Protein Information

Name angiopoietin 1
Synonyms AGP1; AGP1; Ang1; AGPT; ANG 1; ANGPT 1; ANGPT1; Angiopoietin 1 precursor…

Compound Information

Name carbon tetrachloride
CAS tetrachloromethane

Reference List

PubMed Abstract RScore(About this table)
15135347 Kimura H, Mochida S, Inao M, Matsui A, Fujiwara K: Angiopoietin/tie receptors system may play a role during reconstruction and capillarization of the hepatic sinusoids after partial hepatectomy and liver necrosis in rats. Hepatol Res. 2004 May;29(1):51-59.

Hepatic mRNA expressions of angiopoietin-1, angiopoietin-2 and tie-2 were increased at 168h after 70% liver resection with sinusoidal reconstruction in rats, and also at 48h with sinusoidal capillarization in the liver of rats given carbon tetrachloride (CCl (4)).
8(0,0,1,3) Details
18823985 Taura K, De Minicis S, Seki E, Hatano E, Iwaisako K, Osterreicher CH, Kodama Y, Miura K, Ikai I, Uemoto S, Brenner DA: Hepatic stellate cells secrete angiopoietin 1 that induces angiogenesis in liver fibrosis. Gastroenterology. 2008 Nov;135(5):1729-38. Epub 2008 Aug 3.

7(0,0,0,7) Details
19650157 Osterreicher CH, Taura K, De Minicis S, Seki E, Penz-Osterreicher M, Kodama Y, Kluwe J, Schuster M, Oudit GY, Penninger JM, Brenner DA: Angiotensin-converting-enzyme 2 inhibits liver fibrosis in mice. Hepatology. 2009 Sep;50(3):929-38.

The aim of this study was to characterize the long-term effects of gene deletion of ACE2 in the liver, to define the role of ACE2 in acute and chronic liver disease, and to characterize the role of Ang (1-7) in hepatic stellate cell (HSC) activation.
Ace2 KO mice showed increased liver fibrosis following bile duct ligation for 21 days or chronic carbon tetrachloride (CCl (4)) treatment.
2(0,0,0,2) Details