| 17168729 |
Kongkathip N, Hasitapan K, Pradidphol N, Kirtikara K, Jongkona N, Kongkathip B: Synthesis of novel 2-(2'-cyclopentyl)- and 2-(2'-cyclohexyl) substituted 1-naphthol derivatives with anticyclooxygenase activity. Curr Med Chem. 2006;13(30):3663-74.
Two of them, 2-((1-(hydroxymethyl) cyclopentyl) methyl) naphthalene-1-ol (8) and 2-((1-(hydroxymethyl) cyclohexyl) methyl)-naphthalene-1-ol (9) showed anticyclooxygenase activity on COX-2 with IC (50) values of 19.90 microM and 7.77 microM, respectively and 9 also inhibited COX-1 (5.55 microM), while the other six were inactive on both isozymes. |
112(1,2,2,2) |
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