| Name | alkaline phosphatase |
|---|---|
| Synonyms | ALP 1; Alkaline phosphatase; ALPG; ALPPL; ALPPL 2; ALPPL2; GCAP; Germ cell alkaline phosphatase… |
| Name | carbon tetrachloride |
|---|---|
| CAS | tetrachloromethane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19298238 | Salam OM, Sleem AA, Omara EA, Hassan NS: Hepatoprotective effects of misoprostol and silymarin on carbon tetrachloride-induced hepatic damage in rats. Fundam Clin Pharmacol. 2009 Apr;23(2):179-88. Epub 2009 Mar 9. Misoprostol, given at 100 or 1000 microg/kg, decreased aspartate aminotransferase (AST) by 28 and 43.6% and alkaline phosphatase (ALP) by 19.3% and 53.4% respectively. |
1(0,0,0,1) | Details |
| 18761048 | Hsu YW, Tsai CF, Chang WH, Ho YC, Chen WK, Lu FJ: Protective effects of Dunaliella salina--a carotenoids-rich alga, against carbon tetrachloride-induced hepatotoxicity in mice. Food Chem Toxicol. 2008 Oct;46(10):3311-7. Epub 2008 Aug 12. CCl (4) induced liver damage and significantly (p <0.05) increased the activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) in serum and decreased the activities of superoxide dismutase (SOD), catalase, peroxidase (GSH-Px), and GSH content in liver whereas increased hepatic malondialdehyde (MDA) content as compared with control group. |
1(0,0,0,1) | Details |
| 20183308 | Ahmed B, Khan S, Verma A, Habibullah: Antihepatotoxic activity of debelalactone, a new oxirano-furanocoumarin from Phyllanthus debilis. J Asian Nat Prod Res. 2009 Aug;11(8):687-92. Debelalactone exhibited a significant antihepatotoxic activity by reducing the elevated levels of serum enzymes such as serum transaminase (SGOT) by 59.14%, serum transaminase (SGPT) by 61.84%, and alkaline phosphatase (ALP) by 85.93%; while the total protein (TP) levels were increased by 110.35%, when compared with standard drug silymarin that have decreased SGOT by 77.03%, SGPT by 69.67%, ALP by 93.18%, and increased TP levels by 100.48%, respectively, against CCl (4)-induced toxicity in Wistar rats. |
1(0,0,0,1) | Details |
| 15702514 | Al-Howiriny TA, Al-Sohaibani MO, Al-Said MS, Al-Yahya MA, El-Tahir KH, Rafatullah S: Hepatoprotective properties of Commiphora opobalsamum ("Balessan"), a traditional medicinal plant of Saudi Arabia. Drugs Exp Clin Res. 2004;30(5-6):213-20. This extract has been shown to possess significant protective effect by lowering serum transaminase levels (serum transaminase and serum glutamate pyruvate transaminase), alkaline phosphatase and Pretreatment with an extract of Balessan prevented the prolongation of the barbiturate sleeping time associated with carbon tetrachloride-induced liver damage in mice. |
1(0,0,0,1) | Details |
| 19527736 | Cho YK, Yun JW, Park JH, Kim HJ, Park DI, Sohn CI, Jeon WK, Kim BI, Jin W, Kwon YH, Shin MK, Yoo TM, Kang JH, Park CS: Deleterious effects of silymarin on the expression of genes controlling endothelial nitric oxide synthase activity in carbon tetrachloride-treated rat livers. Life Sci. 2009 Aug 12;85(7-8):281-90. Epub 2009 Jun 13. Serum was assayed for hepatic enzymes like alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) activities. |
1(0,0,0,1) | Details |
| 15489557 | Shahjahan M, Sabitha KE, Jainu M, Shyamala Devi CS: Effect of Solanum trilobatum against carbon tetrachloride induced hepatic damage in albino rats. Indian J Med Res. 2004 Sep;120(3):194-8. RESULTS: Levels of marker enzymes such as transminase (ALT), transaminase (AST), alkaline phosphatase (ALP), and lactate dehydrogenase (LDH) were increased significantly in CCl4 treated rats (group II). |
1(0,0,0,1) | Details |
| 15511003 | Shukla S, Bhadauria M, Jadon A: Effect of propolis extract on acute carbon tetrachloride induced hepatotoxicity. Indian J Exp Biol. 2004 Oct;42(10):993-7. Administration of bolus dose of CCl4 (1.5 ml/kg, ip) resulted in elevation of serum transaminases and serum alkaline phosphatase activities. |
1(0,0,0,1) | Details |
| 20067861 | Roy CK, Das AK: Comparative evaluation of different extracts of leaves of Psidium guajava Linn. for hepatoprotective activity. Pak J Pharm Sci. 2010 Jan;23(1):15-20. P. guajava ethyl leaf extract (200 mg/kg, p.o.) significantly reduced the elevated serum levels of aspartate aminotransferase, alanine aminotransferase and in carbon tetrachloride induced hepatotoxicity whereas P. guajava aqueous leaf extract (200 mg/kg, p.o.) significantly reduced the elevated serum levels of alkaline phosphatase, alanine aminotransferase and in carbon tetrachloride induced hepatotoxicity. |
112(1,2,2,2) | Details |
| 20350579 | Hsu YW, Tsai CF, Chuang WC, Chen WK, Ho YC, Lu FJ: Protective effects of hydride against carbon tetrachloride-induced hepatotoxicity in mice. Food Chem Toxicol. 2010 Mar 26. The results showed that oral administration of hydride significantly reduced the elevated serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), triglyceride (TG), and and the level of malondialdehyde (MDA) in the liver that were induced by CCl (4) in mice. |
1(0,0,0,1) | Details |
| 17175085 | Bhattacharjee R, Sil PC: Protein isolate from the herb, Phyllanthus niruri L. (Euphorbiaceae), plays hepatoprotective role against carbon tetrachloride induced liver damage via its antioxidant properties. Food Chem Toxicol. 2007 May;45(5):817-26. Epub 2006 Nov 11. Administration of CCl (4) increased the serum glutamate pyruvate transaminase (GPT) and alkaline phosphatase (ALP) levels of mice sera along with increased lipid peroxidation and reduced levels of antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT) in the liver. |
1(0,0,0,1) | Details |
| 18807755 | Manjrekar AP, Jisha V, Bag PP, Adhikary B, Pai MM, Hegde A, Nandini M: Effect of Phyllanthus niruri Linn. treatment on liver, kidney and testes in CCl4 induced hepatotoxic rats. Indian J Exp Biol. 2008 Jul;46(7):514-20. Activities of transaminase, transaminase and alkaline phosphatase enzymes were significantly reduced in the curative group (P. niruri treatment after CCl4 injection). |
1(0,0,0,1) | Details |
| 16227642 | Abdel Salam OM, Baiuomy AR, El-Shenawy SM, Hassan NS: Effect of pentoxifylline on hepatic injury caused in the rat by the administration of carbon tetrachloride or Pharmacol Rep. 2005 Sep-Oct;57(5):596-603. The administration of PTX at 72 mg/kg, conferred significant protection against the hepatotoxic actions of CCl4, reducing serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) levels to 31%, 59.2% and 63%, respectively. |
1(0,0,0,1) | Details |
| 16610055 | Ji G, Wang L, Zhang SH, Liu JW, Zheng PY, Liu T: Effect of Chinese medicine Qinggan Huoxuefang on inducing HSC apoptosis in alcoholic liver fibrosis rats. World J Gastroenterol. 2006 Apr 7;12(13):2047-52. METHODS: Wistar rats were divided into three groups at random: normal control group (12),micro-amount carbon tetrachloride group (CCl (4))(12) and model group A (60). Blood samples were used for evaluation of transaminase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), gamma-glutamyltransferase (gamma-GT). |
1(0,0,0,1) | Details |
| 15581276 | Ozardali I, Bitiren M, Karakilcik AZ, Zerin M, Aksoy N, Musa D: Effects of on histopathological and enzymatic changes in experimental liver injury of rats. Exp Toxicol Pathol. 2004 Oct;56(1-2):59-64. Thus, GSHPx may prevent the harmful effects of free radicals and may reduce the formation of the reactive metabolites of carbon tetrachloride. |
