| Name | cytochrome P450 (protein family or complex) |
|---|---|
| Synonyms | cytochrome P450; cytochrome P 450; CYP450; CYP 450 |
| Name | carbon tetrachloride |
|---|---|
| CAS | tetrachloromethane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19140516 | Zabrodskii PF, Drevko BI, Mandych VG, Germanchuk VG, Balashov SV, Kuz'min AV: [Changes in the toxicity and immunotoxity of tetrachloromethane and carbophos under the action of 2,4,6-triphenyl-4H-selenopyran and their connection with cytochrome P-450 dependent monooxygenase system]. Eksp Klin Farmakol. 2008 Nov-Dec;71(6):42-4. It is established in experiments on noninbred rats that 2,4,6-triphenyl-4H-selenopyrane (peroral administration in a dose of 0.8 mg/kg during 3 days) induces cytochrome P450, thus increasing the toxicity and immunotoxicity of carbon tetrachloride (metabolized via "lethal synthesis"), and reduces the analogous effects of carbophos, the biotransformation of which proceeds via the formation of low-toxicity and nontoxic metabolites. |
32(0,1,1,2) | Details |
| 16434548 | Joshi M, Tyndale RF: Induction and recovery time course of rat brain CYP2E1 after treatment. Drug Metab Dispos. 2006 Apr;34(4):647-52. Epub 2006 Jan 24. CYP2E1, the primary -metabolizing cytochrome P450, metabolizes endogenous substrates (e.g., and drugs (e.g., chlorzoxazone) and bioactivates procarcinogens (e.g., tobacco-specific nitrosamines) and toxins (e.g., carbon tetrachloride). |
31(0,1,1,1) | Details |
| 16162422 | Qin LQ, Wang PY, Wang Y, Kaneko T, Hoshi K, Sato A: Voglibose potentiates the hepatotoxicity of carbon tetrachloride and by inducing CYP2E1 in rats. Hepatol Res. 2005 Sep;33(1):50-6. Epub 2005 Sep 12. METHOD:: In the present study, we studied the effects of voglibose on the hepatotoxicity of carbon tetrachloride (CCl (4)) and in rats, since both of these agents exert their effects through isoforms of cytochrome P450. |
7(0,0,1,2) | Details |
| 19177741 | Ibrahim ZS, Ishizuka M, Soliman M, ElBohi K, Sobhy W, Muzandu K, Elkattawy AM, Sakamoto KQ, Fujita S: Protection by Nigella sativa against carbon tetrachloride-induced downregulation of hepatic cytochrome P450 isozymes in rats. Jpn J Vet Res. 2008 Nov;56(3):119-28. |
7(0,0,1,2) | Details |
| 19067753 | Bhadauria M, Nirala SK, Shrivastava S, Sharma A, Johri S, Chandan BK, Singh B, Saxena AK, Shukla S: Emodin reverses CCl induced hepatic cytochrome P450 (CYP) enzymatic and ultrastructural changes: The in vivo evidence. Hepatol Res. 2009 Mar;39(3):290-300. Epub 2008 Dec 2. Aim: The curative effect of emodin (1,3,8-trihydroxy-6-methyl anthraquinone), an active compound of the plant species Ventilago maderaspatana Gaertn, was evaluated against carbon tetrachloride (CCl (4)) induced hepatic cytochrome P450 (CYP) enzymatic and ultrastructural alterations in rats. |
7(0,0,1,2) | Details |
| 17606319 | Jia N, Liu X, Wen J, Qian L, Qian X, Wu Y, Fan G: A proteomic method for analysis of CYP450s protein expression changes in carbon tetrachloride induced male rat liver microsomes. Toxicology. 2007 Jul 31;237(1-3):1-11. Epub 2007 May 5. Cytochrome P450 is an important monooxygenase in biology. |
4(0,0,0,4) | Details |
| 19595748 | Chan WH, Liao JW, Chou CP, Chan PK, Wei CF, Ueng TH: Induction of CYP1A1, 2B, 2E1 and 3A in rat liver by organochlorine pesticide dicofol. Toxicol Lett. 2009 Oct 28;190(2):150-5. Epub 2009 Jul 10. The present study has determined the ability of dicofol, an organochlorine pesticide, to induce cytochrome P450 using rats treated with 1, 10, and 25mg/kg dicofol intraperitoneally for 4 days. |
