Protein Information

Name CCl 3
Synonyms CCL 3; CCL3; G0/G1 switch regulatory protein 19 1; G0S19 1; G0S19 1 protein; LD78 alpha; LD78ALPHA; MIP 1 alpha Tonsillar lymphocyte LD78 alpha protein…

Compound Information

Name carbon tetrachloride
CAS tetrachloromethane

Reference List

PubMed Abstract RScore(About this table)
18440118 Soni B, Visavadiya NP, Madamwar D: Ameliorative action of cyanobacterial phycoerythrin on CCl (4)-induced toxicity in rats. Toxicology. 2008 Jun 3;248(1):59-65. Epub 2008 Mar 18.

The in vivo metabolism of carbon tetrachloride to trichloromethyl (CCl (3)) and peroxy trichloromethyl (OOCCl (3)) radicals has been extensively reported to cause acute liver damage like cirrhosis, steatosis and necrosis.
31(0,1,1,1) Details
17405876 Pan X, Hussain FN, Iqbal J, Feuerman MH, Hussain MM: Inhibiting proteasomal degradation of microsomal triglyceride transfer protein prevents CCl4-induced steatosis. J Biol Chem. 2007 Jun 8;282(23):17078-89. Epub 2007 Apr 3.

Carbon tetrachloride (CCl (4)) interferes with triglyceride secretion and causes steatosis, fibrosis, and necrosis.
This modification was prevented by the inhibition of P450 oxygenases, indicating that CCl (3)(.) generated by these enzymes targets MTP for degradation.
1(0,0,0,1) Details
15998439 Liu GT, Li Y, Wei HL, Zhang H, Xu JY, Yu LH: Mechanism of protective action of bicyclol against CCl-induced liver injury in mice. Liver Int. 2005 Aug;25(4):872-9.


Mechanistic studies demonstrated that bicyclol significantly inhibited CCl (4)-induced lipid peroxidation of liver microsomes and (14) CCl (4) covalent binding to microsomal lipids and proteins in vitro, and decreased the level of the trichloromethyl free radical (*CCl (3)) generated from CCl (4) metabolism by NADPH-reduced liver microsomes.
1(0,0,0,1) Details
19635677 Lee M, Oh J: Sonolysis of trichloroethylene and carbon tetrachloride in aqueous solution. Ultrason Sonochem. 2010 Jan;17(1):207-12. Epub 2009 Jul 3.

The enhancement of TCE degradation is attributed to both the increase of hydroxyl radical concentration by scavenging of CT for hydrogen atoms and the generation of chlorine-containing radicals such as CCl (3)(*), CCl (2)(*), Cl (*), and HClO from pyrolysis of CT during sonolysis of CT.
1(0,0,0,1) Details
17134213 Lu G, Lan J, Li C, Wang W, Wang C: Theoretical study of CCl (4) adsorption and hydrogenation on a Pt (111) surface. J Phys Chem B. 2006 Dec 7;110(48):24541-8.

The adsorption and hydrogenation of carbon tetrachloride (CCl (4)) on a Pt (111) surface have been investigated using density functional theory (DFT).
The hydrogenation of CCl (3). was studied at the on-top site of the Pt (15) cluster, and the calculated activation energy is 5.06 kcal/mol.
1(0,0,0,1) Details
19317396 Chen CH, Hsiao J, Su MD: Abstraction reactions of heavy cyclobutenes with carbon tetrachloride. J Phys Chem A. 2009 Apr 16;113(15):3602-9.

All the interactions involve a Cl or CCl (3) shift via a two-center transition state.
1(0,0,0,1) Details
16246573 Chen H, Cooks RG, Meurer EC, Eberlin MN: Hydrogen/Chlorine exchange reactions of gaseous carbanions. J Am Soc Mass Spectrom. 2005 Dec;16(12):2045-51. Epub 2005 Oct 24.


For example, reaction between the nitromethyl anion CH (2) NO (2)(-) and carbon tetrachloride CCl (4) forms the ion CHClNO (2)(-).
0(0,0,0,0) Details