| Name | STAT1 |
|---|---|
| Synonyms | ISGF 3; STAT 1; STAT1; STAT91; Signal transducer and activator of transcription 1; Signal transducer and activator of transcription 1 alpha/beta; Transcription factor ISGF 3; Transcription factor ISGF 3 components p91/p84… |
| Name | carbon tetrachloride |
|---|---|
| CAS | tetrachloromethane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17133483 | Jeong WI, Park O, Radaeva S, Gao B: STAT1 inhibits liver fibrosis in mice by inhibiting stellate cell proliferation and stimulating NK cell cytotoxicity. Hepatology. 2006 Dec;44(6):1441-51. Our findings show that disruption of the STAT1 gene accelerated liver fibrosis and hepatic stellate cell (HSC) proliferation in an in vivo model of carbon tetrachloride (CCl4)-induced liver fibrosis. |
12(0,0,1,7) | Details |
| 18166357 | Jeong WI, Park O, Gao B: Abrogation of the antifibrotic effects of natural killer cells/interferon-gamma contributes to acceleration of liver fibrosis. Gastroenterology. 2008 Jan;134(1):248-58. Epub 2007 Sep 29. Such resistance was due to diminished IFN-gamma activation of signal transducer and activator of transcription 1 (STAT1) in HSCs from -fed mice caused by the induction of suppressors of cytokine signaling proteins and the production of oxidative stress. Liver fibrosis was induced by administration of carbon tetrachloride (CCl (4)) for 2 weeks. |
2(0,0,0,2) | Details |