Protein Information

Name FGF2
Synonyms FGF 13; FGF2; FGF13; FHF 2; FHF2; Fibroblast growth factor 13; Fibroblast growth factor homologous factor 2; Fibroblast growth factor 13s…

Compound Information

Name carbon tetrachloride
CAS tetrachloromethane

Reference List

PubMed Abstract RScore(About this table)
17093919 Ishikawa T, Terai S, Urata Y, Marumoto Y, Aoyama K, Murata T, Mizunaga Y, Yamamoto N, Nishina H, Shinoda K, Sakaida I: Administration of fibroblast growth factor 2 in combination with bone marrow transplantation synergistically improves carbon-tetrachloride-induced liver fibrosis in mice. Cell Tissue Res. 2007 Mar;327(3):463-70. Epub 2006 Nov 9.

Here, we investigated the effect of FGF2 treatment together with BMT on liver fibrosis in mice treated with carbon tetrachloride (CCl (4)).
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16228231 Ishikawa T, Terai S, Urata Y, Marumoto Y, Aoyama K, Sakaida I, Murata T, Nishina H, Shinoda K, Uchimura S, Hamamoto Y, Okita K: Fibroblast growth factor 2 facilitates the differentiation of transplanted bone marrow cells into hepatocytes. Cell Tissue Res. 2006 Feb;323(2):221-31. Epub 2005 Oct 14.

We have developed an in vivo mouse model, the green fluorescent protein (GFP)/carbon tetrachloride (CCl (4)) model, and have previously reported that transplanted GFP-positive bone marrow cells (BMCs) differentiate into hepatocytes via hepatoblast intermediates.
In liver samples, the expression of FGF1 and FGF2 and of FGF receptors (FGFRs; FGFR1, FGFR2) was significantly elevated with time after bone marrow transplantation (BMT) compared with other factors, and co-expression of GFP and FGFs or FGFRs could be detected.
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16929488 Huang X, Yu C, Jin C, Yang C, Xie R, Cao D, Wang F, McKeehan WL: Forced expression of hepatocyte-specific fibroblast growth factor 21 delays initiation of chemically induced hepatocarcinogenesis. Mol Carcinog. 2006 Dec;45(12):934-42.


Thus overexpression of FGF1 or FGF2 may be a consequence rather than contributor to hepatoma progression.
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