| Name | P85 |
|---|---|
| Synonyms | ARHGEF 7; PAK3; p85; p50; ARHGEF7; BETA PIX; COOL 1; COOL1… |
| Name | ethylene oxide |
|---|---|
| CAS | oxirane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18275966 | Bharatiya B, Aswal VK, Hassan PA, Bahadur P: Influence of a hydrophobic diol on the micellar transitions of Pluronic P85 in aqueous solution. J Colloid Interface Sci. 2008 Apr 15;320(2):452-9. Epub 2008 Feb 2. Micellization behavior of an amphiphilic ethylene oxide-propylene oxide-ethylene oxide tri-block copolymer Pluronic P85 [(EO)(26)(PO)(39)-(EO)(26)] in aqueous solution and in the presence of a hydrophobic C (14) diol (also known as Surfynol104) was examined by physico-chemical methods such as viscometry, cloud point (CP) and scattering techniques viz. dynamic light scattering (DLS) and small angle neutron scattering (SANS). |
83(1,1,1,3) | Details |
| 17375940 | Artzner F, Geiger S, Olivier A, Allais C, Finet S, Agnely F: Interactions between poloxamers in aqueous solutions: micellization and gelation studied by differential scanning calorimetry, small angle X-ray scattering, and rheology. Langmuir. 2007 Apr 24;23(9):5085-92. Epub 2007 Mar 22. Poloxamers F88 (EO97PO39EO97) and P85 (EO27PO39EO27) are triblock copolymers of ethylene oxide (EO) and propylene oxide (PO), which have the same hydrophobic PO block. |
34(0,1,1,4) | Details |
| 18729494 | Sahay G, Batrakova EV, Kabanov AV: Different internalization pathways of polymeric micelles and unimers and their effects on vesicular transport. Bioconjug Chem. 2008 Oct;19(10):2023-9. Epub 2008 Aug 27. A block copolymer of poly (ethylene oxide) (PEO) and poly (propylene oxide) (PPO), Pluronic P85 (P85), below critical micelle concentration (CMC) exists as single molecule coils (unimers) and above CMC forms 14.6 nm aggregated micelles with a hydrophobic PPO core and hydrophilic PEO shell. |
33(0,1,1,3) | Details |
| 16471557 | Lauw Y, Leermakers FA, Cohen Stuart MA: Self-consistent-field analysis of the micellization of carboxy-modified poly (ethylene oxide)-poly (propylene oxide)-poly (ethylene oxide) triblock copolymers. J Phys Chem B. 2006 Jan 12;110(1):465-77. The micellization properties of carboxy-modified Pluronics P85 (poly (ethylene oxide)-poly (propylene oxide)-poly (ethylene oxide) (PEO-PPO-PEO) triblock copolymers) are investigated by means of a molecularly realistic self-consistent-field theory. |
32(0,1,1,2) | Details |
| 20053933 | Price TO, Farr SA, Yi X, Vinogradov S, Batrakova E, Banks WA, Kabanov AV: Transport across the blood-brain barrier of pluronic leptin. . J Pharmacol Exp Ther. 2010 Apr;333(1):253-63. Epub 2010 Jan 6. Chemical modification of polypeptides with amphiphilic poly (ethylene oxide)-poly (propylene oxide) block copolymers (Pluronic) is a promising technology to improve efficiency of delivery of polypeptides to the brain. In the present study, we determined the effects of Pluronic P85 (P85) with intermediate hydrophilic-lipophilic balance conjugated with leptin via a degradable SS bond [leptin (ss)-P85] on food intake, clearance, stability, and BBB uptake. |
4(0,0,0,4) | Details |
| 19064283 | Gaymalov ZZ, Yang Z, Pisarev VM, Alakhov VY, Kabanov AV: The effect of the nonionic block copolymer pluronic P85 on gene expression in mouse muscle and antigen-presenting cells. Biomaterials. 2009 Feb;30(6):1232-45. Epub 2008 Dec 7. We describe here Pluronic P85 (P85), a triblock copolymer of ethylene oxide (EO) and propylene oxide (PO) EO (26)-PO (40)-EO (26). |
10(0,0,1,5) | Details |
