| Name | transferase |
|---|---|
| Synonyms | 4' phosphopantetheinyl transferase; 4' phosphopantetheinyl transferase; AASD PPT; AASDHPPT; AASDPPT; Alpha aminoadipic semialdehyde dehydrogenase phosphopantetheinyl transferase; Aminoadipate semialdehyde dehydrogenase phosphopantetheinyl transferase; CGI 80… |
| Name | ethylene dibromide |
|---|---|
| CAS | 1,2-dibromoethane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 7581478 | Guengerich FP, Thier R, Persmark M, Taylor JB, Pemble SE, Ketterer B: Conjugation of carcinogens by theta class glutathione s-transferases: mechanisms and relevance to variations in human risk. Pharmacogenetics. 1995;5 Spec No:S103-7. A genetic deficiency in the GSH S-transferase mu class gene M1 has been hypothesized to lead to greater risk of lung cancer in smokers. Expression of the cDNA vector increased the mutagenicity of ethylene dibromide and several methylene dihalides. |
4(0,0,0,4) | Details |
| 1636057 | Danni O, Aragno M, Tamagno E, Ugazio G: In vivo studies on halogen compound interactions. Res Commun Chem Pathol Pharmacol. 1992 Jun;76(3):355-66. The compounds were selected on the basis of their metabolic pathways: carbon tetrachloride (CT) and trichlorobromomethane (TCBM) undergo a dehalogenation via P450-dependent enzyme system, 1,2-dichloroethane (DCE) and 1,2-dibromoethane (DBE) are mainly conjugated with the cytosolic (GSH) by means of the GSH-S-transferase. |
2(0,0,0,2) | Details |
| 8378332 | Thier R, Taylor JB, Pemble SE, Humphreys WG, Persmark M, Ketterer B, Guengerich FP: Expression of mammalian glutathione S-transferase 5-5 in Salmonella typhimurium TA1535 leads to base-pair mutations upon exposure to dihalomethanes. Proc Natl Acad Sci U S A. 1993 Sep 15;90(18):8576-80. A plasmid vector containing rat GSH S-transferase 5-5 was transfected into the Salmonella typhimurium tester strain TA1535, which then produced active enzyme. |
2(0,0,0,2) | Details |
| 8620575 | Aragno M, Tamagno E, Danni O, Chiarpotto E, Biasi F, Scavazza A, Albano E, Poli G, Dianzani MU: In vivo potentiation of 1,2-dibromoethane hepatotoxicity by through inactivation of glutathione-s-transferase. Chem Biol Interact. 1996 Jan 5;99(1-3):277-88. When DBE was administered to disulfiram- and EtOH-pretreated rats, a marked increase of liver cytolysis was shown and cytosolic GSH-transferase activity was further inhibited if compared to that induced by EtOH treatment alone. |
1(0,0,0,1) | Details |
| 12542971 | Guengerich FP: Activation of dihaloalkanes by thiol-dependent mechanisms. J Biochem Mol Biol. 2003 Jan 31;36(1):20-7. Recently the DNA repair protein O6-alkylguanine transferase has been shown to produce cytotoxicity and genotoxicity by means of a thiol-dependent process with similarities to the reactions. |
1(0,0,0,1) | Details |
| 6376058 | MacFarland RT, Gandolfi AJ, Sipes IG: Extra-hepatic GSH-dependent metabolism of 1,2-dibromoethane (DBE) and 1,2-dibromo-3-chloropropane (DBCP) in the rat and mouse. Drug Chem Toxicol. 1984;7(3):213-27. Rates of metabolism for DBE and DBCP represented only a small fraction of the total cytosolic GSH S-transferase activity. |
1(0,0,0,1) | Details |
| 6373030 | White RD, Petry TW, Sipes IG: The bioactivation of 1,2-dibromoethane in rat hepatocytes: deuterium isotope effect. Chem Biol Interact. 1984 Apr;49(1-2):225-33. These data suggest that the GSH transferase mediated metabolism of EDB is responsible for the genotoxic effects of EDB observed in hepatocytes. |
1(0,0,0,1) | Details |
