| Name | lactate dehydrogenase (protein family or complex) |
|---|---|
| Synonyms | LDH; lactate dehydrogenase; lactate dehydrogenases |
| Name | carbon tetrachloride |
|---|---|
| CAS | tetrachloromethane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19775523 | Yukawa H, Noguchi H, Oishi K, Takagi S, Hamaguchi M, Hamajima N, Hayashi S: Cell transplantation of adipose tissue-derived stem cells in combination with attenuated acute liver failure in mice. Cell Transplant. 2009;18(5):611-8. The effect of adipose tissue-derived stem cells (ASCs) in combination with transplantation on acute liver failure mice with carbon tetrachloride (CCl (4)) injection was investigated. The injection of into the caudal tail vein decreased slightly the activities of the alanine aminotransferase (ALT), asparate aminotransferase (AST), and lactate dehydrogenase (LDH) in plasma. |
1(0,0,0,1) | Details |
| 16038630 | Cai Y, Gong LK, Qi XM, Li XH, Ren J: Apoptosis initiated by carbon tetrachloride in mitochondria of rat primary cultured hepatocytes. Acta Pharmacol Sin. 2005 Aug;26(8):969-75. METHODS: Several cytotoxicity endpoints, including WST-8 metabolism, lactate dehydrogenase leakage and morphological changes, were examined. |
1(0,0,0,1) | Details |
| 17299060 | Chakass D, Philippe D, Erdual E, Dharancy S, Malapel M, Dubuquoy C, Thuru X, Gay J, Gaveriaux-Ruff C, Dubus P, Mathurin P, Kieffer BL, Desreumaux P, Chamaillard M: micro-Opioid receptor activation prevents acute hepatic inflammation and cell death. Gut. 2007 Jul;56(7):974-81. Epub 2007 Feb 13. MOR-deficient mice were used to evaluate the essential regulatory role of MOR during carbon tetrachloride (CCl (4))-induced hepatitis. The role of DAMGO in cell death was investigated using terminal deoxynucleotidyl transferase-mediated nick-end labelling (TUNEL) analysis and quantification of lactate dehydrogenase release. |
1(0,0,0,1) | Details |
| 17002669 | Lee SJ, Oh PS, Lim KT: Hepatoprotective and hypolipidaemic effects of glycoprotein isolated from Gardenia jasminoides ellis in mice. Clin Exp Pharmacol Physiol. 2006 Oct;33(10):925-33. In CCl4 (1.0 mL/kg)-treated mice, pretreatment with GJE glycoprotein (80 mg/kg) blocked lactate dehydrogenase release and the formation of thiobarbituric acid-reactive substances. |
1(0,0,0,1) | Details |
| 15772367 | Farkas D, Tannenbaum SR: Characterization of chemically induced hepatotoxicity in collagen sandwiches of rat hepatocytes. Toxicol Sci. 2005 Jun;85(2):927-34. Epub 2005 Mar 16. Cell function and viability was measured by analyzing the secretions of urea and albumin and the release of lactate dehydrogenase. However, no significant toxicity could be measured following exposures to 5 mM carbon tetrachloride, 1 mM N, N-dimethylformamide (DMF), 1 mM vinyl and 1 mM |
1(0,0,0,1) | Details |
| 19242656 | Liu J, Tan H, Sun Y, Zhou S, Cao J, Wang F: The preventive effects of -superoxide dismutase on carbon tetrachloride-induced acute liver failure and hepatic fibrosis in mice. Mol Cell Biochem. 2009 Jul;327(1-2):219-28. Epub 2009 Feb 26. Biochemical indicators, such as glutamic oxaloacetic transaminase/glutamic pyruvic transaminase (GOT/GPT), GSH lactate dehydrogenase (LDH), and malondialdehyde (MDA) were determined 24 h after CCl4 treatment. |
1(0,0,0,1) | Details |
| 16041732 | Nkosi CZ, Opoku AR, Terblanche SE: Effect of pumpkin seed (Cucurbita pepo) protein isolate on the activity levels of certain plasma enzymes in CCl4-induced liver injury in low-protein fed rats. Phytother Res. 2005 Apr;19(4):341-5. The effects of pumpkin seed (Cucurbita pepo) protein isolate on the activity levels of lactate dehydrogenase (LD), transaminase (ALT), transaminase (AST) and alkaline phosphatase (ALP) against carbon tetrachloride (CCl4)-induced acute liver injury in low-protein fed rats were investigated. |
