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Romero G, Sanchez E, Pujol M, Perez P, Codony X, Holenz J, Buschmann H, Pauwels PJ: Efficacy of selective 5-HT6 receptor ligands determined by monitoring 5-HT6 receptor-mediated cAMP signaling pathways. Br J Pharmacol. 2006 Aug;148(8):1133-43. Epub 2006 Jul 24.
Two novel selective 5-HT6 receptor ligands E-6801 (6-chloro-N-(3-(2-(dimethylamino) ethyl)-1H-indol-5-yl) imidazo [2,1-b] thiazo le-5-sulfonamide) and E-6837 (5-chloro-N-(3-(2-(dimethylamino) ethyl)-1H-indol-5-yl) naphthalene-2-sulfon amide) were investigated and compared to the putative 5-HT6 receptor antagonists SB-271046 (5-chloro-N-(4-methoxy-3-(piperazin-1-yl) phenyl)-3-methylbenzo [b] thiophene -2-sulfonamide) and Ro 04-06790 (N-(2,6-bis (methylamino) pyrimidin-4-yl)-4-aminobenzenesulfonamide) using a cAMP-mediated pathway. 2. |
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