0(0,0,0,0) | Details |
| 16426832 | Zhang S, Ji G, Liu J: Reversal of chemical-induced liver fibrosis in Wistar rats by puerarin. J Nutr Biochem. 2006 Jul;17(7):485-91. Epub 2005 Oct 10. In the present study, we investigated the effects of puerarin on liver fibrosis in Wistar rats induced by plus carbon tetrachloride administration. |
0(0,0,0,0) | Details |
| 20070855 | Ahmadi A, Ebrahimzadeh MA, Ahmad-Ashrafi S, Karami M, Mahdavi MR, Saravi SS: Hepatoprotective, antinociceptive and antioxidant activities of cimetidine, and as H receptor antagonists. Fundam Clin Pharmacol. 2010 Jan 13. The hepatoprotective effects of cimetidine, and against hepatotoxicity induced by carbon tetrachloride (CCl (4)) were determined by measuring the levels of serum enzymes transaminase (ALT), transaminase (AST) and alkaline phosphatase (ALP) activities in mice. |
6(0,0,1,1) | Details |
| 18639619 | Chandan BK, Saxena AK, Shukla S, Sharma N, Gupta DK, Singh K, Suri J, Bhadauria M, Qazi GN: Hepatoprotective activity of Woodfordia fruticosa Kurz flowers against carbon tetrachloride induced hepatotoxicity. J Ethnopharmacol. 2008 Sep 26;119(2):218-24. Epub 2008 Jun 28. WF4 showed significant hepatoprotective activity against carbon tetrachloride induced hepatotoxicity as evident by restoration of serum transaminases, alkaline phosphatase, and triglycerides. |
6(0,0,1,1) | Details |
| 19568713 | Cao HX, Sun H, Jiang XG, Lu HT, Zhang GM, Wang XJ, Sun WJ, Wu ZM, Wang P, Liu L, Zhou J: Comparative study on the protective effects of Yinchenhao Decoction against liver injury induced by alpha-naphthylisothiocyanate and carbon tetrachloride. Chin J Integr Med. 2009 Jun;15(3):204-9. Epub 2009 Jul 2. METHODS: The liver injury in the model rat was induced by alpha-naphthylisothiocyanate (ANIT) and carbon tetrachloride (CCl (4) ) respectively, and the effects of Yinchenhao Decoction (, YCHD), a proved effective Chinese medical formula for treating the dampness-heat jaundice syndrome in clinic, on the two liver injury models were evaluated by analyzing the serum level of alanine aminotransferase (ALT), asparate aminotransferase (AST), alkaline phosphatase (ALP), malondialchehyche (MDA), total (T-BIL), superoxide dismutase (SOD), peroxidase (GSH-PX) as well as the ratio of liver weight to body weight. |
6(0,0,1,1) | Details |
| 15573529 | Venukumar MR, Latha MS: Effect of Coscinium fenestratum on hepatotoxicity in rats. Indian J Exp Biol. 2004 Aug;42(8):792-7. Anti-hepatotoxic activity of extract of Coscinium fenestratum stem (MEC) was investigated against carbon tetrachloride-induced hepatopathy in rats. Anti-hepatotoxic effect was studied by assaying the activities of serum marker enzymes like aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, gamma glutamyl transpeptidase, lactate dehydrogenase etc. and glucose (6) phosphate dehydrogenase in liver. |
1(0,0,0,1) | Details |
| 17897074 | Fernandez-Martinez E, Bobadilla RA, Morales-Rios MS, Muriel P, Perez-Alvarez VM: derivatives: structure-activity relationship as hepatoprotective agents. Med Chem. 2007 Sep;3(5):475-9. The activities of gamma-glutamyl transpeptidase, alkaline phosphatase and alanine aminotransferase were measured in serum. |
1(0,0,0,1) | Details |
| 17010209 | Manna P, Sinha M, Sil PC: Aqueous extract of Terminalia arjuna prevents carbon tetrachloride induced hepatic and renal disorders. BMC Complement Altern Med. 2006 Sep 30;6:33. Serum marker enzymes, namely, glutamate pyruvate transaminase (GPT) and alkaline phosphatase (ALP) were estimated in the sera of all study groups. |
1(0,0,0,1) | Details |
| 20046731 | Dandagi PM, Patil MB, Mastiholimath VS, Gadad AP, Dhumansure RH: Development and evaluation of hepatoprotective polyherbal formulation containing some indigenous medicinal plants. Indian J Pharm Sci. 2008 Mar-Apr;70(2):265-8. Petroleum ether (60-80 degrees ), chloroform, and aqueous extracts of Ferula asafetida, Momordica charantia Linn and Nardostachys jatamansi were evaluated for hepatoprotective activity against carbon tetrachloride-induced liver toxicity in Wistar rats. Formulation F3 has shown significant hepatoprotective effect by reducing the elevated serum enzyme levels such as transaminase, glutamate pyruvate transaminase and alkaline phosphatase. |
1(0,0,0,1) | Details |
| 17306079 | Huang J, Ren RN, Chen XM, Ye LY: [An experimental study on hepatotoxicity of in young rats] . Zhongguo Dang Dai Er Ke Za Zhi. 2007 Feb;9(1):54-8. The ones in the positive control group (Group E) were treated by injection of 10% carbon tetrachloride dissolved in olive oil subcutaneously at a dose of 5 mL/kg twice a week. |
0(0,0,0,0) | Details |
| 15900909 | Augusti KT, Anuradha, Prabha SP, Smitha KB, Sudheesh M, George A, Joseph MC: Nutraceutical effects of garlic oil, its nonpolar fraction and a Ficus as compared to in CCl4 induced liver damage in rats. Indian J Exp Biol. 2005 May;43(5):437-44. Carbon tetrachloride feeding (3.2g/kg/72hr) for one month increased significantly the serum and tissue lipid profile and deranged the enzyme levels viz; alkaline phosphatase, transaminase, transaminase, glutathionze reductase, HMGCoA reductase, catalase, gluc.6.PDH and malic enzyme in rats. |
6(0,0,1,1) | Details |
| 16213120 | Rao GM, Rao CV, Pushpangadan P, Shirwaikar A: Hepatoprotective effects of rubiadin, a major constituent of Rubia cordifolia Linn. J Ethnopharmacol. 2006 Feb 20;103(3):484-90. Epub 2005 Oct 5. The substantially elevated serum enzymatic activities of serum glutamic oxaloacetic transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), serum alkaline phosphatase (SALP) and gamma-glutamyltransferase (gamma-GT) due to carbon tetrachloride treatment were dose dependently restored towards normalization. |
6(0,0,1,1) | Details |
| 16945181 | Maiti K, Mukherjee K, Gantait A, Saha BP, Mukherjee PK: Enhanced therapeutic potential of -phospholipid complex in rats. J Pharm Pharmacol. 2006 Sep;58(9):1227-33. -phospholipid complex was prepared and assessed for antioxidant activity in carbon tetrachloride intoxicated rats at a dose level of 100 mg kg-1 (p.o.). Liver function tests were studied by assessing serum transaminase, serum glutamate pyruvate transaminase, serum alkaline phosphatase and total |
1(0,0,0,1) | Details |
| 19922789 | Moon KH, Lee YM, Song BJ: Inhibition of hepatic mitochondrial aldehyde dehydrogenase by carbon tetrachloride through JNK-mediated phosphorylation. Free Radic Biol Med. 2010 Feb 1;48(3):391-8. Epub 2009 Nov 14. Incubation with alkaline phosphatase significantly restored the suppressed ALDH2 activity with a concurrent alkaline pI shift of the ALDH2 spots. |
1(0,0,0,1) | Details |
| 18358653 | Wang T, Sun NL, Zhang WD, Li HL, Lu GC, Yuan BJ, Jiang H, She JH, Zhang C: Protective effects of dehydrocavidine on carbon tetrachloride-induced acute hepatotoxicity in rats. J Ethnopharmacol. 2008 May 8;117(2):300-8. Epub 2008 Feb 14. RESULTS: Both pre-treatment with DC prior to CCl4 administration and post-treatment with DC after CCl4 administration significantly prevented increases in serum enzymatic activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), alkaline phosphatase (ALP) and total (TBIL). |
1(0,0,0,1) | Details |
