| Name | epoxide hydrolase |
|---|---|
| Synonyms | EPHX; EPHX 1; EPHX1; EPHX1 protein; EPOX; Epoxide hydratase; Epoxide hydrolase; Epoxide hydrolase 1… |
| Name | ethylene oxide |
|---|---|
| CAS | oxirane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17416773 | Haufroid V, Merz B, Hofmann A, Tschopp A, Lison D, Hotz P: Exposure to ethylene oxide in hospitals: biological monitoring and influence of glutathione S-transferase and epoxide hydrolase polymorphisms. Cancer Epidemiol Biomarkers Prev. 2007 Apr;16(4):796-802. This cross-sectional study aimed at examining (a) whether the urinary excretion of a metabolite of ethylene oxide, 2-hydroxyethyl (HEMA), could be used for monitoring occupational exposure and (b) whether glutathione S-transferase (GST) and epoxide hydrolase genotypes influenced biological monitoring. |
38(0,1,2,3) | Details |
| 12767152 | Funar-Timofei S, Suzuki T, Paier JA, Steinreiber A, Faber K, Fabian WM: Quantitative structure-activity relationships for the enantioselectivity of oxirane ring-opening catalyzed by epoxide hydrolases. J Chem Inf Comput Sci. 2003 May-Jun;43(3):934-40. |
3(0,0,0,3) | Details |
| 12926852 | Paier J, Stockner T, Steinreiber A, Faber K, Fabian WM: Enantioselectivity of epoxide hydrolase catalysed oxirane ring opening: a 3D QSAR study. J Comput Aided Mol Des. 2003 Jan;17(1):1-11. |
3(0,0,0,3) | Details |
| 16386346 | Godderis L, Aka P, Mateuca R, Kirsch-Volders M, Lison D, Veulemans H: Dose-dependent influence of genetic polymorphisms on DNA damage induced by styrene oxide, ethylene oxide and gamma-radiation. Toxicology. 2006 Feb 15;219(1-3):220-9. Epub 2005 Dec 28. EPHX1 and GSTs play an important role in the detoxification of electrophiles and oxidative stress. |
2(0,0,0,2) | Details |
| 15668107 | Paulsson B, Rannug A, Henderson AP, Golding BT, Tornqvist M, Warholm M: In vitro studies of the influence of glutathione transferases and epoxide hydrolase on the detoxification of acrylamide and glycidamide in blood. Mutat Res. 2005 Feb 7;580(1-2):53-9. In a parallel experiment, incubation with ethylene oxide was used as positive control. |
2(0,0,0,2) | Details |
| 14976339 | Himmelstein MW, Carpenter SC, Hinderliter PM: Kinetic modeling of beta-chloroprene metabolism: I. Toxicol Sci. 2004 May;79(1):18-27. Epub 2004 Feb 19. This study investigated the species-dependent in vitro kinetics of CD oxidation and subsequent 1-CEO metabolism by microsomal epoxide hydrolase and cytosolic glutathione S-transferases in liver and lung, tissues that are prone to tumor induction. |
2(0,0,0,2) | Details |
| 16288948 | Eick JD, Smith RE, Pinzino CS, Kostoryz EL: Stability of silorane dental monomers in aqueous systems. J Dent. 2006 Jul;34(6):405-10. Epub 2005 Nov 9. Siloranes were mixed in aqueous solutions with and without 1% tetrahydrofuran (THF) containing either liver esterase or epoxide hydrolase at pH 7.4, or dilute HCl at pH 1.4. |
2(0,0,0,2) | Details |
| 16870169 | Munter T, Cottrell L, Ghai R, Golding BT, Watson WP: The metabolism and molecular toxicology of chloroprene. Chem Biol Interact. 2007 Mar 20;166(1-3):323-31. Epub 2006 Jun 3. Epoxide (2a/2b) was a substrate for mammalian microsomal epoxide hydrolases, which showed preferential hydrolysis of the (S)-enantiomer (2b). |
2(0,0,0,2) | Details |
| 17193739 | Hurst HE: Toxicology of 1,3-butadiene, chloroprene, and isoprene. Rev Environ Contam Toxicol. 2007;189:131-79. These metabolites are detoxified through hydrolysis by epoxide hydrolase enzymes and through conjugation with with the aid of glutathione S-transferase. Melnick and Sills (2001) compared the carcinogenic potentials of these three dienes, along with that of ethylene oxide, which also acts through an epoxide intermediate. |
1(0,0,0,1) | Details |
| 18175006 | Kona J: Theoretical study on the mechanism of a ring-opening reaction of oxirane by the active-site aspartic dyad of HIV-1 protease. Org Biomol Chem. 2008 Jan 21;6(2):359-65. Epub 2007 Dec 6. Here we also briefly discuss differences between the epoxide ring-opening reaction in HIV-1 protease and epoxide hydrolase, and the accuracy of the DFT method used. |
1(0,0,0,1) | Details |