| Name | gelatinase |
|---|---|
| Synonyms | 92 kDa gelatinase; Neutrophil collagenase; 92 kDa type IV collagenase; CLG4B; Collagenase type IV B; Collagenase type V; GEL B; GELB… |
| Name | carbon tetrachloride |
|---|---|
| CAS | tetrachloromethane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16762003 | Roderfeld M, Geier A, Dietrich CG, Siewert E, Jansen B, Gartung C, Roeb E: Cytokine blockade inhibits hepatic tissue inhibitor of metalloproteinase-1 expression and up-regulates matrix metalloproteinase-9 in toxic liver injury. Hepatology. 2004 Mar;39(3):635-44. Male Sprague-Dawley rats were treated with carbon tetrachloride (CCl4) in the presence and absence of specific TNF-alpha and IL-1beta inhibitors. |
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| 18506890 | Aram G, Potter JJ, Liu X, Torbenson MS, Mezey E: Lack of inducible synthase leads to increased hepatic apoptosis and decreased fibrosis in mice after chronic carbon tetrachloride administration. Hepatology. 2008 Jun;47(6):2051-8. Liver matrix metalloproteinase-9 (MMP-9) mRNA and MMP-2 mRNA were increased more in the WT than in the iNOS (-/-) mice after CCl (4). |
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| 15565662 | Sakaida I, Terai S, Yamamoto N, Aoyama K, Ishikawa T, Nishina H, Okita K: Transplantation of bone marrow cells reduces CCl4-induced liver fibrosis in mice. Hepatology. 2004 Dec;40(6):1304-11. BMCs of green fluorescent protein (GFP) mice were transplanted into 4-week carbon tetrachloride (CCl4)-treated C57BL6 mice through the tail vein, and the mice were treated for 4 more weeks with CCl4 (total, 8 weeks). Sirius red and GFP staining clearly indicated migrated BMCs existing along with fibers, with strong expression of matrix metalloproteinase (MMP)-9 shown by anti-MMP-9 antibodies and in situ hybridization. |
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| 20178458 | Rabani V, Shahsavani M, Gharavi M, Piryaei A, Azhdari Z, Baharvand H: Mesenchymal stem cell infusion therapy in carbon tetrachloride-induced liver fibrosis model affects matrix metalloproteinase expression. Cell Biol Int. 2010 Feb 23. |
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| 16507762 | Roderfeld M, Weiskirchen R, Wagner S, Berres ML, Henkel C, Grotzinger J, Gressner AM, Matern S, Roeb E: Inhibition of hepatic fibrogenesis by matrix metalloproteinase-9 mutants in mice. Cell Tissue Res. 2007 Mar;327(3):463-70. Epub 2006 Nov 9. |
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| 16116963 | Peng X, Wang B, Wang T, Zhao Q: Expression of basic fibroblast growth factor in rat liver fibrosis and hepatic stellate cells. 528. Liver fibrosis was induced by subcutaneous injection of carbon tetrachloride. HSCs were isolated by the combined methods of collagenase IV perfusion and density gradient centrifugation. |
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| 19114984 | Liu Y, Lui EL, Friedman SL, Li L, Ye T, Chen Y, Poon RT, Wo J, Kok TW, Fan ST: PTK787/ZK22258 attenuates stellate cell activation and hepatic fibrosis in vivo by inhibiting VEGF signaling. Lab Invest. 2009 Feb;89(2):209-21. Epub 2008 Dec 29. These beneficial effects were associated with reduced phosphorylation of Akt and suppressed mRNA expression of procollagen-(I), TIMP-1, matrix metalloproteinase-9 and CD31. In a murine fibrotic liver, PTK/ZK attenuated collagen deposition and alpha-SMA expression in carbon tetrachloride-induced fibrosis in both a 'prevention' and 'treatment' dosing scheme. |
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| 15057751 | Siller-Lopez F, Sandoval A, Salgado S, Salazar A, Bueno M, Garcia J, Vera J, Galvez J, Hernandez I, Ramos M, Aguilar-Cordova E, Armendariz-Borunda J: Treatment with human metalloproteinase-8 gene delivery ameliorates experimental rat liver cirrhosis. Aquat Toxicol. 2005 Aug 15;74(1):70-81. BACKGROUND & AIMS: An extrahepatic human neutrophil collagenase complementary DNA (matrix metalloprotease-8) cloned in an adenovirus vector was used as a therapeutic agent in cirrhosis. |
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| 14999682 | Nakamura K, Nonaka H, Saito H, Tanaka M, Miyajima A: Hepatocyte proliferation and tissue remodeling is impaired after liver injury in oncostatin M receptor knockout mice. FASEB J. 2006 Mar;20(3):444-54. Mice deficient in the OSM receptor (OSMR (-/-)) showed impaired liver regeneration with persistent parenchymal necrosis after carbon tetrachloride (CCl (4)) exposure. In contrast to wildtype mice, CCl (4) administration only marginally induced expression of tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2 genes in OSMR (-/-) mice, correlating with the increased gelatinase activity of matrix metalloproteinase (MMP)-9 and matrix degradation in injured livers. |
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| 15793858 | Zheng WD, Zhang LJ, Shi MN, Chen ZX, Chen YX, Huang YH, Wang XZ: Expression of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-1 in hepatic stellate cells during rat hepatic fibrosis and its intervention by IL-10. Liver Int. 2006 Jun;26(5):579-86. At the beginning of the 7 (th) and 11 (th) wk, rats in each group were routinely perfused with pronase E and type IV collagenase through portal vein catheter and the suspension was centrifuged by 11% Nycodenz density gradient to isolate hepatic stellate cells (HSCs). |
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| 18507761 | Yan C, Zhou L, Han YP: Contribution of hepatic stellate cells and matrix metalloproteinase 9 in acute liver failure. Liver Int. 2008 Aug;28(7):959-71. Epub 2008 May 27. METHODS: Mice were given lipopolysaccharide (LPS) and beta-galactosamine (GA) or carbon tetrachloride to create ALF and establish the association of IL-1, MMP-9, and caspase-3 in acute liver failure. |