| 17727797 | Uskokovic-Markovic S, Milenkovic M, Topic A, Kotur-Stevuljevic J, Stefanovic A, Antic-Stankovic J: Protective effects of tungstophosphoric acid and tungstate on chemically induced liver necrosis in wistar rats. J Pharm Pharm Sci. 2007;10(3):340-9. The induced liver necrosis by carbon tetrachloride (CCl4) and thioacetamide (TAA) are exemplary models for experimental liver necrosis caused by free radicals. METHODS: Hepatoprotective effects of TPA and ST on acute liver necrosis, chemically induced, were evaluated by the activity of serum enzymes (alkaline phosphatase, transaminase and transaminase), oxidative stress parameters (activity of xanthine oxidase, concentrations of malondialdehyde and production of antioxidative defence markers (concentration of and histopathology in Wistar rats. |
1(0,0,0,1) | Details |
| 16176146 | Choi J, Park JK, Lee KT, Park KK, Kim WB, Lee JH, Jung HJ, Park HJ: In vivo antihepatotoxic effects of Ligularia fischeri var. spiciformis and the identification of the active component, 3,4-dicaffeoylquinic acid. J Med Food. 2005 Fall;8(3):348-52. Pretreatment with DCQA (5 and 10 mg/kg, p.o.) significantly reduced serum aminotransferases and sorbitol dehydrogenase, gamma-glutamyltransferase, alkaline phosphatase, and lactate dehydrogenase activities during CCl4- or GalN-induced hepatotoxicity, suggesting that DCQA is a major principle for the antihepatotoxic activity of L. fischeri var. spiciformis. |
1(0,0,0,1) | Details |
| 19702178 | Krithika R, Verma RJ: Mitigation of carbon tetrachloride-induced damage by Phyllanthus amarus in liver of mice. Acta Pol Pharm. 2009 Jul-Aug;66(4):439-44. Carbon tetrachloride administration caused a significant increase in liver and serum transaminase (ALT), transaminase (AST), alkaline phosphatase (ALP) and acid phosphatase (ACP), while total protein content significantly decreased as compared to vehicle control. |
6(0,0,1,1) | Details |
| 16041732 | Nkosi CZ, Opoku AR, Terblanche SE: Effect of pumpkin seed (Cucurbita pepo) protein isolate on the activity levels of certain plasma enzymes in CCl4-induced liver injury in low-protein fed rats. Phytother Res. 2005 Apr;19(4):341-5. The effects of pumpkin seed (Cucurbita pepo) protein isolate on the activity levels of lactate dehydrogenase (LD), transaminase (ALT), transaminase (AST) and alkaline phosphatase (ALP) against carbon tetrachloride (CCl4)-induced acute liver injury in low-protein fed rats were investigated. |
6(0,0,1,1) | Details |
| 17135160 | Rajkapoor B, Jayakar B, Kavimani S, Murugesh N: Protective effect of Indigofera aspalathoides against CCl4-induced hepatic damage in rats. J Herb Pharmacother. 2006;6(1):49-54. The activity was evaluated by using biochemical parameters, such as serum glutamate pyruvate transaminase (SGPT), serum transaminase (SGOT), alkaline phosphatase (ALP), total and gama transpeptidase (GGTP). |
1(0,0,0,1) | Details |
| 19345075 | Yan F, Zhang QY, Jiao L, Han T, Zhang H, Qin LP, Khalid R: Synergistic hepatoprotective effect of Schisandrae lignans with Astragalus polysaccharides on chronic liver injury in rats. Phytomedicine. 2009 Sep;16(9):805-13. Epub 2009 Apr 2. Subcutaneous injection of 10% CCl (4) twice a week for 3 months resulted in significantly (p <0.001) elevated serum alanine aminotransferase (ALT), asparate aminotransferase (AST), alkaline phosphatase (ALP) activities compared to controls. |
1(0,0,0,1) | Details |
| 20046723 | Manjunatha BK, Vidya SM: Hepatoprotective Activity of Vitex trifolia against Carbon Tetrachloride-induced Hepatic Damage. Indian J Pharm Sci. 2008 Mar-Apr;70(2):241-5. To assess the hepatoprotective activity of the extracts, various biochemical parameters viz., total total protein, transaminase, transaminase and alkaline phosphatase activities were determined. |
1(0,0,0,1) | Details |
| 16890175 | Chidambara Murthy KN, Rajesha J, Vanitha A, Swamy MM, Ravishankar GA: Protective effect of Dunaliella salina-A marine micro alga, against carbon tetrachloride-induced hepatotoxicity in rats. Hepatol Res. 2005 Dec;33(4):313-9. The degree of hepatoprotection was measured up on challenging animals with toxin (2.0gkg (-1) of carbon tetrachloride) by estimation of biochemical parameters like, serum transaminases (serum transaminase (S) AST and serum transaminase (S) ALT), serum alkaline phosphatase and total protein. |
6(0,0,1,1) | Details |
| 16379566 | Murthy KN, Rajesha J, Swamy MM, Ravishankar GA: Comparative evaluation of hepatoprotective activity of carotenoids of microalgae. J Med Food. 2005 Winter;8(4):523-8. The degree of hepatoprotection was measured by estimation of biochemical parameters like serum transaminases [serum transaminase (SGOT) and serum glutamate pyruvate transaminase (SGPT)], serum alkaline phosphatase, total albumin, and total protein. |
2(0,0,0,2) | Details |
| 18029340 | Bhadauria M, Nirala SK, Shukla S: Duration-dependent hepatoprotective effects of propolis extract against carbon tetrachloride-induced acute liver damage in rats. Adv Ther. 2007 Sep-Oct;24(5):1136-45. Administration of CCl 4 caused a sharp elevation in the activity of serum transaminases and serum alkaline phosphatase. |
2(0,0,0,2) | Details |
| 18691629 | Gowri Shankar NL, Manavalan R, Venkappayya D, David Raj C: Hepatoprotective and antioxidant effects of Commiphora berryi (Arn) Engl bark extract against CCl (4)-induced oxidative damage in rats. Food Chem Toxicol. 2008 Sep;46(9):3182-5. Epub 2008 Jul 22. Intraperitoneal injection of CCl (4), administered twice a week, produced a marked elevation in the serum levels of transaminase, transaminase, alkaline phosphatase and |
1(0,0,0,1) | Details |
| 18783728 | Zeashan H, Amresh G, Singh S, Rao CV: Hepatoprotective activity of Amaranthus spinosus in experimental animals. Food Chem Toxicol. 2008 Nov;46(11):3417-21. Epub 2008 Aug 22. The hepatoprotective and antioxidant activity of 50% ethanolic extract of whole plant of Amaranthus spinosus (ASE) was evaluated against carbon tetrachloride (CCl4) induced hepatic damage in rats. The substantially elevated serum enzymatic levels of serum transaminase (AST), serum glutamate pyruvate transaminase (ALT), serum alkaline phosphatase (SALP) and total were restored towards normalization significantly by the ASE in a dose dependent manner. |
1(0,0,0,1) | Details |
| 19496777 | Singh D, Singh R, Singh P, Gupta RS: Effects of Embelin on Lipid Peroxidation and Free Radical Scavenging Activity against Liver Damage in Rats. Basic Clin Pharmacol Toxicol. 2009 May 26. Carbon tetrachloride (CCl (4)) treatment to rats has been more susceptible to peroxidative damage through production of reactive metabolites, namely trichloromethyl-free radicals ( and/or ) as measured by thiobarbituric acid reactive species. The activities of marker enzymes - transaminases (AST, ALT), alkaline phosphatase (ALP), gamma-glutamyl transpeptidase (GGT), lactate dehydrogenase (LDH) - along with the total and total protein levels were altered significantly (P |
1(0,0,0,1) | Details |
| 16117622 | Shahjahan M, Vani G, Devi CS: Protective effect of Indigofera oblongifolia in CCl4-induced hepatotoxicity. J Med Food. 2005 Summer;8(2):261-5. The present study aimed at assessing the protective effect of Indigofera oblongifolia on carbon tetrachloride (CCl4-induced hepatotoxicity. The activities of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and lactate dehydrogenase were significantly (P < .001) increased in serum of CCl4-induced animals when compared with control animals. |
1(0,0,0,1) | Details |
