| 17168729 |
Kongkathip N, Hasitapan K, Pradidphol N, Kirtikara K, Jongkona N, Kongkathip B: Synthesis of novel 2-(2'-cyclopentyl)- and 2-(2'-cyclohexyl) substituted 1-naphthol derivatives with anticyclooxygenase activity. Curr Med Chem. 2006;13(30):3663-74.
Two of them, 2-((1-(hydroxymethyl) cyclopentyl) methyl) naphthalene-1-ol (8) and 2-((1-(hydroxymethyl) cyclohexyl) methyl)-naphthalene-1-ol (9) showed anticyclooxygenase activity on COX-2 with IC (50) values of 19.90 microM and 7.77 microM, respectively and 9 also inhibited COX-1 (5.55 microM), while the other six were inactive on both isozymes. |
62(0,2,2,2) |
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| 18922933 |
Subramaniam D, Giridharan P, Murmu N, Shankaranarayanan NP, May R, Houchen CW, Ramanujam RP, Balakrishnan A, Vishwakarma RA, Anant S: Activation of apoptosis by 1-hydroxy-5,7-dimethoxy-2-naphthalene-carboxaldehyde, a novel compound from Aegle marmelos. Cancer Res. 2008 Oct 15;68(20):8573-81.
Immunostaining for CD31 showed that there was a significant reduction in microvessels in the HDNC-treated animals, coupled with decreased cyclooxygenase-2, interleukin-8, and vascular endothelial growth factor mRNA. |
1(0,0,0,1) |
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