| 9672661 | Hawkins WE, Walker WW, James MO, Manning CS, Barnes DH, Heard CS, Overstreet RM: Carcinogenic effects of 1,2-dibromoethane (ethylene dibromide; EDB) in Japanese medaka (Oryzias latipes). Mutat Res. 1998 Mar 20;399(2):221-32. SDS-PAGE of hepatic cytosolic fractions of EDB-exposed medaka showed a pronounced increase in a band at 26,000 Da, the expected position for GSH-S-transferase. |
1(0,0,0,1) | Details |
| 8453739 | Chiarpotto E, Biasi F, Aragno M, Scavazza A, Danni O, Albano E, Poli G: Change of liver metabolism of 1,2-dibromoethane during simultaneous treatment with carbon tetrachloride. Cell Biochem Funct. 1993 Mar;11(1):71-5. In fact, CCl4 significantly inactivated hepatocyte total -transferase, i.e. the DBE detoxification pathway. |
1(0,0,0,1) | Details |
| 6206071 | Arfellini G, Bartoli S, Colacci A, Mazzullo M, Galli MC, Prodi G, Grilli S: In vivo and in vitro binding of 1,2-dibromoethane and 1,2-dichloroethane to macromolecules in rat and mouse organs. J Cancer Res Clin Oncol. 1984;108(2):204-13. An indication of the presence of a microsomal GSH transferase was achieved for the activation of dibromoethane. |
1(0,0,0,1) | Details |
| 3532707 | Sipes IG, Wiersma DA, Armstrong DJ: The role of in the toxicity of xenobiotic compounds: metabolic activation of 1,2-dibromoethane by Adv Exp Med Biol. 1986;197:457-67. Although the cytochrome P-450 metabolite is reactive and will covalently bind to protein and nucleic acid to some extent, and the GSH S-transferase system conjugates it and under conditions of low DBE exposure is able to detoxify it. |
1(0,0,0,1) | Details |
| 11272109 | Elliott BM, Ashby J: Ethylene dibromide and disulfiram: studies in vivo and in vitro on the mechanism of the observed synergistic carcinogenic response. Carcinogenesis. 1980;1(12):1049-57. However, when added to a rat liver S-9 fraction in vitro, disulfiram decreased transferase activity and only depressed the dehydrogenase activity after a period of preincubation. |
1(0,0,0,1) | Details |
| 2311185 | Kim DH, Guengerich FP: Formation of the DNA adduct S-[2-(N7-guanyl) ethyl] from ethylene dibromide: effects of modulation of and glutathione S-transferase levels and lack of a role for sulfation. Carcinogenesis. 1990 Mar;11(3):419-24. These results suggest that induction of the Phase II enzyme GSH S-transferase can be detrimental in the case of ethylene dibromide and that decreases in GSH levels reduce DNA alkylation in rats. |
32(0,1,1,2) | Details |
| 6750385 | Brimer PA, Tan EL, Hsie AW: Effect of metabolic activation on the cytotoxicity and mutagenicity of 1,2-dibromoethane in the CHO/HGPRT system. Mutat Res. 1982 Aug;95(2-3):377-88. When ethylene dibromide (EtBr2) was assayed with the Chinese hamster ovary/- phosphoribosyl transferase (CHO/HGPRT) system coupled with a rat liver metabolic activation system (S9), which contains Ca2+ (Ca, Mg-S9), the cytotoxicity of EtBr2 was greatly increased over that obtained when was omitted from the Ca, Mg-S9 or when EtBr2 was assayed as a direct-acting agent. |
31(0,1,1,1) | Details |
| 7035935 | Tan EL, Hsie AW: Mutagenicity and cytotoxicity of haloethanes as studied in the CHO/HGPRT system. Mutat Res. 1981 Oct;90(2):183-91. When haloethanes were being tested as direct-acting agents in the Chinese hamster ovary cell/- phosphoribosyl transferase (CHO/HGPRT) system, ethylene dibromide (EtBr2) exhibited more cytotoxic and mutagenic activity than ethylene dichloride (EtCl2), and the mixed halogenated congener ethylene bromochloride (EtBrCl) had an intermediate effect. |
6(0,0,1,1) | Details |