| 17049775 | Jadon A, Bhadauria M, Shukla S: Protective effect of Terminalia belerica Roxb. and against carbon tetrachloride induced damage in albino rats. J Ethnopharmacol. 2007 Jan 19;109(2):214-8. Epub 2006 Aug 12. Toxicant caused significant increase in the activities of serum transaminases and serum alkaline phosphatase. |
1(0,0,0,1) | Details |
| 18989868 | Nogueira CW, Borges LP, Souza AC: Oral administration of diphenyl diselenide potentiates hepatotoxicity induced by carbon tetrachloride in rats. J Appl Toxicol. 2009 Mar;29(2):156-64. The liver and kidney were utilized for determination of histopathology, biochemical (ALT) and alanine (AST) aminotransferases, alkaline phosphatase (ALP), total bilirrubin (TB) and gamaglutamyl transferase (GGT)] and toxicological parameters [thiobarbituric reactive species (TBARS) levels, catalase activity, nonprotein thiols (NPSH) and aminolevulinate dehydratase (-ALA-D) activity]. |
1(0,0,0,1) | Details |
| 16376022 | Agarwal M, Srivastava VK, Saxena KK, Kumar A: Hepatoprotective activity of Beta vulgaris against CCl4-induced hepatic injury in rats. Fitoterapia. 2006 Feb;77(2):91-3. Epub 2005 Dec 20. Hepatotoxicity and its prevention were assessed by serum markers viz. triglyceride, amino transferase and alkaline phosphatase. |
1(0,0,0,1) | Details |
| 19294768 | Al-Rejaie SS, Aleisa AM, Al-Yahya AA, Bakheet SA, Alsheikh A, Fatani AG, Al-Shabanah OA, Sayed-Ahmed MM: Progression of diethylnitrosamine-induced hepatic carcinogenesis in -depleted rats. World J Gastroenterol. 2009 Mar 21;15(11):1373-80. RESULTS: Administration of DENA resulted in a significant increase in transaminase (ALT), gamma-glutamyl transferase (G-GT), alkaline phosphatase (ALP), total thiobarbituric acid reactive substances (TBARS) and total / (NOx) and a significant decrease in (GSH), peroxidase (GSHPx), catalase (CAT) and total content in liver tissues. Rats in group 4 (DENA group) were injected with a single dose of DENA (200 mg/kg, i.p.) and 2 wk later received a single dose of carbon tetrachloride (2 mL/kg) by gavage as 1:1 dilution in corn oil. |
1(0,0,0,1) | Details |
| 15507327 | Ozbek H, Citoglu GS, Dulger H, Ugras S, Sever B: Hepatoprotective and anti-inflammatory activities of Ballota glandulosissima. J Ethnopharmacol. 2004 Dec;95(2-3):143-9. extract of Ballota glandulosissima Hub.-Mor & Patzak (Lamiaceae) (BG) was investigated for anti-inflammatory activity using the carrageenan-induced rat paw oedema test and for hepatoprotective effect on carbon tetrachloride (CCl (4))-induced hepatotoxicity in rats. Biochemical parameters of hepatic damage such as serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and concentrations were determined. |
1(0,0,0,1) | Details |
| 19382721 | Girish C, Koner BC, Jayanthi S, Rao KR, Rajesh B, Pradhan SC: Hepatoprotective activity of six polyherbal formulations in CCl4-induced liver toxicity in mice. Indian J Exp Biol. 2009 Apr;47(4):257-63. The serum biochemical parameters such as transaminases, transaminases and alkaline phosphatase were estimated. |
1(0,0,0,1) | Details |
| 19742242 | Shaarawy SM, Tohamy AA, Elgendy SM, Elmageed ZY, Bahnasy A, Mohamed MS, Kandil E, Matrougui K: Protective effects of garlic and silymarin on NDEA-induced rats hepatotoxicity. Int J Biol Sci. 2009 Aug 11;5(6):549-57. BACKGROUND: The present study was conducted to investigate the chemopreventive effects of garlic extract and silymarin on N-nitrosodiethylamine (NDEA) and carbon tetrachloride (CCl (4))-induced hepatotoxicity in male albino rats. Serum transaminase (AST), transaminase (ALT), alkaline phosphatase (ALP), hepatic lipid peroxidation (LPO), superoxide dismutase (SOD), (GSH), glutathione-S-transferase (GST) and glutathione reductase (GSR) were measured. |
1(0,0,0,1) | Details |
| 17105706 | Khan SA, Ahmad B, Alam T: Synthesis and antihepatotoxic activity of some new chalcones containing 1, 4 - dioxane ring system. Pak J Pharm Sci. 2006 Oct;19(4):290-4. The synthesized compounds were evaluated for antihepatotoxic activity against carbon tetrachloride induced hepatotoxicity in albino rats. The degree of protection was measured by using biochemical parameters like serum glutamic oxaloacetic transaminase (SGOT), serum glutamic transaminase (SGPT), alkaline phosphatase (ALKP), total protein (TP) and total albumin (TA). |
1(0,0,0,1) | Details |
| 18949895 | Krishnakumar NM, Latha PG, Suja SR, Shine VJ, Shyamal S, Anuja GI, Sini S, Pradeep S, Shikha P, Unni PK, Rajasekharan S: Hepatoprotective effect of Hibiscus hispidissimus Griffith, ethanolic extract in and CCl4 induced hepatotoxicity in Wistar rats. Indian J Exp Biol. 2008 Sep;46(9):653-9. In the present study, the effect of the ethanolic extract of Hibiscus hispidissimus whole plant on (PCM)-induced and carbon tetrachloride (CCl4)-induced liver damage in healthy Wistar albino rats was studied. The results showed that significant hepatoprotective effects were obtained against liver damage induced by PCM and CCl4 as evidenced by decreased levels of serum enzymes, transaminase (SGOT), glutamate pyruvate transaminase (SGPT), serum alkaline phosphatase (SAKP), serum (SB) and an almost normal histological architecture of the liver of the treated groups compared to the toxin controls. |
1(0,0,0,1) | Details |
| 18481019 | Kang KS, Kim ID, Kwon RH, Lee JY, Kang JS, Ha BJ: The effects of fucoidan extracts on CCl (4)-induced liver injury. Arch Pharm Res. 2008 May;31(5):622-7. Epub 2008 May 15. The aim of this study was to elucidate the antioxidant properties of fucoidan extracts (FE) against CCl (4)-induced oxidative stress by monitoring the levels of transaminase (GOT), glutamate pyruvate transaminase (GPT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT) and peroxidase (GPx). |
1(0,0,0,1) | Details |
| 19429383 | Sathesh Kumar S, Ravi Kumar B, Krishna Mohan G: Hepatoprotective effect of Trichosanthes cucumerina Var cucumerina L. on carbon tetrachloride induced liver damage in rats. J Ethnopharmacol. 2009 Jun 22;123(2):347-50. Epub 2009 Mar 3. Various biochemical parameters like amino transferase (ALT), amino transferase (AST), alkaline phosphatase (ALP), total (TB), total protein (TP) and albumin (ALB) levels were estimated in serum as well as the (GSH) and malondialdehyde (MDA) levels in the liver were determined. |
1(0,0,0,1) | Details |
| 19446540 | Singh BN, Singh BR, Sarma BK, Singh HB: Potential chemoprevention of N-nitrosodiethylamine-induced hepatocarcinogenesis by polyphenolics from Acacia nilotica bark. Chem Biol Interact. 2009 Sep 14;181(1):20-8. Epub 2009 May 14. Chemopreventive potential of Acacia nilotica bark extract (ANBE) against single intraperitoneal injection of N-nitrosodiethylamine (NDEA, 200mg/kg) followed by weekly subcutaneous injections of carbon tetrachloride (CCl (4), 3 ml/kg) for 6 weeks induced hepatocellular carcinoma (HCC) in rats was studied. The levels of liver injury and liver cancer markers such as transaminase (ALT), transaminase (AST), alkaline phosphatase (ALP), gamma-glutamyl transferase (gamma-GT), total level (TBL), alpha-feto protein (AFP) and carcinoembryonic antigen (CEA) were substantially increased following NDEA treatment. |
1(0,0,0,1) | Details |
