Protein Information

Name fibronectin
Synonyms CIG; MSF; Cold insoluble globulin; FINC; FN; FN1; Fibronectin; Fibronectin 1…

Compound Information

Name ethylene oxide
CAS oxirane

Reference List

PubMed Abstract RScore(About this table)
17546412 Hodde J, Janis A, Ernst D, Zopf D, Sherman D, Johnson C: Effects of sterilization on an extracellular matrix scaffold: part I. J Mater Sci Mater Med. 2007 Apr;18(4):537-43.

Fibronectin and glycosaminoglycans are retained in SIS following oxidation by peracetic acid and alkylation using ethylene oxide gas.
81(1,1,1,1) Details
12857094 Pompe T, Zschoche S, Herold N, Salchert K, Gouzy MF, Sperling C, Werner C: Maleic anhydride copolymers--a versatile platform for molecular biosurface engineering. Biomacromolecules. 2003 Jul-Aug;4(4):1072-9.

Examples concern the impact of the substrate-anchorage of fibronectin on the formation of cell-matrix adhesions, the orientation of endothelial cells according to lateral anti-adhesive micropatterns using grafted poly (ethylene oxide), and the spacer-dependent activity of immobilized synthetic thrombin inhibitors.
31(0,1,1,1) Details
18549295 Belegrinou S, Mannelli I, Lisboa P, Bretagnol F, Valsesia A, Ceccone G, Colpo P, Rauscher H, Rossi F: pH-dependent immobilization of proteins on surfaces functionalized by plasma-enhanced chemical vapor deposition of poly (acrylic acid)- and poly (ethylene oxide)-like films. Langmuir. 2008 Jul 15;24(14):7251-61. Epub 2008 Jun 13.

The interaction of the proteins bovine serum albumin (BSA), lysozyme (Lys), lactoferrin (Lf), and fibronectin (Fn) with surfaces of protein-resistant poly (ethylene oxide) (PEO) and protein-adsorbing poly (acrylic acid) (PAA) fabricated by plasma-enhanced chemical vapor deposition has been studied with quartz crystal microbalance with dissipation monitoring (QCM-D).
31(0,1,1,1) Details
17022092 Ji Y, Ghosh K, Li B, Sokolov JC, Clark RA, Rafailovich MH: Dual-syringe reactive electrospinning of cross-linked hyaluronic acid hydrogel nanofibers for tissue engineering applications. Macromol Biosci. 2006 Oct 20;6(10):811-7.

Poly (ethylene oxide) (PEO) is added into the spinning solution as a viscosity modifier to facilitate the fiber formation and is selectively removed with water after the electrospinning process.
A cell morphology study on fibronectin (FN)-adsorbed HA nanofibrous scaffolds shows that the NIH 3T3 fibroblasts migrate into the scaffold through the nanofibrous network, and demonstrate an elaborate three-dimensional dendritic morphology within the scaffold, which reflects the dimensions of the electrospun HA nanofibers.
2(0,0,0,2) Details
15348694 Kontio R, Salo A, Suuronen R, Lindqvist C, Meurman JH, Virtanen I: Fibrous wound repair associated with biodegradable poly-L/D-lactide copolymer implants: study of the expression of tenascin and cellular fibronectin. J Mater Sci Mater Med. 1998 Oct;9(10):603-9.

Ethylene-oxide and gamma-irradiation sterilized PLA plate-type implants were inserted into the dorsal subcutaneous tissue of ten adult rabbits.
2(0,0,0,2) Details
16556462 Ji Y, Ghosh K, Shu XZ, Li B, Sokolov JC, Prestwich GD, Clark RA, Rafailovich MH: Electrospun three-dimensional hyaluronic acid nanofibrous scaffolds. Biomaterials. 2006 Jul;27(20):3782-92. Epub 2006 Mar 23.

In order to facilitate the fiber formation during electrospinning, Poly (ethylene oxide) (PEO) was added into the aqueous solution of HA-DTPH at an optimal weight ratio of 1:1.
NIH 3T3 fibroblasts were seeded on fibronectin-adsorbed HA-DTPH nanofibrous scaffolds for 24h in vitro.
1(0,0,0,1) Details
14870943 Bumgardner JD, Wiser R, Elder SH, Jouett R, Yang Y, Ong JL: Contact angle, protein adsorption and osteoblast precursor cell attachment to chitosan coatings bonded to titanium. J Biomater Sci Polym Ed. 2003;14(12):1401-9.

Similarly, chitosan-coated surfaces exhibited significantly greater (P < 0.001) albumin adsorption, fibronectin adsorption and cell attachment, as compared to the control Ti surfaces.
Samples were sterilized by ethylene oxide gas prior to experiments.
1(0,0,0,1) Details
16995792 Burks CA, Bundy K, Fotuhi P, Alt E: Characterization of 75:25 poly (l-lactide-co-epsilon-caprolactone) thin films for the endoluminal delivery of adipose-derived stem cells to abdominal aortic aneurysms. Tissue Eng. 2006 Sep;12(9):2591-600.


Ethylene oxide treatment significantly increased the stiffness and yield stress of the films, which exhibit > 700% elongation.
0(0,0,0,0) Details
16540288 Ekholm M, Helander P, Hietanen J, Lindqvist C, Salo A, Kellomaki M, Suuronen R: A histological and immunohistochemical study of tissue reactions to solid poly (ortho ester) in rabbits. Int J Oral Maxillofac Surg. 2006 Jul;35(7):631-5. Epub 2006 Mar 15.


Resorption times and the effect of 2 different sterilization methods (gamma radiation and ethylene oxide) upon resorption were also evaluated.
0(0,0,0,0) Details