| Name | osteopontin |
|---|---|
| Synonyms | BNSP; Spp1; BSPI; Bone sialoprotein; Bone sialoprotein 1; ETA 1; ETA1; Early T lymphocyte activation 1… |
| Name | carbon tetrachloride |
|---|---|
| CAS | tetrachloromethane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16221502 | Lorena D, Darby IA, Gadeau AP, Leen LL, Rittling S, Porto LC, Rosenbaum J, Desmouliere A: Osteopontin expression in normal and fibrotic liver. altered liver healing in osteopontin-deficient mice. J Hepatol. 2006 Feb;44(2):383-90. Epub 2005 Aug 15. METHODS: Fibrosis was induced in mice and rats by carbon tetrachloride (CCl4) treatment or bile duct ligation. |
12(0,0,0,12) | Details |
| 15908265 | Koh HS, Matsui A, Mimura S, Inao M, Saitoh E, Ohno A, Nagoshi S, Yoshimoto T, Mochida S, Fujiwara K: Increased cytoprotective function in the liver of transgenic mice expressing osteopontin in hepatocytes. Hepatol Res. 2005 May;32(1):46-51. Liver necrosis in the centrilobular areas developed after carbon tetrachloride treatment, but its histological extent and plasma ALT activities were significantly smaller in the transgenic mice aged 8 weeks than in the wild-type C57BL/6 control mice. |
5(0,0,0,5) | Details |
| 15548383 | Lee SH, Seo GS, Park YN, Yoo TM, Sohn DH: Effects and regulation of osteopontin in rat hepatic stellate cells. Biochem Pharmacol. 2004 Dec 15;68(12):2367-78. Northern and western blot analyses showed that OPN was increasingly expressed during the progressive activation of cultured rat HSCs, and a significant increase in OPN was observed in carbon tetrachloride-induced rat liver fibrosis. |
2(0,0,0,2) | Details |
| 17890765 | Ramaiah SK, Rittling S: Pathophysiological role of osteopontin in hepatic inflammation, toxicity, and cancer. Toxicol Sci. 2008 May;103(1):4-13. Epub 2007 Sep 22. In the liver, it has been reported that hepatic Kupffer cells secrete OPN facilitating macrophage infiltration into necrotic areas following carbon tetrachloride liver toxicity. |
2(0,0,0,2) | Details |
| 17696803 | Ramaiah SK, Rittling S: Role of osteopontin in regulating hepatic inflammatory responses and toxic liver injury. Expert Opin Drug Metab Toxicol. 2007 Aug;3(4):519-26. In the liver, it has been reported that hepatic Kupffer cells secrete OPN facilitating macrophage infiltration in necrotic areas following carbon tetrachloride liver toxicity. |
2(0,0,0,2) | Details |
| 15070743 | Huh CG, Factor VM, Sanchez A, Uchida K, Conner EA, Thorgeirsson SS: Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repair. Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4477-82. The delayed healing was associated with a persistent inflammatory reaction, over-production of osteopontin, early and prominent dystrophic calcification, and impaired hepatocyte scattering/migration into diseased areas. |
1(0,0,0,1) | Details |
| 17484886 | De Minicis S, Seki E, Uchinami H, Kluwe J, Zhang Y, Brenner DA, Schwabe RF: Gene expression profiles during hepatic stellate cell activation in culture and in vivo. Gastroenterology. 2007 May;132(5):1937-46. Epub 2007 Feb 21. RESULTS: Two thousand seventy-three probe sets were differentially expressed in at least 1 of 3 models of HSC activation, including novel genes that encode proinflammatory and antiapoptotic mediators; transcription factors; cell surface receptors; and cytoskeleton components such as CXCL14, survivin, septin 4, osteopontin, PRX1, LMCD1, GPR91, leiomodin, and anillin. |
1(0,0,0,1) | Details |