| 19524009 | Hsu YW, Tsai CF, Chen WK, Lu FJ: Protective effects of seabuckthorn (Hippophae rhamnoides L.) seed oil against carbon tetrachloride-induced hepatotoxicity in mice. Food Chem Toxicol. 2009 Sep;47(9):2281-8. Epub 2009 Jun 11. Our results showed that oral administration of SBT seed oil at doses of 0.26, 1.30, and 2.60 mg/kg for 8 weeks significantly reduced the elevated levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), triglyceride (TG), and at least 13% in serum, and the level of malondialdehyde (MDA) in liver at least 22%, that was induced by CCl (4) (1 mL/kg) in mice. |
1(0,0,0,1) | Details |
| 16708894 | Baheti JR, Goyal RK, Shah GB: Hepatoprotective activity of Hemidesmus indicus R. br. in rats. Indian J Exp Biol. 2006 May;44(5):399-402. Treatment of rats with and CCl4 produced a significant increase in the levels of serum glutamate pyruvate transaminase (SGPT), serum transaminase (SGOT), alkaline phosphatase (ALP), total and direct |
1(0,0,0,1) | Details |
| 19398917 | Galicia-Moreno M, Rodriguez-Rivera A, Reyes-Gordillo K, Segovia J, Shibayama M, Tsutsumi V, Vergara P, Moreno MG, Muriel P: prevents carbon tetrachloride-induced liver cirrhosis: role of liver transforming growth factor-beta and oxidative stress. Eur J Gastroenterol Hepatol. 2009 Aug;21(8):908-14. Alkaline phosphatase, alanine aminotransferase, and gamma-glutamyltranspeptidase were measured in plasma. |
1(0,0,0,1) | Details |
| 20069380 | Abdel Salam OM, Sleem AA, Shafee N: Hepatoprotective effects of the donor isosorbide-5-mononitrate alone and in combination with the natural hepatoprotectant, silymarin, on carbon tetrachloride-induced hepatic injury in rats. Inflammopharmacology. 2010 Jan 14. Serum aspartate aminotransferase (AST) levels decreased by 19.8, 22.7 and 59.4%, respectively, while alkaline phosphatase (ALP) decreased by 26.1 and 32.6% by the drug at 3.6 and 7.2 mg/kg, respectively. |
1(0,0,0,1) | Details |
| 19747501 | Domitrovic R, Jakovac H, Tomac J, Sain I: Liver fibrosis in mice induced by carbon tetrachloride and its reversion by Toxicol Appl Pharmacol. 2009 Dec 15;241(3):311-21. Epub 2009 Sep 8. CCl (4)-intoxication increased serum aminotransferase and alkaline phosphatase levels and disturbed hepatic antioxidative status. |
1(0,0,0,1) | Details |
| 16629373 | Roy CK, Kamath JV, Asad M: Hepatoprotective activity of Psidium guajava Linn. leaf extract. Indian J Exp Biol. 2006 Apr;44(4):305-11. The study was designed to evaluate the hepatoprotective activity of P. guajava in acute experimental liver injury induced by carbon tetrachloride, or thioacetamide and chronic liver damage induced by carbon tetrachloride. In the acute liver damage induced by different hepatotoxins, P. guajava leaf extracts (250 and 500mg/kg, po) significantly reduced the elevated serum levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and |
1(0,0,0,1) | Details |
| 16600545 | Sureshkumar SV, Mishra SH: Hepatoprotective effect of extracts from Pergularia daemia Forsk. J Ethnopharmacol. 2006 Sep 19;107(2):164-8. Epub 2006 Apr 5. The aqueous and ethanolic extracts obtained from aerial parts of Pergularia daemia were evaluated for hepatoprotective activity in rats by inducing liver damage by carbon tetrachloride. The ethanolic extract at an oral dose of 200 mg/kg exhibited a significant (P <0.05) protective effect by lowering serum levels of glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, alkaline phosphatase, total and total and increasing the levels of total protein and albumin levels as compared to silymarin used as a positive control. |
1(0,0,0,1) | Details |
| 17373378 | Qureshi AA, Prakash T, Patil T, Viswanath Swamy AH, Gouda AV, Prabhu K, Setty SR: Hepatoprotective and antioxidant activities of flowers of Calotropis procera (Ait) R. Indian J Exp Biol. 2007 Mar;45(3):304-10. Pre-treatment with 70% ethanolic extract (CPA) reduced the biochemical markers of hepatic injury like serum glutamate pyruvate transaminase, serum transaminase, alkaline phosphatase, HDL and tissue (GSH) levels. |
1(0,0,0,1) | Details |
| 19783517 | Anandan R, Jayakar B, Karar B, Babuji S, Manavalan R, Kumar RS: Effect of extract of flowers of Vitex trifolia Linn. on CCL4 induced hepatic injury in rats. Pak J Pharm Sci. 2009 Oct;22(4):391-4. CCl4 induced a significant rise in serum glutamate pyruvate transaminase (SGPT), serum transaminase (SGOT), alkaline phosphatase (ALP), total and gamma transpeptidase (GGTP). |
1(0,0,0,1) | Details |
| 20064503 | Khadeer Ahamed MB, Krishna V, Dandin CJ: In vitro antioxidant and in vivo prophylactic effects of two gamma-lactones isolated from Grewia tiliaefolia against hepatotoxicity in carbon tetrachloride intoxicated rats. Eur J Pharmacol. 2010 Apr 10;631(1-3):42-52. Epub 2010 Jan 11. The treatment with methanolic extract, EHGL and GAGL at oral doses of 100, 150 and 60 mg/kg respectively with concomitant CCl (4) intraperitoneal injection (1 ml/kg) significantly reduced the elevated plasma levels of aminotransferases, alkaline phosphatase and the incidence of liver necrosis compared with the CCl (4)-injected group without affecting the concentrations of serum and hepatic markers. |
1(0,0,0,1) | Details |
| 19420997 | Murugesan GS, Sathishkumar M, Jayabalan R, Binupriya AR, Swaminathan K, Yun SE: Hepatoprotective and curative properties of Kombucha tea against carbon tetrachloride-induced toxicity. J Microbiol Biotechnol. 2009 Apr;19(4):397-402. In the present study, KT along with black tea (BT) and black tea manufactured with tea fungus enzymes (enzyme-processed tea, ET) was evaluated for hepatoprotective and curative properties against CCl4-induced toxicity, using male albino rats as an experimental model by analyzing transaminase, transaminase, and alkaline phosphatase in plasma and malondialdehyde content in plasma and liver tissues. |
1(0,0,0,1) | Details |
| 18277467 | Abdel Salam OM, Oraby FH, Hassan NS: Vinpocetine ameliorates acute hepatic damage caused by administration of carbon tetrachloride in rats. Acta Biol Hung. 2007 Dec;58(4):411-9. The results showed that vinpocetine administered to CCl4-treated rats decreased the elevated alanine aminotransferase (ALT) by 49.3, 58.1 and 63.6%, aspartate aminotransferase (AST) by 10.5, 22.6 and 27.2% and alkaline phosphatase (ALP) by 52.5, 59.6 and 64.9%, respectively, and in a dose-dependent manner. |
1(0,0,0,1) | Details |
| 18605733 | Botsoglou NA, Taitzoglou IA, Botsoglou E, Lavrentiadou SN, Kokoli AN, Roubies N: Effect of long-term dietary administration of oregano on the alleviation of carbon tetrachloride-induced oxidative stress in rats. J Agric Food Chem. 2008 Aug 13;56(15):6287-93. Epub 2008 Jul 8. Treatment with CCl 4 of rats from the CCl 4 group caused a significant increase in transaminase (AST), transaminase (ALT), and alkaline phosphatase (ALP) in serum, whereas it decreased and triglyceride content as compared to the control. |
1(0,0,0,1) | Details |
| 19662719 | Yuvaraj P, Subramoniam A: Hepatoprotective property of Thespesia populnea against carbon tetrachloride induced liver damage in rats. J Basic Clin Physiol Pharmacol. 2009;20(2):169-77. The water suspension (500 mg/kg b.wt.) of leaf, flower and stem bark of T. populnea showed varying levels of protective action against CCl4-induced liver damage as evidenced from significant reduction in the activities of serum marker enzymes for liver damage transaminase, transaminase, and alkaline phosphatase), and levels when compared with CCl4-intoxicated control rats. |
1(0,0,0,1) | Details |
