| Name | TIMP 2 |
|---|---|
| Synonyms | CSC 21K; Metalloproteinase inhibitor 2; Metalloproteinase inhibitor 2 precursor; TIMP metallopeptidase inhibitor 2; TIMP 2; TIMP2; Tissue inhibitor of metalloproteinase 2; Tissue inhibitor of metalloproteinases 2… |
| Name | carbon tetrachloride |
|---|---|
| CAS | tetrachloromethane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18996463 | Mu Y, Liu P, Du G, Du J, Wang G, Long A, Wang L, Li F: Action mechanism of Yi Guan Jian Decoction on CCl4 induced cirrhosis in rats. J Ethnopharmacol. 2009 Jan 12;121(1):35-42. Epub 2008 Oct 18. At 12th weekend, the rats were sacrificed for sampling and detection of liver function, histological changes of liver tissue, liver tissue content and expression of alpha-SMA, CD68, MMP-13, TIMP-1, TIMP-2, Caspase-12, HGFalpha, MMP-2, MMP-9 and hepatocyte apoptotic index. |
3(0,0,0,3) | Details |
| 17156884 | Fernandez-Varo G, Morales-Ruiz M, Ros J, Tugues S, Munoz-Luque J, Casals G, Arroyo V, Rodes J, Jimenez W: Impaired extracellular matrix degradation in aortic vessels of cirrhotic rats. J Hepatol. 2007 Mar;46(3):440-6. Epub 2006 Nov 13. Extracellular matrix (ECM) turnover was estimated by measuring matrix metalloproteinases (MMPs) activity and protein expression of collagen IV, MMP-2, MMP-9 and tissue inhibitor of MMPs (TIMP)-2. |
3(0,0,0,3) | Details |
| 19220677 | Luo L, Zhou A: Antifibrotic activity of anisodamine in vivo is associated with changed intrahepatic levels of matrix metalloproteinase-2 and its inhibitor tissue inhibitors of metalloproteinases-2 and transforming growth factor beta1 in rats with carbon tetrachloride-induced liver injury. J Gastroenterol Hepatol. 2009 Jun;24(6):1070-6. Epub 2009 Feb 12. The reverse transcription polymerase chain reaction was used to detect the expressions of matrix metalloproteinase-2 (MMP2) and tissue inhibitor of metalloproteinase-2 (TIMP2) mRNA in livers and the ratio of MMP2 and TIMP2 was measured. |
3(0,0,0,3) | Details |
| 16332368 | Garciade Leon Mdel C, Montfort I, Tello Montes E, Lopez Vancell R, Olivos Garcia A, Gonzalez Canto A, Nequiz-Avendano M, Perez-Tamayo R: Hepatocyte production of modulators of extracellular liver matrix in normal and cirrhotic rat liver. Exp Mol Pathol. 2006 Feb;80(1):97-108. Epub 2005 Dec 5. In addition, we clearly detected the messenger ribonucleic acids (mRNA) of four matrix metalloproteinases (MMP-2, MMP-3, MMP-10, and MMP-13) and of two tissue inhibitors of matrix metalloproteinases (TIMP-1 and TIMP-2) in hepatocytes from both normal and cirrhotic rats by RT-PCR and by in situ hybridization. |
2(0,0,0,2) | Details |
| 16676162 | Young SC, Wang CJ, Lin JJ, Peng PL, Hsu JL, Chou FP: Protection effect of piper betel leaf extract against carbon tetrachloride-induced liver fibrosis in rats. Arch Toxicol. 2007 Jan;81(1):45-55. Epub 2006 May 5. The histological examination showed the PBL extract protected liver from the damage induced by CCl (4) by decreasing alpha-smooth muscle actin (alpha-sma) expression, inducing active matrix metalloproteinase-2 (MMP2) expression though Ras/Erk pathway, and inhibiting TIMP2 level that consequently attenuated the fibrosis of liver. |
1(0,0,0,1) | Details |
| 15860571 | Fiorucci S, Rizzo G, Antonelli E, Renga B, Mencarelli A, Riccardi L, Orlandi S, Pruzanski M, Morelli A, Pellicciari R: A farnesoid x receptor-small heterodimer partner regulatory cascade modulates tissue metalloproteinase inhibitor-1 and matrix metalloprotease expression in hepatic stellate cells and promotes resolution of liver fibrosis. J Pharmacol Exp Ther. 2005 Aug;314(2):584-95. Epub 2005 Apr 28. Exposure of HSCs to FXR ligands increases small heterodimer partner (SHP) mRNA by 3-fold and reduces basal and thrombin-stimulated expression of alpha1 (I) collagen, alpha-smooth muscle actin (alpha-SMA), TIMP-1, and TIMP-2 by approximately 60 to 70%, whereas it increased matrix metalloprotease (MMP)-2 activity by 2-fold. |
