| Name | STAT3 |
|---|---|
| Synonyms | APRF; Acute phase response factor; STAT 3; STAT3; Signal transducer and activator of transcription 3; signal transducer and activator of transcription 3 (acute phase response factor); signal transducer and activator of transcription 3 isoform 1; Acute phase response factors… |
| Name | carbon tetrachloride |
|---|---|
| CAS | tetrachloromethane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 20211986 | Meng Z, Wang Y, Wang L, Jin W, Liu N, Pan H, Liu L, Wagman L, Forman BM, Huang W: FXR Regulates Liver Repair after CCl4-Induced Toxic Injury. Mol Endocrinol. 2010 Mar 8. Here we show that FXR is essential to promote liver repair after carbon tetrachloride (CCl4)-induced injury. During the early stages of liver repair after CCl4 treatment, we observed overproduction of TNFalpha and a strong decrease of phosphorylation and DNA-binding activity of signal transducer and activator of transcription 3 in livers from FXR (-/-) mice. |
2(0,0,0,2) | Details |
| 15760680 | Sudo K, Yamada Y, Moriwaki H, Saito K, Seishima M: Lack of tumor necrosis factor receptor type 1 inhibits liver fibrosis induced by carbon tetrachloride in mice. Cytokine. 2005 Mar 7;29(5):236-44. Furthermore, a marked reduction in procollagen and TGF-beta synthesis was observed in TNFR-1 KO mice, which also had little detectable NF-kappa B, STAT3, and AP1 binding, and reduced levels of liver interleukin-6 (IL-6) mRNA compared to WT and TNFR-2 KO mice. |
2(0,0,0,2) | Details |
| 18547752 | Yamaji K, Ochiai Y, Ohnishi K, Yawata A, Chikuma T, Hojo H: Up-regulation of hepatic heme oxygenase-1 expression by locally induced interleukin-6 in rats administered carbon tetrachloride intraperitoneally. Toxicol Lett. 2008 Jul 10;179(3):124-9. Epub 2008 May 2. Activation of the signal transducer and activator of transcription factor 3 (STAT3), which promotes HO-1 expression, peaked together with plasma levels of IL-6 after i.p. |
2(0,0,0,2) | Details |
| 18371088 | Rio A, Gassull MA, Aldeguer X, Ojanguren I, Cabre E, Fernandez E: Reduced liver injury in the interleukin-6 knockout mice by chronic carbon tetrachloride administration. Eur J Clin Invest. 2008 May;38(5):306-16. Epub 2008 Mar 26. Although the level of active protein was lower, activation of signal transducer and activator of transcription 3 still takes place in knockout mice. |
1(0,0,0,1) | Details |
| 14999682 | Nakamura K, Nonaka H, Saito H, Tanaka M, Miyajima A: Hepatocyte proliferation and tissue remodeling is impaired after liver injury in oncostatin M receptor knockout mice. Hepatology. 2004 Mar;39(3):635-44. Mice deficient in the OSM receptor (OSMR (-/-)) showed impaired liver regeneration with persistent parenchymal necrosis after carbon tetrachloride (CCl (4)) exposure. The activation of STAT3 and expression of immediate early genes and cyclins were decreased in OSMR (-/-) liver, indicating that OSM signaling is required for hepatocyte proliferation and tissue remodeling during liver regeneration. |
1(0,0,0,1) | Details |
| 20015528 | Hackl C, Mori A, Moser C, Lang SA, Dayoub R, Weiss TS, Schlitt HJ, Geissler EK, Hellerbrand C, Stoeltzing O: Effect of heat-shock protein-90 (HSP90) inhibition on human hepatocytes and on liver regeneration in experimental models. Surgery. 2009 Dec 14. Effects of HSP90 inhibition on liver regeneration and repair were determined in a murine hepatectomy model and in a model with acute carbon tetrachloride (CCl (4))-induced liver damage. RESULTS: Inhibition of HSP90 effectively diminished the constitutive phosphorylation of Akt, Erk, and STAT3 in PHHs. |
1(0,0,0,1) | Details |
| 16212920 | Pan H, Hong F, Radaeva S, Gao B: Hydrodynamic gene delivery of interleukin-22 protects the mouse liver from concanavalin A-, carbon tetrachloride-, and Fas ligand-induced injury via activation of STAT3. Cell Mol Immunol. 2004 Feb;1(1):43-9. |
83(1,1,1,3) | Details |
| 20196117 | Horiguchi N, Lafdil F, Miller AM, Park O, Wang H, Rajesh M, Mukhopadhyay P, Fu XY, Pacher P, Gao B: Dissociation between liver inflammation and hepatocellular damage induced by carbon tetrachloride in myeloid cell-specific signal transducer and activator of transcription 3 gene knockout mice. Hepatology. 2010 Jan 28. |
16(0,0,2,6) | Details |
| 17660847 | Moh A, Iwamoto Y, Chai GX, Zhang SS, Kano A, Yang DD, Zhang W, Wang J, Jacoby JJ, Gao B, Flavell RA, Fu XY: Role of STAT3 in liver regeneration: survival, DNA synthesis, inflammatory reaction and liver mass recovery. Lab Invest. 2007 Oct;87(10):1018-28. Epub 2007 Jul 30. In another model of liver regeneration induced by subcutaneous injection of carbon tetrachloride (CCl (4)), hepatocyte DNA synthesis in the CCl (4)-treated L-Stat3 (-/-) mice also decreased as compared with Stat3 (f/+) mice at 40 h after injection but not at other time points. |
6(0,0,0,6) | Details |
| 15122762 | Radaeva S, Sun R, Pan HN, Hong F, Gao B: Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation. Hepatology. 2004 May;39(5):1332-42. IL-22 messenger RNA and protein expression are significantly elevated in T cell-mediated hepatitis induced by concanavalin A (ConA) but are less extensively elevated in the carbon tetrachloride-induced liver injury model. |
4(0,0,0,4) | Details |
| 19332876 | Hosui A, Kimura A, Yamaji D, Zhu BM, Na R, Hennighausen L: Loss of STAT5 causes liver fibrosis and cancer development through increased TGF-{beta} and STAT3 activation. J Exp Med. 2009 Apr 13;206(4):819-31. Epub 2009 Mar 30. Liver-specific signal transducer and activator of transcription (STAT) 5A/B-null mice (STAT5-LKO) were treated with carbon tetrachloride (CCl (4)), and histological analyses revealed liver fibrosis and tumors. |
5(0,0,0,5) | Details |
| 17009398 | Salazar-Montes A, Ruiz-Corro L, Sandoval-Rodriguez A, Lopez-Reyes A, Armendariz-Borunda J: Increased DNA binding activity of NF-kappaB, STAT-3, SMAD3 and AP-1 in acutely damaged liver. World J Gastroenterol. 2006 Oct 7;12(37):5995-6001. |
3(0,0,0,3) | Details |