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| 16220565 | Rusu MA, Tamas M, Puica C, Roman I, Sabadas M: The hepatoprotective action of ten herbal extracts in CCl4 intoxicated liver. Phytother Res. 2005 Sep;19(9):744-9. Biochemical parameters, including serum transaminase activity (GPT and GOT), histoenzymological measurements (lactate dehydrogenase, LDH; succinate dehydrogenase, SDH, cytochromoxidase, CyOx; Mg (2+)-dependent triphosphatase, -ase) and histochemical (Sudan black) and histological examinations (haematoxylin-eosin staining) of the liver were investigated. |
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| 18022343 | Lee SJ, Lim KT: Glycoprotein of Zanthoxylum piperitum DC has a hepatoprotective effect via anti-oxidative character in vivo and in vitro. Toxicol In Vitro. 2008 Mar;22(2):376-85. Epub 2007 Oct 14. In addition, administration of ZPDC glycoprotein (20mg/kg) lowers the levels of lactate dehydrogenase, transaminase, and thiobarbituric acid reactive substances, whereas increases that of accompanying the normalizing effects on the activity of hepatic anti-oxidant enzymes (superoxide dismutase, catalase, and peroxidase) in mouse model of carbon tetrachloride-stimulated acute liver injury. |
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| 16393475 | Lee SJ, Oh PS, Ko JH, Lim K, Lim KT: Protective effect of glycoprotein isolated from Ulmus davidiana Nakai on carbon tetrachloride-induced mouse liver injury. J Pharm Pharmacol. 2006 Jan;58(1):143-52. We evaluated lipid peroxidation in / oxidase (G/GO)-induced BNL CL.2 cells and measured thiobarbituric acid reactive substances (TBARS), lactate dehydrogenase (LDH), (NO), antioxidant enzyme (superoxide dismutase (SOD), catalase (CAT) and peroxidase (GPx)), activity of cytotoxic-related signals (hepatic cytochrome c, nuclear factor-kappa B (NF-kappaB) and activator protein-1 (AP-1)) and levels of plasma lipids (triglyceride (TG) and total (TC)) in carbon tetrachloride (CCl (4,) 1.0 mL kg (-1))-induced A/J mouse. |
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| 15950962 | Park EY, Ki SH, Ko MS, Kim CW, Lee MH, Lee YS, Kim SG: Garlic oil and DDB, comprised in a pharmaceutical composition for the treatment of patients with viral hepatitis, prevents acute liver injuries potentiated by deficiency in rats. Chem Biol Interact. 2005 Jun 30;155(1-2):82-96. GO+DDB pretreatment effectively prevented increases in plasma aminotransferases or lactate dehydrogenase activities in rats exposed to BSO+CCl4, compared to GO or DDB treatment alone. |
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| 15991578 | Pradeep K, Mohan CV, Anand KG, Karthikeyan S: Effect of pretreatment of Cassia fistula Linn. leaf extract against subacute CCl4 induced hepatotoxicity in rats. Indian J Exp Biol. 2005 Jun;43(6):526-30. CCl4 alone treatment (0.lml of liquid paraffin/100g body weight, ip) for 7 days followed by 0.l ml of CCl4 (in liquid parafiin/100g body weight, ip) from day 8 till day 14, caused a 16 fold increase in lipid peroxidation and a 50% reduction in catalase and glutathione reductase in liver tissue of rats accompanied by an increase in the activities of transaminases. alkaline phosphatase, lactate dehydrogenase and gamma - glutamyl transpeptidase in serum as compared to liquid paraffin treated control. |
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| 15194653 | Thirunavukkarasu C, Yang Y, Subbotin VM, Harvey SA, Fung J, Gandhi CR: Endothelin receptor antagonist TAK-044 arrests and reverses the development of carbon tetrachloride induced cirrhosis in rats. Gut. 2004 Jul;53(7):1010-9. TAK-044 treatment caused significant amelioration of portal hypertension, systemic hypotension, and liver injury (reduced activities of serum aspartate aminotransferase, alanine aminotransferase, and lactate dehydrogenase), and improved hepatic synthetic capacity (increased serum albumin concentration) in both groups of rats relative to vehicle treated rats. |
