrosis. Inflammation. 2008 Aug;31(4):215-21. Epub 2008 Apr 22. To assess the effect of infliximab, an anti-tumor necrosis factor (TNF)-alpha agent, on the carbon tetrachloride (CCl (4))-induced hepatic fibrosis in rats. |
6(0,0,1,1) | Details |
| 14991939 | Wang JJ, Gao GW, Gao RZ, Liu CA, Ding X, Yao ZX: Effects of tumor necrosis factor, endothelin and on hyperdynamic circulation of rats with acute and chronic portal hypertension. World J Gastroenterol. 2004 Mar 1;10(5):689-93. METHODS: Chronic portal hypertension was induced in Wistar rats by injection of carbon tetrachloride. |
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| 19250650 | Urtasun R, Cubero FJ, Vera M, Nieto N: Reactive species switch on early extracellular matrix remodeling via induction of MMP1 and TNFalpha. Gastroenterology. 2009 Apr;136(4):1410-22 |
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| 17659698 | Zhang HY, Han DW, Zhao ZF, Liu MS, Wu YJ, Chen XM, Ji C: Multiple pathogenic factor-induced complications of cirrhosis in rats: a new model of hepatopulmonary syndrome with intestinal endotoxemia. World J Gastroenterol. 2007 Jul 7;13(25):3500-7. In rats with cirrhosis, there were a decreased PaO (2) and PaCO (2) in arterial blood, markedly decreased arterial O (2) content, a significantly increased alveolar to arterial gradient, an increased number of bacterial translocated within mesenteric lymph node, a significant higher level of LPS and tumor necrosis factor-alpha (TNF-alpha) in plasma, and a significant greater ratio of Tc99m-MAA brain-over-lung radioactivity. |
1(0,0,0,1) | Details |
| 17093919 | Ishikawa T, Terai S, Urata Y, Marumoto Y, Aoyama K, Murata T, Mizunaga Y, Yamamoto N, Nishina H, Shinoda K, Sakaida I: Administration of fibroblast growth factor 2 in combination with bone marrow transplantation synergistically improves carbon-tetrachloride-induced liver fibrosis in mice. Cell Tissue Res. 2007 Mar;327(3):463-70. Epub 2006 Nov 9. Our earlier study also demonstrated that administration of FGF2 in combination with bone marrow transplantation (BMT) synergistically activated tumor necrosis factor-alpha signaling and significantly improved liver function and prognosis more than BMT alone. |
1(0,0,0,1) | Details |
| 17383825 | Reyes-Gordillo K, Segovia J, Shibayama M, Vergara P, Moreno MG, Muriel P: protects against acute liver damage in the rat by inhibiting NF-kappaB, proinflammatory cytokines production and oxidative stress. Biochim Biophys Acta. 2007 Jun;1770(6):989-96. Epub 2007 Feb 22. an anti-inflammatory and antioxidant compound, was evaluated for its ability to suppress acute carbon tetrachloride-induced liver damage. Therefore, in this study we determined the concentrations of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6) mRNA, and NF-kappaB activation. |
1(0,0,0,1) | Details |
| 18263696 | Peng Z, Fernandez P, Wilder T, Yee H, Chiriboga L, Chan ES, Cronstein BN: Ecto-5'-nucleotidase (CD73) -mediated extracellular production plays a critical role in hepatic fibrosis. FASEB J. 2008 Jul;22(7):2263-72. Epub 2008 Feb 8. After CCl (4) treatment, the mRNA level of A (1), A (2A), A (2B), and A (3) receptors, tumor necrosis factor-alpha, interleukin (IL) -1beta, IL-13r alpha1, matrix metalloproteinase (MMP)-2, MMP-14, tissue inhibitor of metalloproteinase (TIMP) -1, and TIMP-2, and IL-13 level increased markedly in both CD73KO and WT mice, but Col1 alpha1, Col3 alpha1, and transforming growth factor-beta1 mRNA increased much more in WT mice than that in KO mice. |
1(0,0,0,1) | Details |