| 15386534 | Kus I, Ogeturk M, Oner H, Sahin S, Yekeler H, Sarsilmaz M: Protective effects of against carbon tetrachloride-induced hepatotoxicity in rats: a light microscopic and biochemical study. Cell Biochem Funct. 2005 May-Jun;23(3):169-74. Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), total and conjugated levels were determined. |
1(0,0,0,1) | Details |
| 16213687 | Shanmugasundaram P, Venkataraman S: Hepatoprotective and antioxidant effects of Hygrophila auriculata (K. J Ethnopharmacol. 2006 Mar 8;104(1-2):124-8. Epub 2005 Oct 5. The activity was assessed by monitoring the various liver function tests, viz. transaminase, transaminase (AST), alkaline phosphatase (ALP), total protein and total |
1(0,0,0,1) | Details |
| 19824117 | Pradeep HA, Khan S, Ravikumar K, Ahmed MF, Rao MS, Kiranmai M, Reddy DS, Ahamed SR, Ibrahim M: Hepatoprotective evaluation of Anogeissus latifolia: in vitro and in vivo studies. World J Gastroenterol. 2009 Oct 14;15(38):4816-22. AIM: To evaluate the hepatoprotective activity of a hydroalcoholic extract of the bark of Anogeissus latifolia; in vitro in primary rat hepatocyte monolayer culture and in vivo in the liver of Wistar rats intoxicated by carbon tetrachloride (CCl (4)). Biochemical parameters including serum transaminases [aspartate aminotransferase (AST) and alanine aminotransferase (ALT)] and alkaline phosphatase (ALP) in serum were analyzed. |
1(0,0,0,1) | Details |
| 17585689 | Vidya SM, Krishna V, Manjunatha BK, Mankani KL, Ahmed M, Singh SD: Evaluation of hepatoprotective activity of Clerodendrum serratum L. Indian J Exp Biol. 2007 Jun;45(6):538-42. The extract of C. serratum roots and ursolic acid isolated from it were evaluated for hepatoprotective activity against carbon tetrachloride induced toxicity in male Wistar strain rats. The parameters studied were estimation of liver function serum markers such as serum total total protein, transaminase, transaminase and alkaline phosphatase activities. |
1(0,0,0,1) | Details |
| 16914248 | Jayakumar T, Ramesh E, Geraldine P: Antioxidant activity of the oyster mushroom, Pleurotus ostreatus, on CCl (4)-induced liver injury in rats. Food Chem Toxicol. 2006 Dec;44(12):1989-96. Epub 2006 Jul 12. Intraperitoneal administration of CCl (4) (2ml/kg) to rats for 4 days resulted in significantly elevated (p <0.05) serum levels of glutamic oxaloacetic transaminase (SGOT), glutamic pyruvate transaminase (SGPT) and alkaline phosphatase (SALP) compared to controls. |
1(0,0,0,1) | Details |
| 15350811 | Kus I, Colakoglu N, Pekmez H, Seckin D, Ogeturk M, Sarsilmaz M: Protective effects of phenethyl ester (CAPE) on carbon tetrachloride-induced hepatotoxicity in rats. Acta Histochem. 2004;106(4):289-97. Serum aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, total and conjugated levels and hepatic malondialdehyde (MDA) contents were determined. |
1(0,0,0,1) | Details |
| 19067753 | Bhadauria M, Nirala SK, Shrivastava S, Sharma A, Johri S, Chandan BK, Singh B, Saxena AK, Shukla S: Emodin reverses CCl induced hepatic cytochrome P450 (CYP) enzymatic and ultrastructural changes: The in vivo evidence. Hepatol Res. 2009 Mar;39(3):290-300. Epub 2008 Dec 2. Aim: The curative effect of emodin (1,3,8-trihydroxy-6-methyl anthraquinone), an active compound of the plant species Ventilago maderaspatana Gaertn, was evaluated against carbon tetrachloride (CCl (4)) induced hepatic cytochrome P450 (CYP) enzymatic and ultrastructural alterations in rats. Results: The CCl (4) induced-toxic effects were observed with sharp elevation in the release of serum transaminases, alkaline phosphatase, lactate dehydrogenase and gamma-glutamyl transpeptidase. |
1(0,0,0,1) | Details |
| 17291700 | Chandan BK, Saxena AK, Shukla S, Sharma N, Gupta DK, Suri KA, Suri J, Bhadauria M, Singh B: Hepatoprotective potential of Aloe barbadensis Mill. against carbon tetrachloride induced hepatotoxicity. J Ethnopharmacol. 2007 May 22;111(3):560-6. Epub 2007 Jan 14. AB-4 showed significant hepatoprotective activity against CCl4 induced hepatotoxicity as evident by restoration of serum transaminases, alkaline phosphatase, and triglycerides. |
1(0,0,0,1) | Details |
| 15237443 | Pilichos C, Perrea D, Demonakou M, Preza A, Donta I: Management of carbon tetrachloride-induced acute liver injury in rats by syngeneic hepatocyte transplantation in spleen and peritoneal cavity. World J Gastroenterol. 2004 Jul 15;10(14):2099-102. In the final survivors, LFT (except alkaline phosphatase) and hepatic histology returned to normal, independently of their previous therapy. |
1(0,0,0,1) | Details |
| 15299229 | Hewawasam RP, Jayatilaka KA, Pathirana C, Mudduwa LK: Hepatoprotective effect of Epaltes divaricata extract on carbon tetrachloride induced hepatotoxicity in mice. Indian J Med Res. 2004 Jul;120(1):30-4. Blood and liver tissue were collected for the assessment of serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and liver level. |
1(0,0,0,1) | Details |
| 18006644 | Fu Y, Zheng S, Lin J, Ryerse J, Chen A: protects the rat liver from CCl4-caused injury and fibrogenesis by attenuating oxidative stress and suppressing inflammation. Mol Pharmacol. 2008 Feb;73(2):399-409. Epub 2007 Nov 15. The current study evaluates the in vivo role of in protecting the liver against injury and fibrogenesis caused by carbon tetrachloride (CCl (4)) in rats and further explores the underlying mechanisms. This report demonstrates that significantly protects the liver from injury by reducing the activities of serum aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase, and by improving the histological architecture of the liver. |
1(0,0,0,1) | Details |
| 17983713 | Jain A, Soni M, Deb L, Jain A, Rout SP, Gupta VB, Krishna KL: Antioxidant and hepatoprotective activity of ethanolic and aqueous extracts of Momordica dioica Roxb. leaves. J Ethnopharmacol. 2008 Jan 4;115(1):61-6. Epub 2007 Sep 19. In present study, the hepatoprotective activity of ethanolic and aqueous extracts of Momordica dioica Roxb. leaves were evaluated against carbon tetrachloride (CCl4) induced hepatic damage in rats. The substantially elevated serum enzymatic levels of serum transaminase (AST), serum glutamate pyruvate transaminase (ALT), serum alkaline phosphatase (SALP) and total were restored towards normalization significantly by the extracts. |
1(0,0,0,1) | Details |
| 18397232 | Gressner OA, Lahme B, Siluschek M, Rehbein K, Weiskirchen R, Gressner AM: Intracrine signalling of activin A in hepatocytes upregulates connective tissue growth factor (CTGF/CCN2) expression. Liver Int. 2008 Nov;28(9):1207-16. Epub 2008 Apr 7. RESULTS: Using alkaline phosphatase alpha-alkaline phosphatase staining, it is demonstrated that activin A becomes increasingly detectable during the course of CCl (4)-liver damage. |
1(0,0,0,1) | Details |
| 19405380 | Preethi KC, Kuttan R: Hepato and reno protective action of Calendula officinalis L. flower extract. Indian J Exp Biol. 2009 Mar;47(3):163-8. The activities of serum marker enzymes of liver injury like glutamate pyruvate transaminase (SGPT), oxaloacetate transaminase (SGOT) and alkaline phosphatase (ALP) which were increased by CCl4 injection was found to be significantly reduced by the pretreatment of the flower extract at 100 and 250 mg/kg body weight. |
1(0,0,0,1) | Details |
