| Name | alanine aminotransferase |
|---|---|
| Synonyms | AAT1; AAT1; GPT; ALT 1; ALT1; Alanine aminotransferase; Alanine aminotransferase 1; GPT 1… |
| Name | carbon tetrachloride |
|---|---|
| CAS | tetrachloromethane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18078039 | Sapozhnikova TA, Zarudii FS, Baschenko NZh, Makara NS, Khisamutdinova RIu, Gabdrakhmanova SF, Ivanova NA, Nazarov VS: [Hepatoprotective effect of 2-demethoxycarbonyl-2-ethoxycarbonyl-11-deoxymisoprostol]. Eksp Klin Farmakol. 2007 Jul-Aug;70(4):30-1. 2-Demethoxycarbonyl-2-ethoxycarbonyl-11-deoxymisoprostol (11-DMP) produces antioxidant effect on the models of toxic hepatitis induced by and carbon tetrachloride. The drug normalizes the lipid peroxidation (LPO) prosess in rat liver of the rat and the levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in the rat blood, thus demonstrating hepatoprotective action. |
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| 17265553 | Liao JC, Lin KH, Cheng HY, Wu JB, Hsieh MT, Peng WH: Actinidia rubricaulis attenuates hepatic fibrosis induced by carbon tetrachloride in rats. Am J Chin Med. 2007;35(1):81-8. AR reduced the elevated levels of serum --transaminase (sGOT) and glutamate-pyruvate-transaminase (sGPT) caused by CCl (4) at weeks 1, 3, 6, and 8. |
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| 16149112 | Hemmings SJ, Song X: The effects of dietary flaxseed on the Fischer 344 rat. Cell Biochem Funct. 2005 Nov-Dec;23(6):389-98. While CCl (4) treatment increased the level of the liver injury marker plasma alanine aminotransferase (ALT) in RC rats, this CCl (4) effect was significantly attenuated in FC rats. The hepatotoxic effect of carbon tetrachloride (CCl (4)) administered by gavage at 0.25 ml CCl (4) (1:1 in olive oil) per 100 g body weight was examined 24 h later in regular chow fed (RC) and 10% flax chow fed (FC) male and female Fischer 344 rats. |
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| 19779110 | Peng HY, Chu YC, Chen SJ, Chou ST: Hepatoprotection of chlorella against carbon tetrachloride-induced oxidative damage in rats. In Vivo. 2009 Sep-Oct;23(5):747-54. The GPE had a significant protective effect against liver injuries, as well as oxidative stress induced by CCl (4), resulting in reduced lipid peroxidation and improved serum biochemical parameters such as aspartate aminotransferase and alanine aminotransferase. |
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| 19056764 | Kamada Y, Yoshida Y, Saji Y, Fukushima J, Tamura S, Kiso S, Hayashi N: Transplantation of basic fibroblast growth factor-pretreated adipose tissue-derived stromal cells enhances regression of liver fibrosis in mice. Am J Physiol Gastrointest Liver Physiol. 2009 Feb;296(2):G157-67. Epub 2008 Dec 4. In the in vivo study, ADSC isolated from green fluorescent protein-transgenic mice were transplanted into carbon tetrachloride-injured C57BL6/J mice liver. bFGF-treated ADSC expressed several liver-specific marker genes and demonstrated liver-related functions such as albumin secretion, synthesis, urea production, and low-density lipoprotein uptake. Importantly, pretreatment of ADSC with bFGF for 1 wk enhanced the repopulation rate of ADSC in mice liver, attenuated liver fibrosis, and restored normal serum alanine aminotransferase and albumin levels. |
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| 18949895 | Krishnakumar NM, Latha PG, Suja SR, Shine VJ, Shyamal S, Anuja GI, Sini S, Pradeep S, Shikha P, Unni PK, Rajasekharan S: Hepatoprotective effect of Hibiscus hispidissimus Griffith, ethanolic extract in and CCl4 induced hepatotoxicity in Wistar rats. Indian J Exp Biol. 2008 Sep;46(9):653-9. In the present study, the effect of the ethanolic extract of Hibiscus hispidissimus whole plant on (PCM)-induced and carbon tetrachloride (CCl4)-induced liver damage in healthy Wistar albino rats was studied. The results showed that significant hepatoprotective effects were obtained against liver damage induced by PCM and CCl4 as evidenced by decreased levels of serum enzymes, transaminase (SGOT), glutamate pyruvate transaminase (SGPT), serum alkaline phosphatase (SAKP), serum (SB) and an almost normal histological architecture of the liver of the treated groups compared to the toxin controls. |
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| 18598176 | Kim HY, Kim JH, Lee SA, Chang HE, Park MH, Hwang SJ, Lee JY, Mok C, Hong SG: Saengshik, a formulated health food, prevents liver damage in CCl4-induced mice and increases antioxidant activity in elderly women. J Med Food. 2008 Jun;11(2):323-30. The activity of the antioxidant enzyme superoxide dismutase was increased, and the level of glutamate pyruvate transaminase was decreased. |
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| 15344427 | Lee SE, Song KH, Liu J, Kwon HJ, Youn SB, Lee YW, Cho SH, Kim DH: The effectiveness of auriculoacupoint treatment for artificially induced acute hepatic injury in dogs. Am J Chin Med. 2004;32(3):445-51. This study was to investigate effects of auriculoacupoint (AAP) treatment on carbon tetrachloride (CCl4)-induced acute hepatic injury in ten dogs (four females and six males). Compared to the control group, serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities in the experimental group were significantly decreased at the 4th day (p < 0.05) and at the 5th day (p < 0.05), respectively. |
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| 19736546 | Goo MJ, Ki MR, Lee HR, Yang HJ, Yuan DW, Hong IH, Park JK, Hong KS, Han JY, Hwang OK, Kim DH, Do SH, Cohn RD, Jeong KS: Helicobacter pylori promotes hepatic fibrosis in the animal model. Lab Invest. 2009 Nov;89(11):1291-303. Epub 2009 Sep 7. To elucidate the pathological effect of H. pylori infection on the progression of hepatic fibrosis, C57BL/6 mice and Sprague-Dawley rats were orally inoculated with H. pylori, and hepatic fibrosis was induced with carbon tetrachloride (CCl (4)) administration. Significant increase in the fibrotic score as well as in serum alanine aminotransferase and aspartate aminotransferase levels was shown in the CCl (4)+H. pylori group compared with that in the CCl (4)-treated group. |
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| 19416217 | Bennett RG, Heimann DG, Tuma DJ: Relaxin reduces fibrosis in models of progressive and established hepatic fibrosis. Ann N Y Acad Sci. 2009 Apr;1160:348-9. In the prevention study, relaxin reduced collagen and smooth muscle actin content and significantly reduced serum levels of the liver enzymes alanine aminotransferase and aspartate aminotransferase. |
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| 17705141 | Sangameswaran B, Reddy TC, Jayakar B: Hepatoprotective effect of leaf extracts of Andrographis lineata nees on liver damage caused by carbon tetrachloride in rats. Phytother Res. 2008 Jan;22(1):124-6. The biochemical parameters such as serum transaminase, serum glutamate pyruvate transaminase, serum and alkaline phosphatase were estimated to assess the liver function. |
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| 20079350 | Sun H, Che QM, Zhao X, Pu XP: Antifibrotic effects of chronic baicalein administration in a CCl4 liver fibrosis model in rats. Eur J Pharmacol. 2010 Apr 10;631(1-3):53-60. Epub 2010 Jan 13. The aim of this study was to assess whether chronic baicalein administration could prevent liver fibrosis induced by carbon tetrachloride (CCl (4)) in rats and investigate its possible protective mechanism. The antifibrotic effects of baicalein were assessed directly by hepatic histology and indirectly by measuring levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), hepatic laminin and procollagen type III (PCIII) in serum, as well as and matrix metalloproteinases (MMPs) in liver. |
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| 17534399 | Fan J, Li X, Li P, Li N, Wang T, Shen H, Siow Y, Choy P, Gong Y: Saikosaponin-d attenuates the development of liver fibrosis by preventing hepatocyte injury. Biochem Cell Biol. 2007 Apr;85(2):189-95. A hepatocyte culture was also used to investigate how SSd can protect hepatocytes from oxidative injury induced by carbon tetrachloride. The results showed that SSd significantly reduced collagen I deposition in the liver and alanine aminotransferase level in the serum. |
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| 14758042 | Sato N, Abe S, Yamada T, Iwasaki K, Ohtake Y, Ohkubo Y: Relationship between liver injury and transglutaminase activities in guinea pigs and rats. Biol Pharm Bull. 2004 Feb;27(2):236-8. Serum alanine aminotransferase (ALT) level increased 1 d after CCl (4) treatment of both in guinea pigs and rats since TGaese activity was greatly higher in guinea pigs than rats. |
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| 17761835 | Ikeda H, Kume Y, Tejima K, Tomiya T, Nishikawa T, Watanabe N, Ohtomo N, Arai M, Arai C, Omata M, Fujiwara K, Yatomi Y: Rho-kinase inhibitor prevents hepatocyte damage in acute liver injury induced by carbon tetrachloride in rats. Am J Physiol Gastrointest Liver Physiol. 2007 Oct;293(4):G911-7. Epub 2007 Aug 30. |
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| 16569754 | Panuganti SD, Khan FD, Svensson CK: Enhanced xenobiotic-induced hepatotoxicity and Kupffer cell activation by restraint-induced stress. J Pharmacol Exp Ther. 2006 Jul;318(1):26-34. Epub 2006 Mar 28. We tested the hypothesis that environmental stress is a predisposing factor for liver injury by examining the effect of acute restraint on liver injury provoked by carbon tetrachloride (CCl4) and allyl |
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| 17306079 | Huang J, Ren RN, Chen XM, Ye LY: [An experimental study on hepatotoxicity of in young rats] . Zhongguo Dang Dai Er Ke Za Zhi. 2007 Feb;9(1):54-8. The ones in the positive control group (Group E) were treated by injection of 10% carbon tetrachloride dissolved in olive oil subcutaneously at a dose of 5 mL/kg twice a week. |
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| 15581276 | Ozardali I, Bitiren M, Karakilcik AZ, Zerin M, Aksoy N, Musa D: Effects of on histopathological and enzymatic changes in experimental liver injury of rats. Exp Toxicol Pathol. 2004 Oct;56(1-2):59-64. Thus, GSHPx may prevent the harmful effects of free radicals and may reduce the formation of the reactive metabolites of carbon tetrachloride. |
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| 17177172 | Kim SJ, Jung YS, Yoon MY, Kim YC: Comparative effects of dimethylsulfoxide on metabolism and toxicity of carbon tetrachloride and dichloromethane. J Appl Toxicol. 2007 Jan-Feb;27(1):25-31. |
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| 16303155 | Mohamed MA, Marzouk MS, Moharram FA, El-Sayed MM, Baiuomy AR: Phytochemical constituents and hepatoprotective activity of Viburnum tinus. Phytochemistry. 2005 Dec;66(23):2780-6. Epub 2005 Nov 21. CCl4-induced hepatotoxicity has been evaluated in terms of the determination of alanine aminotransferase (ALT), aspartate aminotransferase (AST), lipid peroxide and levels in serum and compared using adult male rats weighing 150-180 g. |
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| 16278809 | Ohta Y, Imai Y, Matsura T, Kitagawa A, Yamada K: Preventive effect of neutropenia on carbon tetrachloride-induced hepatotoxicity in rats. J Appl Toxicol. 2006 Mar-Apr;26(2):178-86. In rats treated once with CCl4 (1 ml kg (-1), i.p.), the serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), indices of liver cell damage, and the hepatic activity of myeloperoxidase (MPO), an index of tissue neutrophil infiltration, increased at 6 h after the intoxication and further increased at 24 h. |
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| 18397225 | Tsai JH, Liu JY, Wu TT, Ho PC, Huang CY, Shyu JC, Hsieh YS, Tsai CC, Liu YC: Effects of silymarin on the resolution of liver fibrosis induced by carbon tetrachloride in rats. J Viral Hepat. 2008 Jul;15(7):508-14. Epub 2008 Apr 4. Moreover, silymarin significantly decreased the elevation of aspartate aminotransferase (AST), alanine aminotransferase, and alkaline phosphatase in serum, and also reversed the altered expressions of alpha-smooth muscle actin in liver tissue. |
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| 16823256 | Ko JH, Lim KT: Glycoprotein isolated from Ulmus davidiana NAKAI protects against carbon tetrachloride-induced liver injury in the mouse. J Pharmacol Sci. 2006 Jul;101(3):205-13. Epub 2006 Jul 6. We evaluated the activities of alanine aminotransferase (ALT), lactate dehydrogenase (LDH), thiobarbituric acid-reactive substances (TBARS), and antioxidant enzymes [superoxide dismutase (SOD), catalase (CAT), peroxidase (GPx)] activities in CCl4-treated mice. |
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| 18317933 | Wang MY, Nowicki D, Anderson G, Jensen J, West B: Liver protective effects of Morinda citrifolia (Noni). Plant Foods Hum Nutr. 2008 Jun;63(2):59-63. Epub 2008 Mar 4. This study evaluated the protective effects of Noni fruit juice on acute liver injury induced by carbon tetrachloride (CCl (4)) in female Sprague-Dawley (SD) rats. Furthermore, serum alanine aminotransferase and aspartate aminotransferase levels were significantly lower in the Noni group than the placebo group. |
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| 17886222 | Ahn TH, Yang YS, Lee JC, Moon CJ, Kim SH, Jun W, Park SC, Kim JC: Ameliorative effects of pycnogenol on carbon tetrachloride-induced hepatic oxidative damage in rats. Phytother Res. 2007 Nov;21(11):1015-9. A single oral dose of CCl4 (1.25 mL/kg) produced significantly increased levels of serum aminotransferase (AST) and alanine aminotransferase (ALT) activities. |
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| 18481019 | Kang KS, Kim ID, Kwon RH, Lee JY, Kang JS, Ha BJ: The effects of fucoidan extracts on CCl (4)-induced liver injury. Arch Pharm Res. 2008 May;31(5):622-7. Epub 2008 May 15. The aim of this study was to elucidate the antioxidant properties of fucoidan extracts (FE) against CCl (4)-induced oxidative stress by monitoring the levels of transaminase (GOT), glutamate pyruvate transaminase (GPT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT) and peroxidase (GPx). |
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| 19595748 | Chan WH, Liao JW, Chou CP, Chan PK, Wei CF, Ueng TH: Induction of CYP1A1, 2B, 2E1 and 3A in rat liver by organochlorine pesticide dicofol. Toxicol Lett. 2009 Oct 28;190(2):150-5. Epub 2009 Jul 10. Dicofol pretreatment at 25mg/kg increased CCl4-induced serum alanine aminotransferase activity by 4.3-fold and aspartate aminotransferase activity by 4.1-fold. |
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| 20069380 | Abdel Salam OM, Sleem AA, Shafee N: Hepatoprotective effects of the donor isosorbide-5-mononitrate alone and in combination with the natural hepatoprotectant, silymarin, on carbon tetrachloride-induced hepatic injury in rats. Inflammopharmacology. 2010 Jan 14. Liver damage was assessed by determining serum enzyme activities and hepatic histopathology. 5-ISMN given at the above doses conferred significant protection against the hepatotoxic actions of CCl (4) in rats, reducing serum alanine aminotransferase (ALT) levels by 31.2, 39.3 and 61.6%, respectively, when compared with controls. |
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| 17143353 | Almurshed KS: Protective effect of black and green tea against carbon tetrachloride-induced oxidative stress in rats. Saudi Med J. 2006 Dec;27(12):1804-9. RESULTS: The present study demonstrates that there was a significant (p <0.001) increase in alanine aminotransferase (ALT) activity, TBARS, and in vitro hemolysis; and a significant (p <0.05) decrease in total plasma antioxidant status by CCl4 injection. |
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| 18178045 | Wang N, Li P, Wang Y, Peng W, Wu Z, Tan S, Liang S, Shen X, Su W: Hepatoprotective effect of Hypericum japonicum extract and its fractions. J Ethnopharmacol. 2008 Feb 28;116(1):1-6. Epub 2007 Aug 19. OBJECTIVE: To investigate the hepatoprotective activity of different parts of Hypericum japonicum against carbon tetrachloride (CCl (4))-induced hepatitis and alpha-naphthyl-isothiocyanate (ANIT)-induced cholestasis. Levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and total (T-BIL) in serum were evaluated. |
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| 18987472 | Zhang JJ, Meng XK, Dong C, Qiao JL, Zhang RF, Yue GQ, Zhong HY: Development of a new animal model of liver cirrhosis in swine. Eur Surg Res. 2009;42(1):35-9. Epub 2008 Nov 6. This study aimed to develop a new experimental model of liver cirrhosis in swine by using carbon tetrachloride (CCl (4)) and Alanine aminotransferase (ALT), aspartate aminotransferase (AST), albumin, and portal venous pressure (PVP) levels were determined throughout CCl (4) treatment. |
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| 18697572 | Kuriakose GC, Kurup GM: Antioxidant activity of Aulosira fertilisima on CCl4 induced hepatotoxicity in rats. Indian J Exp Biol. 2008 Jan;46(1):52-9. Carbon tetrachloride (CCl4) is used as a model for liver injury. Liver damage is detected by the measurement of the activities of serum enzymes like aspartate aminotransferase, alanine aminotransferase, gamma glutamyl transpeptidase and alkaline phosphatase which were released in to the blood from damaged cells. |
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| 16609998 | Cheung PY, Zhang Q, Zhang YO, Bai GR, Lin MC, Chan B, Fong CC, Shi L, Shi YF, Chun J, Kung HF, Yang M: Effect of WeiJia on carbon tetrachloride induced chronic liver injury. World J Gastroenterol. 2006 Mar 28;12(12):1912-7. Degree of fibrosis were measured and serological markers for liver fibrosis and function including (HA), type IV collagen (CIV), gamma-glutamyl transferase (gamma-GT), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were determined. |
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| 17097021 | Zhang ZT, Jiang P, Wang Y, Li JS, Xue JG, Zhou YZ, Yuan Z: Effects of hepatotrophic factors on the liver after portacaval shunt in rats with portal hypertension. Chin Med J. 2006 Oct 20;119(20):1727-33. METHODS: Intrahepatic portal hypertension (IHPH) was induced by intragastric administration of carbon tetrachloride, and end-to-side PCS was performed. The levels of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were tested biochemically and those of (HA) and laminin (LN) were measured by radioimmunoassay. |