2(0,0,0,2) | Details |
| 17984565 | Antelava NA, Gogoluari MI, Gogoluari LI, Pirtskhalaishvili NN, Okudzhava MV: [Efficacy and safety of heptral, vitamin B6 and during toxic hepatitis induced by CCL4]. Georgian Med News. 2007 Sep;(150):53-6. Cytochrome P450, cytochrome b5, reduced glutation,activity of glutationetranspherase and content of ATP in hepatocytes were measured by the spectrophotometric techniques,but content of by chromophtography techniques. |
2(0,0,0,2) | Details |
| 16076768 | Chan WH, Sun WZ, Ueng TH: Induction of rat hepatic cytochrome P-450 by ketamine and its toxicological implications. J Toxicol Environ Health A. 2005 Sep;68(17-18):1581-97. |
2(0,0,0,2) | Details |
| 17973928 | Chen M, Xu D, Hu XL, Wang H: Effects of liver fibrosis on pharmacokinetics in rats. Clin Exp Pharmacol Physiol. 2008 Mar;35(3):287-94. Epub 2007 Oct 31. The present study was designed to observe the changes in pharmacokinetics in rats with early liver fibrosis with respect to alterations in cytochrome P450 3A (CYP3A) and P-glycoprotein (P-gp). 2. A rat liver fibrosis model was successfully established using several inducers, including a high-fat diet, and carbon tetrachloride. |
1(0,0,0,1) | Details |
| 15997120 | Tasduq SA, Mondhe DM, Gupta DK, Baleshwar M, Johri RK: Reversal of fibrogenic events in liver by Emblica officinalis (fruit), an Indian natural drug. Biol Pharm Bull. 2005 Jul;28(7):1304-6. A hydroalcoholic (50%) extract of Emblica officinalis (fruit) (EO-50) reduced the severity of hepatic fibrosis induced by carbon tetrachloride (CCl4) and thioacetamide (TAA). Hepatic parameters monitored were the levels of lipid peroxidation (LPO) and and the activities of catalase, peroxidase (GPx), Na+,K+-ATPase and cytochrome P450 (CYP 450 2E1) hydroxylation). |
1(0,0,0,1) | Details |
| 18657875 | Khurana S, Mukhopadhyay A: In vitro transdifferentiation of adult hematopoietic stem cells: an alternative source of engraftable hepatocytes. J Hepatol. 2008 Dec;49(6):998-1007. Epub 2008 Jun 18. Cellular changes were determined by examining ultrastructure, and the functional activity was confirmed by cytochrome p450 enzyme assay. |
1(0,0,0,1) | Details |
| 16614485 | Mizuguchi S, Takemura S, Minamiyama Y, Kodai S, Tsukioka T, Inoue K, Okada S, Suehiro S: S-allyl attenuated CCl4-induced oxidative stress and pulmonary fibrosis in rats. Biofactors. 2006;26(1):81-92. This study examined effects of S-allyl (SAC) on carbon tetrachloride (CCl4)-induced interstitial pulmonary fibrosis in Wistar rats. Although CCl4 is mainly metabolized by hepatic cytochrome P450, CCl4 induced systemic inflammation and some organ fibrosis. |
1(0,0,0,1) | Details |
| 16445600 | Yim HK, Jung YS, Kim SY, Kim YC: Contrasting changes in phase I and phase II metabolism of in male mice pretreated with carbon tetrachloride. Basic Clin Pharmacol Toxicol. 2006 Feb;98(2):225-30. Expression of cytochrome P450 (CYP) isozymes was determined using antibodies of 2E1 and 1A2 as probes. |
1(0,0,0,1) | Details |
| 18547752 | Yamaji K, Ochiai Y, Ohnishi K, Yawata A, Chikuma T, Hojo H: Up-regulation of hepatic heme oxygenase-1 expression by locally induced interleukin-6 in rats administered carbon tetrachloride intraperitoneally. Toxicol Lett. 2008 Jul 10;179(3):124-9. Epub 2008 May 2. The present data indicate that hepatic HO-1 is up-regulated by endogenously produced IL-6, in addition to its up-regulation by heme derived from cytochrome P450 which has already been reported in rats administered i.p. |