| 16121714 | Manjunatha BK, Vidya SM, Dhiman P, Pallavi R, Mankani KL: Hepatoprotective activity of Leucas hirta against CCl4 induced hepatic damage in rats. Indian J Exp Biol. 2005 Aug;43(8):722-7. and aqueous leaf extracts of L. hirta demonstrated hepatoprotective activity against carbon tetrachloride induced liver damage in rats. The parameters studied were serum total total protein, transaminase, transaminase and alkaline phosphatase activities. |
1(0,0,0,1) | Details |
| 17705141 | Sangameswaran B, Reddy TC, Jayakar B: Hepatoprotective effect of leaf extracts of Andrographis lineata nees on liver damage caused by carbon tetrachloride in rats. Phytother Res. 2008 Jan;22(1):124-6. The biochemical parameters such as serum transaminase, serum glutamate pyruvate transaminase, serum and alkaline phosphatase were estimated to assess the liver function. |
1(0,0,0,1) | Details |
| 19069545 | Patrick-Iwuanyanwu KC, Wegwu MO, Ayalogu EO: Prevention of CCl4-induced liver damage by ginger, garlic and . Pak J Biol Sci. 2007 Feb 15;10(4):617-21. The hepatoprotective effects of garlic (Allium sativum), ginger (Zingiber officinale) and pre-treatment against carbon tetrachloride (CCl4)-induced liver damage in male wistar albino rats were investigated. Serum amino transferase, amino transferase and alkaline phosphatase levels, 24 h after CCl4 administration, decreased significantly (p < or = 0.05) in rats pre-treated with garlic, ginger, and various mixtures of garlic and ginger than in CCl4-treated rats only. |
1(0,0,0,1) | Details |
| 16941609 | Yemitan OK, Izegbu MC: Protective effects of Zingiber officinale (Zingiberaceae) against carbon tetrachloride and -induced hepatotoxicity in rats. Phytother Res. 2006 Nov;20(11):997-1002. |
0(0,0,0,0) | Details |
| 20177577 | Sisodia SS, Bhatnagar M: Hepatoprotective activity of Eugenia jambolana Lam. in carbon tetrachloride treated rats. Indian J Pharmacol. 2009 Feb;41(1):23-7. MATERIALS AND METHODS: Liver damage in rats treated with CCl (4) (1ml/kg/Bw, administered subcutaneously, on alternate days for one week) was studied by assessing parameters such as serum transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP), acid phosphatase (ACP) and (total and direct). |
1(0,0,0,1) | Details |
| 16438391 | Ramkumar KM, Anuradha CV: Short-term dietary restriction modulates liver lipid peroxidation in carbon tetrachloride-intoxicated rats. J Basic Clin Physiol Pharmacol. 2005;16(4):245-56. Lipid peroxidation, as thiobarbituric acid reactive substance, conjugated dienes, lipid hydroperoxides and the hepatic markers transaminase, aspartic transaminase, and alkaline phosphatase were significantly decreased in food-restricted rats. |
1(0,0,0,1) | Details |
| 15997120 | Tasduq SA, Mondhe DM, Gupta DK, Baleshwar M, Johri RK: Reversal of fibrogenic events in liver by Emblica officinalis (fruit), an Indian natural drug. Biol Pharm Bull. 2005 Jul;28(7):1304-6. A hydroalcoholic (50%) extract of Emblica officinalis (fruit) (EO-50) reduced the severity of hepatic fibrosis induced by carbon tetrachloride (CCl4) and thioacetamide (TAA). Improved liver function was observed by measuring the levels of aminotransaminase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and in serum. |
1(0,0,0,1) | Details |
| 18397225 | Tsai JH, Liu JY, Wu TT, Ho PC, Huang CY, Shyu JC, Hsieh YS, Tsai CC, Liu YC: Effects of silymarin on the resolution of liver fibrosis induced by carbon tetrachloride in rats. J Viral Hepat. 2008 Jul;15(7):508-14. Epub 2008 Apr 4. Moreover, silymarin significantly decreased the elevation of aspartate aminotransferase (AST), alanine aminotransferase, and alkaline phosphatase in serum, and also reversed the altered expressions of alpha-smooth muscle actin in liver tissue. |
1(0,0,0,1) | Details |
| 18806959 | Lee HS, Jung KH, Hong SW, Park IS, Lee C, Han HK, Lee DH, Hong SS: Morin protects acute liver damage by carbon tetrachloride (CCl (4)) in rat. Arch Pharm Res. 2008 Sep;31(9):1160-5. Epub 2008 Sep 20. CCl (4) challenge elevated serum transaminase (ALT), transaminase (AST), and alkaline phosphatase (ALP) levels, but these effects were prevented by the pretreatment of rats with morin. |
1(0,0,0,1) | Details |
| 16052059 | Gogolauri MI, Antelava NA: [Effect of heptral and on the hepatic functions during toxic hepatitis]. Georgian Med News. 2005 Jun;(123):57-60. The aim of study was to evaluate effectiveness of heptral (S-Adonosylmethionine- and during the acute toxic damage of the liver induced by carbon tetrachloride. The activity of aspartat-and alaninaminotransferases, alkaline phosphatase, the content of free and total billirubine in the blood, as well as total oxidant and antioxidant activity of the blood, were measured by the spectrophotometric techniques. |
1(0,0,0,1) | Details |
| 15266956 | Bhattacharyya D, Pandit S, Mukherjee R, Das N, Sur TK: Hepatoprotective effect of Himoliv, a polyherbal formulation in rats. Indian J Physiol Pharmacol. 2003 Oct;47(4):435-40. The effect of Himoliv (HV) was evaluated in carbon tetrachloride or induced hepatotoxicity in rats. The liver damage was evidenced by elevated levels of serum transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT) and serum alkaline phosphatase (ALP) and hepatic thiobarbituric acid reacting substances (TBARS) and superoxide dismutase (SOD). |
1(0,0,0,1) | Details |
| 20060873 | Botsoglou N, Taitzoglou I, Zervos I, Botsoglou E, Tsantarliotou M, Chatzopoulou PS: Potential of long-term dietary administration of rosemary in improving the antioxidant status of rat tissues following carbon tetrachloride intoxication. Food Chem Toxicol. 2010 Mar;48(3):944-50. Epub 2010 Jan 12. Results showed that feeding rosemary before CCl (4) treatment resulted in decline (P <0.05) of the increased transaminase, transaminase and alkaline phosphatase activities and increase (P <0.05) of the reduced and triacylglycerols in serum. |
1(0,0,0,1) | Details |
| 18572298 | Bhadauria M, Nirala SK, Shukla S: Multiple treatment of propolis extract ameliorates carbon tetrachloride induced liver injury in rats. Food Chem Toxicol. 2008 Aug;46(8):2703-12. Epub 2008 Apr 27. Multiple treatment of propolis significantly prevented the release of transaminases, alkaline phosphatase, lactate dehydrogenase, gamma-glutamyl transpeptidase, urea and in serum; improved the activity of hepatic microsomal drug metabolizing enzymes, i.e., hydroxylase and amidopyrine-N-demethylase; significantly inhibited lipid peroxidation and markedly enhanced in liver and kidney as well as brought altered carbohydrate contents (blood sugar and tissue protein contents (serum, microsomal and tissue protein) and lipid contents (serum and tissue triglycerides, serum cholesterol, total and esterified in tissue) towards control. |
1(0,0,0,1) | Details |
| 18695788 | Martinez JA, Ramos SG, Meirelles MS, Verceze AV, Arantes MR, Vannucchi H: [Effects of on bleomycin-induced lung injury: a preliminary study]. J Bras Pneumol. 2008 Jul;34(7):445-52. METHODS: Male Wistar rats, with mean weight of 250 g, were used in four experimental models: inhaled carbon tetrachloride; intraperitoneal carbon tetrachloride; partial portal vein ligation; and bile duct ligation (BDL). RESULTS: There were statistically significant differences between the BDL control and BDL experimental groups: aspartate aminotransferase (105.3 +/- 43 vs. 500.5 +/- 90.3 IU/L); alanine aminotransferase (78.75 +/- 37.7 vs. 162.75 +/- 35.4 IU/L); alkaline phosphatase (160 +/- 20.45 vs. 373.25 +/- 45.44 IU/L); arterial tension (85.25 +/- 8.1 vs. 49.9 +/- 22.5 mmHg); and saturation (95 +/- 0.7 vs. 73.3 +/- 12.07%). |
