| Name | cardiac troponin C |
|---|---|
| Synonyms | Cardiac troponin C; TN C; TNC; TNNC; TNNC 1; TNNC1; troponin C type 1 (slow); troponin C type 1 (slow)s |
| Name | naphthalene |
|---|---|
| CAS | naphthalene |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17932326 | Robinson P, Griffiths PJ, Watkins H, Redwood CS: Dilated and hypertrophic cardiomyopathy mutations in troponin and alpha-tropomyosin have opposing effects on the affinity of cardiac thin filaments. Circ Res. 2007 Dec 7;101(12):1266-73. Epub 2007 Oct 11. To assess whether this functional phenomenon was a direct result of altered Ca (2+) affinity or was caused by altered troponin-tropomyosin switching, we assessed Ca (2+) binding of the regulatory site of cardiac troponin C in wild-type or mutant troponin complex and thin filaments using a fluorescent probe (2-[4'-{iodoacetamido}aniline]-naphthalene-6-sulfonate) attached to Cys35 of cardiac troponin C. |
81(1,1,1,1) | Details |
| 20116385 | Oleszczuk M, Robertson IM, Li MX, Sykes BD: Solution structure of the regulatory domain of human cardiac troponin C in complex with the switch region of cardiac troponin I and W7: The basis of W7 as an inhibitor of cardiac muscle contraction. J Mol Cell Cardiol. 2010 Jan 29. The structure reveals that the W7 naphthalene ring interacts with the terminal methyl groups of M47, M60, and M81 as well as aliphatic and aromatic side chains of several other residues in the hydrophobic pocket of cNTnC. |
2(0,0,0,2) | Details |
| 18212018 | Lim CC, Yang H, Yang M, Wang CK, Shi J, Berg EA, Pimentel DR, Gwathmey JK, Hajjar RJ, Helmes M, Costello CE, Huo S, Liao R: A novel mutant cardiac troponin C disrupts molecular motions critical for binding affinity and cardiomyocyte contractility. Biophys J. 2008 May 1;94(9):3577-89. Epub 2008 Jan 22. Force-pCa relationships in TnC ((E59D,D75Y)) reconstituted rabbit psoas fibers and fluorescence spectroscopy of TnC ((E59D,D75Y)) labeled with 2-[(4'-iodoacetamide)- naphthalene-6- showed a decrease in myofilament Ca (2+) sensitivity and Ca (2+) binding affinity, respectively. |
1(0,0,0,1) | Details |