| Name | laminin (protein family or complex) |
|---|---|
| Synonyms | Laminin; Laminins |
| Name | carbon tetrachloride |
|---|---|
| CAS | tetrachloromethane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15029393 | Neves LB, Catarino RM, Silva MR, Parise ER: [Increased serum levels of laminin in the experimental cirrhosis induced by carbon tetrachloride]. Arq Gastroenterol. 2003 Jul-Sep;40(3):173-6. Epub 2004 Mar 15. |
22(0,0,3,7) | Details |
| 19322917 | Hong RT, Xu JM, Mei Q: ameliorates experimental hepatic fibrosis induced by carbon tetrachloride in rats. World J Gastroenterol. 2009 Mar 28;15(12):1452-8. Serum (HA), laminin (LN), and procollagen III N-terminal peptide (PIIINP) were determined by radioimmunoassay. |
2(0,0,0,2) | Details |
| 17565644 | Tu CT, Guo JS, Wang M, Wang JY: Antifibrotic activity of rofecoxib in vivo is associated with reduced portal hypertension in rats with carbon tetrachloride-induced liver injury. J Gastroenterol Hepatol. 2007 Jun;22(6):877-84. The activated, alpha smooth muscle actin (alpha-SMA) positive hepatic stellate cells (HSCs) and the protein levels of collagen types I, III, IV, as well as laminin and two fibrogenic mediators, vascular endothelial growth factor (VEGF) and connective tissue growth factor (CTGF) in the livers, were detected with immunohistochemical staining and western blot methods, respectively. |
2(0,0,0,2) | Details |
| 20079350 | Sun H, Che QM, Zhao X, Pu XP: Antifibrotic effects of chronic baicalein administration in a CCl4 liver fibrosis model in rats. Eur J Pharmacol. 2010 Apr 10;631(1-3):53-60. Epub 2010 Jan 13. The aim of this study was to assess whether chronic baicalein administration could prevent liver fibrosis induced by carbon tetrachloride (CCl (4)) in rats and investigate its possible protective mechanism. The antifibrotic effects of baicalein were assessed directly by hepatic histology and indirectly by measuring levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), hepatic laminin and procollagen type III (PCIII) in serum, as well as and matrix metalloproteinases (MMPs) in liver. |
2(0,0,0,2) | Details |
| 17661067 | Chiu CC, Huang GT, Chou SH, Chien CT, Chiou LL, Chang MH, Lee HS, Chen DS: Characterization of cytokeratin 19-positive hepatocyte foci in the regenerating rat liver after 2-AAF/CCl4 injury. Histochem Cell Biol. 2007 Sep;128(3):217-26. Epub 2007 Jul 28. Partial hepatectomy or carbon tetrachloride (CCl4) injury, following treatment of rats with 2-acetylaminofluorene (2-AAF) to inhibit proliferation of hepatocytes, induces proliferation of oval cells and possibly their differentiation into nodular foci of hepatocytes when higher doses of 2-AAF are used. These foci were positive for alpha-fetoprotein, less positive for synthetase 1, and more positive for laminin in the basement membrane lining. |
2(0,0,0,2) | Details |
| 16097048 | Li X, Meng Y, Yang XS, Mi LF, Cai SX: ACEI attenuates the progression of CCl4-induced rat hepatic fibrogenesis by inhibiting TGF-beta1, PDGF-BB, NF-kappaB and MMP-2,9. World J Gastroenterol. 2005 Aug 21;11(31):4807-11. Serum laminin (LN) and (HA) were measured using radioimmunoassays. |
1(0,0,0,1) | Details |
| 20333785 | Yang FR, Fang BW, Lou JS: Effects of Haobie Yangyin Ruanjian Decoction on hepatic fibrosis induced by carbon tetrachloride in rats. World J Gastroenterol. 2010 Mar 28;16(12):1458-64. Serum levels of (HA), type IV collagen (CIV), type III precollagen (PCIII) and laminin (LN) were assayed with radioimmunoassay. |
