Protein Information

Name hemoglobin (protein family or complex)
Synonyms Hemoglobin; Hemoglobins

Compound Information

Name methylene chloride
CAS dichloromethane

Reference List

PubMed Abstract RScore(About this table)
1900959 Andersen ME, Clewell HJ 3rd, Gargas ML, MacNaughton MG, Reitz RH, Nolan RJ, McKenna MJ: Physiologically based pharmacokinetic modeling with dichloromethane, its metabolite, carbon monoxide, and blood carboxyhemoglobin in rats and humans. Toxicol Appl Pharmacol. 1991 Mar 15;108(1):14-27.

Dichloromethane (methylene chloride, DCM) and other dihalomethanes are metabolized to carbon monoxide (CO) which reversibly binds hemoglobin and is eliminated by exhalation.
82(1,1,1,2) Details
9285047 Cedrati N, Bonneaux F, Labrude P, Maincent P: Structure and stability of human hemoglobin microparticles prepared with a double emulsion technique. Artif Cells Blood Substit Immobil Biotechnol. 1997 Sep;25(5):457-62.

Hemoglobin concentration, surfactant concentration i.e. poly (vinylic alcohol), amounts of polymer and solvent (methylene chloride), duration and speed of stirring.
14(0,0,1,9) Details
7994411 Cedrati N, Maincent P, Thomas F, Labrude P, Vigneron C: Preparation and characterisation of poly (lactic acid) hemoglobin microspheres. Artif Cells Blood Substit Immobil Biotechnol. 1994;22(3):867-73.

An aqueous solution of hemoglobin was emulsified into a solution of polymer in methylene chloride to form a W/O emulsion.
12(0,0,1,7) Details
8286954 Sakai H, Takeoka S, Yokohama H, Seino Y, Nishide H, Tsuchida E: Purification of concentrated hemoglobin using organic solvent and heat treatment. Protein Expr Purif. 1993 Dec;4(6):563-9.

2(0,0,0,2) Details
2753027 Manabe S, Kanai Y, Wada O: Exposure level monitor of 3-amino-1,4-dimethyl-5H-pyrido [4,3-b] indole, a dietary carcinogen, in rabbits. Environ Mol Mutagen. 1989;14(1):34-41.

The present investigation describes a method for the detection of minute amounts of 3-amino-1,4-dimethyl-5H-pyrido [4,3-b] indole (Trp-P-1), a carcinogenic tryptophan pyrolysate, bound to the hemoglobin of erythrocytes and plasma from rabbits dosed orally with the dietary carcinogen.
The method consists of the acid-induced release of the dietary carcinogen adducts as the free carcinogen and their extraction with methylene chloride and subsequent quantitation by high-performance liquid chromatography (HPLC).
2(0,0,0,2) Details
8571372 Krishnan K, Pelekis M: Hematotoxic interactions: occurrence, mechanisms and predictability. Toxicology. 1995 Dec 28;105(2-3):355-64.


The available data on the binary chemical interactions involving hematotoxicants, particularly organic chemicals causing a reduction in either the number of white/red blood cells or the capacity of hemoglobin to transport oxygen, are limited.
1(0,0,0,1) Details