| 17609512 | Krupka TM, Weinberg BD, Wu H, Ziats NP, Exner AA: Effect of intratumoral injection of carboplatin combined with pluronic P85 or L61 on experimental colorectal carcinoma in rats. Exp Biol Med. 2007 Jul;232(7):950-7. Pluronic, a poly (ethylene oxide)-poly (propylene oxide)-poly (ethylene oxide) block copolymer, has been shown to enhance the cytotoxic activity of anticancer drugs in various cell lines. |
7(0,0,0,7) | Details |
| 19963266 | Sahay G, Gautam V, Luxenhofer R, Kabanov AV: The utilization of pathogen-like cellular trafficking by single chain block copolymer. Biomaterials. 2010 Mar;31(7):1757-64. Epub 2009 Dec 5. Amphiphilic triblock copolymer, poly (ethylene oxide)-b-poly (propylene oxide)-b-poly (ethylene oxide), Pluronic P85, is unexpectedly shown to utilize sophisticated cellular trafficking mechanisms and enter brain microvessel endothelial cells and primary neurons that are poorly penetrable. |
6(0,0,1,1) | Details |
| 20074598 | Batrakova EV, Li S, Brynskikh AM, Sharma AK, Li Y, Boska M, Gong N, Mosley RL, Alakhov VY, Gendelman HE, Kabanov AV: Effects of pluronic and doxorubicin on drug uptake, cellular metabolism, apoptosis and tumor inhibition in animal models of MDR cancers. J Control Release. 2010 Jan 13. Pluronic (triblock copolymers of poly (ethylene oxide) (PEO) and poly (propylene oxide) (PPO), PEO-b-PPO-b-PEO) were previously shown to sensitize MDR tumors to antineoplastic agents. This study uses animal models of Lewis lung carcinoma (3LL-M27) and T-lymphocytic leukemia (P388/ADR and P388) derived solid tumors to delineate mechanisms of sensitization of MDR tumors by Pluronic P85 (P85) in vivo. |
4(0,0,0,4) | Details |
| 20000432 | Clover B, Hammouda B: SANS from P85/-d under Pressure. Langmuir. 2009 Dec 10. Pluronics are triblock copolymers of poly (ethylene oxide)-poly (propylene oxide)-poly (ethylene oxide). |
3(0,0,0,3) | Details |
| 16154658 | Yang Z, Zhu J, Sriadibhatla S, Gebhart C, Alakhov V, Kabanov A: Promoter- and strain-selective enhancement of gene expression in a mouse skeletal muscle by a polymer excipient Pluronic P85. J Control Release. 2005 Nov 28;108(2-3):496-512. Epub 2005 Sep 9. Amphiphilic triblock copolymers of ethylene oxide and propylene oxide (Pluronic) significantly enhanced expression of plasmid DNA in the skeletal muscle. |
3(0,0,0,3) | Details |
| 18447367 | Yi X, Batrakova E, Banks WA, Vinogradov S, Kabanov AV: Protein conjugation with amphiphilic block copolymers for enhanced cellular delivery. Bioconjug Chem. 2008 May;19(5):1071-7. Epub 2008 Apr 16. Modification of a model protein, horseradish peroxidase (HRP), with amphiphilic block copolymer poly (ethylene oxide)-b-poly (propylene oxide)-b-poly (ethylene oxide) (Pluronic), was previously shown to enhance the transport of this protein across the blood-brain barrier in vivo and brain microvessel endothelial cells in vitro. Four monoamine Pluronic derivatives (L81, P85, L121, P123) were synthesized and successfully conjugated to a model protein, HRP, via biodegradable or nondegradable linkers (dithiobis (succinimidyl (DSP), dimethyl 3,3'-dithiobispropionimidate (DTBP), and disuccinimidyl propionate (DSS)). |
2(0,0,0,2) | Details |
| 19957968 | Krupka TM, Solorio L, Wilson RE, Wu H, Azar N, Exner AA: Formulation and characterization of echogenic lipid-pluronic nanobubbles. Mol Pharm. 2010 Feb 1;7(1):49-59. In this work, we present a novel strategy for formulation of nanosized, echogenic lipid bubbles by incorporating the surfactant Pluronic, a triblock copolymer of ethylene oxide copropylene oxide coethylene oxide into the formulation. Five Pluronics (L31, L61, L81, L64 and P85) with a range of molecular weights (M (w): 1100 to 4600 Da) were incorporated into the lipid shell either before or after lipid film hydration and before addition of perfluorocarbon gas. |
