| Name | xanthine oxidase |
|---|---|
| Synonyms | XDH; XDHA; XO; XOD; XOR; Xanthene dehydrogenase; Xanthine dehydrogenase; Xanthine dehydrogenase/oxidase… |
| Name | carbon tetrachloride |
|---|---|
| CAS | tetrachloromethane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18036097 | Venugopal SK, Wu J, Catana AM, Eisenbud L, He SQ, Duan YY, Follenzi A, Zern MA: Lentivirus-mediated dismutase1 gene delivery protects against oxidative stress-induced liver injury in mice. Liver Int. 2007 Dec;27(10):1311-22. METHODS: In vitro SOD1 efficacy was tested against two ROS-generating systems: /xanthine oxidase (HX/XO) and hydroxyethyl radicals (HER), whereas in vivo SOD1 efficacy was evaluated in carbon tetrachloride (CCl4)-induced liver injury in C57BL/6 mice. |
6(0,0,1,1) | Details |
| 18385828 | Ohta Y, Ohashi K, Matsura T, Tokunaga K, Kitagawa A, Yamada K: Octacosanol attenuates disrupted hepatic reactive species metabolism associated with acute liver injury progression in rats intoxicated with carbon tetrachloride. J Clin Biochem Nutr. 2008 Mar;42(2):118-25. In the liver of CCl (4)-intoxicated rats, increases in lipid peroxide (LPO) concentration and myeloperoxidase activity and decreases in superoxixde dismutase activity and (GSH) concentration occurred 6 h after intoxication and these changes were enhanced with an increase in xanthine oxidase activity and a decrease in catalase activity at 24 h. |
2(0,0,0,2) | Details |
| 17144473 | Niu XF, He LC, Fan T, Li Y: [Protecting effect of brevifolin and 8,9-single-epoxy brevifolin of Phyllanthus simplex on rat liver injury]. Zhongguo Zhong Yao Za Zhi. 2006 Sep;31(18):1529-32. MDA content or SOD activity in serum and liver tissue was measured by thiobarbituric acid chromatometry and xanthine oxidase methods, respectively. |
1(0,0,0,1) | Details |
| 17727797 | Uskokovic-Markovic S, Milenkovic M, Topic A, Kotur-Stevuljevic J, Stefanovic A, Antic-Stankovic J: Protective effects of tungstophosphoric acid and tungstate on chemically induced liver necrosis in wistar rats. J Pharm Pharm Sci. 2007;10(3):340-9. The induced liver necrosis by carbon tetrachloride (CCl4) and thioacetamide (TAA) are exemplary models for experimental liver necrosis caused by free radicals. METHODS: Hepatoprotective effects of TPA and ST on acute liver necrosis, chemically induced, were evaluated by the activity of serum enzymes (alkaline phosphatase, transaminase and transaminase), oxidative stress parameters (activity of xanthine oxidase, concentrations of malondialdehyde and production of antioxidative defence markers (concentration of and histopathology in Wistar rats. |
1(0,0,0,1) | Details |
| 18830880 | Khan TH, Sultana S: Antioxidant and hepatoprotective potential of Aegle marmelos Correa. against CCl4-induced oxidative stress and early tumor events. J Enzyme Inhib Med Chem. 2009 Apr;24(2):320-7. Pre-treatment with A. marmelos suppressed lipid peroxidation (LPO), xanthine oxidase (XO) and release of serum toxicity marker enzymes viz, SGOT, LDH, SGPT dose-dependently and significantly (p < 0.001). In conclusion, carbon tetrachloride-induced liver toxicity was strikingly attenuated by A. marmelos treatment and the study gives some insight into the mechanisms involved in diminution of free radical generating toxicants and enhancement of the antioxidant armory, hence preventing further tissue damage, injury and hyperproliferation. |
1(0,0,0,1) | Details |
| 20096342 | Khan RA, Khan MR, Sahreen S: Evaluation of Launaea procumbens use in renal disorders: a rat model. J Ethnopharmacol. 2010 Mar 24;128(2):452-61. Epub 2010 Jan 21. INTRODUCTION: Carbon tetrachloride exerts its toxicity in rat kidneys through oxidative stress. RESULTS: CCl (4) exposure led to a significant oxidative stress in kidneys which was remarkably attenuated with co-administration of various fractions and rutin thereby increased the level of CAT, POD, SOD, GSH, GSR, GST, GSH-Px, quinone reductase, while reduced the xanthine oxidase, gamma-GT, TBARS, H (2) O (2), tissue proteins and DNA fragmentation%. |
1(0,0,0,1) | Details |
| 16557555 | Natarajan SK, Ramamoorthy P, Thomas S, Basivireddy J, Kang G, Ramachandran A, Pulimood AB, Balasubramanian KA: Intestinal mucosal alterations in rats with carbon tetrachloride-induced cirrhosis: changes in glycosylation and luminal bacteria. Hepatology. 2006 Apr;43(4):837-46. Inhibition of xanthine oxidase using tungstate or antioxidant supplementation using reversed the oxidative stress, changes in brush border membrane sugar content, and bacterial adherence. |
1(0,0,0,1) | Details |
| 16278809 | Ohta Y, Imai Y, Matsura T, Kitagawa A, Yamada K: Preventive effect of neutropenia on carbon tetrachloride-induced hepatotoxicity in rats. J Appl Toxicol. 2006 Mar-Apr;26(2):178-86. The liver of CCl4 -treated rats showed an increase in the concentration of thiobarbituric acid reactive substances (TBARS), an index of lipid peroxidation, and decreases in superoxide dismutase (SOD) activity and (GSH) concentration at 6 h after the intoxication followed by a further increase in TBARS concentration and further decreases in SOD activity and GSH concentration at 24 h with increased xanthine oxidase (XO) activity at 24 h. |
1(0,0,0,1) | Details |
| 18022343 | Lee SJ, Lim KT: Glycoprotein of Zanthoxylum piperitum DC has a hepatoprotective effect via anti-oxidative character in vivo and in vitro. Toxicol In Vitro. 2008 Mar;22(2):376-85. Epub 2007 Oct 14. In hepatocyte cell lines (Chang liver and BNL CL.2 cells), the results showed that ZPDC glycoprotein has an inhibitory effect on /xanthine oxidase- or / oxidase-induced cytotoxicity in a dose-dependent manner. In addition, administration of ZPDC glycoprotein (20mg/kg) lowers the levels of lactate dehydrogenase, transaminase, and thiobarbituric acid reactive substances, whereas increases that of accompanying the normalizing effects on the activity of hepatic anti-oxidant enzymes (superoxide dismutase, catalase, and peroxidase) in mouse model of carbon tetrachloride-stimulated acute liver injury. |
1(0,0,0,1) | Details |
| 15062871 | Pawa S, Ali S: Liver necrosis and fulminant hepatic failure in rats: protection by oxyanionic form of Biochim Biophys Acta. 2004 Apr 5;1688(3):210-22. Supplementation of animals with tungstate for 7 weeks before the induction of liver injury by chemicals including thioacetamide (TAA), carbon tetrachloride (CCl (4)), or chloroform (CHCl (3)) could protect progression of hepatic injury. The activity of xanthine oxidase, which generates reactive species (ROS) as a by-product, was also determined and found to be perturbed. |
1(0,0,0,1) | Details |