1(0,0,0,1) | Details |
| 19080687 | Sun C, Li DG, Chen YW, Chen YW, Wang BC: [Effects of gene-transfected bone marrow-derived liver stem cell transplantation on accumulation of extracellular matrix in rats with liver fibrosis]. Zhonghua Yi Xue Za Zhi. 2008 Oct 21;88(38):2685-9. Twenty-seven female rats were randomly divided into 3 equal groups to undergo subcutaneous injection of carbon tetrachloride to establish liver fibrosis models and then randomly divided into 3 equal groups: model group injected with normal saline via caudal vein, BDLSC group injected with 2 x 10 (6) BDLSCs via caudal vein, and BDLSC-uPA group injected with 2 x 10 (6) AduPA-transfected BDLSCs. Eight weeks later the serum levels of transaminase (ALT), aspartate aminotransferase (AST), total (TBIL), albumin (ALB), and ECM levels, i.e., laminin (LN), and procollagen III (PC III), were detected. |
1(0,0,0,1) | Details |
| 17278221 | Dang SS, Wang BF, Cheng YA, Song P, Liu ZG, Li ZF: Inhibitory effects of saikosaponin-d on CCl4-induced hepatic fibrogenesis in rats. World J Gastroenterol. 2007 Jan 28;13(4):557-63. The levels of alanine aminotransferase (ALT), triglyeride (TG), albumin (ALB), globulin (GLB), (HA) and laminin (LN) in serum and the content of (HYP) in liver were measured by biochemical examinations and radioimmuneoassay, respectively. |
1(0,0,0,1) | Details |
| 16437743 | Liu SQ, Yu JP, Chen HL, Luo HS, Chen SM, Yu HG: Therapeutic effects and molecular mechanisms of Ginkgo biloba extract on liver fibrosis in rats. Am J Chin Med. 2006;34(1):99-114. Rat liver fibrosis was induced by intraperitoneal injection of carbon tetrachloride (CCl4) twice a week for 8 weeks. The histopathologic score of fibrosis, liver function and the levels of plasma (HA) and laminin (LN) were significantly improved in rats treated with CCl4 + EGB, compared with those treated with CCl4 only (p < 0.01 or p < 0.05). |
1(0,0,0,1) | Details |
| 19567170 | Deng ZY, Li J, Jin Y, Chen XL, Lu XW: Effect of oxymatrine on the p38 mitogen-activated protein kinases signalling pathway in rats with CCl4 induced hepatic fibrosis. Chin Med J. 2009 Jun 20;122(12):1449-54. We obesrved changes in deposition of collagen, (HA), laminin (LN), collagen type IV (CIV), procollagen III (PCIII) and (Hyp), a-smooth muscle actin (alpha-SMA) and phosphor-p38 (pp38). |
1(0,0,0,1) | Details |
| 14761280 | Li X, Meng Y, Yang XS, Zhang ZS, Wu PS, Zou JL: [Perindopril attenuates the progression of CCl4-inducing rat hepatic fibrosis]. Zhonghua Gan Zang Bing Za Zhi. 2004 Jan;12(1):32-4. Serum laminin (LN) and (HA) were measured using radio-immunity technique. |
1(0,0,0,1) | Details |
| 17574357 | Sun WY, Wei W, Wu L, Gui SY, Wang H: Effects and mechanisms of extract from Paeonia lactiflora and Astragalus membranaceus on liver fibrosis induced by carbon tetrachloride in rats. J Ethnopharmacol. 2007 Jul 25;112(3):514-23. Epub 2007 Apr 24. Administration of PAE decreased CCl (4)-induced elevation of serum transaminase activities, laminin and procollagen type III levels, and contents of in liver tissue by approximately 30-60%. |
1(0,0,0,1) | Details |