1(0,0,0,1) | Details |
| 18706400 | Liu J, Wu Q, Lu YF, Pi J: New insights into generalized hepatoprotective effects of oleanolic acid: key roles of metallothionein and Nrf2 induction. Biochem Pharmacol. 2008 Oct 1;76(7):922-8. Epub 2008 Jul 23. Oleanolic acid (OA) is a natural triperpenoid that protects against a variety of hepatotoxicants such as carbon tetrachloride, cadmium, and bromobenzene. OA treatment also increased the expression of genes related to cell proliferation and suppressed the expression of several cytochrome P450 genes possibly to switch cellular metabolic energy to an acute-phase response. |
1(0,0,0,1) | Details |
| 19496777 | Singh D, Singh R, Singh P, Gupta RS: Effects of Embelin on Lipid Peroxidation and Free Radical Scavenging Activity against Liver Damage in Rats. Basic Clin Pharmacol Toxicol. 2009 May 26. Carbon tetrachloride (CCl (4)) treatment to rats has been more susceptible to peroxidative damage through production of reactive metabolites, namely trichloromethyl-free radicals ( and/or ) as measured by thiobarbituric acid reactive species. After the induction of liver damage by CCl (4) intoxication to rats, the concentration of lipid peroxidation was significantly (P liver and serum, along with concomitant decrease in the levels of antioxidants and cytochrome P450 enzyme in liver as compared to vehicle controls. |
1(0,0,0,1) | Details |
| 19915331 | Asaoka Y, Sakai H, Hirata A, Sasaki J, Goryo M, Miyamoto Y, Yanai T, Masegi T, Okada K: Detection of Initiation Activity of 1,2-Dimethylhydrazine in in vivo Medium-Term Liver Initiation Assay System using 4-Week-Old Rats without Hepatocellular Proliferative Stimuli during the Test Chemical Treatment Period. J Vet Med Sci. 2010 Feb;72(1):43-53. Epub 2009 Nov 13. In this study, we confirmed that 4-week-old and 4.5-week-old male rats have high hepatocyte proliferation activity and similar enzyme activities of hepatic Cytochrome P450 subtypes as compared with 8-week-old male rats. Four-week-old rats were orally administered DMH (single dose, 4 or 16 mg/kg; or 4-day repeat, 1 or 4 mg/kg); subsequently, these rats were treated promotion treatment consisted of administration of 2-acetylaminofluorene and carbon tetrachloride. |
1(0,0,0,1) | Details |
| 16700327 | Ochenashko OV, Volkova NA, Mazur SP, Somov AY, Fuller BJ, Petrenko AY: Cryopreserved fetal liver cell transplants support the chronic failing liver in rats with CCl4-induced cirrhosis. Cell Transplant. 2006;15(1):23-33. The aim of this work was to test the efficacy of human fetal liver cells to support the chronic failing liver in an experimental model of carbon tetrachloride (CCl4)-induced cirrhosis in rats. Cell transplantation into the spleen normalized total and TBARSs levels and increased albumin levels in blood serum, as well as restoring mitochondrial function and liver detoxification function (assessed by cytochrome P450 contents and activity) compared with the activities seen in the cirrhosis control group. |
1(0,0,0,1) | Details |