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| 20020986 | Bhattacharjee R, Sil PC: Protein Isolate from the Herb Phyllanthus niruri Modulates Carbon Tetrachloride-Induced Cytotoxicity in Hepatocytes. Toxicol Mech Methods. 2007;17(1):41-7. Administration of CCl (4) increased the leakage of glutamate pyruvate transaminase (GPT) by four fold and lactate dehydrogenase (LDH) by 84% in cell suspension, along with increased lipid peroxidation (114%), and reduced the levels of antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT) to almost 30% and 37% of the normal values, respectively. |
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| 17188414 | Lee CP, Shih PH, Hsu CL, Yen GC: Hepatoprotection of tea seed oil (Camellia oleifera Abel.) against CCl4-induced oxidative damage in rats. Food Chem Toxicol. 2007 Jun;45(6):888-95. Epub 2006 Nov 21. The results showed that a tea seed oil diet significantly (p <0.05) lowered the serum levels of hepatic enzyme markers (alanine aminotransferase, aspartate aminotransferase, and lactate dehydrogenase), inhibited fatty degeneration, reduced the content of the peroxidation product malondialdehyde, and elevated the content of GSH. |
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| 19928576 | Novikov VE, Klimkina EI: [Effects of hypoxen on morphological and functional state of the liver under of exogenous intoxication conditions]. Eksp Klin Farmakol. 2009 Sep-Oct;72(5):43-5. It is established that the drug decreases the activity of transaminases and lactate dehydrogenase, the total level in the blood serum, and the rate of free-radical lipid oxidation in the liver. |
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| 19576190 | Krithika R, Mohankumar R, Verma RJ, Shrivastav PS, Mohamad IL, Gunasekaran P, Narasimhan S: Isolation, characterization and antioxidative effect of phyllanthin against CCl4-induced toxicity in HepG2 cell line. Chem Biol Interact. 2009 Oct 30;181(3):351-8. Epub 2009 Jul 1. In addition, the toxin treatment initiated lipid peroxidation (LPO), caused leakage of enzymes like transaminase (ALT) and lactate dehydrogenase (LDH) with a significant decrease in (GSH) levels. |
1(0,0,0,1) | Details |
| 16823256 | Ko JH, Lim KT: Glycoprotein isolated from Ulmus davidiana NAKAI protects against carbon tetrachloride-induced liver injury in the mouse. J Pharmacol Sci. 2006 Jul;101(3):205-13. Epub 2006 Jul 6. We evaluated the activities of alanine aminotransferase (ALT), lactate dehydrogenase (LDH), thiobarbituric acid-reactive substances (TBARS), and antioxidant enzymes [superoxide dismutase (SOD), catalase (CAT), peroxidase (GPx)] activities in CCl4-treated mice. |
1(0,0,0,1) | Details |
| 15971120 | Park EJ, Zhao YZ, Kim YC, Sohn DH: Protective effect of (S)-bakuchiol from Psoralea corylifolia on rat liver injury in vitro and in vivo. Planta Med. 2005 Jun;71(6):508-13. Primary rat hepatocyte intoxication was induced by tert-butyl hydroperoxide (tBH), carbon tetrachloride (CCl4) or D-galactosamine (D-GalN). In vitro, the cellular leakage of lactate dehydrogenase and cell viability following treatment with hepatotoxicants were significantly improved by bakuchiol treatment at a concentration range of 25-200 microM for tBH, 100-200 microM for CCl4 and 100-200 microM for D-GalN-induced hepatocyte injury. |
1(0,0,0,1) | Details |
| 15630193 | Fukao T, Hosono T, Misawa S, Seki T, Ariga T: Chemoprotective effect of diallyl trisulfide from garlic against carbon tetrachloride-induced acute liver injury of rats. Biofactors. 2004;21(1-4):171-4. In the CCl4-induced acute liver injury model of rats, DATS (10 micromol/kg) significantly suppressed the increase in plasma lactate dehydrogenase (LDH) and aspartate aminotransferase (AST) activities. |
