Protein Information

Name hemoglobin (protein family or complex)
Synonyms Hemoglobin; Hemoglobins

Compound Information

Name ethylene oxide
CAS oxirane

Reference List

PubMed Abstract RScore(About this table)
16457610 Huang YF, Hsieh MM, Tseng WL, Chang HT: On-line concentration of microheterogeneous proteins by capillary electrophoresis using SDS and PEO as additives. J Proteome Res. 2006 Feb;5(2):429-36.

We further demonstrate the capability of this method to detect low amounts of proteins through the detection of 45 nM hemoglobin after injecting ca. 1.0 microL of ultradilute lysed red blood cells.
To improve the stacking and separation efficiencies of proteins, we added either 0.01% sodium dodecyl sulfate (SDS) or 0.01% poly (ethylene oxide) (PEO) to the Tris-borate solutions (pH 10.0) used to prepare the protein samples.
1(0,0,0,1) Details
15986466 Zhang Y, Zhu W, Wang B, Yu L, Ding J: Postfabrication encapsulation of model protein drugs in a negatively thermosensitive hydrogel. J Pharm Sci. 2005 Aug;94(8):1676-84.

The hydrogel comprises mainly poly (ethylene oxide)-poly (propylene oxide)-poly (ethylene oxide) block copolymer, and oligo (lactide).
The model proteins Hemoglobin and Bovine Serum Albumin were loaded into the hydrogel films by soaking the gels at 4 degrees C, at which the hydrogel film was swollen.
1(0,0,0,1) Details
17053297 Ogawa M, Oyama T, Isse T, Yamaguchi T, Murakami T, Endo Y, Kawamoto T: Hemoglobin adducts as a marker of exposure to chemical substances, especially PRTR class I designated chemical substances. J Occup Health. 2006 Sep;48(5):314-28.

Hemoglobin adduct levels were elevated after exposures to styrene, MDI, MDA, 1, 3-butadiene, ethylene oxide, acrylamide and acrylonitrile.
16(0,0,2,6) Details
16828349 Ahn HS, Shin HS: Determination of ethylene oxide-hemoglobin adduct by silylation and gas chromatography-electron impact-mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2006 Nov 7;843(2):202-8. Epub 2006 Jul 7.
13(0,0,2,3) Details
18442283 Rameez S, Alosta H, Palmer AF: Biocompatible and biodegradable polymersome encapsulated hemoglobin: a potential oxygen carrier. Bioconjug Chem. 2008 May;19(5):1025-32. Epub 2008 Apr 29.

This work describes the development of polymersome-encapsulated hemoglobin (PEH) self-assembled from biodegradable and biocompatible amphiphilic diblock copolymers composed of poly (ethylene oxide) (PEO), poly (caprolactone) (PCL), and poly (lactide) (PLA).
8(0,0,1,3) Details
15066576 Wu KY, Chiang SY, Huang TH, Tseng YS, Chen YL, Kuo HW, Hsieh CL: Formation of N-(2-hydroxyethyl) valine in human hemoglobin-effect of lifestyle factors. Mutat Res. 2004 Apr 11;559(1-2):73-82.

The formation of N-(2-hydroxyethyl) valine (HEV) in hemoglobin has been considered as a biomarker to assess exogenous and endogenous exposures to ethylene oxide (EO) and/or ethylene (ET).
7(0,0,1,2) Details
15026775 Bono R, Vincenti M, Schiliro T, Traversi D, Pignata C, Scursatone E, Dotti G, Gilli G: Cotinine and N-(2-hydroxyethyl) valine as markers of passive exposure to tobacco smoke in children. J Expo Anal Environ Epidemiol. 2005 Jan;15(1):66-73.

Another marker of active tobacco smoking is the N-(2-hydroxyethyl) valine (HOEtVal) which results from the reaction between ethylene oxide (EtO) and the N-terminal valine of hemoglobin.
6(0,0,1,1) Details
20000689 Rameez S, Bamba I, Palmer AF: Large scale production of vesicles by hollow fiber extrusion: a novel method for generating polymersome encapsulated hemoglobin dispersions. Langmuir. 2010 Apr 6;26(7):5279-85.

The first half of this study describes a method for generating empty polymersomes composed of different molecular weight amphiphilic poly (butadiene-b-ethylene oxide) (PBD-b-PEO) diblock copolymers on a large scale (50-100 mL) using a HF membrane.
3(0,0,0,3) Details
16750522 Hurst HE, Ali MY: Analyses of (1-chloroethenyl) oxirane headspace and hemoglobin N-valine adducts in erythrocytes indicate selective detoxification of (1-chloroethenyl) oxirane enantiomers. Chem Biol Interact. 2007 Mar 20;166(1-3):332-40. Epub 2006 May 2.

2(0,0,0,2) Details
12806356 Alfa MJ, Nemes R: Inadequacy of manual cleaning for reprocessing single-use, triple-lumen sphinctertomes: simulated-use testing comparing manual with automated cleaning methods. Am J Infect Control. 2003 Jun;31(4):193-207.

Our objective was to use thickened artificial test soil containing microorganisms to perform simulated-use tests combined with in-situ and destructive testing to evaluate cleaning efficacy and ethylene oxide sterilization of single-use triple lumen sphinctertomes.
Destructive testing was done to determine the levels of residual protein, carbohydrate, hemoglobin, endotoxin, and viable bacteria in the cleaned device.
1(0,0,0,1) Details
15668107 Paulsson B, Rannug A, Henderson AP, Golding BT, Tornqvist M, Warholm M: In vitro studies of the influence of glutathione transferases and epoxide hydrolase on the detoxification of acrylamide and glycidamide in blood. Mutat Res. 2005 Feb 7;580(1-2):53-9.

In this study, the doses of acrylamide or glycidamide measured as specific adducts to hemoglobin (Hb) were analysed in blood samples after in vitro incubation with these compounds.
In a parallel experiment, incubation with ethylene oxide was used as positive control.
1(0,0,0,1) Details