| 17151463 | Morita H, Yoshikawa H, Takizawa T, Shirai M, Akahori F, Yoshimura T: The formation of g=2.49-species of cytochrome P450 in the rat liver by PCB126 oral administration: identification of heme axial ligands by EPR spectroscopy. Biosci Biotechnol Biochem. 2006 Dec;70(12):2974-81. Epub 2006 Dec 7. The EPR spectra of the livers from the control group, carbon tetrachloride-, 3-methylcholanthrene-, and 3,3',4,4',5-pentachlorobiphenyl (PCB126)-treated rats exhibited an EPR spectrum at g=2.40, 2.24, and 1.93, which is characteristic of P450 in a resting state. |
1(0,0,0,1) | Details |
| 15779771 | Bauder MB, Palace VP, Hodson PV: Is oxidative stress the mechanism of blue sac disease in retene-exposed trout larvae?. Environ Toxicol Chem. 2005 Mar;24(3):694-702. The signs of BSD include cytochrome P450 (CYP1A) induction, edema, hemorrhaging, and craniofacial deformities, indicating membrane damage, circulatory failure, and impaired development. To test if the underlying cause was oxidative stress, rainbow trout (Oncorhynchus mykiss) larvae were exposed to waterborne retene or to known prooxidants (paraquat, t-butyl hydroperoxide, and carbon tetrachloride) in the presence or absence of an antioxidant. |
1(0,0,0,1) | Details |
| 15992118 | Wu J, Danielsson A, Zern MA: Toxicity of hepatotoxins: new insights into mechanisms and therapy. Expert Opin Investig Drugs. 1999 May;8(5):585-607. Liver injury caused by hepatotoxins, such as carbon tetrachloride (CCl4), and is characterised by varying degrees of hepatocyte degeneration and cell death via either apoptosis or necrosis. The metabolism of hepatotoxins by cytochrome P-450 enzyme subtypes is a key step of the intoxication; therefore, enzyme inhibitors are shown to minimise the hepatotoxin-associated liver damage. |
1(0,0,0,1) | Details |
| 15988118 | Kose N, Yamamoto K, Sai Y, Isawa M, Suwa T, Nakashima E: Prediction of clearance in CCl4-treated rats using in vivo CYP1A2 and CYP3A2 contents assessed with the PKCYP test. Drug Metab Pharmacokinet. 2005 Jun;20(3):168-76. We previously established a method to predict the drug metabolism capacity of injured liver based on pharmacokinetic estimation of the amount of cytochrome P450 (CYP) in vivo (PKCYP test), by introducing the apparent liver-to-blood free concentration gradient in vivo (qg) as a parameter. |
1(0,0,0,1) | Details |
| 15619608 | Matsunaga NK, Isawa M, Kizu J, Miyazaki N, Takanaka A, Nakashima E: Application of the PKCYP test to predict clearance mediated by CYP1A2 in a rat acute liver injury model. Drug Metab Pharmacokinet. 2003;18(5):296-302. We previously established a method for assessing in vivo drug-metabolizing capacity by pharmacokinetic estimation of the quantity of cytochrome P450 (CYP) in vivo (PKCYP test), in which an apparent liver-to-blood free concentration gradient in vivo (qg) is introduced (Matsunaga et al., Jpn. This method was applied to estimate the amount of CYP2C11 in rats treated with carbon tetrachloride (CCl (4)-treated rats). |
1(0,0,0,1) | Details |
| 15250698 | Blair E, Greaves J, Farmer PJ: High-temperature electrocatalysis using thermophilic P450 CYP119: dehalogenation of CCl4 to CH4. J Am Chem Soc. 2004 Jul 21;126(28):8632-3. The use of a thermophilic cytochrome P450, CYP119, in electrocatalytic dehalogenations of C1 halocarbon solvents is studied. |
1(0,0,0,1) | Details |
