Protein Information

Name aldehyde dehydrogenase (protein family or complex)
Synonyms aldehyde dehydrogenase; aldehyde dehydrogenases

Compound Information

Name ethylene dichloride
CAS 1,2-dichloroethane

Reference List

PubMed Abstract RScore(About this table)
7765836 Janssen DB, van der Ploeg JR, Pries F: Genetics and biochemistry of 1,2-dichloroethane degradation. . Biodegradation. 1994 Dec;5(3-4):249-57.


The haloalkane dehalogenase and an aldehyde dehydrogenase are plasmid encoded.
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18467461 Mena-Benitez GL, Gandia-Herrero F, Graham S, Larson TR, McQueen-Mason SJ, French CE, Rylott EL, Bruce NC: Engineering a catabolic pathway in plants for the degradation of 1,2-dichloroethane. Plant Physiol. 2008 Jul;147(3):1192-8. Epub 2008 May 8.


DhlA converts 1,2-DCA to 2-chloroethanol, which is then metabolized to the phytotoxic 2-chloroacetaldehyde, then chloroacetic acid, by endogenous plant alcohol dehydrogenase and aldehyde dehydrogenase activities, respectively.
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10417708 Naested H, Fennema M, Hao L, Andersen M, Janssen DB, Mundy J: A bacterial haloalkane dehalogenase gene as a negative selectable marker in Arabidopsis. Plant J. 1999 Jun;18(5):571-6.


In Xanthobacter, these alcohols are further catabolized by alcohol and aldehyde dehydrogenase activities, and by the product of the dhlB gene to a second halide and a hydroxyacid.
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1575500 van den Wijngaard AJ, van der Kamp KW, van der Ploeg J, Pries F, Kazemier B, Janssen DB: Degradation of 1,2-dichloroethane by Ancylobacter aquaticus and other facultative methylotrophs. Appl Environ Microbiol. 1992 Mar;58(3):976-83.


In all strains tested, DCE was degraded by initial hydrolytic dehalogenation to 2-chloroethanol, followed by oxidation by a phenazine methosulfate-dependent alcohol dehydrogenase and an NAD-dependent aldehyde dehydrogenase.
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