| Name | proliferating cell nuclear antigen |
|---|---|
| Synonyms | Cyclin; DNA polymerase delta auxillary protein; PCNA; Proliferating cell nuclear antigen; DNA polymerase delta auxillary proteins; Proliferating cell nuclear antigens |
| Name | carbon tetrachloride |
|---|---|
| CAS | tetrachloromethane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 14763511 | Yuan RH, Ogawa A, Ogawa E, Neufeld D, Zhu L, Shafritz DA: p27Kip1 inactivation provides a proliferative advantage to transplanted hepatocytes in DPPIV/Rag2 double knockout mice after repeated host liver injury. Cell Transplant. 2003;12(8):907-19. DPPIV (-/-)/Rag (-/-) mice were transplanted with wt hepatocytes or p27 null mouse hepatocytes, which show enhanced cell cycle activity due to disruption of the Kip1 cyclin kinase inhibitor gene, and liver repopulation was assessed under nonproliferative versus proliferative experimental conditions. |
1(0,0,0,1) | Details |
| 17574579 | Colakoglu T, Keskek M, Colakoglu S, Can B, Sayek I: Serum endostatin levels and regenerative capacities of normal and cirrhotic livers following partial hepatectomy in mice: the response to different resection sizes. J Surg Res. 2007 Dec;143(2):337-43. Epub 2007 Jun 14. MATERIALS AND METHODS: Sixty noncirrhotic and 36 carbon tetrachloride-induced cirrhotic mice were included in the study. Liver regeneration was evaluated by the proliferating cell nuclear antigen-labeling index. |
1(0,0,0,1) | Details |
| 19496198 | Jin SZ, Meng XW, Han MZ, Sun X, Sun LY, Liu BR: Stromal cell derived factor-1 enhances bone marrow mononuclear cell migration in mice with acute liver failure. World J Gastroenterol. 2009 Jun 7;15(21):2657-64. The labeled cells were subsequently infused into the caudal veins of BALB/c mice with hepatic injury induced by carbon tetrachloride and 2-acetylaminofluorene. The expression of proliferating cell nuclear antigen and albumin was quantified with manual methods in both groups. |
1(0,0,0,1) | Details |
| 20203062 | von Montfort C, Beier JI, Kaiser JP, Guo L, Joshi-Barve S, Pritchard MT, States JC, Arteel GE: PAI-1 plays a protective role in CCl4-induced hepatic fibrosis in mice: role of hepatocyte division. Am J Physiol Gastrointest Liver Physiol. 2010 Mar 4. However, its role in more severe models of hepatic fibrosis (e.g., carbon tetrachloride; CCl (4)) has not been determined and is important for extrapolation to human disease. Proliferation and apoptosis were assessed by PCNA and TUNEL staining, respectively, as well as by indices of cell cycle (e.g., p53, cyclin D1). |
1(0,0,0,1) | Details |
| 19386599 | Okumura N, Koh T, Hasebe Y, Seki T, Ariga T: A novel function of thrombin-activatable fibrinolysis inhibitor during rat liver regeneration and in growth-promoted hepatocytes in primary culture. J Biol Chem. 2009 Jun 12;284(24):16553-61. Epub 2009 Apr 22. In rat models, partial hepatectomy or carbon tetrachloride (CCl4)-induced acute liver injury suppressed the levels of plasma TAFI activity and hepatic TAFI mRNA, whereas this operation markedly increased both the hepatic plasmin activity and the level of proliferating cell nuclear antigen. |
31(0,1,1,1) | Details |
| 18955732 | Ikeda H, Watanabe N, Ishii I, Shimosawa T, Kume Y, Tomiya T, Inoue Y, Nishikawa T, Ohtomo N, Tanoue Y, Iitsuka S, Fujita R, Omata M, Chun J, Yatomi Y: regulates regeneration and fibrosis after liver injury via sphingosine 1-phosphate receptor 2. J Lipid Res. 2009 Mar;50(3):556-64. Epub 2008 Oct 27. Nuclear 5-bromo-2'-deoxy- labeling, proliferating cell nuclear antigen (PCNA) staining in hepatocytes, and the ratio of liver weight to body weight were enhanced at 48 h in S1P (2)-deficient mice after a single carbon tetrachloride (CCl (4)) injection. |
7(0,0,1,2) | Details |
| 20038333 | Lan L, Chen YW, Sun C, Liu BW, Sun QL, Li DG: [Effect of interleukin 10 gene-modified bone marrow-derived liver stem cells transplantation on hepatic inflammatory response and liver regeneration in hepatic fibrosis rats]. Zhonghua Gan Zang Bing Za Zhi. 2009 Dec;17(12):915-20. METHODS: 50 female Wistar rats were randomly divided into 4 groups: (1) control group: 10 rats were subcutaneously injected with olive oil for 8 weeks; (2) fibrosis groups: 16 rats were subcutaneously injected with carbon tetrachloride (CCl4) for 8 weeks to induce liver fibrosis; (3) BDLSC group: 12 rats were subcutaneously injected with CCl4 for 8 weeks, and were transplanted with 2 x 10 (5) BDLSC at week 4; (4) BDLSC/IL-10 group: 12 rats were subcutaneously injected with CCl4 for 8 weeks, and were transplanted with 2 x 10 (5) IL-10 gene-modified BDLSC at week 4. The expression of hepatocyte growth factor (HGF) was quantified by real-time RT-PCR, and the expression of proliferating cell nuclear antigen (PCNA) was determined by immunohistochemistry. |