| 16472598 | Radaeva S, Sun R, Jaruga B, Nguyen VT, Tian Z, Gao B: Natural killer cells ameliorate liver fibrosis by killing activated stellate cells in NKG2D-dependent and tumor necrosis factor-related apoptosis-inducing ligand-dependent manners. Cytokine. 2005 Mar 7;29(5):236-44. METHODS: Liver fibrosis was induced either by feeding mice with the 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) diet or by injecting them with carbon tetrachloride. |
4(0,0,0,4) | Details |
| 17917259 | Lee CH, Park SW, Kim YS, Kang SS, Kim JA, Lee SH, Lee SM: Protective mechanism of glycyrrhizin on acute liver injury induced by carbon tetrachloride in mice. Biol Pharm Bull. 2007 Oct;30(10):1898-904. CCl (4) increased the level of circulating tumor necrosis factor-alpha markedly, which was reduced by glycyrrhizin. |
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| 15123356 | Ramirez MJ, Ibanez A, Navasa M, Casals E, Morales-Ruiz M, Jimenez W, Arroyo V, Rodes J: High-density lipoproteins reduce the effect of endotoxin on cytokine production and systemic hemodynamics in cirrhotic rats with ascites. J Hepatol. 2004 Mar;40(3):424-30. METHODS: The study was performed in control and rats with carbon-tetrachloride induced cirrhosis with ascites. The effects of 25 microg/kg of endotoxin on the serum concentration of TNFalpha and mean arterial pressure (MAP) were determined after treatment with HDL (80 mg/kg) or saline. |
3(0,0,0,3) | Details |
| 16510928 | Topuria D, Kakabadze Z, Lobdjanidze N, Chavchanidze N: Anti-hepato-cytotoxic serum treatment results in acute liver failure. . Georgian Med News. 2006 Jan;(130):111-5. Elevated serum concentrations of bacterial endotoxin, tumor necrosis factor-a, and interleukin-1 and interleukin-6 have been found in FHF, but the specific roles of these inflammatory factors are unclear. |
1(0,0,0,1) | Details |
| 19787836 | Peng XD, Dai LL, Huang CQ, He CM, Chen LJ: Correlation between anti-fibrotic effect of baicalin and serum cytokines in rat hepatic fibrosis. World J Gastroenterol. 2009 Oct 7;15(37):4720-5. Except for the normal control group, all rats in the other groups were administered with carbon tetrachloride to induce hepatic fibrosis. Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), transforming growth factor (TGF)-beta1, tumor necrosis factor (TNF)-alpha, interleukin (IL)-6 and IL-10 were measured. |
1(0,0,0,1) | Details |
| 15158334 | Black D, Bird MA, Samson CM, Lyman S, Lange PA, Schrum LW, Qian T, Lemasters JJ, Brenner DA, Rippe RA, Behrns KE: Primary cirrhotic hepatocytes resist TGFbeta-induced apoptosis through a ROS-dependent mechanism. J Hepatol. 2004 Jun;40(6):942-51. METHODS: Hepatocytes were isolated from normal and CCl (4)-treated mice and treated with TGFbeta, TNFalpha, and UV-C, known apoptotic agents. |
2(0,0,0,2) | Details |
| 16943688 | Paul SC, Lv P, Xiao YJ, An P, Liu SQ, Luo HS: Thalidomide in rat liver cirrhosis: blockade of tumor necrosis factor-alpha via inhibition of degradation of an inhibitor of nuclear factor-kappaB. Am J Chin Med. 2009;37(6):1085-97. METHODS: Liver cirrhosis was achieved by intraperitoneal injection of carbon tetrachloride thrice weekly, and thalidomide (10 or 100 mg/kg/day) was given daily by intragastric route for 8 weeks. |
2(0,0,0,2) | Details |
| 20144743 | Pulavendran S, Vignesh J, Rose C: Differential anti-inflammatory and anti-fibrotic activity of transplanted mesenchymal vs. hematopoietic stem cells in carbon tetrachloride-induced liver injury in mice. Int Immunopharmacol. 2010 Apr;10(4):513-9. Epub 2010 Feb 6. Immunostaining for the expression of tumor necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6), alpha smooth muscle actin (alpha-SMA) and type I collagen proteins was carried out and the expression of these mRNAs was also studied. |