1(0,0,0,1) | Details |
| 19067753 | Bhadauria M, Nirala SK, Shrivastava S, Sharma A, Johri S, Chandan BK, Singh B, Saxena AK, Shukla S: Emodin reverses CCl induced hepatic cytochrome P450 (CYP) enzymatic and ultrastructural changes: The in vivo evidence. Hepatol Res. 2009 Mar;39(3):290-300. Epub 2008 Dec 2. Aim: The curative effect of emodin (1,3,8-trihydroxy-6-methyl anthraquinone), an active compound of the plant species Ventilago maderaspatana Gaertn, was evaluated against carbon tetrachloride (CCl (4)) induced hepatic cytochrome P450 (CYP) enzymatic and ultrastructural alterations in rats. Results: The CCl (4) induced-toxic effects were observed with sharp elevation in the release of serum transaminases, alkaline phosphatase, lactate dehydrogenase and gamma-glutamyl transpeptidase. |
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| 18266971 | Hamzavi J, Ehnert S, Godoy P, Ciuclan L, Weng H, Mertens PR, Heuchel R, Dooley S: Disruption of the Smad7 gene enhances CCI4-dependent liver damage and fibrogenesis in mice. J Cell Mol Med. 2008 Oct;12(5B):2130-44. Epub 2008 Feb 4. Furthermore, S7DeltaE1 hepatocytes display increased oxidative stress and cell damage in response to CCI4, as measured by reactive species production, depletion, lactate dehydrogenase release and lipid peroxidation. To obtain insight into Smad7-depend-ent protective effects, chronic liver damage was induced in mice by carbon tetrachloride (CCI4) administration. |
1(0,0,0,1) | Details |
| 15489557 | Shahjahan M, Sabitha KE, Jainu M, Shyamala Devi CS: Effect of Solanum trilobatum against carbon tetrachloride induced hepatic damage in albino rats. Indian J Med Res. 2004 Sep;120(3):194-8. RESULTS: Levels of marker enzymes such as transminase (ALT), transaminase (AST), alkaline phosphatase (ALP), and lactate dehydrogenase (LDH) were increased significantly in CCl4 treated rats (group II). |
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| 16930896 | Raja S, Ahamed KF, Kumar V, Mukherjee K, Bandyopadhyay A, Mukherjee PK: Antioxidant effect of Cytisus scoparius against carbon tetrachloride treated liver injury in rats. J Ethnopharmacol. 2007 Jan 3;109(1):41-7. Epub 2006 Jul 20. CCl (4) injection induced oxidative stress by a significant rise in serum transaminases (SGOT), serum glutamate pyruvate transaminases (SGPT), lactate dehydrogenase (LDH) and thiobarbituric acid reactive substances (TBARS) along with reduction of superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH), glutathione peroxidase (GPx), glutathione-s-transferase (GST) and glutathione reductase (GRD). |
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| 18226198 | Babenko NA, Shakhova EG: Effects of flavonoids on sphingolipid turnover in the toxin-damaged liver and liver cells. Lipids Health Dis. 2008 Jan 28;7:1. Addition of the CCl4 or to isolated hepatocyte suspensions caused loss of cell viability and increased the lactate dehydrogenase release from the cells into supernatant and level in the cells. |
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| 15242491 | Mikami K, Otaka M, Goto T, Miura K, Ohshima S, Yoneyama K, Lin JG, Watanabe D, Segawa D, Kataoka E, Odashima M, Watanabe S: Induction of a 72-kDa heat shock protein and protection against lipopolysaccharide-induced liver injury in cirrhotic rats. J Gastroenterol Hepatol. 2004 Aug;19(8):884-90. In this study, we investigated the cytoprotective effect of HSP72 on lipopolysaccharide (LPS)-induced liver injury in carbon tetrachloride (CCl (4))-induced cirrhotic rats. Liver injury was assessed biochemically transaminase, transaminase, lactate dehydrogenase, and histologically. |
