| Name | calmodulin |
|---|---|
| Synonyms | CALM; CAM; CALM 1; CALM 2; CALM 3; CALM1; CALM2; CALM3… |
| Name | naphthalene |
|---|---|
| CAS | naphthalene |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16765480 | Syam Prakash SR, Jayabaskaran C: Heterologous expression and biochemical characterization of two -dependent protein kinase isoforms CaCPK1 and CaCPK2 from chickpea. J Plant Physiol. 2006 Nov;163(11):1083-93. Epub 2006 Jun 12. The kinase activity of the recombinant enzymes was calmodulin independent and sensitive to CaM antagonists W7 [N-(6-aminohexyl)-5-chloro-1-naphthalene sulphonamide] and calmidazoilum. |
82(1,1,1,2) | Details |
| 16912065 | Lee-Kwon W, Goo JH, Zhang Z, Silldorff EP, Pallone TL: Vasa recta voltage-gated Na+ channel Nav1.3 is regulated by calmodulin. . Am J Physiol Renal Physiol. 2007 Jan;292(1):F404-14. Epub 2006 Aug 15. In patch-clamp experiments, Na (V) currents were suppressed by calmodulin inhibitory peptide (CIP; 100 nM) or the CaM inhibitor N-(6-aminohexyl)-5-chloro-1-naphthalene-sulphonamide hydrochloride (W7). |
33(0,1,1,3) | Details |
| 16651714 | Cho HJ, Kang HC, Ju YC, Lee HS, Kim HS, Park HJ: Augmentation of Ca2+-induced microsomal triglyceride transfer protein activity by supply enhances hypertriglyceridemia in vivo. Biol Pharm Bull. 2006 May;29(5):889-95. However, the MTP activity was reduced in response to the calmodulin antagonist N-(6-aminohexyl)-5-chloro-1-naphthalene sulfonamide (W-7, Ki=25 microM), the intracellular Ca2+ chelator BAPTA-AM, and the extracellular Ca2+ chelator EDTA. |
31(0,1,1,1) | Details |
| 18803664 | Li C, Xie W, Bai W, Li Z, Zhao Y, Liu H: Calmodulin binds to maize lipid transfer protein and modulates its lipids binding ability. FEBS J. 2008 Nov;275(21):5298-308. Epub 2008 Sep 17. Furthermore, we tested the effects of CaM on the lipid-binding activity of Zm-LTP in the presence of Ca (2+), EGTA, N-(6-aminohexyl)-5-chloro-1-naphthalene sulfonamide and trifluoperazine respectively. |
2(0,0,0,2) | Details |
| 20172594 | Wang Z, Li S, Shi Q, Yan R, Liu G, Dai K: Calmodulin antagonists induce platelet apoptosis. Thromb Res. 2010 Apr;125(4):340-50. Epub 2010 Feb 20. Here we show that CaM antagonists N-(6-aminohexyl)-5-chloro-1-naphthalene sulfonamide (W7), tamoxifen (TMX), and trifluoperazine (TFP) induce apoptotic events in human platelets, including depolarization of mitochondrial inner transmembrane potential, caspase-3 activation, and exposure. |
2(0,0,0,2) | Details |
| 17507104 | Liu PF, Chang WC, Wang YK, Munisamy SB, Hsu SH, Chang HY, Wu SH, Pan RL: Differential regulation of Ku gene expression in etiolated mung bean hypocotyls by auxins. Biochim Biophys Acta. 2007 Jul-Aug;1769(7-8):443-54. Epub 2007 Apr 10. Further analysis using specific inhibitors of auxin signaling showed that the stimulation of VrKu expression by 2,4-dichlorophenoxyacetic acid (2,4-D) was suppressed by intracellular Ca (2+) chelators, calmodulin antagonists, and /calmodulin dependent protein kinase inhibitors, suggesting the involvement of calmodulin in the signaling pathway. On the other hand, exogenous (IAA) and alpha-naphthalene (NAA) stimulated VrKu expression through the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway. |
1(0,0,0,1) | Details |
| 20116385 | Oleszczuk M, Robertson IM, Li MX, Sykes BD: Solution structure of the regulatory domain of human cardiac troponin C in complex with the switch region of cardiac troponin I and W7: The basis of W7 as an inhibitor of cardiac muscle contraction. J Mol Cell Cardiol. 2010 Jan 29. The solution structure of Ca (2+)-bound regulatory domain of cardiac troponin C (cNTnC) in complex with the switch region of troponin I (cTnI (147-163)) and the calmodulin antagonist, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfinamide (W7), has been determined by NMR spectroscopy. The structure reveals that the W7 naphthalene ring interacts with the terminal methyl groups of M47, M60, and M81 as well as aliphatic and aromatic side chains of several other residues in the hydrophobic pocket of cNTnC. |
1(0,0,0,1) | Details |
| 18726272 | Li C, Xiang Z, Ling Q, Shang K: Effects of calmodulin and calmodulin binding protein BP-10 on phosphorylation of thylakoid membrane protein. Sci China C Life Sci. 1998 Feb;41(1):64-70. At the same time, the phosphorylation can also be inhibited by EGTA or CaM antagonists, such as TFP (trifluoperazine) and W-7 (N-(6-aminohexyl)-5-chloro-l-naphthalene sulfonamide). |
1(0,0,0,1) | Details |