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| 20093790 | Kim HY, Kim JK, Choi JH, Jung JY, Oh WY, Kim DC, Lee HS, Kim YS, Kang SS, Lee SH, Lee SM: Hepatoprotective effect of pinoresinol on carbon tetrachloride-induced hepatic damage in mice. Gastroenterology. 2006 Feb;130(2):435-52. The levels of protein and mRNA expression of inflammatory mediators, including tumor necrosis factor-alpha, inducible synthase, and cyclooxygenase-2, were significantly increased after CCl4 injection; and these increases were attenuated by pinoresinol. |
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| 17569148 | Zhong JY, Cong HQ, Zhang LH: Inhibitory effects of grape procyanidins on free radical-induced cell damage in rat hepatocytes in vitro. Exp Biol Med. 2004 Sep;229(8):857-63. AIM: To study the protective effect of grape procyanidins on oxidative injury induced by and carbon tetrachloride in rat hepatocytes. Cell proliferation, apoptosis and TNFalpha mRNA expression were subsequently determined using MTT assay, cell death ELISA and in situ hybridization. |
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| 18317297 | Joseph B, Bhargava KK, Tronco GG, Palestro CJ, Gupta S: Systemic and local release of inflammatory cytokines regulates hepatobiliary excretion of 99mTc-mebrofenin. Nucl Med Commun. 2008 Apr;29(4):336-44. METHODS: Acute liver injury was induced in Fischer 344 rats with 0.25-1 ml/kg single doses of carbon tetrachloride followed by studies of animals over 4 weeks. Additional rats were treated with lipopolysaccharide, interleukin-6 or tumor necrosis factor-alpha to activate inflammatory events. |
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| 17299060 | Chakass D, Philippe D, Erdual E, Dharancy S, Malapel M, Dubuquoy C, Thuru X, Gay J, Gaveriaux-Ruff C, Dubus P, Mathurin P, Kieffer BL, Desreumaux P, Chamaillard M: micro-Opioid receptor activation prevents acute hepatic inflammation and cell death. Pathobiology. 2006;73(2):82-92. MOR-deficient mice were used to evaluate the essential regulatory role of MOR during carbon tetrachloride (CCl (4))-induced hepatitis. Whereas MOR gene expression increased transiently in the model of acute liver injury and TNFalpha-treated HepG2 cells, an impaired expression of MOR mRNA in human chronic hepatitis C samples was found. |
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| 18006644 | Fu Y, Zheng S, Lin J, Ryerse J, Chen A: protects the rat liver from CCl4-caused injury and fibrogenesis by attenuating oxidative stress and suppressing inflammation. Mol Pharmacol. 2008 Feb;73(2):399-409. Epub 2007 Nov 15. The current study evaluates the in vivo role of in protecting the liver against injury and fibrogenesis caused by carbon tetrachloride (CCl (4)) in rats and further explores the underlying mechanisms. dramatically suppresses inflammation by reducing levels of inflammatory cytokines, including interferon-gamma, tumor necrosis factor-alpha, and interleukin-6. |
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| 19637241 | Sakai T, Liu L, Teng X, Ishimaru N, Mukai-Sakai R, Tran NH, Kim SM, Sano N, Hayashi Y, Kaji R, Fukui K: Inflammatory disease and cancer with a decrease in Kupffer cell numbers in Nucling-knockout mice. Int J Cancer. 2010 Mar 1;126(5):1079-94. In the background of Nucling-KO mice, we observed the up-regulation of TNFalpha, spontaneous NF-kappaB-activation and the induction of galectin-3 expression in liver. |