| 16652398 | Li G, Xie Q, Shi Y, Li D, Zhang M, Jiang S, Zhou H, Lu H, Jin Y: Inhibition of connective tissue growth factor by siRNA prevents liver fibrosis in rats. J Gene Med. 2006 Jul;8(7):889-900. METHODS: Some rats received carbon tetrachloride (CCl4) by subcutaneous injections every three days for six consecutive weeks, and meantime they also obtained either siRNA (0.1 mg/kg) targeting CTGF, saline or a control siRNA by intraportal vein injection to rats' liver at the same pattern. Six weeks after CCl4 injection, prominent upregulations were observed in the gene expressions of CTGF, type I, III collagen, laminin, tissue inhibitor metal proteinase-1 (TIMP-1) and transforming growth factor-beta1 (TGF-beta1) in saline or control siRNA-treated rats livers. |
1(0,0,0,1) | Details |
| 16381635 | Liu SQ, Yu JP, He L, Yu HG, Luo HS: [Effects of nuclear factor kappaB and transforming growth factor beta1 in the anti-liver fibrosis process using Ginkgo biloba extract]. Zhonghua Gan Zang Bing Za Zhi. 2005 Dec;13(12):903-7. Radioimmunoassay was exploited to evaluate serum (HA) and laminin (LN) levels. |
1(0,0,0,1) | Details |
| 19761824 | Wang L, Cheng D, Wang H, Di L, Zhou X, Xu T, Yang X, Liu Y: The hepatoprotective and antifibrotic effects of Saururus chinensis against carbon tetrachloride induced hepatic fibrosis in rats. J Ethnopharmacol. 2009 Dec 10;126(3):487-91. Epub 2009 Sep 15. Evaluated with liver index, serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), (HA), hepatic malondialdehyde (MDA) content, and superoxide dismutase (SOD) activity, total (TC), triglyceride (TG), total lipoprotein (TP), albumin (ALB), (HYP), total antioxidant capacity (T-AOC), laminin (LN), type III collagen terminal peptide (PC-IIINP), and type IV collagen (IV-C), as well as with histopathologic changes of liver. |
1(0,0,0,1) | Details |
| 19230414 | Geng WX, Ding HY, Yi YS: [Prevention and treatment of experimental liver fibrosis in rats by Semen Hoveniae extracts]. Zhong Yao Cai. 2008 Oct;31(10):1550-2. METHODS: Rats liver fiborsis model was induced by carbon tetrachloride (CCl4). The level of serum procollgan type-III (PC-III), (HA), laminin (LN) and liver function were measured, respectively. |
1(0,0,0,1) | Details |
| 17097021 | Zhang ZT, Jiang P, Wang Y, Li JS, Xue JG, Zhou YZ, Yuan Z: Effects of hepatotrophic factors on the liver after portacaval shunt in rats with portal hypertension. Chin Med J. 2006 Oct 20;119(20):1727-33. METHODS: Intrahepatic portal hypertension (IHPH) was induced by intragastric administration of carbon tetrachloride, and end-to-side PCS was performed. The levels of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were tested biochemically and those of (HA) and laminin (LN) were measured by radioimmunoassay. |
1(0,0,0,1) | Details |
| 16943688 | Paul SC, Lv P, Xiao YJ, An P, Liu SQ, Luo HS: Thalidomide in rat liver cirrhosis: blockade of tumor necrosis factor-alpha via inhibition of degradation of an inhibitor of nuclear factor-kappaB. Pathobiology. 2006;73(2):82-92. METHODS: Liver cirrhosis was achieved by intraperitoneal injection of carbon tetrachloride thrice weekly, and thalidomide (10 or 100 mg/kg/day) was given daily by intragastric route for 8 weeks. Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), prealbumin (PA), (HA) and laminin (LN), and (HYP), NF-kappaBp65, alpha-smooth muscle actin (alpha-SMA) protein and TNF-alpha mRNA were studied in the liver, IkappaBalpha and TNF-alpha protein in the cytoplasm and NF-kappaBp65 protein in the nucleus. |
1(0,0,0,1) | Details |