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| 15963578 | Krasnov A, Koskinen H, Rexroad C, Afanasyev S, Molsa H, Oikari A: Transcriptome responses to carbon tetrachloride and pyrene in the kidney and liver of juvenile rainbow trout (Oncorhynchus mykiss). World J Gastroenterol. 2005 Aug 21;11(31):4788-93. Pyrene and CCl (4) caused opposite effects on expression of several genes, including HSP-27, macrophage receptor Marco, metalloproteinases (MMP9 and MMP13), and delta-6 fatty acid desaturase. |
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| 15586409 | Yao HW, Li J, Chen JQ, Xu SY: [The active metabolite of leflunomide A771726 inhibits proliferation and collagen synthesis of hepatic stellate cell]. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2004 Nov;33(6):515-8 METHODS: HSC and Kupffer cells were isolated from the rat liver by collagenase IV and pronase perfusion, and purified by density gradient separation. |
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| 19747501 | Domitrovic R, Jakovac H, Tomac J, Sain I: Liver fibrosis in mice induced by carbon tetrachloride and its reversion by Toxicol Appl Pharmacol. 2009 Dec 15;241(3):311-21. Epub 2009 Sep 8. treatment has increased hepatic matrix metalloproteinase-9 levels and metallothionein (MT) I/II expression, eliminated fibrinous deposits and restored architecture of the liver in a dose-dependent manner. |
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| 17093919 | Ishikawa T, Terai S, Urata Y, Marumoto Y, Aoyama K, Murata T, Mizunaga Y, Yamamoto N, Nishina H, Shinoda K, Sakaida I: Administration of fibroblast growth factor 2 in combination with bone marrow transplantation synergistically improves carbon-tetrachloride-induced liver fibrosis in mice. Biol Trace Elem Res. 2010 Jan;133(1):83-97. Epub 2009 Jun 2. Transplantation of BMCs and concurrent treatment with FGF2 caused a statistically significant reduction in CCl (4)-induced liver fibrosis that was accompanied by strong expression of matrix metalloproteinase 9 as compared with FGF2-only treatment or BMT alone. |
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| 18624898 | Watanabe M, Murata S, Hashimoto I, Nakano Y, Ikeda O, Aoyagi Y, Matsuo R, Fukunaga K, Yasue H, Ohkohchi N: Platelets contribute to the reduction of liver fibrosis in mice. J Gastroenterol Hepatol. 2009 Jan;24(1):78-89. Epub 2008 Jun 25. METHODS: To induce liver fibrosis, C57BL6 female mice were injected i.p. with 1 mL/kg carbon tetrachloride (CCl (4)) twice a week for 8 weeks. Platelets suppressed increments in mRNA expression for transforming growth factor-beta, and increased matrix metalloproteinase-9 expression in the liver. |
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| 19488682 | Ding M, Potter JJ, Liu X, Torbenson MS, Mezey E: supplementation decreases hepatic fibrosis in mice after chronic carbon tetrachloride administration. J Huazhong Univ Sci Technolog Med Sci. 2005;25(2):166-9 Liver matrix metalloproteinase-9 increased after CCl (4) with Se supplementation. |
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| 17944888 | Hsiao Y, Zou T, Ling CC, Hu H, Tao XM, Song HY: Disruption of tissue-type plasminogen activator gene in mice aggravated liver fibrosis. Gastroenterology. 2004 Apr;126(4):1122-33; discussion 949. The aim of this study is to investigate the role of tPA in carbon tetrachloride (CCl (4))-induced liver fibrosis. On the other hand, the decrease of matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9) activities, metalloproteinase-13 (MMP-13) expression and a marked increase of tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) expression were found in the liver of CCl (4) administrated tPA (-/-) mice compared with wild-type counterparts. |
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| 16097045 | Shi MN, Zheng WD, Zhang LJ, Chen ZX, Wang XZ: Effect of IL-10 on the expression of HSC growth factors in hepatic fibrosis rat. J Hepatol. 2007 Dec;47(6):834-43. Epub 2007 Sep 25. At the beginning of the 7th and 11th wk, rats in each group were routinely perfused with pronase E and type IV collagenase through a portal vein catheter and the suspension obtained from the liver was spun by centrifugation with 11% Nycodenz density gradient to isolate HSCs. |
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| 17714472 | Asano Y, Iimuro Y, Son G, Hirano T, Fujimoto J: Hepatocyte growth factor promotes remodeling of murine liver fibrosis, accelerating recruitment of bone marrow-derived cells into the liver. Hepatol Res. 2007 Dec;37(12):1080-94. Epub 2007 Aug 20. Methods: C57BL/6 J mice were treated with carbon tetrachloride (CCl (4)) for 10 weeks. This phenomenon was accompanied byincreased gelatinase activity in the liver. |
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| 17935821 | Miura K, Yoshino R, Hirai Y, Goto T, Ohshima S, Mikami K, Yoneyama K, Watanabe D, Sato M, Senoo H, Kodama Y, Osawa Y, Brenner DA, Watanabe S: Epimorphin, a morphogenic protein, induces proteases in rodent hepatocytes through NF-kappaB. 222. First, we explored the relationship between epimorphin expression and distribution of protease-positive cells in carbon tetrachloride-induced acute liver injury. In vitro, epimorphin induced matrix metalloproteinase (MMP) 9, MMP 3 and urokinase type plasminogen activator (uPA) in hepatocytes. |
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