1(0,0,0,1) | Details |
| 16011737 | Srinivasan M, Rukkumani R, Ram Sudheer A, Menon VP: a natural protector against carbon tetrachloride-induced toxicity. Fundam Clin Pharmacol. 2005 Aug;19(4):491-6. The activities of liver markers transaminase, transaminase, alkaline phosphatase, gamma-glutamyl transferase), lipid peroxidative index (thiobarbituric acid-reactive substances, hydroperoxides, protein carbonyl content), the antioxidant status (superoxide dismutase, catalase, peroxidase and were used as biomarkers to monitor the protective role of FA. |
1(0,0,0,1) | Details |
| 18695789 | Vercelino R, Tieppo J, Forgiarini Junior LA, Dias AS, Marroni CA, Marroni NP: [Experimental models for assessment of pulmonary alterations in hepatopulmonary syndrome]. J Bras Pneumol. 2008 Jul;34(7):453-60. METHODS: Male Wistar rats, with mean weight of 250 g, were used in four experimental models: inhaled carbon tetrachloride; intraperitoneal carbon tetrachloride; partial portal vein ligation; and bile duct ligation (BDL). RESULTS: There were statistically significant differences between the BDL control and BDL experimental groups: aspartate aminotransferase (105.3 +/- 43 vs. 500.5 +/- 90.3 IU/L); alanine aminotransferase (78.75 +/- 37.7 vs. 162.75 +/- 35.4 IU/L); alkaline phosphatase (160 +/- 20.45 vs. 373.25 +/- 45.44 IU/L); arterial tension (85.25 +/- 8.1 vs. 49.9 +/- 22.5 mmHg); and saturation (95 +/- 0.7 vs. 73.3 +/- 12.07%). |
1(0,0,0,1) | Details |
| 15700767 | Ogeturk M, Kus I, Kavakli A, Zararsiz I, Ilhan N, Sarsilmaz M: Effects of on carbon tetrachloride-induced changes in rat serum. J Physiol Biochem. 2004 Sep;60(3):205-10. Serum urea, total protein, albumin, aspartate aminotransferase (AST), alanine aminotransferase (ALT), total and conjugated alkaline phosphatase (ALP), gamma-glutamyl transferase (gamma-GT), total iron, and levels were determined. |
1(0,0,0,1) | Details |
| 18440118 | Soni B, Visavadiya NP, Madamwar D: Ameliorative action of cyanobacterial phycoerythrin on CCl (4)-induced toxicity in rats. Toxicology. 2008 Jun 3;248(1):59-65. Epub 2008 Mar 18. Carbon tetrachloride (CCl (4)) is largely used as solvent in chemical industries. Results demonstrated that C-PE dose-responsively ameliorates CCl (4)-toxicity by significantly decreasing (P <0.05) organs weight, aminotransferases, alkaline phosphatase, lipid profile, and malondialdehyde (MDA) concentrations with rise in body weight, food intake, hemoglobin, protein, and FRAP values. |
1(0,0,0,1) | Details |
| 15036476 | Rajesh MG, Latha MS: Preliminary evaluation of the antihepatotoxic activity of Kamilari, a polyherbal formulation. J Ethnopharmacol. 2004 Mar;91(1):99-104. Hepatoprotective efficacy of Kamilari, a polyherbal preparation was studied in carbon tetrachloride (CCl4)-induced liver dysfunction in albino rats by determining different biochemical parameters in serum and tissues. In serum, the activities of enzymes like aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and the concentrations of protein and were evaluated. |
1(0,0,0,1) | Details |
| 20192593 | Poojari R, Gupta S, Maru G, Khade B, Bhagwat S: Sida rhombifolia ssp. retusa Seed Extract Inhibits DEN Induced Murine Hepatic Preneoplasia and Carbon Tetrachloride Hepatotoxicity. Asian Pac J Cancer Prev. 2009;10(6):1107-12. Treatment with seed extract significantly inhibited the increase in DEN/CCl4 induced activities of pre-cancerous marker enzymes; gamma-glutamyl transpeptidase, glutathione-S-transferase, hepatotoxicity marker enzymes; glutamate pyruvate transaminase, transaminase and alkaline phosphatase as well as lipid peroxidase. |
1(0,0,0,1) | Details |
| 18697572 | Kuriakose GC, Kurup GM: Antioxidant activity of Aulosira fertilisima on CCl4 induced hepatotoxicity in rats. Indian J Exp Biol. 2008 Jan;46(1):52-9. Carbon tetrachloride (CCl4) is used as a model for liver injury. Liver damage is detected by the measurement of the activities of serum enzymes like aspartate aminotransferase, alanine aminotransferase, gamma glutamyl transpeptidase and alkaline phosphatase which were released in to the blood from damaged cells. |
1(0,0,0,1) | Details |
| 17429801 | Chavez E, Reyes-Gordillo K, Segovia J, Shibayama M, Tsutsumi V, Vergara P, Moreno MG, Muriel P: prevents fibrosis, NF-kappaB activation and TGF-beta increases induced by chronic CCl4 treatment in rats. J Appl Toxicol. 2008 Jan;28(1):35-43. Alanine aminotransferase, alkaline phosphatase and bilirubins were increased by CCl (4), but afforded some degree of protection. |
1(0,0,0,1) | Details |
| 18007553 | Alvarez GC, Madrid-Marina V, Jimenez-Mendez R, Buitimea AL, Roman MB, Cortez-Gomez R, Esparza JR, Rodriguez-Fragoso L: Combined therapy with danazol, pegilated interferon, and ribavirin improves thrombocytopenia and liver injury in rats with fibrosis. Ann Hepatol. 2007 Oct-Dec;6(4):233-41. In contrast, danazol + PEG-IFN + ribavirin reduced total levels by 61%, alkaline phosphatase activity by 45%, ALT activity by 76%, and gamma-GTP activity by 74% (P < 0.05). |
1(0,0,0,1) | Details |
| 18811677 | Galicia-Moreno M, Rodriguez-Rivera A, Reyes-Gordillo K, Segovia J, Shibayama M, Tsutsumi V, Vergara P, Moreno MG, Fernandez-Martinez E, Perez-Alvarez VM, Muriel P: Trolox down-regulates transforming growth factor-beta and prevents experimental cirrhosis. Basic Clin Pharmacol Toxicol. 2008 Nov;103(5):476-81. Epub 2008 Sep 22. Alkaline phosphatase, gamma-glutamyl transpeptidase and alanine aminotransferase increased in the group receiving CCl4; trolox completely or partially prevented these alterations. |
1(0,0,0,1) | Details |
| 18654853 | Wang MY, Anderson G, Nowicki D, Jensen J: Hepatic protection by noni fruit juice against CCl (4)-induced chronic liver damage in female SD rats. Plant Foods Hum Nutr. 2008 Sep;63(3):141-5. Epub 2008 Jul 25. Serum alkaline phosphatase (ALP), aspartate aminotransferase (AST), transaminase (ALT), total (TC), triglycerides (TG), low-density lipoprotein (LDL), and very low-density lipoprotein (VLDL) levels were increased in the placebo group compared with the TNJ group. |
1(0,0,0,1) | Details |
| 15991578 | Pradeep K, Mohan CV, Anand KG, Karthikeyan S: Effect of pretreatment of Cassia fistula Linn. leaf extract against subacute CCl4 induced hepatotoxicity in rats. Indian J Exp Biol. 2005 Jun;43(6):526-30. CCl4 alone treatment (0.lml of liquid paraffin/100g body weight, ip) for 7 days followed by 0.l ml of CCl4 (in liquid parafiin/100g body weight, ip) from day 8 till day 14, caused a 16 fold increase in lipid peroxidation and a 50% reduction in catalase and glutathione reductase in liver tissue of rats accompanied by an increase in the activities of transaminases. alkaline phosphatase, lactate dehydrogenase and gamma - glutamyl transpeptidase in serum as compared to liquid paraffin treated control. |
1(0,0,0,1) | Details |
| 18436364 | Lee KJ, Choi JH, Khanal T, Hwang YP, Chung YC, Jeong HG: Protective effect of phenethyl ester against carbon tetrachloride-induced hepatotoxicity in mice. Toxicology. 2008 Jun 3;248(1):18-24. Epub 2008 Mar 20. Pretreatment with CAPE prior to administration of CCl (4) significantly prevented the increases in serum aspartate aminotransferase and alkaline phosphatase activities, hepatic lipid peroxidation formation, and depletion of content. |
1(0,0,0,1) | Details |