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| 17318332 | Wang FR, Ai H, Chen XM, Lei CL: Hepatoprotective effect of a protein-enriched fraction from the maggots (Musca domestica) against CCl4-induced hepatic damage in rats. Biotechnol Lett. 2007 Jun;29(6):853-8. Epub 2007 Feb 22. The hepatoprotective potential of a protein-enriched fraction (PEF) isolated from the maggots of housefly (Musca domestica) was evaluated in rats against carbon tetrachloride (CCl4)-induced acute hepatic damage. Activities of serum aspartate aminotransferase and alanine aminotransferase increased by 4- and 13-fold induced by CCl4, were significantly inhibited by pretreatment with 50, 100 and 200 mg PEF/kg. |
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| 15818738 | Song SL, Gong ZJ, Zhang QR, Huang TX: Effects of Chinese traditional compound, JinSanE, on expression of TGF-beta1 and TGF-beta1 type II receptor mRNA, Smad3 and Smad7 on experimental hepatic fibrosis in vivo. World J Gastroenterol. 2005 Apr 21;11(15):2269-76. The activities of several serum fibrosis-associated enzymes, alanine aminotransferase (ALT), aspartate aminotransferase (AST), the levels of serum (HA) were assayed. In this study, the therapeutic effects of Chinese traditional compound decoction, JinSanE, and the changes of TGF-beta/Smad signaling pathway system in carbon tetrachloride (CCl (4))-induced rat experimental liver fibrosis were examined. |
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| 18598162 | Wu SJ, Lin YH, Chu CC, Tsai YH, Chao JC: or saikosaponin a improves hepatic antioxidant capacity and protects against CCl4-induced liver injury in rats. J Med Food. 2008 Jun;11(2):224-9. After 8 weeks, supplementation with and/or saikosaponin a significantly decreased plasma alanine aminotransferase and aspartate aminotransferase activities, as well as plasma and hepatic and triglyceride levels. |
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| 17877538 | Smyth R, Munday MR, York MJ, Clarke CJ, Dare T, Turton JA: Comprehensive characterization of serum clinical chemistry parameters and the identification of urinary superoxide dismutase in a carbon tetrachloride-induced model of hepatic fibrosis in the female Hanover Wistar rat. Int J Exp Pathol. 2007 Oct;88(5):361-76. Liver fibrosis was evident at 6 weeks in Experiments 1 and 2, and the activity of serum enzymes (including alanine aminotransferase, aspartate aminotransferase and dehydrogenase) was increased. |
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| 19646978 | Yasuda Y, Shimizu M, Sakai H, Iwasa J, Kubota M, Adachi S, Osawa Y, Tsurumi H, Hara Y, Moriwaki H: (-)- prevents carbon tetrachloride-induced rat hepatic fibrosis by inhibiting the expression of the PDGFRbeta and IGF-1R. Chem Biol Interact. 2009 Dec 10;182(2-3):159-64. Epub 2009 Jul 30. Drinking water with 0.1% significantly decreased the serum levels of both aspartate aminotransferase and alanine aminotransferase raised by CCl4, thus indicating an improvement of liver injury. |
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| 17879412 | Xue H, Guo H, Li YC, Hao ZM: Heme oxygenase-1 induction by hemin protects liver cells from ischemia/reperfusion injury in cirrhotic rats. World J Gastroenterol. 2007 Oct 28;13(40):5384-90. improved serum manganese superoxide dismutase (MnSOD) (6 h: 131.3 +/- 17.6 vs 107.0 +/- 13.9, P < 0.01; 12 h: 141.4 +/- 12.5 vs 118.3 +/- 10.2, P < 0.01), lessened liver cell injury, decreased caspase-3 (6 h: 166.7 +/- 8.1 vs 145.5 +/- 14.6, P < 0.01; 12 h: 172.8 +/- 3.8 vs 148.0 +/- 6.5, P < 0.01) and NF-kappaB expression (6 h: 150.2 +/- 8.6 vs 139.7 +/- 6.0, P < 0.01; 12 h: 151.1 +/- 5.9 vs 148.1 +/- 5.3, P > 0.05) and serum alanine aminotransferase (ALT) (6 h: 413.3 +/- 104.1 vs 626.8 +/- 208.2, P < 0.01; 12 h: 322.2 +/- 98.8 vs 425.8 +/- 115.4, P < 0.05), aspartate aminotransferase (AST) (6 h: 665.2 +/- 70.1 vs 864.3 +/- 70.4, P < 0.01; 12 h: 531.1 +/- 98.6 vs 664.4 +/- 115.6, P < 0.01), malondialdehyde (MDA) levels (6 h: 11.1 +/- 2.17 vs 13.5 +/- 2.01, P < 0.01; 12 h: 9.36 +/- 1.10 vs 10.8 +/- 1.62, P < 0.05) in the I/R + hemin group when compared with the I/R group. |
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| 15514851 | Gao J, Dou H, Tang XH, Xu LZ, Fan YM, Zhao XN: Inhibitory effect of TCCE on CCl4-induced overexpression of IL-6 in acute liver injury. Acta Biochim Biophys Sin. 2004 Nov;36(11):767-72. This study was designed to characterize the protective effects of the chloroform fraction of the extract of T. catappa leaves (TCCE) against carbon tetrachloride (CCl4)-induced hepatotoxicity in mice, and analyze the changes in expression level of interleukin-6 (IL-6) in the process. It was found that TCCE pretreatment (10 or 30 mg/kg, ig) protected mice from CCl4 toxicity, as evidenced by the reversed alterations in serum alanine aminotransferase (sALT) and serum aspartate aminotransferase (sAST) activities. |
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| 16173536 | Tang XH, Gao J, Fang F, Chen J, Xu LZ, Zhao XN, Xu Q: Hepatoprotection of oleanolic acid is related to its inhibition on mitochondrial permeability transition. Am J Chin Med. 2005;33(4):627-37. The protective effects of oleanolic acid (OA) on carbon tetrachloride (CCl4)-induced liver mitochondrial damage and the possible mechanisms were investigated. Pretreatment with OA prior to the administration of CCl4 significantly suppressed the increases of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) (4.2- and 19.9-fold, respectively) in a dose-dependent manner in mice. |
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| 15299229 | Hewawasam RP, Jayatilaka KA, Pathirana C, Mudduwa LK: Hepatoprotective effect of Epaltes divaricata extract on carbon tetrachloride induced hepatotoxicity in mice. Indian J Med Res. 2004 Jul;120(1):30-4. Blood and liver tissue were collected for the assessment of serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and liver level. |
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| 19336974 | Mochizuki M, Shimizu S, Urasoko Y, Umeshita K, Kamata T, Kitazawa T, Nakamura D, Nishihata Y, Ohishi T, Edamoto H: Carbon tetrachloride-induced hepatotoxicity in pregnant and lactating rats. J Toxicol Sci. 2009 Apr;34(2):175-81. Hepatotoxicity in CCl4-treated pregnant rats evaluated by blood chemistry (alanine aminotransferase (ALT), aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) activities) and histopathological finding (area of damaged hepatocytes) was minimal on GD19, being weaker than that in non-pregnant rats. |
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| 17544377 | Okumura H, Katoh M, Minami K, Nakajima M, Yokoi T: Change of drug excretory pathway by CCl4-induced liver dysfunction in rat. Biochem Pharmacol. 2007 Aug 1;74(3):488-95. Epub 2007 May 3. Depending on the serum levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT), urinary CMZ excretion was increased, whereas fecal CMZ excretion was decreased in rat with liver dysfunction. |
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| 17708605 | Qiu JF, Zhang ZQ, Chen W, Wu ZY: Cystamine ameliorates liver fibrosis induced by carbon tetrachloride via inhibition of tissue transglutaminase. World J Gastroenterol. 2007 Aug 28;13(32):4328-32. The levels of alanine aminotransferase (ALT) and total bile acid (TBA) at the 4 wk and 8 wk time points were decreased in the cystamine group compared with those in fibrosis controls (P < 0.01). |
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| 17481882 | Zhen MC, Wang Q, Huang XH, Cao LQ, Chen XL, Sun K, Liu YJ, Li W, Zhang LJ: Green tea polyphenol inhibits oxidative damage and preventive effects on carbon tetrachloride-induced hepatic fibrosis. J Nutr Biochem. 2007 Dec;18(12):795-805. Epub 2007 May 3. caused significant amelioration of liver injury (reduced activities of serum alanine aminotransferase and aspartate aminotransferase). |
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| 17541932 | Rivera H, Shibayama M, Tsutsumi V, Perez-Alvarez V, Muriel P: and trimethylated protect from acute liver damage induced by CCl4 in the rat. J Appl Toxicol. 2008 Mar;28(2):147-55. Both compounds partially but significantly prevented the increase in the activity of alanine aminotransferase; this result agrees with observations in the histological analysis. |
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| 19069636 | Quintanilha LF, Mannheimer EG, Carvalho AB, Paredes BD, Dias JV, Almeida AS, Gutfilen B, Barbosa da Fonseca LM, Resende CM, Rezende GF, Campos de Carvalho AC, Goldenberg RC: Bone marrow cell transplant does not prevent or reverse murine liver cirrhosis. Cell Transplant. 2008;17(8):943-53. Blood analyses were performed to assess liver injury and function by the assessment of alanine aminotransferase and albumin. Female Wistar rats were fed a liquid diet and received intraperitoneal injections of carbon tetrachloride (CCl4) over 15 weeks. |
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| 17265550 | Liu J, Cho SN, Song KH, Kim DH, Kim MC, Cho SW: The effect of oculo-acupuncture on acute hepatic injury induced by carbon tetrachloride in dogs. Am J Chin Med. 2007;35(1):53-61. Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and gamma glutamyl transpeptidase (GGT) activities were measured in both control and experimental groups. |
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| 19783517 | Anandan R, Jayakar B, Karar B, Babuji S, Manavalan R, Kumar RS: Effect of extract of flowers of Vitex trifolia Linn. on CCL4 induced hepatic injury in rats. Pak J Pharm Sci. 2009 Oct;22(4):391-4. CCl4 induced a significant rise in serum glutamate pyruvate transaminase (SGPT), serum transaminase (SGOT), alkaline phosphatase (ALP), total and gamma transpeptidase (GGTP). |
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| 15386534 | Kus I, Ogeturk M, Oner H, Sahin S, Yekeler H, Sarsilmaz M: Protective effects of against carbon tetrachloride-induced hepatotoxicity in rats: a light microscopic and biochemical study. Cell Biochem Funct. 2005 May-Jun;23(3):169-74. Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), total and conjugated levels were determined. |
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| 15013185 | Achliya GS, Wadodkar SG, Dorle AK: Evaluation of hepatoprotective effect of Amalkadi Ghrita against carbon tetrachloride-induced hepatic damage in rats. J Ethnopharmacol. 2004 Feb;90(2-3):229-32. The hepatoprotective activity of AG was evaluated by measuring levels of serum marker enzymes like serum transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP), and acid phosphatase (ACP). |
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| 18840618 | Young TH, Tang HS, Chao YC, Lee HS, Hsiong CH, Pao LH, Hu OY: Quantitative rat liver function test by single point method. Lab Anim. 2008 Oct;42(4):495-504. Rats were treated either with carbon tetrachloride (CCl (4)) alone (1 mL/kg, intraperitoneally [i.p.]) for one day or with isoniazid (INH) alone (150 mg/kg, i.p.) or (in order to ameliorate the effects of INH) with a combination of INH and bis-p-nitrophenyl (BNPP) (25 mg/kg, i.p.) for 21 days. Hepatotoxicity was assayed by plasma aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities and scores of histological activity index-necroinflammation (HAI-NI) of the respective liver specimens. |
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| 17175085 | Bhattacharjee R, Sil PC: Protein isolate from the herb, Phyllanthus niruri L. (Euphorbiaceae), plays hepatoprotective role against carbon tetrachloride induced liver damage via its antioxidant properties. Food Chem Toxicol. 2007 May;45(5):817-26. Epub 2006 Nov 11. Administration of CCl (4) increased the serum glutamate pyruvate transaminase (GPT) and alkaline phosphatase (ALP) levels of mice sera along with increased lipid peroxidation and reduced levels of antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT) in the liver. |
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| 17828713 | Reyes-Gordillo K, Muriel P, Castaneda-Hernandez G, Favari L: Pharmacokinetics of diclofenac in rats intoxicated with CCL4, and in the regenerating liver. Biopharm Drug Dispos. 2007 Nov;28(8):415-22. One day after CCl (4) administration, indicators of necrosis (alanine aminotransferase), cholestasis (gamma-glutamyl transpeptidase) and regeneration (alpha-fetoprotein) were significantly increased; these effects were reversed after 3 days. |
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| 18308943 | Carvalho AB, Quintanilha LF, Dias JV, Paredes BD, Mannheimer EG, Carvalho FG, Asensi KD, Gutfilen B, Fonseca LM, Resende CM, Rezende GF, Takiya CM, de Carvalho AC, Goldenberg RC: Bone marrow multipotent mesenchymal stromal cells do not reduce fibrosis or improve function in a rat model of severe chronic liver injury. Stem Cells. 2008 May;26(5):1307-14. Epub 2008 Feb 28. Fourteen female Wistar rats were fed exclusively an alcoholic liquid diet and received intraperitoneal injections of carbon tetrachloride every other day during 15 weeks. Blood analysis was performed to evaluate alanine aminotransferase (ALT), aspartate aminotransferase (AST), and albumin before cell therapy and 1 and 2 months after cell or placebo infusion. |
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| 15027814 | Chan WY, Chau FT, Lee KK, Kwong WH, Yew DT: Substitution for natural musk in Pien Tze Huang does not affect its hepatoprotective activities. Hum Exp Toxicol. 2004 Jan;23(1):35-47. Previous studies showed that Pien Tze Huang, a Chinese folk medicine well known for its therapeutic activity in treating liver diseases, protected the liver against carbon tetrachloride (CCl4)-induced damage in mice. When used in treating mice with CCl4- or galactosamine-induced liver damage, both the original and new formulations of Pien Tze Huang were found to be able to suppress to a similar extent both the histopathological changes in the liver and the elevation of serum alanine aminotransferase and aspartate aminotransferase. |
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| 19405380 | Preethi KC, Kuttan R: Hepato and reno protective action of Calendula officinalis L. flower extract. Indian J Exp Biol. 2009 Mar;47(3):163-8. The activities of serum marker enzymes of liver injury like glutamate pyruvate transaminase (SGPT), oxaloacetate transaminase (SGOT) and alkaline phosphatase (ALP) which were increased by CCl4 injection was found to be significantly reduced by the pretreatment of the flower extract at 100 and 250 mg/kg body weight. |
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| 19913046 | Shim JY, Kim MH, Kim HD, Ahn JY, Yun YS, Song JY: Protective action of the immunomodulator ginsan against carbon tetrachloride-induced liver injury via control of oxidative stress and the inflammatory response. Toxicol Appl Pharmacol. 2010 Feb 1;242(3):318-25. Epub 2009 Nov 11. Ginsan treatment markedly suppressed the serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, and hepatic histological necrosis increased by CCl (4) treatment. |
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| 20120966 | Uskova MA, Vasil'eva MA, Trusov NV, Avrem'eva LI, Guseva GV, Aksenov IV, Kravchenko LV: [Evaluation of antioxidant and hepatoprotective properties of strain Lactobacillus casei 114001 in carbon tetrachloride-induced liver toxicity model]. Vopr Pitan. 2009;78(5):24-30. Membrane damage by toxin was reduced in rats, treated with L.c.: alanine aminotransferase activity in plasma and nonsedimentable activity of lysosomal enzymes in liver were significantly decreased. |
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| 15354541 | Okovityi SV: [New derivatives of triazino- and imidazoindole with hepatoprotective activity]. Biomed Khim. 2004 May-Jun;50(3):293-303. Among indoles, 1,2,4-triazino [5,6-b]- and [6,5-b] as well as imidazo [4,5-b] series the compounds, decreasing concentration of alanine aminotransferase, aspartate aminotransferase and total in blood serum and reducing hexenal sleep duration were found. |
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| 19917719 | Ge J, Rudnick DA, He J, Crimmins DL, Ladenson JH, Bessler M, Mason PJ: Dyskerin ablation in mouse liver inhibits rRNA processing and cell division. Mol Cell Biol. 2010 Jan;30(2):413-22. Epub 2009 Nov 16. Signs of liver damage including an increase in serum alanine aminotransferase activity and a disordered structure at the histological and macroscopic levels are observed. In response to carbon tetrachloride administration, when wild-type hepatocytes mount a rapid proliferative response, those without dyskerin do not divide. |
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| 19735183 | Hsu CC, Hsu CL, Tsai SE, Fu TY, Yen GC: Protective effect of Millettia reticulata Benth against CCl (4)-induced hepatic damage and inflammatory action in rats. J Med Food. 2009 Aug;12(4):821-8. Pretreatment with WEMRB or PCA significantly lowered the CCl (4)-induced serum levels of hepatic enzyme markers and alanine aminotransferases). |
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| 17680494 | Ibrahim NA, El-Seedi HR, Mohammed MM: Phytochemical investigation and hepatoprotective activity of Cupressus sempervirens L. leaves growing in Egypt. Nat Prod Res. 2007 Aug;21(10):857-66. The hepatoprotective activity of the MeOH extract was carried out in liver homogenate of normal and CCl (4)-treated rats; a significant decrease in transaminase, glutamate pyruvate transaminase, level, and triglycerides, while a significant increase in the total protein level, was observed after the oral administration of MeOH extract. |
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| 16298865 | Jin YS, Heo SI, Lee MJ, Rhee HI, Wang MH: Free radical scavenging and hepatoprotective actions of Quercus aliena acorn extract against CCl4-induced liver. Free Radic Res. 2005 Dec;39(12):1351-8. Pretreatment with Quercus aliena acorn extracts reduced the increase in serum aspartate aminotransferase (AST) and serum alanine aminotransferase (ALT) levels. |
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| 15968718 | Gao H, Zhou YW: Anti-lipid peroxidation and protection of liver mitochondria against injuries by picroside II. World J Gastroenterol. 2005 Jun 28;11(24):3671-4. METHODS: Three animal models of liver damage induced by carbon tetrachloride (CCl (4): 0.1 mL/10 g, ip), D-galactosamine (D-GalN: 500 mg/kg, ip) and (AP: 0.15 g/kg, ip) were respectively treated with various concentrations of picroside II (5, 10, 20 mg/kg, ig). Then we chose the continuously monitoring method (recommended by International Clinical Chemistry League) to analyze serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) values, Marland method to detect the activity of manganese-superoxide dismutase (SOD) in liver mitochondria, TBA colorimetry to determine the content of malonicdialdehyde (MDA) in liver tissue, DTNB method to evaluate the activity of glutathioneperoxidase (GSH-Px) and Lowry method to detect protein level in liver tissue. |