4(0,0,0,4) | Details |
| 16140330 | Ozdogan M, Ersoy E, Dundar K, Albayrak L, Devay S, Gundogdu H: Beneficial effect of hyperbaric oxygenation on liver regeneration in cirrhosis. J Surg Res. 2005 Dec;129(2):260-4. Epub 2005 Sep 2. MATERIALS AND METHODS: The effect of HBO on liver regeneration was studied in a mice model combining carbon tetrachloride induced cirrhosis and partial hepatectomy. Liver regeneration was evaluated by the proliferating cell nuclear antigen-labeling index. |
2(0,0,0,2) | Details |
| 15968720 | Zhang LM, Liu DW, Liu JB, Zhang XL, Wang XB, Tang LM, Wang LQ: Effect of naked eukaryotic expression plasmid encoding rat augmenter of liver regeneration on acute hepatic injury and hepatic failure in rats. World J Gastroenterol. 2005 Jun 28;11(24):3680-5. The rats with acute hepatic injury induced by intraperitoneal injection of 2 mL/kg 50% carbon tetrachloride (CCl (4)) were randomly divided into saline control group and recombinant pcDNA3-ALR plasmid treatment groups. Hepatic histopathological alterations were observed after HE staining, the expression of proliferating cell nuclear antigen (PCNA) in liver tissue was detected by immunohistochemical staining, and the level of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) was determined by biochemical method. |
2(0,0,0,2) | Details |
| 16092975 | Liu Y, Liu P, Liu CH, Hu YY, Xu LM, Mu YP, Du GL: [Proteomic analysis of proliferation and apoptosis in carbon tetrachloride induced rat liver fibrosis]. Zhonghua Gan Zang Bing Za Zhi. 2005 Aug;13(8):563-6. Differentially expressed proteins identified by MALDI-TOF-MS were categorized as proliferation-related proteins/enzymes (proliferating cell nuclear antigen p120, p40 and cyclin F ubiquitin-conjugating enzyme 7 UBC7), and apoptosis-related proteins, mainly caspase-12 which was absent in the control rats. |
1(0,0,0,1) | Details |
| 16609998 | Cheung PY, Zhang Q, Zhang YO, Bai GR, Lin MC, Chan B, Fong CC, Shi L, Shi YF, Chun J, Kung HF, Yang M: Effect of WeiJia on carbon tetrachloride induced chronic liver injury. World J Gastroenterol. 2006 Mar 28;12(12):1912-7. Alpha smooth muscle actin (alpha-SMA) and proliferating cell nuclear antigen (PCNA) immunohistochemistry were also performed. |
2(0,0,0,2) | Details |
| 15178132 | Murali B, Korrapati MC, Warbritton A, Latendresse JR, Mehendale HM: Tolerance of aged Fischer 344 rats against chlordecone-amplified carbon tetrachloride toxicity. Mech Ageing Dev. 2004 Jun;125(6):421-35. Liver tissue repair was measured by [3H-CH3]- (3H-T) incorporation into hepatic nuclear DNA and proliferating cell nuclear antigen (PCNA) immunohistochemistry. |
2(0,0,0,2) | Details |
| 18481824 | Sun C, Li DG, Chen YW, Chen YW, Wang BC, Sun QL, Lu HM: Transplantation of urokinase-type plasminogen activator gene-modified bone marrow-derived liver stem cells reduces liver fibrosis in rats. J Gene Med. 2008 Aug;10(8):855-66. By contrast, the levels of matrix metalloproteinases-2, -3 and -9 mRNA, hepatic growth factor mRNA and proliferating cell nuclear antigen protein increased. In the present study, we investigated the therapeutic effects of uPA gene-modified BDLSC transplantation on carbon tetrachloride (CCl4)-induced liver fibrosis in rats. |
1(0,0,0,1) | Details |
| 15261760 | Taniguchi M, Takeuchi T, Nakatsuka R, Watanabe T, Sato K: Molecular process in acute liver injury and regeneration induced by carbon tetrachloride. Life Sci. 2004 Aug 13;75(13):1539-49. On the other hand, hepatocyte growth factor (HGF) and proliferating cell nuclear antigen (PCNA) were induced in the early stage (6 h) and 36 h, respectively. |
1(0,0,0,1) | Details |
