Protein Information

Name CD4
Synonyms CD4; CD4 antigen (p55); CD4 molecule; CD4mut; T cell antigen T4/LEU3; T cell surface glycoprotein CD4; T cell surface antigen T4/Leu 3; T cell surface glycoprotein CD4 precursor…

Compound Information

Name naphthalene
CAS naphthalene

Reference List

PubMed Abstract RScore(About this table)
17056872 Balzarini J, Van Herrewege Y, Vermeire K, Vanham G, Schols D: Carbohydrate-binding agents efficiently prevent dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN)-directed HIV-1 transmission to T lymphocytes. Mol Pharmacol. 2007 Jan;71(1):3-11. Epub 2006 Oct 20.

In this assay, the CD4-down-regulating cyclotriazodisulfonamide derivative, the CXCR4 and CCR5 coreceptor antagonists 1-[[4-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl) phenyl] methyl] - 1,4,8,11 - tetrazacyclotetradecane (AMD3100) and maraviroc, the gp41-binding enfuvirtide, and the polyanionic substances dextran sulfate (M (r) 5000), sulfated polyvinyl alcohol, and the naphthalene sulfonate polymer PRO-2000 were markedly less efficient or even completely ineffective.
32(0,1,1,2) Details
19179267 Bechtel DG, Waldner CL, Wickstrom M: Associations between immune function in yearling beef cattle and airborne polycyclic aromatic hydrocarbons and PM1.0 near oil and natural gas field facilities. Arch Environ Occup Health. 2009 Spring;64(1):47-58.

The researchers evaluated immune system competence by measuring populations of B-lymphocytes and T-lymphocyte subtypes (CD4, CD8, gammadelta, and WC1) in peripheral circulation (n = 469), and systemic antibody production in response to vaccine administration (n = 446).
The mean concentration of PAHs measured in the ambient air of herds monitored in this study was low, with naphthalene being present in the highest concentration (geometric mean = 5.6 ng/m3; geometric standard deviation = 38), followed by 1-methylnaphthalene (geometric mean = 2.2 ng/m3; geometric standard deviation = 12).
1(0,0,0,1) Details