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| 19327382 | Tung YT, Wu JH, Huang CC, Peng HC, Chen YL, Yang SC, Chang ST: Protective effect of Acacia confusa bark extract and its active compound against carbon tetrachloride-induced chronic liver injury in rats. Food Chem Toxicol. 2009 Jun;47(6):1385-92. Epub 2009 Mar 25. CCl (4)-induced hepatic pathological damage and significantly increased the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and malondialdehyde (MDA) in plasma, and cytochrome P4502E1 (CYP2E1) protein expression in hepatic samples, and decreased the activities of superoxide dismutase (SOD), peroxidase (GPX) and catalase (CAT) in erythrocytes. |
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| 18695789 | Vercelino R, Tieppo J, Forgiarini Junior LA, Dias AS, Marroni CA, Marroni NP: [Experimental models for assessment of pulmonary alterations in hepatopulmonary syndrome]. J Bras Pneumol. 2008 Jul;34(7):453-60. METHODS: Male Wistar rats, with mean weight of 250 g, were used in four experimental models: inhaled carbon tetrachloride; intraperitoneal carbon tetrachloride; partial portal vein ligation; and bile duct ligation (BDL). RESULTS: There were statistically significant differences between the BDL control and BDL experimental groups: aspartate aminotransferase (105.3 +/- 43 vs. 500.5 +/- 90.3 IU/L); alanine aminotransferase (78.75 +/- 37.7 vs. 162.75 +/- 35.4 IU/L); alkaline phosphatase (160 +/- 20.45 vs. 373.25 +/- 45.44 IU/L); arterial tension (85.25 +/- 8.1 vs. 49.9 +/- 22.5 mmHg); and saturation (95 +/- 0.7 vs. 73.3 +/- 12.07%). |
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| 15700767 | Ogeturk M, Kus I, Kavakli A, Zararsiz I, Ilhan N, Sarsilmaz M: Effects of on carbon tetrachloride-induced changes in rat serum. J Physiol Biochem. 2004 Sep;60(3):205-10. Serum urea, total protein, albumin, aspartate aminotransferase (AST), alanine aminotransferase (ALT), total and conjugated alkaline phosphatase (ALP), gamma-glutamyl transferase (gamma-GT), total iron, and levels were determined. |
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| 16930896 | Raja S, Ahamed KF, Kumar V, Mukherjee K, Bandyopadhyay A, Mukherjee PK: Antioxidant effect of Cytisus scoparius against carbon tetrachloride treated liver injury in rats. J Ethnopharmacol. 2007 Jan 3;109(1):41-7. Epub 2006 Jul 20. CCl (4) injection induced oxidative stress by a significant rise in serum transaminases (SGOT), serum glutamate pyruvate transaminases (SGPT), lactate dehydrogenase (LDH) and thiobarbituric acid reactive substances (TBARS) along with reduction of superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH), glutathione peroxidase (GPx), glutathione-s-transferase (GST) and glutathione reductase (GRD). |
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| 16696916 | Wang L, Ji G, Zheng PY, Long AH: [Establishment of a rat model of alcoholic liver fibrosis induced by complex factors]. Zhong Xi Yi Jie He Xue Bao. 2006 May;4(3):281-4. The serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma-glutamyltransferase (gamma-GT) in these three groups were all examined at the 12th week of the induction process. |
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| 17697871 | Young TH, Tang HS, Lee HS, Hsiong CH, Hu OY: Effects of hyperglycemia on quantitative liver functions by the load test in diabetic rats. Metabolism. 2007 Sep;56(9):1265-9. Four groups of animal studies were carried out, as follows: (1) normal control (NC), (2) streptozotocin-induced diabetes (DM), (3) carbon tetrachloride-induced hepatotoxicity (CCl (4)), and (4) streptozotocin-induced diabetes with CCl (4)-induced hepatotoxicity (DM + CCl (4)). A significant increase in hepatic activities of aspartate aminotransferase and alanine aminotransferase was observed in the CCl (4)-treated groups (CCl (4) and DM + CCl (4)) compared with the NC and DM groups (P < .001). |
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| 19596425 | Ko WS, Hsu SL, Chyau CC, Chen KC, Peng RY: Compound Cordyceps TCM-700C exhibits potent hepatoprotective capability in animal model. Fitoterapia. 2010 Jan;81(1):1-7. Epub 2009 Jul 8. A herbal preparation "Compound Codyceps-TCM-700C (CC-700C)" was tested for hepatoprotective effect against the carbon tetrachloride induced liver damages in Sprague-Dawley rat model for a period of 6-weeks. The activities of aspartate aminotransferase (AST) and alanine-aminotransferase (ALT) were more effectively suppressed by CC-700C than Silymarin. |
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| 17374462 | Zuinen R, Yamaji K, Aoki M, Chikuma T, Hojo H: Early induced, high-level interleukin-6 expression in the rat peritoneal cavity into which a hepatotoxicant carbon tetrachloride was administered. Toxicol Lett. 2007 Apr 5;170(1):42-8. Epub 2007 Feb 20. Plasma alanine aminotransferase (ALT) and sorbitol dehydrogenase (SDH) activities peaked at 24h. |
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| 18990340 | Wu T, Liu T, Zheng PY, Xing LJ, Ji G: [Effects of Qinggan Huoxue Recipe and its separated recipes on the expression of tumor necrosis factor-alpha in rats with alcoholic liver injury]. Zhong Xi Yi Jie He Xue Bao. 2008 Nov;6(11):1145-51. METHODS: One hundred male Wistar rats were randomly divided into normal control group (n=10), carbon tetrachloride (CCl4) group (n=10) and ALI group (n=80). After 2-week suitable drugs treatment, the activities of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were analyzed. |
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| 18614423 | Etim OE, Akpan EJ, Usoh IF: Hepatotoxicity of carbon tetrachloride: protective effect of Gongronema latifolium. Pak J Pharm Sci. 2008 Jul;21(3):268-74. Liver enzymes studied included alanine aminotransferase (ALT), aminotraferase (AST), and alkaline phosphates (ALP). |
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| 18989868 | Nogueira CW, Borges LP, Souza AC: Oral administration of diphenyl diselenide potentiates hepatotoxicity induced by carbon tetrachloride in rats. J Appl Toxicol. 2009 Mar;29(2):156-64. The liver and kidney were utilized for determination of histopathology, biochemical (ALT) and alanine (AST) aminotransferases, alkaline phosphatase (ALP), total bilirrubin (TB) and gamaglutamyl transferase (GGT)] and toxicological parameters [thiobarbituric reactive species (TBARS) levels, catalase activity, nonprotein thiols (NPSH) and aminolevulinate dehydratase (-ALA-D) activity]. |
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| 15276869 | Campo GM, Avenoso A, Campo S, D'Ascola A, Ferlazzo AM, Calatroni A: The antioxidant and antifibrogenic effects of the glycosaminoglycans and -4-sulphate in a subchronic rat model of carbon tetrachloride-induced liver fibrogenesis. Chem Biol Interact. 2004 Jul 20;148(3):125-38. At the end of the 6-week treatment period (24 h after the last dose of GAGs), the following parameters were evaluated: (1) serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities, as index of hepatic cell disruption; (2) hepatic conjugated dienes (CD), as index of lipid peroxidation; (3) hepatic TIMPs activity and expression; (4) hepatic superoxide dismutase (SOD) and peroxidase (GPx) activity, as index of endogenous defences; (5) hepatic as index of collagen deposition. |
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| 17278221 | Dang SS, Wang BF, Cheng YA, Song P, Liu ZG, Li ZF: Inhibitory effects of saikosaponin-d on CCl4-induced hepatic fibrogenesis in rats. World J Gastroenterol. 2007 Jan 28;13(4):557-63. The levels of alanine aminotransferase (ALT), triglyeride (TG), albumin (ALB), globulin (GLB), (HA) and laminin (LN) in serum and the content of (HYP) in liver were measured by biochemical examinations and radioimmuneoassay, respectively. |
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| 18044792 | Zhang C, Peng W, Jiang X, Chen B, Zhu J, Zang Y, Zhang J, Zhu T, Qin J: Transgene expression of human PON1 Q in mice protected the liver against CCl4-induced injury. J Gene Med. 2008 Jan;10(1):94-100. After CCl4 had been administrated to induce liver injury, mice were monitored for serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and malonyldialdehyde (MDA). |
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| 19848203 | Hong ZF, Li TJ, Zhao JY: [Effect of total alkaloids of Rubus alceaefolius poiron on gene expressions of CYP2E1 and CYP3A1 in rats with acute liver injury]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2009 Aug;29(8):711-5. The model of acute hepatic injury was established with intra-peritoneal injection of carbon tetrachloride. Serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), and severity of hepatic tissue injury were measured, and the mRNA expressions of CYP2E1 and CYP3A1 in liver tissue were detected by RT-PCR. |
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| 19220677 | Luo L, Zhou A: Antifibrotic activity of anisodamine in vivo is associated with changed intrahepatic levels of matrix metalloproteinase-2 and its inhibitor tissue inhibitors of metalloproteinases-2 and transforming growth factor beta1 in rats with carbon tetrachloride-induced liver injury. J Gastroenterol Hepatol. 2009 Jun;24(6):1070-6. Epub 2009 Feb 12. RESULTS: The serum levels of alanine aminotransferase, aspartate aminotransferase, gamma-glutamyltransferase and of liver fibrosis rats improved significantly by treatment with anisodamine. |
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| 15881884 | Il'nitskaia SI, Vasil'eva ED, Pakharukova MIu, Pivovarova EN, Kaledin VI: [Effect of estragole on glucocorticoid induction of tyrosine aminotransferase and tryprophan oxygenase in the rat and mouse liver]. Ross Fiziol Zh Im I M Sechenova. 2005 Mar;91(3):314-20. In these mice, activities of the marker enzymes of liver damage: alanine aminotransferase (ALAT) and aspartate aminotransferase (AAT) increased in the blood 1.7-2.3-fold as compared with the untreated controls. By contrast, carbon tetrachloride (100 mg/kg) increased the blood AIAT and AsAT activities 135- and 30-fold as compared with the control, but inhibited the TAT and TO induction much less than Estragole did. |
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| 18929613 | Shyu MH, Kao TC, Yen GC: Hsian-tsao (Mesona procumbens Heml.) prevents against rat liver fibrosis induced by CCl (4) via inhibition of hepatic stellate cells activation. Food Chem Toxicol. 2008 Dec;46(12):3707-13. Epub 2008 Sep 26. In this study, the protective effect of extract of Hsian-tsao (Mesona procumbens) (EHT) against liver fibrogenesis in carbon tetrachloride (CCl (4))-injured rats was evaluated. It also decreased the activity of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) and the deposition of collagen in the liver. |
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| 16169207 | Tang X, Gao J, Wang Y, Fan YM, Xu LZ, Zhao XN, Xu Q, Qian ZM: Effective protection of Terminalia catappa L. leaves from damage induced by carbon tetrachloride in liver mitochondria. J Nutr Biochem. 2006 Mar;17(3):177-82. Epub 2005 Aug 10. We found that increases in the activity of serum aspartate aminotransferase and alanine aminotransferase and the level of liver lipid peroxidation (2.0-fold, 5.7-fold and 2.8-fold) induced by CCl4 were significantly inhibited by oral pretreatment with 20, 50 or 100 mg/kg of TCCE. |
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| 18007555 | Balderas-Renteria I, Camacho-Corona Mdel R, Carranza-Rosales P, Lozano-Garza HG, Castillo-Nava D, Alvarez-Mendoza FJ, Tamez-Cantu EM: Hepatoprotective effect of Leucophyllum frutescens on Wistar albino rats intoxicated with carbon tetrachloride. Ann Hepatol. 2007 Oct-Dec;6(4):251-4. Levels of marker enzymes such as alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were increased significantly in CCl (4) treated rats (Group II). |
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| 17983713 | Jain A, Soni M, Deb L, Jain A, Rout SP, Gupta VB, Krishna KL: Antioxidant and hepatoprotective activity of ethanolic and aqueous extracts of Momordica dioica Roxb. leaves. J Ethnopharmacol. 2008 Jan 4;115(1):61-6. Epub 2007 Sep 19. In present study, the hepatoprotective activity of ethanolic and aqueous extracts of Momordica dioica Roxb. leaves were evaluated against carbon tetrachloride (CCl4) induced hepatic damage in rats. The substantially elevated serum enzymatic levels of serum transaminase (AST), serum glutamate pyruvate transaminase (ALT), serum alkaline phosphatase (SALP) and total were restored towards normalization significantly by the extracts. |
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| 18358653 | Wang T, Sun NL, Zhang WD, Li HL, Lu GC, Yuan BJ, Jiang H, She JH, Zhang C: Protective effects of dehydrocavidine on carbon tetrachloride-induced acute hepatotoxicity in rats. J Ethnopharmacol. 2008 May 8;117(2):300-8. Epub 2008 Feb 14. RESULTS: Both pre-treatment with DC prior to CCl4 administration and post-treatment with DC after CCl4 administration significantly prevented increases in serum enzymatic activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), alkaline phosphatase (ALP) and total (TBIL). |
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| 20047614 | Mannheimer EG, Quintanilha LF, Carvalho AB, Paredes BD, Goncalves de Carvalho F, Takyia CM, Resende CM, Ferreira da Motta Rezende G, Carlos Campos de Carvalho A, Schanaider A, Coeli Dos Santos Goldenberg R: Bone marrow cells obtained from cirrhotic rats do not improve function or reduce fibrosis in a chronic liver disease model. Clin Transplant. 2009 Dec 28. Methods: Chronic liver injury was induced in female Wistar rats by the association of an alcoholic diet with intraperitoneal injections of carbon tetrachloride. Blood analysis of alanine aminotransferase (ALT) and albumin levels, ultrasound assessment including the measurement of the portal vein diameter (PVD) and liver echogenicity, histologic evaluation with hematoxylin and eosin and Sirius red staining, and quantification of collagen deposition were performed. |
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| 15641146 | Geng XX, Yang Q, Xie RJ, Luo XH, Han B, Ma L, Li CX, Cheng ML: In vivo effects of Chinese herbal recipe, Danshaohuaxian, on apoptosis and proliferation of hepatic stellate cells in hepatic fibrotic rats. World J Gastroenterol. 2005 Jan 28;11(4):561-6. Then the liver index, serum (HA) and alanine aminotransferase (ALT), degree of hepatic fibrosis, urinary excretion of (Hyp) and expression of collagen types I and III (COL I and III) in these four groups were detected respectively. Except for the normal control group, rat hepatic fibrotic models were induced by subcutaneous injection of carbon tetrachloride (CCl4), drinking giving diet of hyperlipid and hypoprotein for 8 wk. |
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| 19659781 | Ginsburg I, Koren E, Horani A, Mahamid M, Doron S, Muhanna N, Amer J, Safadi R: Amelioration of hepatic fibrosis via Padma Hepaten is associated with altered natural killer T lymphocytes. Clin Exp Immunol. 2009 Jul;157(1):155-64. Hepatic fibrosis and alanine aminotransferase serum levels were decreased significantly in both Padma Hepaten-treated groups compared with the non-treated fibrotic group. Hepatic fibrosis was induced by 6 weeks of biweekly i.p. carbon tetrachloride (CCl4) injections in male C57Bl6 mice. |
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| 19104935 | Wu Q, Gong D, Tian N, Zhu L, Guan L, Yang M, Yuan B, Qiu Q, Lv H, Zou Y: Protection of regenerating liver after partial hepatectomy from carbon tetrachloride hepatotoxicity in rats: roles of mitochondrial uncoupling protein 2 and ATP stores. Dig Dis Sci. 2009 Sep;54(9):1918-25. Epub 2008 Dec 23. After CCl (4) poisoning, the regenerating liver appeared to have less histological damage and lower serum alanine aminotransferase (ALT) levels. |
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| 19702266 | Hsu JD, Kao SH, Tu CC, Li YJ, Wang CJ: Solanum nigrum L. extract inhibits 2-acetylaminofluorene-induced hepatocarcinogenesis through overexpression of glutathione S-transferase and antioxidant enzymes. J Agric Food Chem. 2009 Sep 23;57(18):8628-34. Our previous study has found that SN water extract (SNWE) alleviated carbon tetrachloride-induced liver damage in rats. The serum biomarkers for hepatic injury, transaminase, glutamate pyruvate transaminase, and gamma-glutamyl transferase, and for hepatocarcinogenesis, alpha-fetoprotein, were determined. |
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| 16874658 | Tipoe GL, Leung TM, Liong E, So H, Leung KM, Lau TY, Tom WM, Fung ML, Fan ST, Nanji AA: Inhibitors of inducible (NO) synthase are more effective than an NO donor in reducing carbon-tetrachloride induced acute liver injury. Histol Histopathol. 2006 Nov;21(11):1157-65. Immunohistochemistry (IHC), serum alanine aminotransferase (ALT), serum total analysis, RT-PCR, Western Blotting (WB) and EMSA were done. |
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| 18811677 | Galicia-Moreno M, Rodriguez-Rivera A, Reyes-Gordillo K, Segovia J, Shibayama M, Tsutsumi V, Vergara P, Moreno MG, Fernandez-Martinez E, Perez-Alvarez VM, Muriel P: Trolox down-regulates transforming growth factor-beta and prevents experimental cirrhosis. Basic Clin Pharmacol Toxicol. 2008 Nov;103(5):476-81. Epub 2008 Sep 22. Alkaline phosphatase, gamma-glutamyl transpeptidase and alanine aminotransferase increased in the group receiving CCl4; trolox completely or partially prevented these alterations. |
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| 18782536 | Zhang H, Feng Q, Li HS, Chen SD, Wang XN, Peng JH, Zhang N, Hu YY: [Effects of Qushi Huayu Decoction on cathepsin B and tumor necrosis factor-alpha expression in rats with non-alcoholic steatohepatitis]. Zhong Xi Yi Jie He Xue Bao. 2008 Sep;6(9):928-33. The rats except those in normal group were subcutaneously injected with carbon tetrachloride (CCl (4)) for 4 weeks (twice per week) and simultaneously fed with high-fat and low-protein diet for 2 weeks to induce NASH. After harvest, alanine aminotransferase (ALT) activity and tumor necrosis factor-alpha (TNF-alpha) content in serum as well as triglyceride (TG) and free fatty acid (FFA) in liver tissue were evaluated, and relativity analysis among these parameters was performed. |
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| 17608861 | Desmyter L, Fan YD, Praet M, Jaworski T, Vervecken W, De Hemptinne B, Contreras R, Chen C: Rating of CCl (4)-induced rat liver fibrosis by blood serum glycomics. J Gastroenterol Hepatol. 2007 Jul;22(7):1148-54. Liver injury was assessed biochemically (alanine aminotransferase [ALT] activity, aspartate aminotransferase [AST] activity and total and histologically. |
