Protein Information

Name Glutathione S transferase pi
Synonyms DFN 7; PI; DFN7; FAEES 3; FAEES3; GST class pi; GST3; GSTP 1…

Compound Information

Name ethylene dichloride
CAS 1,2-dichloroethane

Reference List

PubMed Abstract RScore(About this table)
8330352 Simula TP, Glancey MJ, Wolf CR: Human glutathione S-transferase-expressing Salmonella typhimurium tester strains to study the activation/detoxification of mutagenic compounds: studies with halogenated compounds, aromatic amines and aflatoxin B1. Carcinogenesis. 1993 Jul;14(7):1371-6.

Alpha and pi class GSTs, GSTA1-1 and GSTP1-1, were expressed in Salmonella TA100 using a regulatable tac promoter expression system.
The ability of these GST to modulate the mutagenicity of a range of mutagens including ethylene dibromide, ethylene dichloride and methylene dichloride was then investigated.
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10072168 Pott WA, Benjamin SA, Yang RS: Antagonistic interactions of an arsenic-containing mixture in a multiple organ carcinogenicity bioassay. Cancer Lett. 1998 Nov 27;133(2):185-90.


Our results reveal a dose-responsive antagonistic effect of this four-chemical mixture on the development of preneoplastic hepatic lesions (altered hepatocellular foci and glutathione S-transferase pi positive foci) as well as bronchioalveolar hyperplasia and adenoma formation.
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