1(0,0,0,1) | Details |
| 18729495 | Yang Z, Sahay G, Sriadibhatla S, Kabanov AV: Amphiphilic block copolymers enhance cellular uptake and nuclear entry of polyplex-delivered DNA. Bioconjug Chem. 2008 Oct;19(10):1987-94. Epub 2008 Aug 27. Nonionic block copolymers of poly (ethylene oxide) and poly (propylene oxide), Pluronics, are widely used as excipients in pharmaceutics. Addition of Pluronic P123 or P85 to polyethyleneimine-based polyplexes had little effect on polyplex particle size but significantly enhanced pDNA cellular uptake, nuclear translocation, and gene expression in several cell lines. |
1(0,0,0,1) | Details |
| 16706437 | Ganguly R, Aswal VK, Hassan PA, Gopalakrishnan IK, Kulshreshtha SK: Effect of SDS on the self-assembly behavior of the PEO-PPO-PEO triblock copolymer (EO) 20 (PO) 70 (EO) 20. J Phys Chem B. 2006 May 25;110(20):9843-9. The mixed micellar system comprising the poly (ethylene oxide)-poly (propylene oxide)-poly (ethylene oxide)-based triblock copolymer (EO)(20)(PO)(70)(EO)(20) (P123) and the anionic surfactant (SDS) has been investigated in aqueous media by small-angle neutron scattering (SANS) and viscosity measurements. A comparison of the observed results with those for the copolymers (EO)(26)(PO)(40)(EO)(26) (P85) and (EO)(99)(PO)(70)(EO)(99) (F127) suggests that the composition of the copolymers plays a significant role in determining the influence of SDS on the gelation characteristics of the aqueous copolymer solutions. |
1(0,0,0,1) | Details |
| 15271568 | Bergstrand N, Edwards K: Effects of poly (ethylene oxide)-poly (propylene oxide)-poly (ethylene oxide) triblock copolymers on structure and stability of liposomal J Colloid Interface Sci. 2004 Aug 15;276(2):400-7. Upon increasing the copolymer concentration, however, Pluronics with comparably short PPO and PEO segment lengths, such as F87 and P85, could also be used to stabilize the liposomes. |
1(0,0,0,1) | Details |
| 19317476 | George S, Kumbhakar M, Singh PK, Ganguly R, Nath S, Pal H: Fluorescence spectroscopic investigation to identify the micelle to gel transition of aqueous triblock copolymer solutions. J Phys Chem B. 2009 Apr 16;113(15):5117-27. Steady-state and time-resolved fluorescence anisotropy measurements using probes 153 (C153) and 4-heptadecylumbelliferon (HUF) have been carried out to understand the micelle to gel transition of an aqueous triblock copolymer P123 ((EO)(20)-(PO)(70)-(EO)(20)) (EO = ethylene oxide; PO = propylene oxide) solution. Similar studies in other copolymers, such as P85 ((EO)(26)-(PO)(40)-(EO)(26)) and F127 ((EO)(100)-(PO)(65)-(EO)(100)), further demonstrate the potential of probes latched with hydrocarbon chains in displaying a characteristic change for the micelle to gel transition which otherwise remains obscured for normal fluorescent probes. |
1(0,0,0,1) | Details |
| 15982044 | Blomqvist BR, Warnheim T, Claesson PM: Surface rheology of PEO-PPO-PEO triblock copolymers at the air-water interface: comparison of spread and adsorbed layers. Langmuir. 2005 Jul 5;21(14):6373-84. The dilatational rheological properties of monolayers of poly (ethylene oxide)-poly (propylene oxide)-poly (ethylene oxide)-type block copolymers at the air-water interface have been investigated by employing an oscillating ring trough method. The studied polymers were PEO26-PPO39-PEO26 (P85), PEO103-PPO40-PEO103 (F88), and PEO99-PPO65-PEO99 (F127). |
1(0,0,0,1) | Details |