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| 19336974 | Mochizuki M, Shimizu S, Urasoko Y, Umeshita K, Kamata T, Kitazawa T, Nakamura D, Nishihata Y, Ohishi T, Edamoto H: Carbon tetrachloride-induced hepatotoxicity in pregnant and lactating rats. J Toxicol Sci. 2009 Apr;34(2):175-81. Hepatotoxicity in CCl4-treated pregnant rats evaluated by blood chemistry (alanine aminotransferase (ALT), aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) activities) and histopathological finding (area of damaged hepatocytes) was minimal on GD19, being weaker than that in non-pregnant rats. |
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| 20097184 | Kim TH, Kim YW, Shin SM, Kim CW, Yu IJ, Kim SG: Synergistic hepatotoxicity of N,N-dimethylformamide with carbon tetrachloride in association with endoplasmic reticulum stress. Chem Biol Interact. 2010 Mar 30;184(3):492-501. Epub 2010 Jan 25. Treatment of rats with either DMF (50-500mg/kg/day, for 3 days) or a single low dose of CCl (4) (0.2ml/kg) alone caused small increases in plasma transaminases and lactate dehydrogenase activities. |
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| 18358653 | Wang T, Sun NL, Zhang WD, Li HL, Lu GC, Yuan BJ, Jiang H, She JH, Zhang C: Protective effects of dehydrocavidine on carbon tetrachloride-induced acute hepatotoxicity in rats. J Ethnopharmacol. 2008 May 8;117(2):300-8. Epub 2008 Feb 14. RESULTS: Both pre-treatment with DC prior to CCl4 administration and post-treatment with DC after CCl4 administration significantly prevented increases in serum enzymatic activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), alkaline phosphatase (ALP) and total (TBIL). |
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| 16176146 | Choi J, Park JK, Lee KT, Park KK, Kim WB, Lee JH, Jung HJ, Park HJ: In vivo antihepatotoxic effects of Ligularia fischeri var. spiciformis and the identification of the active component, 3,4-dicaffeoylquinic acid. J Med Food. 2005 Fall;8(3):348-52. Pretreatment with DCQA (5 and 10 mg/kg, p.o.) significantly reduced serum aminotransferases and sorbitol dehydrogenase, gamma-glutamyltransferase, alkaline phosphatase, and lactate dehydrogenase activities during CCl4- or GalN-induced hepatotoxicity, suggesting that DCQA is a major principle for the antihepatotoxic activity of L. fischeri var. spiciformis. |
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| 16941609 | Yemitan OK, Izegbu MC: Protective effects of Zingiber officinale (Zingiberaceae) against carbon tetrachloride and -induced hepatotoxicity in rats. Phytother Res. 2006 Nov;20(11):997-1002. |
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| 17410408 | Bhadauria M, Nirala SK, Shukla S: Propolis protects CYP 2E1 enzymatic activity and oxidative stress induced by carbon tetrachloride. Mol Cell Biochem. 2007 Aug;302(1-2):215-24. Epub 2007 Apr 5. Intraperitoneal injection of CCl (4) (1.5 ml/kg) induced hepatotoxicity after 24 h of its administration that was associated with elevated malonyldialdehyde (index of lipid peroxidation), lactate dehydrogenase and gamma-glutamyl transpeptidase release (index of a cytotoxic effect). |
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| 18761070 | Hu XP, Shin JW, Wang JH, Cho JH, Son JY, Cho CK, Son CG: Antioxidative and hepatoprotective effect of CGX, an herbal medicine, against toxic acute injury in mice. J Ethnopharmacol. 2008 Oct 30;120(1):51-5. Epub 2008 Aug 7. RESULTS: Pretreatment with CGX significantly attenuated the elevation in biochemical parameters, such as transaminase (ALT), transaminase (AST), and lactate dehydrogenase (LDH) in serum, and the malondialdehyde concentrations in liver tissue. |