| 19141029 | Yan Y, Xu W, Qian H, Si Y, Zhu W, Cao H, Zhou H, Mao F: Mesenchymal stem cells from human umbilical cords ameliorate mouse hepatic injury in vivo. Liver Int. 2009 Mar;29(3):356-65. Epub 2008 Dec 29. METHODS: Human umbilical cord-derived mesenchymal stem cells, characterized by flow cytometry, were transplanted into carbon tetrachloride (CCl (4))-injured mice, and then followed for determination of localization and differentiation. Terminal deoxynucleotidyl transferase-mediated - nick end labelling and proliferating cell nuclear antigen staining showed that transplanted hUCMSCs could inhibit hepatocyte apoptosis and facilitate proliferation. |
1(0,0,0,1) | Details |
| 19956991 | Hyvonen MT, Sinervirta R, Grigorenko N, Khomutov AR, Vepsalainen J, Keinanen TA, Alhonen L: alpha-Methylspermidine protects against carbon tetrachloride-induced hepatic and pancreatic damage. Amino Acids. 2010 Feb;38(2):575-81. Epub 2009 Dec 3. As assessed by immunostaining of proliferating cell nuclear antigen, MeSpd increased the amount of regenerating hepatocytes in both genotypes. |
1(0,0,0,1) | Details |
| 17060319 | Zhou X, Jamil A, Nash A, Chan J, Trim N, Iredale JP, Benyon RC: Impaired proteolysis of collagen I inhibits proliferation of hepatic stellate cells: implications for regulation of liver fibrosis. J Biol Chem. 2006 Dec 29;281(52):39757-65. Epub 2006 Oct 23. Compared with stellate cells plated on normal collagen I, those plated on a collagenase-resistant form of collagen I (r/r collagen) had reduced incorporation and proliferating cell nuclear antigen expression but increased p21 expression. |
1(0,0,0,1) | Details |
| 19638569 | Mendieta-Condado E, Pichardo-Olvera M, Sanchez-Sevilla L, Chagoya de Sanchez V, Hernandez-Munoz R: administration accelerates progression of the cell cycle during rat liver regeneration induced by one-third hepatectomy. J Pharmacol Exp Ther. 2009 Oct;331(1):122-32. Epub 2009 Jul 28. We have shown that administration is capable of reversing fibrosis in the carbon tetrachloride-induced rat cirrhotic liver, stimulating the diminished proliferative potential of the cirrhotic liver. (100 mg/kg body weight) induced an earlier increase in liver cell proliferation as evidenced by enhanced levels of proliferating cell nuclear antigen, nuclear Ki-67 antigen, and those for cyclins (D1, E, A, and B1), as well as by an increased mitotic index. |
1(0,0,0,1) | Details |
| 20355026 | Chan YC, Chang SC, Liu SY, Yang HL, Hseu YC, Liao JW: Beneficial effects of yam on carbon tetrachloride-induced hepatic fibrosis in rats. J Sci Food Agric. 2010 Jan 15;90(1):161-7. Additionally, yam treatment reduced the area of GGT-positive foci and the index of proliferating cell nuclear antigen (PCNA) in liver.CONCLUSION: Daily administration of yam attenuates CCl (4)-induced hepatic fibrosis in rats in a dose-dependent manner; this attenuation may be related to the antioxidant properties of yams. |
1(0,0,0,1) | Details |
| 15334679 | He Y, Zhou J, Dou KF, Chen Y, Yan QG, Li HM: Autocrine expression of hepatocyte growth factor and its cytoprotective effect on hepatocyte poisoning. World J Gastroenterol. 2004 Oct 1;10(19):2827-30. DNA synthesis was observed by using PCNA stain immunohistochemistry. Acute liver cell damage was induced by carbon tetrachloride. |
1(0,0,0,1) | Details |
| 14999682 | Nakamura K, Nonaka H, Saito H, Tanaka M, Miyajima A: Hepatocyte proliferation and tissue remodeling is impaired after liver injury in oncostatin M receptor knockout mice. Hepatology. 2004 Mar;39(3):635-44. Mice deficient in the OSM receptor (OSMR (-/-)) showed impaired liver regeneration with persistent parenchymal necrosis after carbon tetrachloride (CCl (4)) exposure. |
0(0,0,0,0) | Details |
| 17166617 | Abe W, Ikejima K, Lang T, Okumura K, Enomoto N, Kitamura T, Takei Y, Sato N: Low molecular weight heparin prevents hepatic fibrogenesis caused by carbon tetrachloride in the rat. J Hepatol. 2007 Feb;46(2):286-94. Epub 2006 Oct 25. |
0(0,0,0,0) | Details |
| 19218347 | Lee SP, Savard CE, Kuver R: Gallbladder epithelial cells that engraft in mouse liver can differentiate into hepatocyte-like cells. Am J Pathol. 2009 Mar;174(3):842-53. Epub 2009 Feb 13. Recipient mice with severe-combined immunodeficiency underwent retrorsine treatment and either partial hepatectomy before transplantation or carbon tetrachloride treatment following transplantation. |
0(0,0,0,0) | Details |