Protein Information

Name brains
Synonyms BPG dependent PGAM 1; Brain; CDABP0006; PGAM 1; PGAM B; PGAM1; PGAM1 protein; PGAMA…

Compound Information

Name endrin
CAS

Reference List

PubMed Abstract RScore(About this table)
15092385 Blus LJ, Henny CJ, Grove RA: Rise and fall of endrin usage in Washington State fruit orchards: effects on wildlife. Environ Pollut. 1989;60(3-4):331-49.

Of 194 birds found dead, brains of 125 were analysed; endrin toxicosis accounted for > 24% of the total and 37% of those analysed.
6(0,0,1,1) Details
963324 Fabacher DL, Chambers H: Uptake and storage of 14C-labeled endrin by the livers and brains of pesticide-susceptible and resistant mosquitofish. Bull Environ Contam Toxicol. 1976 Aug;16(2):203-7.
6(0,0,1,1) Details
6247694 Kaiser TE, Reichel WL, Locke LN, Cromartie E, Krynitsky AJ, Lamont TG, Mulhern BM, Prouty RM, Stafford CJ, Swineford DM: Organochlorine pesticide, PCB, and PBB residues and necropsy data for bald eagles from 29 states--1975-77. Pestic Monit J. 1980;13(4):145-9.

Brains of five eagles contained possible lethal levels of dieldrin, and two eagles possibly died of endrin poisoning.
6(0,0,1,1) Details
2430161 Cole LM, Casida JE: Polychlorocycloalkane insecticide-induced convulsions in mice in relation to disruption of the GABA-regulated chloride ionophore. Life Sci. 1986 Nov 17;39(20):1855-62.

The brain P2 membranes of treated mice contain the parent compound with each of the PCCAs plus activation products of some of the cyclodienes, i.e. endosulfan sulfate from alpha- and beta-endosulfan and 12-ketoendrin from isodrin and endrin.
The finding that the brains of treated mice contain sufficient PCCA or its activation products to achieve a magnitude of [35S] TBPS binding site inhibition correlated with the severity of the poisoning signs supports the hypothesis that the acute toxicity of PCCA insecticides to mammals is due to disruption of the GABA-regulated chloride ionophore.
1(0,0,0,1) Details
6793997 Ohlendorf HM, Swineford DM, Locke LN: Organochlorine residues and mortality of herons. Pestic Monit J. 1981 Mar;14(4):125-35.

Brains of birds found dead or moribund were analyzed to determine whether the birds had died of organochlorine poisoning.
Endrin, mirex, toxaphene, and HCB were found least often (8, 9, 9, and 9 carcasses, respectively).
1(0,0,0,1) Details