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| 18782536 | Zhang H, Feng Q, Li HS, Chen SD, Wang XN, Peng JH, Zhang N, Hu YY: [Effects of Qushi Huayu Decoction on cathepsin B and tumor necrosis factor-alpha expression in rats with non-alcoholic steatohepatitis]. Zhong Xi Yi Jie He Xue Bao. 2008 Sep;6(9):928-33. The rats except those in normal group were subcutaneously injected with carbon tetrachloride (CCl (4)) for 4 weeks (twice per week) and simultaneously fed with high-fat and low-protein diet for 2 weeks to induce NASH. |
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| 16698588 | Yuan GJ, Gong ZJ, Sun XM, Zheng SH, Li X: Tea polyphenols inhibit expressions of iNOS and TNF-alpha and prevent lipopolysaccharide-induced liver injury in rats. Hepatobiliary Pancreat Dis Int. 2006 May;5(2):262-7. BACKGROUND: Tea polyphenols have been shown to protect against carbon tetrachloride (CCl4)-induced liver injury, liver fibrosis, hepatic ischemia-reperfusion injury. Serum tumor necrosis factor-alpha (TNF-alpha) levels and liver malondialdehyde (MDA) contents were determined. |
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| 19836219 | Quan J, Yin X, Xu H: Boschniakia rossica prevents the carbon tetrachloride-induced hepatotoxicity in rat. Cytokine. 2008 Nov;44(2):229-33. Epub 2008 Sep 23. Furthermore, serum tumor necrosis factor-alpha (TNF-alpha), hepatic level, inducible synthase (iNOS) and cyclooxygenase-2 (COX-2) protein contents were elevated while cytochrome P450 2E1 (CYP2E1) expression and function were inhibited. |
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| 20211986 | Meng Z, Wang Y, Wang L, Jin W, Liu N, Pan H, Liu L, Wagman L, Forman BM, Huang W: FXR Regulates Liver Repair after CCl4-Induced Toxic Injury. Mol Endocrinol. 2010 Mar 8. Here we show that FXR is essential to promote liver repair after carbon tetrachloride (CCl4)-induced injury. During the early stages of liver repair after CCl4 treatment, we observed overproduction of TNFalpha and a strong decrease of phosphorylation and DNA-binding activity of signal transducer and activator of transcription 3 in livers from FXR (-/-) mice. |
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| 15743782 | Oakley F, Mann J, Nailard S, Smart DE, Mungalsingh N, Constandinou C, Ali S, Wilson SJ, Millward-Sadler H, Iredale JP, Mann DA: Nuclear factor-kappaB1 (p50) limits the inflammatory and fibrogenic responses to chronic injury. Am J Pathol. 2005 Mar;166(3):695-708. Mice received repeated hepatic injuries throughout 12 weeks by intraperitoneal injection of the hepatotoxin carbon tetrachloride. This phenotype was associated with elevated hepatic expression of tumor necrosis factor (TNF)-alpha, which was localized to regions of the liver associated with inflammation and fibrosis. |
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| 18806959 | Lee HS, Jung KH, Hong SW, Park IS, Lee C, Han HK, Lee DH, Hong SS: Morin protects acute liver damage by carbon tetrachloride (CCl (4)) in rat. J Pharmacol Sci. 2010 Jan;112(1):105-12. To identify the mechanism of protective activity of morin in CCl (4)-induced hepatotoxicity in rats, we investigated expressions of tumor necrosis factor alpha (TNF-alpha), interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and inducible (iNOS). |
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| 18721153 | Kimura K, Nagaki M, Matsuura T, Moriwaki H, Kakimi K: Pathological role of CD44 on NKT cells in carbon tetrachloride-mediated liver injury. Hepatol Res. 2009 Jan;39(1):93-105. Epub 2008 Aug 19. Furthermore, MIP-2 derived from NKT cells or tumor necrosis factor alpha from macrophages contributed to exacerbation of the liver injury, since neutralization of MIP-2 provided significant protection against liver injury in CD44KO mice. |
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