| Name | caspase (protein family or complex) |
|---|---|
| Synonyms | caspase; caspases |
| Name | carbon tetrachloride |
|---|---|
| CAS | tetrachloromethane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18724385 | Campo GM, Avenoso A, Campo S, Nastasi G, Traina P, D'Ascola A, Rugolo CA, Calatroni A: The antioxidant activity of -4-sulphate, in carbon tetrachloride-induced acute hepatitis in mice, involves NF-kappaB and caspase activation. Br J Pharmacol. 2008 Nov;155(6):945-56. Epub 2008 Aug 25. |
35(0,1,1,5) | Details |
| 19966836 | Dai L, Ji H, Kong XW, Zhang YH: Antifibrotic effects of ZK14, a novel -donating biphenyldicarboxylate derivative, on rat HSC-T6 cells and CCl4-induced hepatic fibrosis. Acta Pharmacol Sin. 2010 Jan;31(1):27-34. Epub 2009 Dec 7. Mitochondrial membrane potential (MMP) and caspase activities were tested. |
2(0,0,0,2) | Details |
| 18507761 | Yan C, Zhou L, Han YP: Contribution of hepatic stellate cells and matrix metalloproteinase 9 in acute liver failure. Liver Int. 2008 Aug;28(7):959-71. Epub 2008 May 27. METHODS: Mice were given lipopolysaccharide (LPS) and beta-galactosamine (GA) or carbon tetrachloride to create ALF and establish the association of IL-1, MMP-9, and caspase-3 in acute liver failure. In contrast, MMP-9 knockout mice were resistant to lethality and absent of caspase-3 activation, demonstrating an MMP-9-dependent activation of caspase in vivo. |
1(0,0,0,1) | Details |
| 19385008 | Tang X, Yang J, Li J: Accelerative effect of leflunomide on recovery from hepatic fibrosis involves TRAIL-mediated hepatic stellate cell apoptosis. Life Sci. 2009 Apr 10;84(15-16):552-7. MAIN METHODS: We harvested Kupffer cells from rats during spontaneous recovery from liver fibrosis induced by carbon tetrachloride (CCl4) and prepared recovery Kupffer cell conditioned medium (KCCM). KEY FINDINGS: Following stimulation with recovery KCCM, HSCs showed a decrease in proliferation and an increase in apoptosis by a caspase-dependent mechanism. |
1(0,0,0,1) | Details |
| 17292878 | Park EJ, Zhao YZ, Kim YC, Sohn DH: Bakuchiol-induced caspase-3-dependent apoptosis occurs through c-Jun NH2-terminal kinase-mediated mitochondrial translocation of Bax in rat liver myofibroblasts. Eur J Pharmacol. 2007 Mar 22;559(2-3):115-23. Epub 2007 Jan 23. Bakuchiol-induced apoptosis was prevented by z-DEVD-fmk, a specific inhibitor of caspase-3, and z-VAD-fmk, a general caspase inhibitor, suggesting that bakuchiol-induced apoptosis occurs through a caspase-3-dependent pathway in vitro. |
1(0,0,0,1) | Details |
| 17466404 | Anselmi K, Stolz DB, Nalesnik M, Watkins SC, Kamath R, Gandhi CR: Gliotoxin causes apoptosis and necrosis of rat Kupffer cells in vitro and in vivo in the absence of oxidative stress: exacerbation by caspase and serine protease inhibition. J Hepatol. 2007 Jul;47(1):103-13. Epub 2007 Apr 5. |
1(0,0,0,1) | Details |
| 18595136 | Tasduq SA, Kaiser PJ, Gupta BD, Gupta VK, Johri RK: Negundoside, an irridiod glycoside from leaves of Vitex negundo, protects human liver cells against -mediated toxicity induced by carbon tetrachloride. World J Gastroenterol. 2008 Jun 21;14(23):3693-709. Decreased mitochondrial membrane potential (MMP), induction of caspases mediated DNA fragmentation and cell cycle arrest, as a result of CCl (4) treatment, were also blocked by NG. |
1(0,0,0,1) | Details |
| 15692606 | Asoh S, Mori T, Nagai S, Yamagata K, Nishimaki K, Miyato Y, Shidara Y, Ohta S: Zonal necrosis prevented by transduction of the artificial anti-death FNK protein. Cell Death Differ. 2005 Apr;12(4):384-94. Here, we show protein transduction domain (PTD)-FNK therapeutics based on protein transduction to prevent necrosis and acute hepatic injury with zonal death induced by carbon tetrachloride (CCl4). |
0(0,0,0,0) | Details |