| 15763544 | Caro AA, Cederbaum AI: Inhibition of CYP2E1 catalytic activity in vitro by Biochem Pharmacol. 2005 Apr 1;69(7):1081-93. Since the K (i) for SAM inhibition of CYP2E1 activity is relatively high, inhibition of CYP2E1 activity is not likely to play a major role in the ability of SAM to protect against the hepatotoxicity produced by toxins requiring metabolic activation by CYP2E1 such as carbon tetrachloride, thioacetamide and carcinogens. The objective of this work was to evaluate the possible in vitro interactions of (SAM) and its metabolites S-(5'- (SAH), 5'-Deoxy-5'-(methylthio) (MTA) and with cytochrome P450 enzymes, in particular CYP2E1. |
1(0,0,0,1) | Details |
| 17539816 | Hubich AI, Bondar AY, Kastsiuk TU, Kastsiuk UA, Lakhvich FA, Sholukh MV: Hepatoprotective action of prostaglandin A (2) analogs under CCl (4)-induced liver injury in vitro. Hepatol Res. 2007 Jun;37(6):416-24. Aim: The cytoprotective effects of six novel synthetic prostaglandin A (2) analogs against carbon tetrachloride (CCl (4)) as a toxic agent were studied with isolated rat liver hepatocytes in vitro. They were also able to inhibit CCl (4) effects via decreasing cytochrome P (450) 2E1 activity. |
1(0,0,0,1) | Details |
| 20233594 | Chen P, Kakan X, Zhang J: Altered circadian rhythm of the clock genes in fibrotic livers induced by carbon tetrachloride. FEBS Lett. 2010 Mar 15. Associatively, the expressions of two important clock-regulated genes peroxisome proliferator-activated receptor alpha and cytochrome P450 oxidoreductase lost circadian rhythm with significantly decreased levels during the light-dark (12/12h) cycle in fibrotic livers. |
1(0,0,0,1) | Details |
| 20182823 | Piryaei A, Valojerdi MR, Shahsavani M, Baharvand H: Differentiation of Bone Marrow-derived Mesenchymal Stem Cells into Hepatocyte-like Cells on Nanofibers and Their Transplantation into a Carbon Tetrachloride-Induced Liver Fibrosis Model. Stem Cell Rev. 2010 Feb 25. production, secretion of albumin and alpha-fetoprotein, and metabolic activity of the CYP450 enzymes were significantly increased within in vitro differentiated HLCs on nanofibers at day 36. |
1(0,0,0,1) | Details |
| 17268055 | Abe S, Suyama S, Chiba S, Nakao H, Ohtake Y, Ohkubo Y: The uptake mechanism of gallium-67 into hepatocytes treated with carbon tetrachloride. Biol Pharm Bull. 2007 Feb;30(2):224-9. Hepatotoxic damages by CCl4 are mostly attributed to radical formed by an action of cytochrome P450. |
1(0,0,0,1) | Details |
| 15931870 | Liang J, Zhang XL, Yang GY, Pang YS, Yuan HF, Liang JS, Huang RB: [Observation of the promotion effect on hepatic stellate cell's apoptosis in rat hepatic fibrosis model]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2005 May;36(3):365-7. OBJECTIVE: To observe the effect of on hepatic stellate cell's apoptosis induced by carbon tetrachloride (CCl4) in rats and to study its protective mechanisms. The hepatic cytochrome P450 (Cyt. |
1(0,0,0,1) | Details |
| 15046820 | Fukao T, Hosono T, Misawa S, Seki T, Ariga T: The effects of allyl sulfides on the induction of phase II detoxification enzymes and liver injury by carbon tetrachloride. Food Chem Toxicol. 2004 May;42(5):743-9. |
0(0,0,0,0) | Details |
| 16182555 | Wang H, Liao ZX, Chen M, Hu XL: Effects of hepatic fibrosis on ofloxacin pharmacokinetics in rats. Pharmacol Res. 2006 Jan;53(1):28-34. Epub 2005 Sep 21. The possible roles of small intestinal P-glycoprotein (P-gp) and cytochrome P450 (CYP) in the bioavailability of ofloxacin were also evaluated. Rat hepatic fibrosis model was successfully induced using complex factors including carbon tetrachloride, and high fat. |