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| 15036476 | Rajesh MG, Latha MS: Preliminary evaluation of the antihepatotoxic activity of Kamilari, a polyherbal formulation. J Ethnopharmacol. 2004 Mar;91(1):99-104. Hepatoprotective efficacy of Kamilari, a polyherbal preparation was studied in carbon tetrachloride (CCl4)-induced liver dysfunction in albino rats by determining different biochemical parameters in serum and tissues. In serum, the activities of enzymes like aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and the concentrations of protein and were evaluated. |
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| 18812033 | Yuan LP, Chen FH, Ling L, Bo H, Chen ZW, Li F, Zhong MM, Xia LJ: Protective effects of total flavonoids of Bidens bipinnata L. against carbon tetrachloride-induced liver fibrosis in rats. J Pharm Pharmacol. 2008 Oct;60(10):1393-402. The results showed that TFB (80 and 160 mg kg (-1)) treatment for 10 weeks significantly reduced the elevated liver index (liver weight/body weight) and spleen index (spleen weight/body weight), elevated levels of serum transaminases (alanine aminotransferase and aspartate aminotransferase), type III procollagen and hepatic |
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| 15266956 | Bhattacharyya D, Pandit S, Mukherjee R, Das N, Sur TK: Hepatoprotective effect of Himoliv, a polyherbal formulation in rats. Indian J Physiol Pharmacol. 2003 Oct;47(4):435-40. The effect of Himoliv (HV) was evaluated in carbon tetrachloride or induced hepatotoxicity in rats. The liver damage was evidenced by elevated levels of serum transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT) and serum alkaline phosphatase (ALP) and hepatic thiobarbituric acid reacting substances (TBARS) and superoxide dismutase (SOD). |
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| 15900908 | Sultana S, Ahmad S, Khan N, Jahangir T: Effect of Emblica officinalis (Gaertn) on CCl4 induced hepatic toxicity and DNA synthesis in Wistar rats. Indian J Exp Biol. 2005 May;43(5):430-6. A single dose of CCl4 (1 ml/kg body weight, po in corn oil) increased the levels of SGOT (serum transaminase), SGPT (serum glutamate pyruvate transaminase), LDH (lactate dehydrogenase), glutathione-S-transferase and depletion in peroxidase and glutathione reductase. |
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| 18277467 | Abdel Salam OM, Oraby FH, Hassan NS: Vinpocetine ameliorates acute hepatic damage caused by administration of carbon tetrachloride in rats. Acta Biol Hung. 2007 Dec;58(4):411-9. The results showed that vinpocetine administered to CCl4-treated rats decreased the elevated alanine aminotransferase (ALT) by 49.3, 58.1 and 63.6%, aspartate aminotransferase (AST) by 10.5, 22.6 and 27.2% and alkaline phosphatase (ALP) by 52.5, 59.6 and 64.9%, respectively, and in a dose-dependent manner. |
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| 16343076 | Ding J, Yu J, Wang C, Hu W, Li D, Luo Y, Luo H, Yu H: Ginkgo biloba extract alleviates liver fibrosis induced by CCl in rats. Liver Int. 2005 Dec;25(6):1224-32. AIMS: To investigate the protective effect of Ginkgo biloba extract (GbE) on liver fibrosis induced by carbon tetrachloride (CCl4) in rats and expressions of transforming growth factor beta1 (TGF-beta1) and collagen I during this period. Blood samples were collected for measurement of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and albumin. |
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| 18404596 | Leal LK, Fonseca FN, Pereira FA, Canuto KM, Felipe CF, Fontenele JB, Pitombeira MV, Silveira ER, Viana GS: Protective effects of amburoside A, a glucoside from Amburana cearensis, against CCl4-induced hepatotoxicity in rats. Planta Med. 2008 Apr;74(5):497-502. Epub 2008 Apr 10. The aim of this study was to investigate the possible beneficial effects of amburoside A, AMB [4-(O-beta- D-glycopyranosyl) benzyl protocatechoate], against carbon tetrachloride (CCl (4)) toxicity in rats. O.) treatments of CCl (4)-intoxicated rats significantly inhibited the increase in serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels, as compared to the group treated with CCl (4) only. |
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| 20038332 | Wu XR, Wang Q, Wang L, Shi SS, Guo WD: [The effect of urokinase on hepatic fibrogenesis in rats] . Zhonghua Gan Zang Bing Za Zhi. 2009 Dec;17(12):910-4. METHODS: Hepatic fibrosis was induced in rats by complex pathogenic factors including subcutaneous injections of carbon tetrachloride, and feeding. The serum levels of hyaluronicacid (HA), alanine aminotransferase (ALT), aspartate aminotransferase (AST), (TBil) and the content of liver (Hyp) were detected using ELISA kits. |
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| 19041730 | Cuciureanu M, Caruntu ID, Paduraru O, Stoica B, Jerca L, Crauciuc E, Nechifor M: The protective effect of montelukast on carbon tetrachloride induced hepatopathy in rat. Prostaglandins Other Lipid Mediat. 2009 Apr;88(3-4):82-8. Epub 2008 Nov 11. One day after the last administration, samples of blood were taken and alanine aminotransferase (ALT), total (TB), direct (DB), malondialdehyde (MDA), catalase (CAT) as well as total antioxidant capacity (TAC) were determined. |
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| 19524009 | Hsu YW, Tsai CF, Chen WK, Lu FJ: Protective effects of seabuckthorn (Hippophae rhamnoides L.) seed oil against carbon tetrachloride-induced hepatotoxicity in mice. Food Chem Toxicol. 2009 Sep;47(9):2281-8. Epub 2009 Jun 11. Our results showed that oral administration of SBT seed oil at doses of 0.26, 1.30, and 2.60 mg/kg for 8 weeks significantly reduced the elevated levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), triglyceride (TG), and at least 13% in serum, and the level of malondialdehyde (MDA) in liver at least 22%, that was induced by CCl (4) (1 mL/kg) in mice. |
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| 19527736 | Cho YK, Yun JW, Park JH, Kim HJ, Park DI, Sohn CI, Jeon WK, Kim BI, Jin W, Kwon YH, Shin MK, Yoo TM, Kang JH, Park CS: Deleterious effects of silymarin on the expression of genes controlling endothelial nitric oxide synthase activity in carbon tetrachloride-treated rat livers. Life Sci. 2009 Aug 12;85(7-8):281-90. Epub 2009 Jun 13. Serum was assayed for hepatic enzymes like alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) activities. |
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| 17624652 | Cowles C, Mally A, Chipman JK: Different mechanisms of modulation of gap junction communication by non-genotoxic carcinogens in rat liver in vivo. Toxicology. 2007 Aug 16;238(1):49-59. Epub 2007 Jun 2. Carbon tetrachloride (CCl (4)) did not affect cell communication (despite a small significant reduction of Cx32 content) at a non-hepatotoxic dose. Both loss of communication and Cx32 expression was observed only at a dose that caused hepatocyte toxicity as evidenced by increased serum alanine aminotransferase activity. |
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| 19938218 | Chao J, Lee MS, Amagaya S, Liao JW, Wu JB, Ho LK, Peng WH: Hepatoprotective effect of shidagonglao on acute liver injury induced by carbon tetrachloride. Am J Chin Med. 2009;37(6):1085-97. Rats pretreated orally with SDGL (EtOH) (100 and 500 mg/kg) and silymarin (200 mg/kg) for 3 consecutive days prior to the administration of a single dose of 50% CCl (4) (0.10 ml/100 g of bw, ip) significantly prevented the increases in the activities of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in CCl (4)-treated rats. |
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| 16676162 | Young SC, Wang CJ, Lin JJ, Peng PL, Hsu JL, Chou FP: Protection effect of piper betel leaf extract against carbon tetrachloride-induced liver fibrosis in rats. Arch Toxicol. 2007 Jan;81(1):45-55. Epub 2006 May 5. Fibrosis and hepatic damage, as reveled by histology and the activities of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were induced in rats by an administration of CCl (4) (8%, 1 ml/kg body weight) thrice a week for 4 weeks. |
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| 16621375 | Shyamal S, Latha PG, Shine VJ, Suja SR, Rajasekharan S, Ganga Devi T: Hepatoprotective effects of Pittosporum neelgherrense Wight&Arn.;, a popular Indian ethnomedicine. J Ethnopharmacol. 2006 Aug 11;107(1):151-5. Epub 2006 Apr 18. In the present study, the effect of the methanolic extract of the stem bark of Pittosporum neelgherrense was studied against carbon tetrachloride (CCl (4))-, d-galactosamine (D-GalN)- and -induced acute hepatotoxicity in Wistar rats. Significant hepatoprotective effects were obtained against liver damage induced by all the three liver toxins, as evident from decreased levels of serum enzymes, transaminase (SGOT), glutamate pyruvate transaminase (SGPT) and an almost normal architecture of the liver in the treated groups, compared to the toxin controls. |
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| 17965434 | Xu H, Guo T, Guo YF, Zhang J, Li Y, Feng W, Jiao B: Characterization and protection on acute liver injury of a polysaccharide MP-I from Mytilus coruscus. Glycobiology. 2008 Jan;18(1):97-103. Epub 2007 Oct 27. MP-I was subjected to investigate the protective effect on carbon tetrachloride (CCl (4)) induced liver damage in male Kunming mice. Pharmacological studies revealed that MP-I could decrease serum alanine aminotransferase (ALT), serum aspartate aminotransferase (AST), and hepatic malondialdehyde aldehydes (MDA) levels, increase the hepatic total superoxide dismutase (T-SOD) activity, and improve hepatic damage in the CCl (4) induced liver injury in mice in a dose-dependent manner. |
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| 17660703 | Qin LQ, Wang Y, Xu JY, Kaneko T, Sato A, Wang PY: One-day dietary restriction changes hepatic metabolism and potentiates the hepatotoxicity of carbon tetrachloride and chloroform in rats. Tohoku J Exp Med. 2007 Aug;212(4):379-87. After the challenge by CHCl (3) and CCl (4), the activities of aspartate aminotransferase and alanine aminotransferase, marker enzymes for liver damage, were elevated remarkably at all food groups. |
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| 17973934 | Zhang BJ, Xu D, Guo Y, Ping J, Chen LB, Wang H: Protection by and anti-oxidant mechanism of against rat liver fibrosis induced by multiple hepatotoxic factors. Clin Exp Pharmacol Physiol. 2008 Mar;35(3):303-9. Epub 2007 Oct 30. Serum levels of alanine aminotransferase (ALT) and serum aspartate aminotransferase (AST), hepatic activity of superoxide dismutase (SOD) and hepatic malondialdehyde (MDA) and hepatic (Hyp) content were determined. |
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| 19824117 | Pradeep HA, Khan S, Ravikumar K, Ahmed MF, Rao MS, Kiranmai M, Reddy DS, Ahamed SR, Ibrahim M: Hepatoprotective evaluation of Anogeissus latifolia: in vitro and in vivo studies. World J Gastroenterol. 2009 Oct 14;15(38):4816-22. AIM: To evaluate the hepatoprotective activity of a hydroalcoholic extract of the bark of Anogeissus latifolia; in vitro in primary rat hepatocyte monolayer culture and in vivo in the liver of Wistar rats intoxicated by carbon tetrachloride (CCl (4)). Biochemical parameters including serum transaminases [aspartate aminotransferase (AST) and alanine aminotransferase (ALT)] and alkaline phosphatase (ALP) in serum were analyzed. |
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| 18829732 | Roomi M, Kalinovsky T, Roomi NW, Ivanov V, Rath M, Niedzwiecki A: A nutrient mixture suppresses carbon tetrachloride-induced acute hepatic toxicity in ICR mice. Hum Exp Toxicol. 2008 Jul;27(7):559-66. Mean serum aspartate aminotransferase and alanine aminotransferase were comparable in groups A and B, increased markedly in group C, and significantly lowered in group D compared with group C. |
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| 19398917 | Galicia-Moreno M, Rodriguez-Rivera A, Reyes-Gordillo K, Segovia J, Shibayama M, Tsutsumi V, Vergara P, Moreno MG, Muriel P: prevents carbon tetrachloride-induced liver cirrhosis: role of liver transforming growth factor-beta and oxidative stress. Eur J Gastroenterol Hepatol. 2009 Aug;21(8):908-14. Alkaline phosphatase, alanine aminotransferase, and gamma-glutamyltranspeptidase were measured in plasma. |
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| 16381635 | Liu SQ, Yu JP, He L, Yu HG, Luo HS: [Effects of nuclear factor kappaB and transforming growth factor beta1 in the anti-liver fibrosis process using Ginkgo biloba extract]. Zhonghua Gan Zang Bing Za Zhi. 2005 Dec;13(12):903-7. Malondialdehyde (MDA), superoxide dismutase (SOD) and peroxidase (GSH-Px) in liver tissues and alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in the sera were also examined. |
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| 18460814 | Baek SH, Park M, Suh JH, Choi HS: Protective effects of an extract of young radish (Raphanus sativus L) cultivated with -radish extract) and of on carbon tetrachloride-induced hepatotoxicity. Biosci Biotechnol Biochem. 2008 May;72(5):1176-82. Epub 2008 May 7. CCl (4) produced a marked increase in the serum level of alanine aminotransferase (ALT), primed lipid peroxidation, and resulted in intense necrosis due to oxidative stress. |
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| 16270387 | Chen L, Pan DD, Zhou J, Jiang YZ: Protective effect of -enriched Lactobacillus on CCl4-induced liver injury in mice and its possible mechanisms. World J Gastroenterol. 2005 Oct 7;11(37):5795-800. AIM: To study the protective effects and mechanisms of Se-enriched lactobacillus on liver injury caused by carbon tetrachloride (CCl4) in mice. Then the activities of the following liver tissue injury-associated enzymes including peroxidase (GSH-Px), superoxide dismutase (SOD), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) as well as malondialdehyde (MDA) content were assayed. |
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| 19066852 | Iida C, Fujii K, Koga E, Washino Y, Kitamura Y, Ichi I, Abe K, Matsura T, Kojo S: Effect of on carbon tetrachloride intoxication in the rat liver. Arch Toxicol. 2009 May;83(5):477-83. Epub 2008 Dec 10. After 12 h, the activity of plasma ALT (alanine aminotransferase) was significantly higher than that of the control group, and plasma ALT and AST (aspartate aminotransferase) activities significantly increased 24 h after CCl (4) administration. |
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| 18795620 | Zhao C, Dai CL, Xu F, Ju XH, Li XD, Wang CY: [Patterns of hepatic cells death during hepatic ischemia/reperfusion injury in cirrhotic rats]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2008 Aug;30(4):455-9. METHODS: Cirrhotic rat model was established by carbon tetrachloride replication. Serum alanine aminotransferase (ALT)/aspartate aminotransferase (AST) levels, Na+ - K+ ATPase, and Ca2+ ATPase were compared. the percentage of apoptotic/oncotic hepatic cells was measured with flow cytometry, and the changes in hepatic cellular structures were observed under transmission electron microscope. |
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| 17202657 | Wang CY, Ma FL, Liu JT, Tian JW, Fu FH: Protective effect of salvianic acid a on acute liver injury induced by carbon tetrachloride in rats. Biol Pharm Bull. 2007 Jan;30(1):44-7. Spectrophotometrical method was used to measure activities of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in serum, activities of superoxide dismutase (SOD), catalase (CAT), and peroxidase (GPx) as well as malondialdehyde (MDA) level in hepatic tissue and the rate of (O2*-) generation in hepatic submitochondrial particles. |
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| 16708894 | Baheti JR, Goyal RK, Shah GB: Hepatoprotective activity of Hemidesmus indicus R. br. in rats. Indian J Exp Biol. 2006 May;44(5):399-402. Treatment of rats with and CCl4 produced a significant increase in the levels of serum glutamate pyruvate transaminase (SGPT), serum transaminase (SGOT), alkaline phosphatase (ALP), total and direct |
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| 17450508 | Moresco RN, Sperotto RL, Bernardi AS, Cardoso RF, Gomes P: Effect of the aqueous extract of Syzygium cumini on carbon tetrachloride-induced hepatotoxicity in rats. Phytother Res. 2007 Aug;21(8):793-5. Blood samples obtained after treatments were measured for aspartate aminotransferase (AST) and alanine aminotransferase (ALT). |
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| 20067861 | Roy CK, Das AK: Comparative evaluation of different extracts of leaves of Psidium guajava Linn. for hepatoprotective activity. Pak J Pharm Sci. 2010 Jan;23(1):15-20. In the acute liver damage induced by different hepatotoxins, P. guajava methanolic leaf extract (200 mg/kg, p.o.) significantly reduced the elevated serum levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and in carbon tetrachloride and induced hepatotoxicity. |
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| 19083419 | Lee HS, Kim HH, Ku SK: Hepatoprotective effects of Artemisiae capillaris herba and Picrorrhiza rhizoma combinations on carbon tetrachloride-induced subacute liver damage in rats. Nutr Res. 2008 Apr;28(4):270-7. Ten weeks of carbon tetrachloride injections caused subacute hepatic damage, manifested as significantly less body weight gain and hepatic protein content, and a higher liver weight, serum aspartate aminotransferase and alanine aminotransferase levels, hepatic malondialdehyde (an index for lipid peroxidation), and (an index for collagen synthesis) concentrations. |
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| 19235544 | Yoshioka T, Yoshida S, Kurosaki T, Teshima M, Nishida K, Nakamura J, Nakashima M, To H, Kitahara T, Sasaki H: Cationic liposomes-mediated plasmid DNA delivery in murine hepatitis induced by carbon tetrachloride. J Liposome Res. 2009 Feb 23:1-7. Liver injury after injection of CCl (4) was confirmed by the determination of serum aspartate aminotransferase and alanine aminotransferase activities. |
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| 17897074 | Fernandez-Martinez E, Bobadilla RA, Morales-Rios MS, Muriel P, Perez-Alvarez VM: derivatives: structure-activity relationship as hepatoprotective agents. Med Chem. 2007 Sep;3(5):475-9. The activities of gamma-glutamyl transpeptidase, alkaline phosphatase and alanine aminotransferase were measured in serum. |
