| Name | GSTT1 |
|---|---|
| Synonyms | GST class theta; GST class theta 1; GSTT 1; GSTT1; GSTT1 protein; Glutathione S transferase theta 1; Glutathione transferase T1 1; glutathione S transferase T1… |
| Name | ethylene oxide |
|---|---|
| CAS | oxirane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 12872524 | Thier R, Bruning T, Roos PH, Rihs HP, Golka K, Ko Y, Bolt HM: Markers of genetic susceptibility in human environmental hygiene and toxicology: the role of selected CYP, NAT and GST genes. Int J Hyg Environ Health. 2003 Jun;206(3):149-71. The human polymorphic GST catalysing conjugation of halomethanes, dihalomethanes, ethylene oxide and a number of other industrial compounds could be characterised as a class theta enzyme (GSTT1) by means of molecular biology. "Conjugator" and "non-conjugator" phenotypes are coincident with the presence and absence of the GSTT1 gene. |
39(0,1,2,4) | Details |
| 16874663 | Diedrich A, Bock HC, Konig F, Schulz TG, Ludwig HC, Herken R, Quondamatteo F: Expression of glutathione S-transferase T1 (GSTT1) in human brain tumours. Histol Histopathol. 2006 Nov;21(11):1199-207. Typical substrates for GSTT1 are industrial compounds, such as dichloromethane and ethylene oxide. |
38(0,1,1,8) | Details |
| 15055296 | Norppa H: Cytogenetic biomarkers. IARC Sci Publ. 2004;(157):179-205. These findings may be explained by reduced detoxification capacity rendered by the altered gene and may be linked with exposure to, for example, heterocyclic amines in the case of NAT2 and endogenously formed ethylene oxide in the case of GSTT1. |
32(0,1,1,2) | Details |
| 15668107 | Paulsson B, Rannug A, Henderson AP, Golding BT, Tornqvist M, Warholm M: In vitro studies of the influence of glutathione transferases and epoxide hydrolase on the detoxification of acrylamide and glycidamide in blood. Mutat Res. 2005 Feb 7;580(1-2):53-9. In this experiment individuals carrying GSTT1 showed lower adduct level increments from ethylene oxide than individuals lacking GSTT1. |
7(0,0,1,2) | Details |
| 16918316 | Bolt HM, Thier R: Relevance of the deletion polymorphisms of the glutathione S-transferases GSTT1 and GSTM1 in pharmacology and toxicology. Curr Drug Metab. 2006 Aug;7(6):613-28. |
3(0,0,0,3) | Details |
| 17416773 | Haufroid V, Merz B, Hofmann A, Tschopp A, Lison D, Hotz P: Exposure to ethylene oxide in hospitals: biological monitoring and influence of glutathione S-transferase and epoxide hydrolase polymorphisms. Cancer Epidemiol Biomarkers Prev. 2007 Apr;16(4):796-802. GSTs (GSTT1, GSTM1, and GSTP1) and epoxide hydrolase (EPHX1) were also genotyped. |
2(0,0,0,2) | Details |
| 16386346 | Godderis L, Aka P, Mateuca R, Kirsch-Volders M, Lison D, Veulemans H: Dose-dependent influence of genetic polymorphisms on DNA damage induced by styrene oxide, ethylene oxide and gamma-radiation. Toxicology. 2006 Feb 15;219(1-3):220-9. Epub 2005 Dec 28. In this study we assessed the dose-dependent effect of genetic polymorphisms in biotransforming (EPHX (Tyr113/His113 and His139/Arg139), GSTP1 (Ile105/Val105), GSTM1 and GSTT1) and DNA repair enzymes (hOGG1 (Ser326/Cys326), XRCC1 (Arg194/Trp194, Arg280/His280, Arg399/Gln399), XRCC3 (Thr241/Met241)) on the induced genotoxicity. |
1(0,0,0,1) | Details |