| Name | cytochrome P450 (protein family or complex) |
|---|---|
| Synonyms | cytochrome P450; cytochrome P 450; CYP450; CYP 450 |
| Name | ethylene dichloride |
|---|---|
| CAS | 1,2-dichloroethane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 6722974 | Casciola LA, Ivanetich KM: Metabolism of chloroethanes by rat liver nuclear cytochrome P-450. . Carcinogenesis. 1984 May;5(5):543-8. |
8(0,0,0,8) | Details |
| 7082482 | Testai E, Citti L, Gervasi PG, Turchi G: [In vitro hepatic cytochrome P-450 destruction induced by 1,2-dichloroethylene]. Boll Soc Ital Biol Sper. 1982 May 15;58(9):513-9. |
4(0,0,0,4) | Details |
| 9654249 | Rodriguez-Arnaiz R: Biotransformation of several structurally related 2B compounds to reactive metabolites in the somatic w/w+ assay of Drosophila melanogaster. Environ Mol Mutagen. 1998;31(4):390-401. The latter have high cytochrome P450-dependent bioactivation capacities. |
2(0,0,0,2) | Details |
| 17426840 | Zabrodskii PF, Mandych VG, Germanchuk VG: Inhibition of cytochrome P-450 with 2-diethylamino-ethyl-2,2-diphenylpropylacetate (SKF-525A) reduces immunotoxicity of chlorinated carbohydrates. Bull Exp Biol Med. 2006 Sep;142(3):324-6. |
2(0,0,0,2) | Details |
| 1664256 | Guengerich FP, Kim DH, Iwasaki M: Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects. Chem Res Toxicol. 1991 Mar-Apr;4(2):168-79. The results collectively indicate that P-450 IIE1 is a major catalyst of the oxidation of styrene, CCl4, CHCl3, CH2Cl2, CH3Cl, CH3CCl3, 1,2-dichloropropane, ethylene dichloride, ethylene dibromide, vinyl vinyl acrylonitrile, vinyl ethyl and trichloroethylene. |
2(0,0,0,2) | Details |
| 6088030 | Loew GH, Rebagliati M, Poulsen M: Metabolism and relative carcinogenic potency of chloroethanes: a quantum chemical structure-activity study. Cancer Biochem Biophys. 1984 Jun;7(2):109-32. Using the all-valence electron, semiempirical molecular orbital method, MNDO, properties have been identified and calculated for eight chloroethanes which can serve as indicators of their extent of transformation to by cytochrome P450 and the subsequent formation of aldehydes by loss of HCl from these |
2(0,0,0,2) | Details |
| 3787626 | Igwe OJ, Hee SS, Wagner WD: Interaction between 1,2-dichloroethane and tetraethylthiuram disulfide (disulfiram). Toxicol Appl Pharmacol. 1986 Nov;86(2):286-97. Exposure to DSF alone decreased cytochrome P450 levels, but in combination with DCE, the decrement of cytochrome P450 was additive in a DCE concentration-dependent manner. |
1(0,0,0,1) | Details |
| 6870950 | McCall SN, Jurgens P, Ivanetich KM: Hepatic microsomal metabolism of the dichloroethanes. Biochem Pharmacol. 1983 Jan 15;32(2):207-13. In addition, reaction mixtures constituted as described above resulted in slight but significant losses (ca. 13%) of hepatic microsomal cytochrome P-450. |
1(0,0,0,1) | Details |
| 1636057 | Danni O, Aragno M, Tamagno E, Ugazio G: In vivo studies on halogen compound interactions. Res Commun Chem Pathol Pharmacol. 1992 Jun;76(3):355-66. TCBM, like CT, reduces the hepatic level of GSH-S-transferase, increasing the amount of DBE available for cytochrome P450-dependent metabolism, with the production of toxic metabolites. |
1(0,0,0,1) | Details |
| 18579268 | Sweeney LM, Saghir SA, Gargas ML: Physiologically based pharmacokinetic model development and simulations for ethylene dichloride (1,2-dichloroethane) in rats. Regul Toxicol Pharmacol. 2008 Aug;51(3):311-23. Epub 2008 May 20. Model structure updates included the addition of extrahepatic metabolism by unspecified enzymes (most likely GSTs or cytochrome P450 enzymes). |
1(0,0,0,1) | Details |