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| 17472474 | Lee HS, Keum KY, Ku SK: Effects of Picrorrhiza rhizoma water extracts on the subacute liver damages induced by carbon tetrachloride. J Med Food. 2007 Mar;10(1):110-7. Animals were sacrificed 10 weeks after oral administration of PR extracts at 50, 100, or 200 mg/kg or silymarin at 100 mg/kg, which were administered simultaneously with CCl (4); changes in body weight, liver weight, and serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were observed along with differences in liver histopathology and histomorphometry. |
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| 17383825 | Reyes-Gordillo K, Segovia J, Shibayama M, Vergara P, Moreno MG, Muriel P: protects against acute liver damage in the rat by inhibiting NF-kappaB, proinflammatory cytokines production and oxidative stress. Biochim Biophys Acta. 2007 Jun;1770(6):989-96. Epub 2007 Feb 22. an anti-inflammatory and antioxidant compound, was evaluated for its ability to suppress acute carbon tetrachloride-induced liver damage. Indicators of necrosis (alanine aminotransferase) and cholestasis (gamma-glutamyl transpeptidase and bilirubins) resulted in significant increases after CCl4 intoxication, but these effects were prevented by treatment. |
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| 18023088 | Li LJ, Yang YG, Zhang ZL, Nie SF, Li Z, Li F, Hua HY, Hu YJ, Zhang HS, Guo YB: Protective effects of medical ozone combined with traditional Chinese medicine against chemically-induced hepatic injury in dogs. World J Gastroenterol. 2007 Dec 7;13(45):5989-94. AIM: To investigate the protective effect of medical ozone (O (3)) combined with Traditional Chinese Medicine (TCM) Yigan Fuzheng Paidu Capsules (YC) against carbon tetrachloride (CCl (4))-induced hepatic injury in dogs. The biochemical and hematological indexes of alanine aminotransferase (ALT), aspartate aminotransferase/alanine aminotransferase (AST/ALT), serum total (TBIL), prothrombin time (PT), blood (AMMO), and blood urea (BUN) were measured after CCl (4) injection. |
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| 19136384 | Ferre N, Martinez-Clemente M, Lopez-Parra M, Gonzalez-Periz A, Horrillo R, Planaguma A, Camps J, Joven J, Tres A, Guardiola F, Bataller R, Arroyo V, Claria J: Increased susceptibility to exacerbated liver injury in hypercholesterolemic ApoE-deficient mice: potential involvement of oxysterols. Am J Physiol Gastrointest Liver Physiol. 2009 Mar;296(3):G553-62. Epub 2009 Jan 8. In this study, apolipoprotein E-deficient (ApoE-/-) mice were evaluated to define potential effects of hypercholesterolemia on the severity of carbon tetrachloride (CCl4)-induced liver injury. After CCl4 challenge, ApoE-/- mice exhibited exacerbated steatosis (Oil Red O staining), necroinflammation (hematoxylin-eosin staining), macrophage infiltration (F4/80 immunohistochemistry), and fibrosis (Sirius red staining and alpha-smooth muscle actin immunohistochemistry) and more severe liver injury [alanine aminotransferase (ALT) and aspartate aminotransferase] than wild-type controls. |
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| 16124044 | Yang Q, Xie RJ, Geng XX, Luo XH, Han B, Cheng ML: Effect of Danshao Huaxian capsule on expression of matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 in fibrotic liver of rats. World J Gastroenterol. 2005 Aug 28;11(32):4953-6. Then, the liver indexes, serum (HA) and alanine aminotransferase (ALT) were examined. |
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| 19054144 | Cui CP, Wei P, Liu Y, Zhang DJ, Wang LS, Wu CT: The protective role of Hepatopoietin Cn on liver injury induced by carbon tetrachloride in rats*. Hepatol Res. 2009 Feb;39(2):200-6. Epub 2008 Nov 26. Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activity in rat serum were measured using biochemical assay. |
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| 17637198 | Zhong MM, Chen FH, Yuan LP, Wang XH, Wu FR, Yuan FL, Cheng WM: Protective effect of total flavonoids from Bidens bipinnata L. against carbon tetrachloride-induced liver injury in mice. J Pharm Pharmacol. 2007 Jul;59(7):1017-25. Oral administration of TFB at doses of 50, 100 and 200 mg kg (-1) for 7 days significantly reduced the elevated relative values of liver weight, serum transaminases (alanine aminotransferase and aspartate aminotransferase) and the hepatic morphologic changes induced by CCl4 in mice. |
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| 15350811 | Kus I, Colakoglu N, Pekmez H, Seckin D, Ogeturk M, Sarsilmaz M: Protective effects of phenethyl ester (CAPE) on carbon tetrachloride-induced hepatotoxicity in rats. Acta Histochem. 2004;106(4):289-97. Serum aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, total and conjugated levels and hepatic malondialdehyde (MDA) contents were determined. |
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| 18800905 | Adaramoye OA, Farombi EO, Nssien M, Idowu SO, Ademowo OG, Adeyemi EO: Hepatoprotective activity of purified fractions from Garcinia kola seeds in mice intoxicated with carbon tetrachloride. J Med Food. 2008 Sep;11(3):544-50. Pretreatment with KV, FI, and FII at a dose of 100 mg/kg of body weight for 2 weeks and then challenge with CCl (4) at a dose of 1.2 g/kg of body weight, three times a week for 2 consecutive weeks, decreased the CCl (4)-induced increase in activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) by 31%, 30%, and 31% and 41%, 55%, and 42%, respectively. |
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| 15637473 | Ryeom HK, Kim SH, Kim JY, Kim HJ, Lee JM, Chang YM, Kim YS, Kang DS: Quantitative evaluation of liver function with MRI Using Gd-EOB-DTPA. Korean J Radiol. 2004 Oct-Dec;5(4):231-9. Hepatic injury was induced to by the intragastric administration of carbon tetrachloride (CCl4) three times a week for three weeks. Liver enzyme (aspartate aminotransferase, AST; alanine aminotransferase, ALT) levels and the plasma indocyanine green (ICG) retention rate 15 minutes after an intravenous injection of ICG (ICG R15), was checked before and after the three-week administration of CCl4. |
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| 16273607 | Yamazaki Y, Kakizaki S, Horiguchi N, Takagi H, Mori M, Negishi M: Role of nuclear receptor CAR in carbon tetrachloride-induced hepatotoxicity. World J Gastroenterol. 2005 Oct 14;11(38):5966-72. RESULTS: Elevation of serum alanine aminotransferase and extension of centrilobular necrosis were slightly inhibited in CAR-/- mice compared to CAR+/+ mice without PB. |
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| 15525453 | Gao J, Tang X, Dou H, Fan Y, Zhao X, Xu Q: Hepatoprotective activity of Terminalia catappa L. leaves and its two triterpenoids. J Pharm Pharmacol. 2004 Nov;56(11):1449-55. The aim of this study was to evaluate the effect of the chloroform extract of Terminalia catappa L. leaves (TCCE) on carbon tetrachloride (CCl (4))-induced acute liver damage and D-galactosamine (D-GalN)-induced hepatocyte injury. In the acute hepatic damage test, remarkable rises in the activity of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) (5.7- and 2.0-fold) induced by CCl (4) were reversed and significant morphological changes were lessened with pre-treatment with 50 and 100 mg kg (-1) TCCE. |
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| 17373378 | Qureshi AA, Prakash T, Patil T, Viswanath Swamy AH, Gouda AV, Prabhu K, Setty SR: Hepatoprotective and antioxidant activities of flowers of Calotropis procera (Ait) R. Indian J Exp Biol. 2007 Mar;45(3):304-10. Pre-treatment with 70% ethanolic extract (CPA) reduced the biochemical markers of hepatic injury like serum glutamate pyruvate transaminase, serum transaminase, alkaline phosphatase, HDL and tissue (GSH) levels. |
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| 18460803 | Takahashi M, Kitamoto D, Imura T, Oku H, Takara K, Wada K: Characterization and bioavailability of liposomes containing a ukon extract. Biosci Biotechnol Biochem. 2008 May;72(5):1199-205. Epub 2008 May 7. Orally administrated LUE at a dose of 10 mg/kg as the extract had a much higher suppressive effect on the serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels, compared to the uncapsuled extract at a dose of 33 mg/kg. The bioactivity of LUE was further examined for its suppressive effect on carbon tetrachloride (CCl (4))-induced liver injury by using mice. |
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| 15673190 | Wu YW, Chen KD, Lin WC: Effect of Ganoderma tsugae on chronically carbon tetrachloride-intoxicated rats. Am J Chin Med. 2004;32(6):841-50. GTE showed obvious reducing actions on the elevated levels of --transaminase (GOT) and glutamate-pyruvate-transaminase (GPT) caused by CCl4 at weeks 3, 6 and 8. |
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| 16556994 | Koyama T, Chounan R, Uemura D, Yamaguchi K, Yazawa K: Hepatoprotective effect of a hot-water extract from the edible thorny oyster Spondylus varius on carbon tetrachloride-induced liver injury in mice. Biosci Biotechnol Biochem. 2006 Mar;70(3):729-31. The edible thorny oyster, Spondylus varius (Mizuiri-shoujou), was found to suppress the carbon tetrachloride-induced increase in serum and alanine aminotransferase activities in mice. |
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| 16379566 | Murthy KN, Rajesha J, Swamy MM, Ravishankar GA: Comparative evaluation of hepatoprotective activity of carotenoids of microalgae. J Med Food. 2005 Winter;8(4):523-8. The degree of hepatoprotection was measured by estimation of biochemical parameters like serum transaminases [serum transaminase (SGOT) and serum glutamate pyruvate transaminase (SGPT)], serum alkaline phosphatase, total albumin, and total protein. |
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| 18093227 | Ikeda E, Yagi K, Kojima M, Yagyuu T, Ohshima A, Sobajima S, Tadokoro M, Katsube Y, Isoda K, Kondoh M, Kawase M, Go MJ, Adachi H, Yokota Y, Kirita T, Ohgushi H: Multipotent cells from the human third molar: feasibility of cell-based therapy for liver disease. Differentiation. 2008 May;76(5):495-505. Epub 2007 Dec 17. TGPCs were examined by the transplantation into a carbon tetrachloride (CCl4)-treated liver injured rat to determine whether this novel cell source might be useful for cell-based therapy to treat liver diseases. The TGPCs prevented the progression of liver fibrosis in the liver of CCl4-treated rats and contributed to the restoration of liver function, as assessed by the measurement of hepatic serum markers aspartate aminotransferase and alanine aminotransferase. |
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| 16829063 | Rivera-Huizar S, Rincon-Sanchez AR, Covarrubias-Pinedo A, Islas-Carbajal MC, Gabriel-Ortiz G, Pedraza-Chaverri J, Alvarez-Rodriguez A, Meza-Garcia E, Armendariz-Borunda J: Renal dysfunction as a consequence of acute liver damage by bile duct ligation in cirrhotic rats. Exp Toxicol Pathol. 2006 Nov;58(2-3):185-95. Epub 2006 Jul 7. RESULTS: Hyperbilirubinemia and increased alanine aminotransferase and aspartate aminotransferase (p <0.05) in rats with BDL were observed since the first day of bile obstruction in cirrhotic rats. |
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| 15194653 | Thirunavukkarasu C, Yang Y, Subbotin VM, Harvey SA, Fung J, Gandhi CR: Endothelin receptor antagonist TAK-044 arrests and reverses the development of carbon tetrachloride induced cirrhosis in rats. Gut. 2004 Jul;53(7):1010-9. TAK-044 treatment caused significant amelioration of portal hypertension, systemic hypotension, and liver injury (reduced activities of serum aspartate aminotransferase, alanine aminotransferase, and lactate dehydrogenase), and improved hepatic synthetic capacity (increased serum albumin concentration) in both groups of rats relative to vehicle treated rats. |
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| 15496496 | Aleksunes LM, Slitt AM, Cherrington NJ, Thibodeau MS, Klaassen CD, Manautou JE: Differential expression of mouse hepatic transporter genes in response to and carbon tetrachloride. Toxicol Sci. 2005 Jan;83(1):44-52. Epub 2004 Oct 20. Plasma and liver samples were collected at 6, 24, and 48 h for assessment of alanine aminotransferase (ALT) activity, total RNA isolation, and histopathological analysis of injury. |
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| 15997120 | Tasduq SA, Mondhe DM, Gupta DK, Baleshwar M, Johri RK: Reversal of fibrogenic events in liver by Emblica officinalis (fruit), an Indian natural drug. Biol Pharm Bull. 2005 Jul;28(7):1304-6. A hydroalcoholic (50%) extract of Emblica officinalis (fruit) (EO-50) reduced the severity of hepatic fibrosis induced by carbon tetrachloride (CCl4) and thioacetamide (TAA). Improved liver function was observed by measuring the levels of aminotransaminase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and in serum. |
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| 19812219 | Hosono-Fukao T, Hosono T, Seki T, Ariga T: Diallyl trisulfide protects rats from carbon tetrachloride-induced liver injury. J Nutr. 2009 Dec;139(12):2252-6. Epub 2009 Oct 7. DATS pretreatment significantly suppressed the CCl (4)-induced elevation of plasma aspartate aminotransferase and alanine aminotransferase activities (P < 0.05). |
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| 15635156 | Aniya Y, Koyama T, Miyagi C, Miyahira M, Inomata C, Kinoshita S, Ichiba T: Free radical scavenging and hepatoprotective actions of the medicinal herb, Crassocephalum crepidioides from the Okinawa Islands. Biol Pharm Bull. 2005 Jan;28(1):19-23. Galactosamine (GalN, 400 mg/kg) and lipopolysaccharide (LPS, 0.5 microg/kg) induced hepatotoxicity of rats as seen by an elevation of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) and of lipid peroxidation in liver homogenates was significantly depressed when the herbal extract was given intraperitoneally 1 and 15 h before GalN and LPS treatment. Similarly, carbon tetrachloride (CCl4) induced liver injury as evidenced by an increase in AST and ALT activities in serum was also inhibited by the extract pretreatment. |
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| 19615318 | Chen JM, Wang L, Liu T, Xing LJ, Zheng PY, Ji G: [Effects of Qinggan Huoxue Recipe and its separated recipes on urokinase-type plasminogen activator and plasminogen activator inhibitor-1 fibrinolytic system in rats with alcoholic liver fibrosis]. Zhong Xi Yi Jie He Xue Bao. 2009 Jul;7(7):642-50. The activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in the serum were analyzed. METHODS: A total of 150 SD rats were divided into three groups: blank group, carbon tetrachloride (C (4)) group and ALF-inducing group. |
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| 16117622 | Shahjahan M, Vani G, Devi CS: Protective effect of Indigofera oblongifolia in CCl4-induced hepatotoxicity. J Med Food. 2005 Summer;8(2):261-5. The present study aimed at assessing the protective effect of Indigofera oblongifolia on carbon tetrachloride (CCl4-induced hepatotoxicity. The activities of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and lactate dehydrogenase were significantly (P < .001) increased in serum of CCl4-induced animals when compared with control animals. |
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| 17188414 | Lee CP, Shih PH, Hsu CL, Yen GC: Hepatoprotection of tea seed oil (Camellia oleifera Abel.) against CCl4-induced oxidative damage in rats. Food Chem Toxicol. 2007 Jun;45(6):888-95. Epub 2006 Nov 21. The results showed that a tea seed oil diet significantly (p <0.05) lowered the serum levels of hepatic enzyme markers (alanine aminotransferase, aspartate aminotransferase, and lactate dehydrogenase), inhibited fatty degeneration, reduced the content of the peroxidation product malondialdehyde, and elevated the content of GSH. |
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| 17084009 | Avasarala S, Yang L, Sun Y, Leung AW, Chan WY, Cheung WT, Lee SS: A temporal study on the histopathological, biochemical and molecular responses of CCl (4)-induced hepatotoxicity in Cyp2e1-null mice. Toxicology. 2006 Dec 7;228(2-3):310-22. Epub 2006 Oct 6. The levels of serum alanine aminotransferase and aspartate aminotransferase, markers for liver injury, were significantly higher at 12h, peaked at 24h and gradually decreased at 48 h after CCl (4) intoxication. |
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| 16629373 | Roy CK, Kamath JV, Asad M: Hepatoprotective activity of Psidium guajava Linn. leaf extract. Indian J Exp Biol. 2006 Apr;44(4):305-11. The study was designed to evaluate the hepatoprotective activity of P. guajava in acute experimental liver injury induced by carbon tetrachloride, or thioacetamide and chronic liver damage induced by carbon tetrachloride. In the acute liver damage induced by different hepatotoxins, P. guajava leaf extracts (250 and 500mg/kg, po) significantly reduced the elevated serum levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and |
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| 19506795 | Tanaka N, Kono H, Ishii K, Hosomura N, Fujii H: Dietary olive oil prevents carbon tetrachloride-induced hepatic fibrosis in mice. J Gastroenterol. 2009;44(9):983-90. Epub 2009 Jun 9. RESULTS: Serum alanine aminotransferase levels and the mRNA expression of TGF-beta and collalpha2 were significantly reduced by treatment of olive oil. |
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| 19085960 | Yang RZ, Park S, Reagan WJ, Goldstein R, Zhong S, Lawton M, Rajamohan F, Qian K, Liu L, Gong DW: Alanine aminotransferase isoenzymes: molecular cloning and quantitative analysis of tissue expression in rats and serum elevation in liver toxicity. Hepatology. 2009 Feb;49(2):598-607. Conclusion: Using animal models of hepatoxicity induced by carbon tetrachloride and we found that both serum ALT1 and ALT2 protein levels were significantly elevated and correlated with ALT activity, providing, for the first time, the molecular basis for the elevated total serum ALT activity. |
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| 17850827 | Watanabe N, Ikeda H, Nakamura K, Ohkawa R, Kume Y, Tomiya T, Tejima K, Nishikawa T, Arai M, Yanase M, Aoki J, Arai H, Omata M, Fujiwara K, Yatomi Y: Plasma lysophosphatidic acid level and serum autotaxin activity are increased in liver injury in rats in relation to its severity. Life Sci. 2007 Sep 1;81(12):1009-15. Epub 2007 Aug 19. Plasma LPA level and serum ATX activity were increased in carbon tetrachloride-induced liver fibrosis correlatively with fibrosis grade, in dimethylnitrosamine-induced acute liver injury correlatively with serum alanine aminotransferase level or in 70% hepatectomy as early as 3 h after the operation. |
