Protein Information

Name arginase
Synonyms ARG 1; ARG1; Arginase; Arginase 1; Arginine amidinase; Canavanase; Liver type arginase; Type I arginase…

Compound Information

Name carbon tetrachloride
CAS tetrachloromethane

Reference List

PubMed Abstract RScore(About this table)
16459053 Mendez JD, De Haro Hernandez R, Conejo VA: Spermine increases arginase activity in the liver after carbon tetrachloride-induced hepatic injury in Long-Evans rats. Biomed Pharmacother. 2006 Feb;60(2):82-5. Epub 2005 Dec 27.

The present study evaluated the possibility that spermine increases arginase activity and reduces liver damage caused by carbon tetrachloride.
94(1,1,3,4) Details
18279670 Murayama H, Ikemoto M, Fukuda Y, Nagata A: Superiority of serum type-I arginase and ornithine carbamyltransferase in the detection of toxicant-induced acute hepatic injury in rats. Clin Chim Acta. 2008 May;391(1-2):31-5. Epub 2008 Jan 31.

METHODS: Rats were administered carbon tetrachloride, allyl alcohol, D-galactosamine, lipopolysaccharide, and concanavalin A and the course of damage was monitored by serum ARG and OCT, together with alanine aminotransferase (ALT) and aspartate aminotransferase (AST).
2(0,0,0,2) Details
15052875 Savilov PN: [The ammonia neutralization function of the liver in chronic active hepatitis]. Patol Fiziol Eksp Ter. 2004 Jan-Mar;(1):24-6.


It is suggested that the reason of these changes is inhibition activity of glutamate dehydrogenase, arginase and short-term depression activity of phosphate-dependent glutaminase.
1(0,0,0,1) Details
20103580 Pooranaperundevi M, Sumiyabanu MS, Viswanathan P, Sundarapandiyan R, Anuradha CV: Insulin resistance induced by high-fructose diet potentiates carbon tetrachloride hepatotoxicity. Toxicol Ind Health. 2010 Mar;26(2):89-104. Epub 2010 Jan 26.

Liver dysfunction in fructose-fed rats was evident from a rise in transaminases, total bilirubin and a decrease in albumin/globulin ratio in plasma and decreases in nitrite, arginase and increase in protein carbonyl and nitrosothiol content in liver.
1(0,0,0,1) Details
16325526 Minin EA, Buchwalow IB, Wellner M, Palmes D, Spiegel HU, Neumann J, Boecker W, Herbst H: L-Arginine-NO-cGMP signaling following acute liver injury in the rat. Exp Toxicol Pathol. 2005 Nov;57(2):161-71. Epub 2005 Oct 5.


To address this issue, we investigated the expression of key enzymes engaged in the control of NO signaling in the rat liver after carbon tetrachloride (CCl4) intoxication and subsequent regeneration.
0(0,0,0,0) Details