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| 19496777 | Singh D, Singh R, Singh P, Gupta RS: Effects of Embelin on Lipid Peroxidation and Free Radical Scavenging Activity against Liver Damage in Rats. Basic Clin Pharmacol Toxicol. 2009 May 26. Carbon tetrachloride (CCl (4)) treatment to rats has been more susceptible to peroxidative damage through production of reactive metabolites, namely trichloromethyl-free radicals ( and/or ) as measured by thiobarbituric acid reactive species. The activities of marker enzymes - transaminases (AST, ALT), alkaline phosphatase (ALP), gamma-glutamyl transpeptidase (GGT), lactate dehydrogenase (LDH) - along with the total and total protein levels were altered significantly (P |
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| 15095147 | Park EJ, Zhao YZ, Kim YH, Lee JJ, Sohn DH: Acanthoic acid from Acanthopanax koreanum protects against liver injury induced by tert-butyl hydroperoxide or carbon tetrachloride in vitro and in vivo. Planta Med. 2004 Apr;70(4):321-7. In vitro, the cellular leakage of lactate dehydrogenase (LDH) following treatment with 1.5 mM tBH for 1 h, was significantly inhibited by co-treatment with acanthoic acid (25 and 5 microg/mL) and the ED (50) of acanthoic acid was 2.58 microg/mL (8.5 microM). |
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| 19695300 | Park EJ, Zhao YZ, Kim YC, Sohn DH: Preventive effects of a purified extract isolated from Salvia miltiorrhiza enriched with tanshinone I, tanshinone IIA and cryptotanshinone on hepatocyte injury in vitro and in vivo. Food Chem Toxicol. 2009 Nov;47(11):2742-8. Epub 2009 Aug 18. In this study, we tested the ability of a purified extract of S. miltiorrhiza (PF2401-SF) and its constituents, tanshinone I, tanshinone IIA, and cryptotanshinone, to protect against acute and subacute liver damage induced by carbon tetrachloride by measuring serum transaminase levels, the reduced form of (GSH), antioxidant enzyme activities, and lipid peroxidation levels in the liver. Tanshinone I, tanshinone IIA, and cryptotanshinon (40 microM), inhibited lactate dehydrogenase leakage, GSH depletion, lipid peroxidation and free radical generation in vitro. |
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| 16117622 | Shahjahan M, Vani G, Devi CS: Protective effect of Indigofera oblongifolia in CCl4-induced hepatotoxicity. J Med Food. 2005 Summer;8(2):261-5. The present study aimed at assessing the protective effect of Indigofera oblongifolia on carbon tetrachloride (CCl4-induced hepatotoxicity. The activities of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and lactate dehydrogenase were significantly (P < .001) increased in serum of CCl4-induced animals when compared with control animals. |
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| 18270870 | Tran TT, Groben P, Pisetsky DS: The release of DNA into the plasma of mice following hepatic cell death by apoptosis and necrosis. Biomarkers. 2008 Mar;13(2):184-200. For this purpose, the effects of varying doses of anti-Fas, or carbon tetrachloride (CCl (4)) were assessed in normal mice. Plasma DNA was measured fluorometrically by the dye PicoGreen while lactate dehydrogenase (LDH) and caspase 3, other molecules released with cell injury or death, were measured by enzymatic assays. |
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| 19903377 | Badr AM, El-Demerdash E, Khalifa AE, Ghoneim AI, Ayoub NA, Abdel-Naim AB: Rubus sanctus protects against carbon tetrachloride-induced toxicity in rat isolated hepatocytes: isolation and characterization of its galloylated flavonoids. J Pharm Pharmacol. 2009 Nov;61(11):1511-20. In addition, RE ameliorated CCl (4)-induced enzyme leakage by 40% for lactate dehydrogenase, 30% for alanine aminotransferase and 20% for aspartate aminotransferase as compared with CCl (4)-treated cells. |