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| 17135160 | Rajkapoor B, Jayakar B, Kavimani S, Murugesh N: Protective effect of Indigofera aspalathoides against CCl4-induced hepatic damage in rats. J Herb Pharmacother. 2006;6(1):49-54. The activity was evaluated by using biochemical parameters, such as serum glutamate pyruvate transaminase (SGPT), serum transaminase (SGOT), alkaline phosphatase (ALP), total and gama transpeptidase (GGTP). |
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| 15902742 | Gui SY, Wei W, Wang H, Wu L, Sun WY, Wu CY: Protective effect of fufanghuangqiduogan against acute liver injury in mice. World J Gastroenterol. 2005 May 21;11(19):2984-9. METHODS: ALI was successfully induced by injecting carbon tetrachloride (CCl4) intraperitoneally and by tail vein injection of Bacillus Calmette Guerin (BCG) and lipopolysaccharide (LPS) in mice, respectively. At the end of the experiment, levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), content of malondialdehyde (MDA), activities of superoxide dismutase (SOD) and peroxidase (GSH-px) in liver homogenate were measured by biochemical methods. |
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| 15210065 | Yao HW, Li J, Chen JQ, Xu SY: Inhibitory effect of leflunomide on hepatic fibrosis induced by CCl4 in rats. Acta Pharmacol Sin. 2004 Jul;25(7):915-20. The alanine aminotransferase (ALT), aspartate aminotransferase (AST), (NO) levels in plasma and (Hyp) contents in liver tissue were assayed by spectrophotometry. |
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| 18624899 | Banas A, Teratani T, Yamamoto Y, Tokuhara M, Takeshita F, Osaki M, Kato T, Okochi H, Ochiya T: Rapid hepatic fate specification of adipose-derived stem cells and their therapeutic potential for liver failure. J Gastroenterol Hepatol. 2009 Jan;24(1):70-7. Epub 2008 Jun 25. Markers of liver injury, alanine aminotransferase, aspartate aminotransferase, as well as were decreased after ASC-derived hepatocyte transplantation. |
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| 17244260 | Wu ZM, Wen T, Tan YF, Liu Y, Ren F, Wu H: Effects of salvianolic acid a on oxidative stress and liver injury induced by carbon tetrachloride in rats. Basic Clin Pharmacol Toxicol. 2007 Feb;100(2):115-20. Administration of CCl (4) to rats caused severe hepatic damage, as demonstrated by the significant increase in the levels of serum alanine aminotransferase, aspartate aminotransferase and classic histological changes including hepatocyte necrosis or apoptosis, haemorrhage, fatty degeneration, etc. |
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| 14992325 | Tasaduq SA, Singh K, Sethi S, Sharma SC, Bedi KL, Singh J, Jaggi BS, Johri RK: Hepatocurative and antioxidant profile of HP-1, a polyherbal phytomedicine. Hum Exp Toxicol. 2003 Dec;22(12):639-45. HP-1 a herbal formulation comprising of Phyllanthus niruri and extracts of Terminalia belerica, Terminalia chebula, Phyllanthus emblica and Tinospora cordifolia has been evaluated for hepatoprotective activity against carbon tetrachloride (CCl4) induced toxicity. Results show that HP-1 reversed the leakage of lactate dehydrogenase (LDH) and glutamate pyruvate transaminase (GPT) and prevented the depletion of (GSH) levels in a primary monolayer culture of rat hepatocytes (in vitro). |
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| 20004152 | D'Argenio G, Amoruso DC, Mazzone G, Vitaglione P, Romano A, Ribecco MT, D'Armiento MR, Mezza E, Morisco F, Fogliano V, Caporaso N: Garlic extract prevents CCl (4)-induced liver fibrosis in rats: The role of tissue transglutaminase. Dig Liver Dis. 2009 Dec 7. Moreover, the liver damage improved and serum alanine aminotransferase was decreased (p <0.05). METHODS: Rat liver fibrosis was induced by intraperitoneal injection of carbon tetrachloride (CCl (4)) for 7 weeks. |
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| 15968720 | Zhang LM, Liu DW, Liu JB, Zhang XL, Wang XB, Tang LM, Wang LQ: Effect of naked eukaryotic expression plasmid encoding rat augmenter of liver regeneration on acute hepatic injury and hepatic failure in rats. World J Gastroenterol. 2005 Jun 28;11(24):3680-5. The rats with acute hepatic injury induced by intraperitoneal injection of 2 mL/kg 50% carbon tetrachloride (CCl (4)) were randomly divided into saline control group and recombinant pcDNA3-ALR plasmid treatment groups. Hepatic histopathological alterations were observed after HE staining, the expression of proliferating cell nuclear antigen (PCNA) in liver tissue was detected by immunohistochemical staining, and the level of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) was determined by biochemical method. |
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| 19787836 | Peng XD, Dai LL, Huang CQ, He CM, Chen LJ: Correlation between anti-fibrotic effect of baicalin and serum cytokines in rat hepatic fibrosis. World J Gastroenterol. 2009 Oct 7;15(37):4720-5. Except for the normal control group, all rats in the other groups were administered with carbon tetrachloride to induce hepatic fibrosis. Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), transforming growth factor (TGF)-beta1, tumor necrosis factor (TNF)-alpha, interleukin (IL)-6 and IL-10 were measured. |
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| 16996028 | Isoda K, Arita E, Kojima M, Ikkaku M, Tashiro F, Yamato E, Miyazaki J, Kawase M, Kondoh M, Yagi K: Protection against CCl4-induced injury in liver by adenovirally introduced thioredoxin gene. Biochem Biophys Res Commun. 2006 Nov 10;350(1):157-61. Epub 2006 Sep 15. Serum aspartate aminotransferase (AST), and alanine aminotransferase (ALT) levels were determined, and liver sections were stained with hematoxylin and eosin. |
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| 15270078 | Lee KJ, Terada K, Oyadomari S, Inomata Y, Mori M, Gotoh T: Induction of molecular chaperones in carbon tetrachloride-treated rat liver: implications in protection against liver damage. Cell Stress Chaperones. 2004 Mar;9(1):58-68. When chaperones were preinduced in the liver by heat treatment, increase in serum alanine aminotransferase activity after CCl4 treatment was significantly attenuated. |
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| 19496198 | Jin SZ, Meng XW, Han MZ, Sun X, Sun LY, Liu BR: Stromal cell derived factor-1 enhances bone marrow mononuclear cell migration in mice with acute liver failure. World J Gastroenterol. 2009 Jun 7;15(21):2657-64. The serum alanine aminotransferase levels in experimental and control groups were measured at different time points (120 +/- 40 vs 118.50 +/- 1.75, P > 0.05; 80.60 +/- 6.50 vs 101.08 +/- 5.67, P < 0.05; 50.74 +/- 5.38 vs 80.47 +/- 4.62, P < 0.05; 30.54 +/- 2.70 vs 60.72 +/- 4.37, P < 0.05; 30.77 +/- 5.36 vs 40.47 +/- 6.50, P < 0.05). The labeled cells were subsequently infused into the caudal veins of BALB/c mice with hepatic injury induced by carbon tetrachloride and 2-acetylaminofluorene. |
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| 18433134 | Seki T, Morimura S, Tabata S, Tang Y, Shigematsu T, Kida K: Antioxidant activity of produced from distilled residues of the Japanese liquor shochu. J Agric Food Chem. 2008 May 28;56(10):3785-90. Consequently, treatment with AFP at 200 mg/kg body weight or higher doses suppressed the elevation of alanine aminotransferase and aspartate aminotransferase levels in serum (P < 0.05). Its antioxidant activity was evaluated in vivo using carbon tetrachloride (CCl (4))-induced acute liver injury mouse models. |
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| 20082759 | Lai TY, Weng YJ, Kuo WW, Chen LM, Chung YT, Lin YM, Tsai FJ, Lee CH, Choong YM, Lai EY, Huang CY, Yeh YL: Taohe Chengqi Tang ameliorates acute liver injury induced by carbon tetrachloride in rats. Zhong Xi Yi Jie He Xue Bao. 2010 Jan;8(1):49-55. Twenty-four hours after CCl (4) injection, the rats were sacrificed to observe liver histopathological changes, and to evaluate activities of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT), and lipid peroxidation (LPO) and (GSH) levels in liver tissues. |
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| 15483417 | Ritter C, Reinke A, Andrades M, Martins MR, Rocha J, Menna-Barreto S, Quevedo J, Moreira JC, Dal-Pizzol F: Protective effect of and deferoxamine on carbon tetrachloride-induced acute hepatic failure in rats. Crit Care Med. 2004 Oct;32(10):2079-83. In addition, the serum levels of alanine aminotransferase, total and prothrombin time in the plus deferoxamine group were significantly lower than those in the or deferoxamine and saline groups. |
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| 15960080 | Aneja R, Upadhyaya G, Prakash S, Dass SK, Chandra R: Ameliorating effect of phytoestrogens on CCl4-induced oxidative stress in the livers of male Wistar rats. Artif Cells Blood Substit Immobil Biotechnol. 2005;33(2):201-13. In the present study, the protective effects, if any, of isoflavone phytoestrogens-- and daidzein on the carbon tetrachloride (CCl4) induced changes in the activity of alanine aminotransferase (ALT), aspartate aminotransferase (AST), glutathione S transferase (GSH) and levels of (GSH) and thiobarbituric acid reactive substances (TBARS)-were studied. |
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| 19239161 | Choi D, Kim SJ, Kwon do Y, Lee SY, Kim YC: depletion by inhibits induction of hepatotoxicity in mice treated acutely with carbon tetrachloride. Adv Exp Med Biol. 2009;643:305-11. Hepatotoxicity caused by carbon tetrachloride (50 microl/kg, ip) in mice fed was decreased, as determined by changes in serum aspartate aminotransferase, alanine aminotransferase and sorbitol dehydrogenase activities. |
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| 19429327 | Shen X, Tang Y, Yang R, Yu L, Fang T, Duan JA: The protective effect of Zizyphus jujube fruit on carbon tetrachloride-induced hepatic injury in mice by anti-oxidative activities. J Ethnopharmacol. 2009 Apr 21;122(3):555-60. Epub 2009 Feb 7. MATERIALS AND METHODS: The alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were detected as biomarker in blood of hepatic injury. |
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| 20354348 | Akachi T, Shiina Y, Ohishi Y, Kawaguchi T, Kawagishi H, Morita T, Mori M, Sugiyama K: Hepatoprotective Effects of Flavonoids from Shekwasha (Citrus depressa) against D-Galactosamine-Induced Liver Injury in Rats. J Nutr Sci Vitaminol. 2010;56(1):60-7. Liver injury-suppressive activity, as assessed by plasma alanine aminotransferase and aspartate aminotransferase activities, was found only in the fraction that was extracted with n-hexane when three fractions were added to the diet and fed to rats. the most important compound in the n-hexane-soluble fraction, also had suppressive effects on liver injuries induced by carbon tetrachloride, and GalN/lipopolysaccharide (LPS) in addition to liver injury induced GalN. |
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| 18761048 | Hsu YW, Tsai CF, Chang WH, Ho YC, Chen WK, Lu FJ: Protective effects of Dunaliella salina--a carotenoids-rich alga, against carbon tetrachloride-induced hepatotoxicity in mice. Food Chem Toxicol. 2008 Oct;46(10):3311-7. Epub 2008 Aug 12. CCl (4) induced liver damage and significantly (p <0.05) increased the activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) in serum and decreased the activities of superoxide dismutase (SOD), catalase, peroxidase (GSH-Px), and GSH content in liver whereas increased hepatic malondialdehyde (MDA) content as compared with control group. |
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| 16227642 | Abdel Salam OM, Baiuomy AR, El-Shenawy SM, Hassan NS: Effect of pentoxifylline on hepatic injury caused in the rat by the administration of carbon tetrachloride or Pharmacol Rep. 2005 Sep-Oct;57(5):596-603. The administration of PTX at 72 mg/kg, conferred significant protection against the hepatotoxic actions of CCl4, reducing serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) levels to 31%, 59.2% and 63%, respectively. |
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| 18427963 | Bahcecioglu IH, Koca SS, Poyrazoglu OK, Yalniz M, Ozercan IH, Ustundag B, Sahin K, Dagli AF, Isik A: Hepatoprotective effect of infliximab, an anti-TNF-alpha agent, on carbon tetrachloride-induced hepatic fibrosis. Inflammation. 2008 Aug;31(4):215-21. Epub 2008 Apr 22. Infliximab reduced the levels of aspartate aminotransferase and alanine aminotransferase (p <0.05 for both). |
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| 19718641 | Liu F, Liu ZD, Wu N, Cong X, Fei R, Chen HS, Wei L: Transplanted endothelial progenitor cells ameliorate carbon tetrachloride-induced liver cirrhosis in rats. Liver Transpl. 2009 Sep;15(9):1092-100. EPCs reduced the expression of alpha-smooth muscle actin, collagen III, and transforming growth factor beta (P < 0.05) as well as levels of aspartate aminotransferase, alanine aminotransferase, and total in the serum (P < 0.05), but at the same time they increased the levels of albumin and Ki67. |
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| 15112349 | Liu QH, Li DG, Huang X, Zong CH, Xu QF, Lu HM: Suppressive effects of 17beta- on hepatic fibrosis in CCl4-induced rat model. World J Gastroenterol. 2004 May 1;10(9):1315-20. RESULTS: Beta-Est treatment reduced aspartate aminotransferase (AST), alanine aminotransferase (ALT), (HA) and type IV collagen (C IV) in sera, suppressed hepatic collagen content, decreased the areas of HSCs positive for alpha-SMA significantly in both intact and ovariectomized female hepatofibrotic rats. |
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| 17195458 | Ueda Y, Yabe K, Taira Z: A bio-defensive function induced by low-dose lipopolysaccharide pre-treatment against CCl4-induced fulminant hepatic failure in rats. Anticancer Res. 2006 Nov-Dec;26(6A):4063-6. In male Donryu rats treated with CCl4 at 1.0 ml/kg i.p., the serum alanine aminotransferase (ALT) increased up to a peak at 24 h. |
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| 20177577 | Sisodia SS, Bhatnagar M: Hepatoprotective activity of Eugenia jambolana Lam. in carbon tetrachloride treated rats. Indian J Pharmacol. 2009 Feb;41(1):23-7. MATERIALS AND METHODS: Liver damage in rats treated with CCl (4) (1ml/kg/Bw, administered subcutaneously, on alternate days for one week) was studied by assessing parameters such as serum transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP), acid phosphatase (ACP) and (total and direct). |
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| 17429801 | Chavez E, Reyes-Gordillo K, Segovia J, Shibayama M, Tsutsumi V, Vergara P, Moreno MG, Muriel P: prevents fibrosis, NF-kappaB activation and TGF-beta increases induced by chronic CCl4 treatment in rats. J Appl Toxicol. 2008 Jan;28(1):35-43. Alanine aminotransferase, alkaline phosphatase and bilirubins were increased by CCl (4), but afforded some degree of protection. |
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| 20192593 | Poojari R, Gupta S, Maru G, Khade B, Bhagwat S: Sida rhombifolia ssp. retusa Seed Extract Inhibits DEN Induced Murine Hepatic Preneoplasia and Carbon Tetrachloride Hepatotoxicity. Asian Pac J Cancer Prev. 2009;10(6):1107-12. Treatment with seed extract significantly inhibited the increase in DEN/CCl4 induced activities of pre-cancerous marker enzymes; gamma-glutamyl transpeptidase, glutathione-S-transferase, hepatotoxicity marker enzymes; glutamate pyruvate transaminase, transaminase and alkaline phosphatase as well as lipid peroxidase. |
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| 18313245 | Yuan LP, Chen FH, Ling L, Dou PF, Bo H, Zhong MM, Xia LJ: Protective effects of total flavonoids of Bidens pilosa L. (TFB) on animal liver injury and liver fibrosis. J Ethnopharmacol. 2008 Mar 28;116(3):539-46. Epub 2008 Jan 20. The hepatoprotective effects of total flavonoids of Bidens pilosa L. (TFB), a traditional Chinese medicine were evaluated in carbon tetrachloride (CCl (4))-induced liver injury in mice and rats. Liver index (liver weight/body weight), serum levels of transaminases (alanine aminotransferase, ALT and aspartate aminotransferase, AST), hepatic malondialdehyde (MDA) content, superoxide dismutase (SOD) and peroxidase (GSH-Px) activities were evaluated following the 10 days treatment in mice. |
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| 16213120 | Rao GM, Rao CV, Pushpangadan P, Shirwaikar A: Hepatoprotective effects of rubiadin, a major constituent of Rubia cordifolia Linn. J Ethnopharmacol. 2006 Feb 20;103(3):484-90. Epub 2005 Oct 5. The substantially elevated serum enzymatic activities of serum glutamic oxaloacetic transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), serum alkaline phosphatase (SALP) and gamma-glutamyltransferase (gamma-GT) due to carbon tetrachloride treatment were dose dependently restored towards normalization. |
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| 15720792 | Chen Y, Liu J, Yang X, Zhao X, Xu H: Oleanolic acid nanosuspensions: preparation, in-vitro characterization and enhanced hepatoprotective effect. J Pharm Pharmacol. 2005 Feb;57(2):259-64. As evidenced by the lower serum alanine aminotransferase activity and liver malondialdehyde content, pre-treatment with oleanolic acid nanosuspensions significantly enhanced the hepatoprotective effect of oleanolic acid against carbon tetrachloride-induced liver injury. |
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| 16388923 | Sanmugapriya E, Venkataraman S: Studies on hepatoprotective and antioxidant actions of Strychnos potatorum Linn. seeds on CCl4-induced acute hepatic injury in experimental rats. J Ethnopharmacol. 2006 Apr 21;105(1-2):154-60. Epub 2006 Jan 4. Both SPP and SPE at the doses 100 and 200 mg/kg, p.o. offered significant (p < 0.001) hepatoprotective action by reducing the serum marker enzymes like serum transaminase (SGOT) and serum glutamate pyruvate transaminase (SGPT). |
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| 15507327 | Ozbek H, Citoglu GS, Dulger H, Ugras S, Sever B: Hepatoprotective and anti-inflammatory activities of Ballota glandulosissima. J Ethnopharmacol. 2004 Dec;95(2-3):143-9. extract of Ballota glandulosissima Hub.-Mor & Patzak (Lamiaceae) (BG) was investigated for anti-inflammatory activity using the carrageenan-induced rat paw oedema test and for hepatoprotective effect on carbon tetrachloride (CCl (4))-induced hepatotoxicity in rats. Biochemical parameters of hepatic damage such as serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and concentrations were determined. |
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| 18705752 | Reyes-Gordillo K, Segovia J, Shibayama M, Tsutsumi V, Vergara P, Moreno MG, Muriel P: prevents and reverses cirrhosis induced by bile duct obstruction or CCl4 in rats: role of TGF-beta modulation and oxidative stress. Fundam Clin Pharmacol. 2008 Aug;22(4):417-27. Alanine aminotransferase, gamma-glutamyl transpeptidase, liver histopathology, reduced and and TGF-beta (mRNA and protein) levels were assessed. |
