| Name | interferon gamma |
|---|---|
| Synonyms | IFG; IFI; IFN gamma; IFNG; IFNgamma; Immune interferon; Interferon gamma; Interferon gamma precursor… |
| Name | carbon tetrachloride |
|---|---|
| CAS | tetrachloromethane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18676278 | Song DP, Dong L: [Effect of peptide YY on hepatic fibrosis in rats] . Nan Fang Yi Ke Da Xue Xue Bao. 2008 Jul;28(7):1261-3. METHOD: Rat models of hepatic fibrosis were established with a subcutaneous injection of carbon tetrachloride and randomized into normal control group, model group, peptide YY (PYY)-treated group, octreotide-treated group, and interferon gamma-treated group. |
7(0,0,1,2) | Details |
| 16278212 | Dooley S, Said HM, Gressner AM, Floege J, En-Nia A, Mertens PR: Y-box protein-1 is the crucial mediator of antifibrotic interferon-gamma effects. J Biol Chem. 2006 Jan 20;281(3):1784-95. Epub 2005 Nov 8. |
3(0,0,0,3) | Details |
| 16472598 | Radaeva S, Sun R, Jaruga B, Nguyen VT, Tian Z, Gao B: Natural killer cells ameliorate liver fibrosis by killing activated stellate cells in NKG2D-dependent and tumor necrosis factor-related apoptosis-inducing ligand-dependent manners. Gastroenterology. 2006 Feb;130(2):435-52. METHODS: Liver fibrosis was induced either by feeding mice with the 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) diet or by injecting them with carbon tetrachloride. The Toll-like receptor 3 ligand, polyinosinic-polycytidylic acid, was used to activate innate immunity cells and mediators, including natural killer cells and interferon gamma. |
3(0,0,0,3) | Details |
| 15030980 | Armbrust T, Kreissig M, Tron K, Ramadori G: Modulation of fibronectin gene expression in inflammatory mononuclear phagocytes of rat liver after acute liver injury. J Hepatol. 2004 Apr;40(4):638-45. Treatment of inflammatory MNP with dexamethasone, or interferon-gamma, or lipopolysaccharide induced a dose-dependent decrease in cFN gene expression, whereas transforming growth factor-beta increased cFN gene expression. |
2(0,0,0,2) | Details |
| 19344719 | Wasmuth HE, Lammert F, Zaldivar MM, Weiskirchen R, Hellerbrand C, Scholten D, Berres ML, Zimmermann H, Streetz KL, Tacke F, Hillebrandt S, Schmitz P, Keppeler H, Berg T, Dahl E, Gassler N, Friedman SL, Trautwein C: Antifibrotic effects of CXCL9 and its receptor CXCR3 in livers of mice and humans. Gastroenterology. 2009 Jul;137(1):309-19 In mice, intrahepatic immune cell subsets were investigated and interferon gamma messenger RNA levels were measured at baseline and after injury. |
2(0,0,0,2) | Details |
| 18166357 | Jeong WI, Park O, Gao B: Abrogation of the antifibrotic effects of natural killer cells/interferon-gamma contributes to acceleration of liver fibrosis. Gastroenterology. 2008 Jan;134(1):248-58. Epub 2007 Sep 29. Liver fibrosis was induced by administration of carbon tetrachloride (CCl (4)) for 2 weeks. |
2(0,0,0,2) | Details |
| 15996030 | Chen M, Wang GJ, Diao Y, Xu RA, Xie HT, Li XY, Sun JG: Adeno-associated virus mediated interferon-gamma inhibits the progression of hepatic fibrosis in vitro and in vivo. World J Gastroenterol. 2005 Jul 14;11(26):4045-51. METHODS: We constructed the recombinant AAV encoding human INF-gamma (rAAV- INF-gamma) and took the primary rat hepatic stellate cells and carbon tetrachloride induced rats as the experimental hepatic fibrosis model in vitro and in vivo. |
2(0,0,0,2) | Details |
| 17657819 | Weng HL, Ciuclan L, Liu Y, Hamzavi J, Godoy P, Gaitantzi H, Kanzler S, Heuchel R, Ueberham U, Gebhardt R, Breitkopf K, Dooley S: Profibrogenic transforming growth factor-beta/activin receptor-like kinase 5 signaling via connective tissue growth factor expression in hepatocytes. 319.e1-3. Epub 2009 Apr 1. Furthermore, an interferon gamma treatment of patients with chronic hepatitis B virus infection induced Smad7 expression in hepatocytes, leading to decreased CTGF expression and fibrogenesis. Similarly, CTGF expression was induced in hepatocytes of carbon tetrachloride-treated mice. |
1(0,0,0,1) | Details |
| 17608861 | Desmyter L, Fan YD, Praet M, Jaworski T, Vervecken W, De Hemptinne B, Contreras R, Chen C: Rating of CCl (4)-induced rat liver fibrosis by blood serum glycomics. J Gastroenterol Hepatol. 2007 Jul;22(7):1148-54. In parallel, the effect of cotreatment with antifibrotic interferon-gamma (IFN-gamma) was studied. |
1(0,0,0,1) | Details |
| 18006644 | Fu Y, Zheng S, Lin J, Ryerse J, Chen A: protects the rat liver from CCl4-caused injury and fibrogenesis by attenuating oxidative stress and suppressing inflammation. Mol Pharmacol. 2008 Feb;73(2):399-409. Epub 2007 Nov 15. The current study evaluates the in vivo role of in protecting the liver against injury and fibrogenesis caused by carbon tetrachloride (CCl (4)) in rats and further explores the underlying mechanisms. dramatically suppresses inflammation by reducing levels of inflammatory cytokines, including interferon-gamma, tumor necrosis factor-alpha, and interleukin-6. |
1(0,0,0,1) | Details |
| 17347453 | Gardner JL, Turner SM, Bautista A, Lindwall G, Awada M, Hellerstein MK: Measurement of liver collagen synthesis by heavy water labeling: effects of profibrotic toxicants and antifibrotic interventions. Am J Physiol Gastrointest Liver Physiol. 2007 Jun;292(6):G1695-705. Epub 2007 Mar 8. Fibrogenesis subsided after withdrawal of CCl (4) exposure and was reduced to various degrees by coadministration of interferon-gamma, or enalapril. A threefold stimulation of collagen fractional synthesis was observed under the maximum dosage of carbon tetrachloride (CCl (4); 1.67 ml/kg). |
1(0,0,0,1) | Details |
| 17626270 | Chen Y, Wei H, Sun R, Dong Z, Zhang J, Tian Z: Increased susceptibility to liver injury in hepatitis B virus transgenic mice involves NKG2D-ligand interaction and natural killer cells. Hepatology. 2007 Sep;46(3):706-15. Interestingly, the presence of NK T cells was necessary for NK cell activation and worked as positive helper cell possibly by producing interferon-gamma and interleukin-4 in this process. |
1(0,0,0,1) | Details |