1(0,0,0,1) | Details |
| 18353473 | Van Aken B: Transgenic plants for phytoremediation: helping nature to clean up environmental pollution. Trends Biotechnol. 2008 May;26(5):225-7. Epub 2008 Mar 18. A recent publication by Doty and colleagues describes the development of transgenic poplars (Populus) overexpressing a mammalian cytochrome P450, a family of enzymes commonly involved in the metabolism of toxic compounds. The engineered plants showed enhanced performance with regards to the metabolism of trichloroethylene and the removal of a range of other toxic volatile organic pollutants, including vinyl carbon tetrachloride, chloroform and |
1(0,0,0,1) | Details |
| 16288784 | Sugiyama T, Nagata J, Yamagishi A, Endoh K, Saito M, Yamada K, Yamada S, Umegaki K: Selective protection of against carbon tetrachloride-induced inactivation of hepatic cytochrome P450 isozymes in rats. Life Sci. 2006 Apr 4;78(19):2188-93. Epub 2005 Nov 8. |
82(1,1,1,2) | Details |
| 14713368 | Lee TY, Wang GJ, Chiu JH, Lin HC: Long-term administration of Salvia miltiorrhiza ameliorates carbon tetrachloride-induced hepatic fibrosis in rats. J Pharm Pharmacol. 2003 Nov;55(11):1561-8. Carbon tetrachloride (CCl4) is metabolized by cytochrome P450 to form a reactive trichloromethyl radical that triggers a chain of lipid peroxidation. |
81(1,1,1,1) | Details |
| 17275847 | Eipel C, Eisold M, Schuett H, Vollmar B: Inhibition of heme oxygenase-1 protects against tissue injury in carbon tetrachloride exposed livers. J Surg Res. 2007 May 1;139(1):113-20. Epub 2007 Feb 1. BACKGROUND/AIMS: During the metabolism of the hepatotoxin carbon tetrachloride (CCl (4)) by cytochrome P450, heme, and free radicals are released. |
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| 19136384 | Ferre N, Martinez-Clemente M, Lopez-Parra M, Gonzalez-Periz A, Horrillo R, Planaguma A, Camps J, Joven J, Tres A, Guardiola F, Bataller R, Arroyo V, Claria J: Increased susceptibility to exacerbated liver injury in hypercholesterolemic ApoE-deficient mice: potential involvement of oxysterols. Am J Physiol Gastrointest Liver Physiol. 2009 Mar;296(3):G553-62. Epub 2009 Jan 8. In this study, apolipoprotein E-deficient (ApoE-/-) mice were evaluated to define potential effects of hypercholesterolemia on the severity of carbon tetrachloride (CCl4)-induced liver injury. Moreover, hepatic cytochrome P-450 expression was unchanged in ApoE-/- mice. |
1(0,0,0,1) | Details |
| 17877147 | Kujawska M, Jodynis-Liebert J, Ewertowska M, Adamska T, Matlawska I, Bylka W: Protective effect of Aquilegia vulgaris (L.) on carbon tetrachloride-induced oxidative stress in rats. Indian J Exp Biol. 2007 Aug;45(8):702-11. |
0(0,0,0,0) | Details |
| 15120965 | Kier LD, Neft R, Tang L, Suizu R, Cook T, Onsurez K, Tiegler K, Sakai Y, Ortiz M, Nolan T, Sankar U, Li AP: Applications of microarrays with toxicologically relevant genes (tox genes) for the evaluation of chemical toxicants in Sprague Dawley rats in vivo and human hepatocytes in vitro. Mutat Res. 2004 May 18;549(1-2):101-13. For instance, carbon tetrachloride and chloroform treatments were found to decrease the expression of the cytochrome P450 isoform 3A1 gene while enhancing the expression of the multiple drug resistance gene MDR1 in liver, clearly demonstrating that the CYP3A1 and MDR1 genes were not co-regulated as postulated by some researchers. |
0(0,0,0,0) | Details |