| Name | sPLA2 |
|---|---|
| Synonyms | GX sPLA2; sPLA2; GXPLA 2; GXPLA2; GXSPLA 2; GXSPLA2; Group 10 secretory phospholipase A2; Group 10 secretory phospholipase A2 precursor… |
| Name | carbon tetrachloride |
|---|---|
| CAS | tetrachloromethane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17142963 | Moon TC, Hwang HS, Quan Z, Son KH, Kim CH, Kim HP, Kang SS, Son JK, Chang HW: Ochnaflavone, naturally occurring biflavonoid, inhibits phospholipase A2 dependent phosphatidylethanolamine degradation in a CCl4-induced rat liver microsome. Biol Pharm Bull. 2006 Dec;29(12):2359-61. This study investigated the protective effects of a group IIA secretory phospholipase A2 (sPLA2-IIA) inhibitor, ochnaflavone, on the progression of carbon tetrachloride (CCl4)-induced acute liver injury in rat liver microsomes in vitro. |
32(0,1,1,2) | Details |
| 18329682 | Bhave VS, Donthamsetty S, Latendresse JR, Muskhelishvili L, Mehendale HM: Secretory phospholipase A2 mediates progression of acute liver injury in the absence of sufficient cyclooxygenase-2. Toxicol Appl Pharmacol. 2008 Apr 15;228(2):225-38. Epub 2008 Jan 3. Under normal conditions, after exposure to low to moderate doses of toxicants, secretory phospholipase A (2) (sPLA (2)) and other hydrolytic enzymes are known to appear in the extracellular spaces in order to cleanup the post-necrotic debris in tissues. |
7(0,0,0,7) | Details |
| 18336855 | Bhave VS, Donthamsetty S, Latendresse JR, Mehendale HM: Inhibition of cyclooxygenase-2 aggravates secretory phospholipase A2-mediated progression of acute liver injury. Toxicol Appl Pharmacol. 2008 Apr 15;228(2):239-46. Epub 2008 Jan 4. Toxicol Appl Pharmacol] showed that in the absence of sufficient induction and co-presence of cyclooxygenase-2 (COX-2), secretory phospholipase A (2) (sPLA (2)) appearing in the intercellular spaces for cleanup of post-necrotic debris seems to contribute to the progression of toxicant-initiated liver injury, possibly by hydrolysis of membrane phospholipids of hepatocytes in the perinecrotic areas. |
3(0,0,0,3) | Details |