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| 14992325 | Tasaduq SA, Singh K, Sethi S, Sharma SC, Bedi KL, Singh J, Jaggi BS, Johri RK: Hepatocurative and antioxidant profile of HP-1, a polyherbal phytomedicine. Hum Exp Toxicol. 2003 Dec;22(12):639-45. HP-1 a herbal formulation comprising of Phyllanthus niruri and extracts of Terminalia belerica, Terminalia chebula, Phyllanthus emblica and Tinospora cordifolia has been evaluated for hepatoprotective activity against carbon tetrachloride (CCl4) induced toxicity. Results show that HP-1 reversed the leakage of lactate dehydrogenase (LDH) and glutamate pyruvate transaminase (GPT) and prevented the depletion of (GSH) levels in a primary monolayer culture of rat hepatocytes (in vitro). |
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| 18572298 | Bhadauria M, Nirala SK, Shukla S: Multiple treatment of propolis extract ameliorates carbon tetrachloride induced liver injury in rats. Food Chem Toxicol. 2008 Aug;46(8):2703-12. Epub 2008 Apr 27. Multiple treatment of propolis significantly prevented the release of transaminases, alkaline phosphatase, lactate dehydrogenase, gamma-glutamyl transpeptidase, urea and in serum; improved the activity of hepatic microsomal drug metabolizing enzymes, i.e., hydroxylase and amidopyrine-N-demethylase; significantly inhibited lipid peroxidation and markedly enhanced in liver and kidney as well as brought altered carbohydrate contents (blood sugar and tissue protein contents (serum, microsomal and tissue protein) and lipid contents (serum and tissue triglycerides, serum cholesterol, total and esterified in tissue) towards control. |
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| 15900908 | Sultana S, Ahmad S, Khan N, Jahangir T: Effect of Emblica officinalis (Gaertn) on CCl4 induced hepatic toxicity and DNA synthesis in Wistar rats. Indian J Exp Biol. 2005 May;43(5):430-6. A single dose of CCl4 (1 ml/kg body weight, po in corn oil) increased the levels of SGOT (serum transaminase), SGPT (serum glutamate pyruvate transaminase), LDH (lactate dehydrogenase), glutathione-S-transferase and depletion in peroxidase and glutathione reductase. |
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| 18481019 | Kang KS, Kim ID, Kwon RH, Lee JY, Kang JS, Ha BJ: The effects of fucoidan extracts on CCl (4)-induced liver injury. Arch Pharm Res. 2008 May;31(5):622-7. Epub 2008 May 15. The aim of this study was to elucidate the antioxidant properties of fucoidan extracts (FE) against CCl (4)-induced oxidative stress by monitoring the levels of transaminase (GOT), glutamate pyruvate transaminase (GPT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT) and peroxidase (GPx). |
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| 15573529 | Venukumar MR, Latha MS: Effect of Coscinium fenestratum on hepatotoxicity in rats. Indian J Exp Biol. 2004 Aug;42(8):792-7. Anti-hepatotoxic activity of extract of Coscinium fenestratum stem (MEC) was investigated against carbon tetrachloride-induced hepatopathy in rats. Anti-hepatotoxic effect was studied by assaying the activities of serum marker enzymes like aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, gamma glutamyl transpeptidase, lactate dehydrogenase etc. and glucose (6) phosphate dehydrogenase in liver. |
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| 16571270 | Mitcheva M, Kondeva M, Vitcheva V, Nedialkov P, Kitanov G: Effect of benzophenones from Hypericum annulatum on carbon tetrachloride-induced toxicity in freshly isolated rat hepatocytes. Redox Rep. 2006;11(1):3-8. Lactate dehydrogenase (LDH) leakage, cell viability and (GSH) depletion were used as signs of cytotoxicity. |
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| 15686116 | Su PH, Takehashi M, Tanaka S, Banasik M, Stedeford T, Ueda K, Muro-Cacho C, Harbison RD: Hepatocellular accumulation of poly (ADP- in male ICR mice treated with a necrogenic dose of carbon tetrachloride. Res Commun Mol Pathol Pharmacol. 2003;113-114:171-9. Lactate dehydrogenase activity was significantly increased by 1.2-fold. |
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