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| 20019074 | Xu L, Gao J, Wang Y, Yu W, Zhao X, Yang X, Zhong Z, Qian ZM: Myrica rubra Extracts Protect the Liver from CCl4-Induced Damage. Evid Based Complement Alternat Med. 2009 Dec 17. Et Zucc fruit extract (MCE) against carbon tetrachloride (CCl (4))-induced liver damage was investigated. Pretreatment with 50 mg kg (-1), 150 mg kg (-1) or 450 mg kg (-1) MCE significantly blocked the CCl (4)-induced increase in both serum aspartate aminotransferase (sAST) and serum alanine aminotransferase (sALT) levels in mice (P < 0.05 or 0.01 vs CCl (4) group). |
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| 20046731 | Dandagi PM, Patil MB, Mastiholimath VS, Gadad AP, Dhumansure RH: Development and evaluation of hepatoprotective polyherbal formulation containing some indigenous medicinal plants. Indian J Pharm Sci. 2008 Mar-Apr;70(2):265-8. Petroleum ether (60-80 degrees ), chloroform, and aqueous extracts of Ferula asafetida, Momordica charantia Linn and Nardostachys jatamansi were evaluated for hepatoprotective activity against carbon tetrachloride-induced liver toxicity in Wistar rats. Formulation F3 has shown significant hepatoprotective effect by reducing the elevated serum enzyme levels such as transaminase, glutamate pyruvate transaminase and alkaline phosphatase. |
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| 17010209 | Manna P, Sinha M, Sil PC: Aqueous extract of Terminalia arjuna prevents carbon tetrachloride induced hepatic and renal disorders. BMC Complement Altern Med. 2006 Sep 30;6:33. Serum marker enzymes, namely, glutamate pyruvate transaminase (GPT) and alkaline phosphatase (ALP) were estimated in the sera of all study groups. |
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| 15573529 | Venukumar MR, Latha MS: Effect of Coscinium fenestratum on hepatotoxicity in rats. Indian J Exp Biol. 2004 Aug;42(8):792-7. Anti-hepatotoxic activity of extract of Coscinium fenestratum stem (MEC) was investigated against carbon tetrachloride-induced hepatopathy in rats. Anti-hepatotoxic effect was studied by assaying the activities of serum marker enzymes like aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, gamma glutamyl transpeptidase, lactate dehydrogenase etc. and glucose (6) phosphate dehydrogenase in liver. |
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| 18951966 | Zou YH, Yang Y, Li J, Wu Q, Li WP, Lu JT, Roberts MS: Potential therapeutic effects of a traditional Chinese formulation, BJ-JN, on liver fibrosis induced by carbon tetrachloride in rats. J Ethnopharmacol. 2008 Dec 8;120(3):452-7. Epub 2008 Oct 1. Evaluated with liver and spleen index, serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), (HA), (NO), hepatic malondialdehyde (MDA) content and superoxide dismutase (SOD) activity, as well as with histopathologic changes of liver. |
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| 15998439 | Liu GT, Li Y, Wei HL, Zhang H, Xu JY, Yu LH: Mechanism of protective action of bicyclol against CCl-induced liver injury in mice. Liver Int. 2005 Aug;25(4):872-9. Oral administration of bicyclol markedly reduced the elevated serum transaminases (alanine aminotransferase (ALT) and aspartate aminotransferase (AST)) and the hepatic morphologic changes induced by CCl (4) in mice. |
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| 20350579 | Hsu YW, Tsai CF, Chuang WC, Chen WK, Ho YC, Lu FJ: Protective effects of hydride against carbon tetrachloride-induced hepatotoxicity in mice. Food Chem Toxicol. 2010 Mar 26. The results showed that oral administration of hydride significantly reduced the elevated serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), triglyceride (TG), and and the level of malondialdehyde (MDA) in the liver that were induced by CCl (4) in mice. |
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| 15702514 | Al-Howiriny TA, Al-Sohaibani MO, Al-Said MS, Al-Yahya MA, El-Tahir KH, Rafatullah S: Hepatoprotective properties of Commiphora opobalsamum ("Balessan"), a traditional medicinal plant of Saudi Arabia. Drugs Exp Clin Res. 2004;30(5-6):213-20. This extract has been shown to possess significant protective effect by lowering serum transaminase levels (serum transaminase and serum glutamate pyruvate transaminase), alkaline phosphatase and Pretreatment with an extract of Balessan prevented the prolongation of the barbiturate sleeping time associated with carbon tetrachloride-induced liver damage in mice. |
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| 17651073 | Salawu SO, Akindahunsi AA: Protective effect of some tropical vegetables against CCl4-induced hepatic damage. J Med Food. 2007 Jun;10(2):350-5. CCl4 at a dose of 0.5 mL/kg of body weight produced liver damage in rats as manifested by the rise in the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and total protein in serum (40.60 +/- 3.50 IU/L, 80.60 +/- 5.10 IU/L, and 73.20 +/- 1.87 g/L, respectively) and in liver homogenate (1,300.00 +/- 7.38 IU/L, 1,660.00 +/- 13.69 IU/L, and 250.00 +/- 7.51 g/L, respectively) compared to the control. |
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| 19477216 | Tsai CF, Hsu YW, Chen WK, Chang WH, Yen CC, Ho YC, Lu FJ: Hepatoprotective effect of electrolyzed reduced water against carbon tetrachloride-induced liver damage in mice. Food Chem Toxicol. 2009 Aug;47(8):2031-6. Epub 2009 May 27. CCl (4)-induced liver lesions include leukocytes infiltration, hepatocyte necrosis, ballooning degeneration, mitosis, calcification, fibrosis and an increase of serum alanine aminotransferase (ALT), and aminotransferase (AST) activity. |
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| 18291569 | Lee KJ, Choi JH, Kim HG, Han EH, Hwang YP, Lee YC, Chung YC, Jeong HG: Protective effect of saponins derived from the roots of Platycodon grandiflorum against carbon tetrachloride induced hepatotoxicity in mice. Food Chem Toxicol. 2008 May;46(5):1778-85. Epub 2008 Jan 18. Pretreatment with CKS prior to the administration of CCl (4) significantly prevented the increase in serum alanine aminotransferase and aspartate aminotransferase activities and hepatic lipid peroxidation formation. |
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| 17963319 | Chang HY, Peng WH, Sheu MJ, Huang GJ, Tseng MC, Lai MT, Ho YL, Chang YS: Hepatoprotective and Antioxidant Effects of Extract from Phellinus merrillii on carbon tetrachloride-induced liver damage. Am J Chin Med. 2007;35(5):793-804. Treatment with PM (0.5, 1 and 2 g/kg) prior to the administration of carbon tetrachloride (1.5 ml/kg in olive oil, 20%) significantly prevented the increased serum alanine aminotransferase (s-GOT) and serum aspartate aminotransferase (s-GPT) in a dose-dependent manner. |
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| 19568713 | Cao HX, Sun H, Jiang XG, Lu HT, Zhang GM, Wang XJ, Sun WJ, Wu ZM, Wang P, Liu L, Zhou J: Comparative study on the protective effects of Yinchenhao Decoction against liver injury induced by alpha-naphthylisothiocyanate and carbon tetrachloride. Chin J Integr Med. 2009 Jun;15(3):204-9. Epub 2009 Jul 2. METHODS: The liver injury in the model rat was induced by alpha-naphthylisothiocyanate (ANIT) and carbon tetrachloride (CCl (4) ) respectively, and the effects of Yinchenhao Decoction (, YCHD), a proved effective Chinese medical formula for treating the dampness-heat jaundice syndrome in clinic, on the two liver injury models were evaluated by analyzing the serum level of alanine aminotransferase (ALT), asparate aminotransferase (AST), alkaline phosphatase (ALP), malondialchehyche (MDA), total (T-BIL), superoxide dismutase (SOD), peroxidase (GSH-PX) as well as the ratio of liver weight to body weight. |
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| 19046688 | Futakawa S, Kitazume S, Oka R, Ogawa K, Hagiwara Y, Kinoshita A, Miyashita K, Hashimoto Y: Development of sandwich enzyme-linked immunosorbent assay systems for plasma beta-galactoside alpha2,6-sialyltransferase, a possible hepatic disease biomarker. Anal Chim Acta. 2009 Jan 5;631(1):116-20. Epub 2008 Oct 22. Using the M2 ELISA, we observed that elevation of plasma ST6Gal I was much faster than elevation of plasma aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in a carbon tetrachloride (CCl (4))-induced mouse liver injury model. |
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| 18815054 | Shibata H, Yoshioka Y, Ohkawa A, Abe Y, Nomura T, Mukai Y, Nakagawa S, Taniai M, Ohta T, Mayumi T, Kamada H, Tsunoda S, Tsutsumi Y: The therapeutic effect of TNFR1-selective antagonistic mutant TNF-alpha in murine hepatitis models. Cytokine. 2008 Nov;44(2):229-33. Epub 2008 Sep 23. In this study, we examined the therapeutic effect of R1antTNF in acute hepatitis using two independent experimental models, induced by carbon tetrachloride (CCl (4)) or concanavalin A (ConA). In a CCl (4)-induced model, treatment with R1antTNF significantly inhibited elevation in the serum level of ALT (alanine aminotransferase), a marker for liver damage. |
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| 15931870 | Liang J, Zhang XL, Yang GY, Pang YS, Yuan HF, Liang JS, Huang RB: [Observation of the promotion effect on hepatic stellate cell's apoptosis in rat hepatic fibrosis model]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2005 May;36(3):365-7. OBJECTIVE: To observe the effect of on hepatic stellate cell's apoptosis induced by carbon tetrachloride (CCl4) in rats and to study its protective mechanisms. Serum alanine aminotransferase (ALT), plasma protein, (HA), procollagen III (PC III), hepatic microsomal drug-metabolizing enzyme and anti-transforming growth factor beta1 (TGF-beta1) were determined. |
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| 17313811 | Hu AB, He XS, Zheng QC, Cai JY: [Curative effects of transplantation of hepatocytes differentiated from embryonic stem cells on treatment of fulminant hepatic failure: experiment with mice]. Zhonghua Yi Xue Za Zhi. 2006 Dec 12;86(46):3280-4. Twenty-four hours later venous blood samples were collected to examine the levels of total (TB), alanine aminotransferase (ALT), ALB, blood sugar (BS), and prothrombin time (PT). Twenty-four hours later carbon tetrachloride was injected intra-peritoneally to induce FHF. |
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| 19322917 | Hong RT, Xu JM, Mei Q: ameliorates experimental hepatic fibrosis induced by carbon tetrachloride in rats. World J Gastroenterol. 2009 Mar 28;15(12):1452-8. Serum activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and protein concentration were measured with routine laboratory methods using an autoanalyzer. |
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| 19793341 | Quan J, Piao L, Wang X, Li T, Yin X: Rossicaside B protects against carbon tetrachloride-induced hepatotoxicity in mice. Basic Clin Pharmacol Toxicol. 2009 Dec;105(6):380-6. Epub 2009 Sep 30. The CCl (4) challenge caused a marked increase in the levels of serum aspartate aminotransferase, alanine aminotransferase and of tumour necrosis factor-alpha, and propagated lipid peroxidation with a concomitant reduction in (GSH) and antioxidative enzyme activities in the liver. |
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| 19345075 | Yan F, Zhang QY, Jiao L, Han T, Zhang H, Qin LP, Khalid R: Synergistic hepatoprotective effect of Schisandrae lignans with Astragalus polysaccharides on chronic liver injury in rats. Phytomedicine. 2009 Sep;16(9):805-13. Epub 2009 Apr 2. Subcutaneous injection of 10% CCl (4) twice a week for 3 months resulted in significantly (p <0.001) elevated serum alanine aminotransferase (ALT), asparate aminotransferase (AST), alkaline phosphatase (ALP) activities compared to controls. |
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| 19775523 | Yukawa H, Noguchi H, Oishi K, Takagi S, Hamaguchi M, Hamajima N, Hayashi S: Cell transplantation of adipose tissue-derived stem cells in combination with attenuated acute liver failure in mice. Cell Transplant. 2009;18(5):611-8. The effect of adipose tissue-derived stem cells (ASCs) in combination with transplantation on acute liver failure mice with carbon tetrachloride (CCl (4)) injection was investigated. The injection of into the caudal tail vein decreased slightly the activities of the alanine aminotransferase (ALT), asparate aminotransferase (AST), and lactate dehydrogenase (LDH) in plasma. |
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| 15816358 | Rincon-Sanchez AR, Covarrubias A, Rivas-Estilla AM, Pedraza-Chaverri J, Cruz C, Islas-Carbajal MC, Panduro A, Estanes A, Armendariz-Borunda J: alleviates kidney and liver damage, decreases plasma renin activity and acute phase response in cirrhotic rats with acute liver damage. Exp Toxicol Pathol. 2005 Mar;56(4-5):291-303. Male Wistar rats treated with carbon tetrachloride (CCl4) for 8 weeks were used for the cirrhosis model. -treatment ameliorated the decrease in urinary excretion, and normalized serum activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and plasma renin observed in cirrhotic rats with ALD. |
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| 17900780 | Yang YS, Ahn TH, Lee JC, Moon CJ, Kim SH, Jun W, Park SC, Kim HC, Kim JC: Protective effects of Pycnogenol on carbon tetrachloride-induced hepatotoxicity in Sprague-Dawley rats. Food Chem Toxicol. 2008 Jan;46(1):380-7. Epub 2007 Aug 21. Hepatotoxicity was assessed 24 h after the CCl4 treatment by measurement of serum aminotransferase (AST) and alanine aminotransferase (ALT) activities, hepatic malondialdehyde (MDA) and (GSH) concentrations, and catalase, superoxide dismutase (SOD), and glutathione-S-transferase (GST) activities. |
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| 16943688 | Paul SC, Lv P, Xiao YJ, An P, Liu SQ, Luo HS: Thalidomide in rat liver cirrhosis: blockade of tumor necrosis factor-alpha via inhibition of degradation of an inhibitor of nuclear factor-kappaB. Pathobiology. 2006;73(2):82-92. METHODS: Liver cirrhosis was achieved by intraperitoneal injection of carbon tetrachloride thrice weekly, and thalidomide (10 or 100 mg/kg/day) was given daily by intragastric route for 8 weeks. Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), prealbumin (PA), (HA) and laminin (LN), and (HYP), NF-kappaBp65, alpha-smooth muscle actin (alpha-SMA) protein and TNF-alpha mRNA were studied in the liver, IkappaBalpha and TNF-alpha protein in the cytoplasm and NF-kappaBp65 protein in the nucleus. |
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| 15056808 | Jiang Y, Liu J, Waalkes M, Kang YJ: Changes in the gene expression associated with carbon tetrachloride-induced liver fibrosis persist after cessation of dosing in mice. Toxicol Sci. 2004 Jun;79(2):404-10. Epub 2004 Mar 31. Hepatic pathological changes observed in the CCl (4)-treated mice included necrosis, inflammation, and fibrosis, along with increased serum alanine aminotransferase activities. |
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| 18695788 | Martinez JA, Ramos SG, Meirelles MS, Verceze AV, Arantes MR, Vannucchi H: [Effects of on bleomycin-induced lung injury: a preliminary study]. J Bras Pneumol. 2008 Jul;34(7):445-52. METHODS: Male Wistar rats, with mean weight of 250 g, were used in four experimental models: inhaled carbon tetrachloride; intraperitoneal carbon tetrachloride; partial portal vein ligation; and bile duct ligation (BDL). RESULTS: There were statistically significant differences between the BDL control and BDL experimental groups: aspartate aminotransferase (105.3 +/- 43 vs. 500.5 +/- 90.3 IU/L); alanine aminotransferase (78.75 +/- 37.7 vs. 162.75 +/- 35.4 IU/L); alkaline phosphatase (160 +/- 20.45 vs. 373.25 +/- 45.44 IU/L); arterial tension (85.25 +/- 8.1 vs. 49.9 +/- 22.5 mmHg); and saturation (95 +/- 0.7 vs. 73.3 +/- 12.07%). |
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| 17869397 | Guo TT, Xu HL, Zhang LX, Zhang JP, Guo YF, Gu JW, He PM: In vivo protective effect of Porphyra yezoensis polysaccharide against carbon tetrachloride induced hepatotoxicity in mice. Regul Toxicol Pharmacol. 2007 Nov;49(2):101-6. Epub 2007 Feb 14. Levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in serum and liver homogenate, content of malondialdehyde (MDA), activities of total superoxide dismutase (T-SOD) in liver were measured by biochemical methods. |
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| 19298238 | Salam OM, Sleem AA, Omara EA, Hassan NS: Hepatoprotective effects of misoprostol and silymarin on carbon tetrachloride-induced hepatic damage in rats. Fundam Clin Pharmacol. 2009 Apr;23(2):179-88. Epub 2009 Mar 9. The results showed that misoprostol (10, 100 or 1000 microg/kg) conferred significant protection against the hepatotoxic actions of CCl (4) in rats, reducing serum alanine aminotransferase (ALT) levels by 24.7%, 42.6% and 49.4%, respectively compared with controls. |
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| 16804984 | He SX, Luo JY, Wang YP, Wang YL, Fu H, Xu JL, Zhao G, Liu EQ: Effects of extract from Ginkgo biloba on carbon tetrachloride-induced liver injury in rats. World J Gastroenterol. 2006 Jun 28;12(24):3924-8. RESULTS: The levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and albumin (Alb) in EGb-protected group were notably improved as compared with the CCl (4)-treated group (P < 0.01). |
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| 15577205 | Abe S, Suyama S, Shishido H, Sato M, Ohtake Y, Sato N, Ohkubo Y: Uptake of gallium-67 by the hepatocytes during liver regeneration in carbon tetrachloride-treated mice. Biol Pharm Bull. 2004 Dec;27(12):1913-5. We recently reported that the peak of serum alanine aminotransferase (ALT) level was 1 d after carbon tetrachloride (CCl4) treatment in rats. |
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| 16140330 | Ozdogan M, Ersoy E, Dundar K, Albayrak L, Devay S, Gundogdu H: Beneficial effect of hyperbaric oxygenation on liver regeneration in cirrhosis. J Surg Res. 2005 Dec;129(2):260-4. Epub 2005 Sep 2. MATERIALS AND METHODS: The effect of HBO on liver regeneration was studied in a mice model combining carbon tetrachloride induced cirrhosis and partial hepatectomy. Serum aspartate aminotransferase and alanine aminotransferase levels were measured to evaluate liver injury. |
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| 16076768 | Chan WH, Sun WZ, Ueng TH: Induction of rat hepatic cytochrome P-450 by ketamine and its toxicological implications. J Toxicol Environ Health A. 2005 Sep;68(17-18):1581-97. In hepatotoxicity study, treatment of rats with 1 ml/kg CCl4 produced a 7-fold increase in serum alanine aminotransferase activity level and a 17-fold rise in rats pretreated with 80 mg/kg ketamine for 4 d. |