1(0,0,0,1) | Details |
| 16420518 | Hui AY, Leung WK, Chan HL, Chan FK, Go MY, Chan KK, Tang BD, Chu ES, Sung JJ: Effect of on experimental liver fibrosis in rat. Liver Int. 2006 Feb;26(1):125-36. There was also more HSC activation, and upregulation of collagen alpha1 (I), heat-shock protein 47, alphaB crystallin, matrix metalloproteinase (MMP)-2, MMP-9 and tissue inhibitor of MMP (TIMP)-2. RESULTS: Liver fibrosis was significantly worse in rats that received both carbon tetrachloride (CCl4) and compared with rats that received CCl4 and gavage of water (P = 0.037). |
1(0,0,0,1) | Details |
| 17094476 | Jeong WI, Do SH, Jeong DH, Hong IH, Park JK, Ran KM, Yang HJ, Yuan DW, Kim SB, Cha MS, Jeong KS: Kinetics of MMP-1 and MMP-3 produced by mast cells and macrophages in liver fibrogenesis of rat. Anticancer Res. 2006 Sep-Oct;26(5A):3517-26. BACKGROUND: The involvement of whether macrophages and mast cells in the kinetics of matrix metalloproteinases-1 (MMP-1), MMP-3 and MMP-9, tissue inhibitors of metalloproteinases-1 (TIMP-1) and TIMP-2 in hepatic fibrosis/cirrhosis was examined. MATERIALS AND METHODS: The MMPs and TIMPs were examined by histopathology, immunohistochemistry and immunoblotting using carbon tetrachloride-induced fibrotic rat liver. |
1(0,0,0,1) | Details |
| 19072832 | Aram G, Potter JJ, Liu X, Wang L, Torbenson MS, Mezey E: Deficiency of reduced form oxidase enhances hepatocellular injury but attenuates fibrosis after chronic carbon tetrachloride administration. Hepatology. 2009 Mar;49(3):911-9. Matrix metalloproteinase-2 (MMP-2) and MMP-9 mRNA increased more in the gp91 (phox (-/-) ) than in WT mice after CCl (4.) Tissue inhibitor of metalloproteinase 1 (TIMP-1) and TIMP-2 increased after CCl (4) only in the gp91 (phox (-/-) ) mice. |
1(0,0,0,1) | Details |
| 14999682 | Nakamura K, Nonaka H, Saito H, Tanaka M, Miyajima A: Hepatocyte proliferation and tissue remodeling is impaired after liver injury in oncostatin M receptor knockout mice. Hepatology. 2004 Mar;39(3):635-44. Mice deficient in the OSM receptor (OSMR (-/-)) showed impaired liver regeneration with persistent parenchymal necrosis after carbon tetrachloride (CCl (4)) exposure. In contrast to wildtype mice, CCl (4) administration only marginally induced expression of tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2 genes in OSMR (-/-) mice, correlating with the increased gelatinase activity of matrix metalloproteinase (MMP)-9 and matrix degradation in injured livers. |
1(0,0,0,1) | Details |
| 18263696 | Peng Z, Fernandez P, Wilder T, Yee H, Chiriboga L, Chan ES, Cronstein BN: Ecto-5'-nucleotidase (CD73) -mediated extracellular production plays a critical role in hepatic fibrosis. FASEB J. 2008 Jul;22(7):2263-72. Epub 2008 Feb 8. After CCl (4) treatment, the mRNA level of A (1), A (2A), A (2B), and A (3) receptors, tumor necrosis factor-alpha, interleukin (IL) -1beta, IL-13r alpha1, matrix metalloproteinase (MMP)-2, MMP-14, tissue inhibitor of metalloproteinase (TIMP) -1, and TIMP-2, and IL-13 level increased markedly in both CD73KO and WT mice, but Col1 alpha1, Col3 alpha1, and transforming growth factor-beta1 mRNA increased much more in WT mice than that in KO mice. |
1(0,0,0,1) | Details |