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| 18724385 | Campo GM, Avenoso A, Campo S, Nastasi G, Traina P, D'Ascola A, Rugolo CA, Calatroni A: The antioxidant activity of -4-sulphate, in carbon tetrachloride-induced acute hepatitis in mice, involves NF-kappaB and caspase activation. Br J Pharmacol. 2008 Nov;155(6):945-56. Epub 2008 Aug 25. KEY RESULTS: CCl4 injection produced: marked elevation of alanine aminotransferase and aspartate aminotransferase; hepatic membrane lipid peroxidation, assayed by levels; and depletion of and superoxide dismutase. |
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| 15022168 | Beissenhirtz MK, Kwan RC, Ko KM, Renneberg R, Scheller FW, Lisdat F: Comparing an in vitro electrochemical measurement of scavenging activity with an in vivo assessment of antioxidant potential in Chinese tonifying herbs. Phytother Res. 2004 Feb;18(2):149-53. The in vitro scavenging activity (as determined by electrochemical measurement) and the in vivo antioxidant potential (as determined by a mouse model of carbon tetrachloride (CCl (4)) hepatotoxicity) of methanolic extracts prepared from 10 Chinese tonifying herbs were compared. The in vivo measurement demonstrated that 80% of the herbal extracts displayed in vivo antioxidant potential, as assessed by the percentage of protection of the activity of plasma alanine aminotransferases and the hepatic regeneration capacity under CCl (4)-intoxicated condition. |
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| 19761824 | Wang L, Cheng D, Wang H, Di L, Zhou X, Xu T, Yang X, Liu Y: The hepatoprotective and antifibrotic effects of Saururus chinensis against carbon tetrachloride induced hepatic fibrosis in rats. J Ethnopharmacol. 2009 Dec 10;126(3):487-91. Epub 2009 Sep 15. Evaluated with liver index, serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), (HA), hepatic malondialdehyde (MDA) content, and superoxide dismutase (SOD) activity, total (TC), triglyceride (TG), total lipoprotein (TP), albumin (ALB), (HYP), total antioxidant capacity (T-AOC), laminin (LN), type III collagen terminal peptide (PC-IIINP), and type IV collagen (IV-C), as well as with histopathologic changes of liver. |
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| 20020986 | Bhattacharjee R, Sil PC: Protein Isolate from the Herb Phyllanthus niruri Modulates Carbon Tetrachloride-Induced Cytotoxicity in Hepatocytes. Toxicol Mech Methods. 2007;17(1):41-7. Administration of CCl (4) increased the leakage of glutamate pyruvate transaminase (GPT) by four fold and lactate dehydrogenase (LDH) by 84% in cell suspension, along with increased lipid peroxidation (114%), and reduced the levels of antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT) to almost 30% and 37% of the normal values, respectively. |
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| 17590492 | Lee KJ, Choi JH, Jeong HG: Hepatoprotective and antioxidant effects of the coffee diterpenes kahweol and cafestol on carbon tetrachloride-induced liver damage in mice. Food Chem Toxicol. 2007 Nov;45(11):2118-25. Epub 2007 May 24. Pretreatment with kahweol and cafestol prior to the administration of CCl (4) significantly prevented the increase in the serum levels of hepatic enzyme markers (alanine aminotransferase and aspartate aminotransferase) and reduced oxidative stress, such as content and lipid peroxidation, in the liver in a dose-dependent manner. |
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| 18981533 | Ulicna O, Vancova O, Waczulikova I, Bozek P, Janega P, Babal P, Liskova S, Greksak M: Does rooibos tea (Aspalathus linearis) support regeneration of rat liver after intoxication by carbon tetrachloride?. Gen Physiol Biophys. 2008 Sep;27(3):179-86. Seven days later in the regeneration phase, the animals treated by RT during whole period of the experiment, and those which drunk RT only during the regeneration period, exhibited a trend for decrease in the activity of alanine aminotransferase and significant decrease in the activity of aspartate aminotransferase and in total content when compared with the water-drinking group. |
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| 19903377 | Badr AM, El-Demerdash E, Khalifa AE, Ghoneim AI, Ayoub NA, Abdel-Naim AB: Rubus sanctus protects against carbon tetrachloride-induced toxicity in rat isolated hepatocytes: isolation and characterization of its galloylated flavonoids. J Pharm Pharmacol. 2009 Nov;61(11):1511-20. In addition, RE ameliorated CCl (4)-induced enzyme leakage by 40% for lactate dehydrogenase, 30% for alanine aminotransferase and 20% for aspartate aminotransferase as compared with CCl (4)-treated cells. |
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| 16945181 | Maiti K, Mukherjee K, Gantait A, Saha BP, Mukherjee PK: Enhanced therapeutic potential of -phospholipid complex in rats. J Pharm Pharmacol. 2006 Sep;58(9):1227-33. -phospholipid complex was prepared and assessed for antioxidant activity in carbon tetrachloride intoxicated rats at a dose level of 100 mg kg-1 (p.o.). Liver function tests were studied by assessing serum transaminase, serum glutamate pyruvate transaminase, serum alkaline phosphatase and total |
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| 15239104 | Asamoto M, Hokaiwado N, Murasaki T, Shirai T: Connexin 32 dominant-negative mutant transgenic rats are resistant to hepatic damage by chemicals. Hepatology. 2004 Jul;40(1):205-10. The present investigation concerned susceptibility to the liver-toxic substances D-galactosamine and carbon tetrachloride. These toxicants induced massive liver cell death and elevated serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels in the wild-type rats; however, much fewer liver cells were damaged and serum enzyme elevation was much lower in the transgenic rats. |
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| 16124045 | Shen XH, Cheng WF, Li XH, Sun JQ, Li F, Ma L, Xie LM: Effects of dietary supplementation with and on rat hepatic stellate cell apoptosis. World J Gastroenterol. 2005 Aug 28;11(32):4957-61. Serum alanine aminotransferase and aspartate aminotransferase were also analyzed. METHODS: An acute liver damage model of rats was established by intraperitoneal injection of carbon tetrachloride (0.3 mL/100 g body weight) twice a week, then the rats were killed at 6, 24, 48, and 72 h after the first and third injection, respectively. |
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| 18006644 | Fu Y, Zheng S, Lin J, Ryerse J, Chen A: protects the rat liver from CCl4-caused injury and fibrogenesis by attenuating oxidative stress and suppressing inflammation. Mol Pharmacol. 2008 Feb;73(2):399-409. Epub 2007 Nov 15. The current study evaluates the in vivo role of in protecting the liver against injury and fibrogenesis caused by carbon tetrachloride (CCl (4)) in rats and further explores the underlying mechanisms. This report demonstrates that significantly protects the liver from injury by reducing the activities of serum aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase, and by improving the histological architecture of the liver. |
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| 20227265 | Coballase-Urrutia E, Pedraza-Chaverri J, Cardenas-Rodriguez N, Huerta-Gertrudis B, Edna Garcia-Cruz M, Ramirez-Morales A, Javier Sanchez-Gonzalez D, Maria Martinez-Martinez C, Camacho-Carranza R, Javier Espinosa-Aguirre J: Hepatoprotective effect of acetonic and methanolic extracts of Heterotheca inuloides against CCl (4)-induced toxicity in rats. Exp Toxicol Pathol. 2010 Mar 11. A model of hepatotoxicity by carbon tetrachloride (CCl (4)) in rats was used in order to evaluate the protective potential of the acetonic and methanolic extracts of Heterotheca inuloides. Pretreatment with the two H. inuloides extracts attenuated the increase in the activity of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) observed in CCl (4)-induced liver injury. |
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| 16282059 | You SF, Zheng PY, Ji G, Wei HF, Zhao J, Zhu PT: [Protective effects of yanggan lidan granules on carbon tetrachloride-induced liver damage in mice]. Zhong Xi Yi Jie He Xue Bao. 2005 Nov;3(6):470-2. Then the levels of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST), as well as the contents of superoxide dismutase (SOD) and malondialdehyde (MDA) in liver tissues were detected. |
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| 15573910 | Wei YH, Jun L, Qiang CJ: Effect of losartan, an angiotensin II antagonist, on hepatic fibrosis induced by CCl4 in rats. Dig Dis Sci. 2004 Oct;49(10):1589-94. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels in plasma and (Hyp) contents in liver tissue were assayed by spectrophotometry. |
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| 16941609 | Yemitan OK, Izegbu MC: Protective effects of Zingiber officinale (Zingiberaceae) against carbon tetrachloride and -induced hepatotoxicity in rats. Phytother Res. 2006 Nov;20(11):997-1002. |
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| 15515113 | Zavodnik LB, Zavodnik IB, Lapshina EA, Belonovskaya EB, Martinchik DI, Kravchuk RI, Bryszewska M, Reiter RJ: Protective effects of against carbon tetrachloride hepatotoxicity in rats. Cell Biochem Funct. 2005 Sep-Oct;23(5):353-9. |
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| 16426832 | Zhang S, Ji G, Liu J: Reversal of chemical-induced liver fibrosis in Wistar rats by puerarin. J Nutr Biochem. 2006 Jul;17(7):485-91. Epub 2005 Oct 10. In the present study, we investigated the effects of puerarin on liver fibrosis in Wistar rats induced by plus carbon tetrachloride administration. |
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| 17285312 | Iida C, Fujii K, Kishioka T, Nagae R, Onishi Y, Ichi I, Kojo S: Activation of mitogen activated protein kinase (MAPK) during carbon tetrachloride intoxication in the rat liver. Arch Toxicol. 2007 Jul;81(7):489-93. Epub 2007 Feb 7. After 12 h the activity of plasma AST (aspartate aminotransferase) and ALT (alanine aminotransferase) was significantly higher than that of the control group and plasma AST and ALT activities increased thereafter. |
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| 18622026 | Shan W, Palkar PS, Murray IA, McDevitt EI, Kennett MJ, Kang BH, Isom HC, Perdew GH, Gonzalez FJ, Peters JM: Ligand activation of peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) attenuates carbon tetrachloride hepatotoxicity by downregulating proinflammatory gene expression. Toxicol Sci. 2008 Oct;105(2):418-28. Epub 2008 Jul 12. Biomarkers of liver toxicity, including serum alanine aminotransferase (ALT) and hepatic tumor necrosis factor (TNF) alpha mRNA, were significantly higher in CCl (4)-treated PPARbeta/delta-null mice compared to wild-type mice. |
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| 16097051 | Dai K, Qi JY, Tian DY: Leptin administration exacerbates thioacetamide-induced liver fibrosis in mice. World J Gastroenterol. 2005 Aug 21;11(31):4822-6. The changes in biochemical markers, such as the levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in serum and superoxide dismutase (SOD), malondialdehyde (MDA) in liver were determined. |
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| 19966836 | Dai L, Ji H, Kong XW, Zhang YH: Antifibrotic effects of ZK14, a novel -donating biphenyldicarboxylate derivative, on rat HSC-T6 cells and CCl4-induced hepatic fibrosis. Acta Pharmacol Sin. 2010 Jan;31(1):27-34. Epub 2009 Dec 7. Levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), (HA), type III collagen (PCIII), and (NO) were assessed, and liver samples were stained with hematoxylin-eosin. |
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| 16831245 | Wen T, Ren F, Liu Y, Wu ZM, Zhao JY: [Expression of Fas antigen and Fas ligand in acute liver injury induced by carbon tetrachloride in rat]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2006 Jul;18(7):417-20. Serum aspartate aminotransferase (ALT) and alanine aminotransferase (AST) levels were also determined. |
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| 16552805 | Yang XJ, Liu J, Ye LB, Yang F, Ye L, Gao JR, Wu ZH: In vitro and in vivo protective effects of proteoglycan isolated from mycelia of Ganoderma lucidum on carbon tetrachloride-induced liver injury. World J Gastroenterol. 2006 Mar 7;12(9):1379-85. The activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were determined with an automatic multifunction-biochemical analyzer and the levels of superoxide dismutase (SOD) and TNF-alpha were determined following the instructions of SOD kit and TNF radioimmunoassay kit. |
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| 19394401 | Ichi I, Kamikawa C, Nakagawa T, Kobayashi K, Kataoka R, Nagata E, Kitamura Y, Nakazaki C, Matsura T, Kojo S: Neutral sphingomyelinase-induced accumulation by oxidative stress during carbon tetrachloride intoxication. Toxicology. 2009 Jun 30;261(1-2):33-40. Epub 2009 Apr 24. After 12 h of oral administration of CCl4 (4 ml/kg body weight as a 1:1 mixture of CCl4 and mineral oil) to rats, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were increased. |
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| 19824107 | Dong MX, Jia Y, Zhang YB, Li CC, Geng YT, Zhou L, Li XY, Liu JC, Niu YC: Emodin protects rat liver from CCl (4)-induced fibrogenesis via inhibition of hepatic stellate cells activation. World J Gastroenterol. 2009 Oct 14;15(38):4753-62. AIM: To investigate the role of emodin in protecting the liver against fibrogenesis caused by carbon tetrachloride (CCl (4)) in rats and to further explore the underlying mechanisms. The activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in serum and hepatic content were assayed by biochemical analyses. |
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| 17721639 | Abdel-Salam OM, Sleem AA, Morsy FA: Effects of biphenyldimethyl-dicarboxylate administration alone or combined with silymarin in the CCL4 model of liver fibrosis in rats. ScientificWorldJournal. 2007 Aug 24;7:1242-55. The effect of biphenyldimethyldicarboxylate (DDB), a synthetic compound, in use for the treatment of chronic hepatitis was studied on hepatic injury caused in rats by administration of carbon tetrachloride (CCl4). The administration of DDB in CCl4-treated rats at 75 or 375 mg/kg resulted in 61.2-76.2% decrease in alanine aminotransferase (ALT) and 46.9-60.8% decrease in aspartate aminotransferase (AST), respectively compared with the CCl4 control group. |
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| 16698588 | Yuan GJ, Gong ZJ, Sun XM, Zheng SH, Li X: Tea polyphenols inhibit expressions of iNOS and TNF-alpha and prevent lipopolysaccharide-induced liver injury in rats. Hepatobiliary Pancreat Dis Int. 2006 May;5(2):262-7. BACKGROUND: Tea polyphenols have been shown to protect against carbon tetrachloride (CCl4)-induced liver injury, liver fibrosis, hepatic ischemia-reperfusion injury. RESULTS: Administration of LPS resulted in liver injury in rats, evidenced by elevated activities of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST), hepatocellular necrosis, and neutrophil infiltration in the liver. |
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| 16547767 | Wu Y, Wang F, Zheng Q, Lu L, Yao H, Zhou C, Wu X, Zhao Y: Hepatoprotective effect of total flavonoids from Laggera alata against carbon tetrachloride-induced injury in primary cultured neonatal rat hepatocytes and in rats with hepatic damage. J Biomed Sci. 2006 Jul;13(4):569-78. Epub 2006 Mar 18. In vitro, TFLA at a concentration range of 1-100 microg/ml improved cell viability and inhibited cellular leakage of two enzymes, hepatocyte aspartate aminotransferase (AST) and alanine aminotransferase (ALT), caused by CCl (4). |
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| 19703545 | Wu YH, Zhang XM, Hu MH, Wu XM, Zhao Y: Effect of Laggera alata on hepatocyte damage induced by carbon tetrachloride in vitro and in vivo. J Ethnopharmacol. 2009 Oct 29;126(1):50-6. Epub 2009 Aug 22. RESULTS: TPLA significantly reduced cellular leakage of hepatocyte aspartate aminotransferase (AST) and alanine aminotransferase (ALT) and improved cell viability in vitro. |
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| 18783728 | Zeashan H, Amresh G, Singh S, Rao CV: Hepatoprotective activity of Amaranthus spinosus in experimental animals. Food Chem Toxicol. 2008 Nov;46(11):3417-21. Epub 2008 Aug 22. The hepatoprotective and antioxidant activity of 50% ethanolic extract of whole plant of Amaranthus spinosus (ASE) was evaluated against carbon tetrachloride (CCl4) induced hepatic damage in rats. The substantially elevated serum enzymatic levels of serum transaminase (AST), serum glutamate pyruvate transaminase (ALT), serum alkaline phosphatase (SALP) and total were restored towards normalization significantly by the ASE in a dose dependent manner. |
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| 16619345 | Yilmaz BS, Ozbek H, Citoglu GS, Ugras S, Bayram I, Erdogan E: Analgesic and hepatotoxic effects of Ononis spinosa L. Phytother Res. 2006 Jun;20(6):500-3. At a dose of 100 mg/kg OS showed an analgesic effect equivalent to at all time points.The hepatoprotective influence of OS on carbon tetrachloride (CCl (4))-induced acute liver toxicity was also studied. |
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| 16595196 | Di Stefano G, Fiume L, Domenicali M, Busi C, Chieco P, Kratz F, Lanza M, Mattioli A, Pariali M, Bernardi M: Doxorubicin coupled to lactosaminated albumin: Effects on rats with liver fibrosis and cirrhosis. Dig Liver Dis. 2006 Jun;38(6):404-8. Epub 2006 Apr 3. Liver fibrosis/cirrhosis was produced by carbon tetrachloride (CCl4) poisoning. |
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| 18038451 | Shan W, Nicol CJ, Ito S, Bility MT, Kennett MJ, Ward JM, Gonzalez FJ, Peters JM: Peroxisome proliferator-activated receptor-beta/delta protects against chemically induced liver toxicity in mice. Hepatology. 2008 Jan;47(1):225-35. Exacerbated carbon tetrachloride (CCl (4)) hepatoxicity was also observed in PPARbeta/delta-null as compared with wild-type mice. |
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| 17617128 | Hidaka I, Hino K, Korenaga M, Gondo T, Nishina S, Ando M, Okuda M, Sakaida I: Stronger Neo-Minophagen C, a glycyrrhizin-containing preparation, protects liver against carbon tetrachloride-induced oxidative stress in transgenic mice expressing the hepatitis C virus polyprotein. Liver Int. 2007 Aug;27(6):845-53. |
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